KEGG   ENZYME: 2.5.1.83
Entry
EC 2.5.1.83                 Enzyme                                 
Name
hexaprenyl diphosphate synthase [(2E,6E)-farnesyl-diphosphate specific];
HexPS (ambiguous);
hexaprenyl pyrophosphate synthetase (ambiguous);
hexaprenyl diphosphate synthase (ambiguous);
(2E,6E)-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase (adding 3 isopentenyl units)
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
(2E,6E)-farnesyl-diphosphate:3-methylbut-3-en-1-yl-diphosphate farnesyltranstransferase (adding 3 units of 3-methylbut-3-en-1-yl)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate + 3 (3-methylbut-3-en-1-yl diphosphate) = 3 diphosphate + all-trans-hexaprenyl diphosphate [RN:R09245]
Reaction(KEGG)
R09245
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]
Product
diphosphate [CPD:C00013];
all-trans-hexaprenyl diphosphate [CPD:C01230]
Comment
The enzyme prefers farnesyl diphosphate to geranylgeranyl diphosphate as an allylic substrate and does not show activity for geranyl diphosphate and prenyl diphosphate [1].
History
EC 2.5.1.83 created 1984 as EC 2.5.1.33, part transferred 2010 to EC 2.5.1.83
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K05355  hexaprenyl-diphosphate synthase
K21274  hexaprenyl-diphosphate synthase small subunit
K21275  hexaprenyl-diphosphate synthase large subunit
Genes
QSU111992756 112011202
CMECYME_CMJ246C
SCEYBR003W(COQ1)
SEUBDI49_0184
SPAOSPAR_B01070
AGOAGOS_AER004W
ERCEcym_5300
KLAKLLA0_E17183g
KMXKLMA_60114(COQ1)
LTHKLTH0G16368g
VPOKpol_1036p41
ZROZYRO0A04620g
CGRCAGL0C04257g
NCSNCAS_0I01970(NCAS0I01970)
NDINDAI_0A06570(NDAI0A06570)
TPFTPHA_0A04460(TPHA0A04460)
TBLTBLA_0F00560(TBLA0F00560)
TDLTDEL_0D04200(TDEL0D04200)
TGBHG536_0G03050
KAFKAFR_0F02550(KAFR0F02550)
KNGKNAG_0J01180(KNAG0J01180)
ZMKHG535_0C02340
PPAPAS_chr4_0819
DHADEHA2B02640g
PICPICST_86778(COQ1)
PGUPGUG_02562
SPAASPAPADRAFT_59987
LELLELG_00499
CALCAALFM_CR00570WA(CaO19.7478)
CTPCTRG_01016
COTCORT_0A03790
CDUCD36_25670
CTENCANTEDRAFT_111901
YLIYALI0C18755g
CLUCLUG_04350
CLUSA9F13_04g01595
CAURCJI97_000697
SLBAWJ20_394(COQ1)
PKZC5L36_0D01990
BNNFOA43_001379
BBRXBRETT_002538
OPAHPODL_03901
SLUDSCDLUD_002533
NCRNCU02305
NTENEUTE1DRAFT124027(NEUTE1DRAFT_124027)
SMPSMAC_08723
PANPODANSg1807
TTTTHITE_2117141
MTMMYCTH_2308814
CTHRCTHT_0016730
MGRMGG_03343
PPEIPpBr36_06486
SSCKSPSK_04068
FGRFGSG_10933
FPUFPSE_06046
FVRFVEG_11617
FOXFOXG_12870
NHENECHADRAFT_93238
TRETRIREDRAFT_68728
TRRM419DRAFT_38563
MAWMAC_09061
MAJMAA_03330
CMTCCM_00496
PLJVFPFJ_02060 VFPFJ_08069
VALVDBG_03289
VDAVDAG_02194
CFJCFIO01_07326
CLUPCLUP02_12999
CHIGCH63R_12248
SAPOSAPIO_CDS3842
ELAUCREL1_11765
PFYPFICI_14449
SSLSS1G_11088
BFUBCIN_02g05540(Bccoq1)
MBEMBM_07123
PSCOLY89DRAFT_649566
GLZGLAREA_07665
AFMAFUA_3G06120
ACTACLA_034080
NFINFIA_071130
AORAO090020000085
ANGANI_1_1348094(An11g10370)
AFVAFLA_010570
ALUCAKAW2_80893A(COQ1)
ACHEACHE_70473A(COQ1)
PCSPc20g07830
PDPPDIP_00870
TMFPMAA_004110
TRGTRUGW13939_11219
CIMCIMG_00484
CPWCPC735_057400
UREUREG_00522
PBLPAAG_05961
ABEARB_07252
TVETRV_03960
AJEHCAG_01245
BGHBDBG_06739
PNOSNOG_03045
PTEPTT_13690
BZECOCCADRAFT_107085
BSCCOCSADRAFT_169302
BORCOCMIDRAFT_22591
AALTCC77DRAFT_951220
ZTRMYCGRDRAFT_73426(COQ1)
PFJMYCFIDRAFT_72669
FFUCLAFUR5_09538
BCOMBAUCODRAFT_34812
NPAUCRNP2_7312
TMLGSTUM_00003780001
SPOSPBPJ4664.01(dps1)
CNECNI01740
CNBCNBH1650
CNGCNAG_04375
CGICGB_H2490W
TMSTREMEDRAFT_15595
PPLPOSPLDRAFT_90841
TVSTRAVEDRAFT_157916
DSQDICSQDRAFT_173926 DICSQDRAFT_176811
PCOPHACADRAFT_168921
SHSSTEHIDRAFT_71092
HIRHETIRDRAFT_308186
PSQPUNSTDRAFT_25993
ADLAURDEDRAFT_110102
FMEFOMMEDRAFT_136957
GTRGLOTRDRAFT_67486
LBCLACBIDRAFT_251291 LACBIDRAFT_335947
CCICC1G_00492 CC1G_05865
ABPAGABI1DRAFT117445(AGABI1DRAFT_117445) AGABI1DRAFT121951(AGABI1DRAFT_121951)
ABVAGABI2DRAFT123328(AGABI2DRAFT_123328) AGABI2DRAFT214023(AGABI2DRAFT_214023)
PCUBJR316_0011391
MPRMPER_08383
MRRMoror_7207 Moror_8053
MOREE1B28_001638 E1B28_004206
SCMSCHCO_02488796(SCHCODRAFT_02488796) SCHCO_02492233(SCHCODRAFT_02492233) SCHCO_02641733(SCHCODRAFT_02641733) SCHCO_02697952(SCHCODRAFT_02697952)
CPUTCONPUDRAFT_116134
SLASERLADRAFT_444711
WSEWALSEDRAFT_59360
WICJ056_004047
UMAUMAG_11674
PFPPFL1_02050
MGLMGL_1241
MRTMRET_2902
MSYMMSY001_0654
PGRPGTG_00683
MLRMELLADRAFT_102532
DFADFA_03641(coq1)
PYOPY17X_0301300
PCBPCHAS_0303000
PBEPBANKA_0300800
PKNPKNH_0418400
PVXPVX_003575
PCYPCYB_042740
FCYFRACYDRAFT_275453
PSOJPHYSODRAFT_336262
GTTGUITHDRAFT_86821
MCLMCCL_1121(hepB2) MCCL_1123(hepB1)
MCAKMCCS_13080(hexs-b) MCCS_13100(hexs-a)
MACRBHM04_03485 BHM04_03495
MBOEHT586_07190 HT586_07200
MARYLAU42_05990 LAU42_06000
MBRUMGG13_06470 MGG13_06480
MEPIKFV12_07710 KFV12_07720
MEQUKFV11_06170
 » show all
Reference
1  [PMID:7174655]
  Authors
Fujii H, Koyama T, Ogura K.
  Title
Hexaprenyl pyrophosphate synthetase from Micrococcus luteus B-P 26. Separation of two essential components.
  Journal
J Biol Chem 257:14610-2 (1982)
  Sequence
Reference
2  [PMID:9515931]
  Authors
Shimizu N, Koyama T, Ogura K
  Title
Molecular cloning, expression, and characterization of the genes encoding the two essential protein components of Micrococcus luteus B-P 26 hexaprenyl diphosphate synthase.
  Journal
J Bacteriol 180:1578-81 (1998)
DOI:10.1128/JB.180.6.1578-1581.1998
  Sequence
Reference
3  [PMID:11514159]
  Authors
Nagaki M, Kimura K, Kimura H, Maki Y, Goto E, Nishino T, Koyama T
  Title
Artificial substrates of medium-chain elongating enzymes, hexaprenyl- and heptaprenyl diphosphate synthases.
  Journal
Bioorg Med Chem Lett 11:2157-9 (2001)
DOI:10.1016/S0960-894X(01)00391-2
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.83
IUBMB Enzyme Nomenclature: 2.5.1.83
ExPASy - ENZYME nomenclature database: 2.5.1.83
BRENDA, the Enzyme Database: 2.5.1.83
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