KEGG   ENZYME: 2.6.1.103
Entry
EC 2.6.1.103                Enzyme                                 

Name
(S)-3,5-dihydroxyphenylglycine transaminase;
HpgT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate [RN:R06634]
Reaction(KEGG)
R06634;
(other) R06626
Substrate
(S)-3,5-dihydroxyphenylglycine [CPD:C12026];
2-oxoglutarate [CPD:C00026]
Product
2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.6.1.103 created 2013
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16423  (S)-3,5-dihydroxyphenylglycine transaminase
Genes
SMAF: D781_2332
SERM: CLM71_12105
SRHZ: FO014_21605
RBAD: H2866_19100
DDA: Dd703_3064
PLU: plu1105
PLUM: A4R40_05450
XAL: XALC_1062
XTN: FD63_09735 FD63_09805
VEU: IXK98_24045
HCH: HCH_01676
BGU: KS03_3097
BGO: BM43_2883
SCO: SCO3227(SCE63.06)
SHY: SHJG_1205
SMAL: SMALA_7754
SBH: SBI_01124
SALS: SLNWT_0925
SALU: DC74_566
SALL: SAZ_03325
STRE: GZL_08684
SLAU: SLA_6886
SFK: KY5_6710c
NDA: Ndas_1742
NAL: B005_2520
NCX: Nocox_13270(noc3)
AMI: Amir_4591
ACTI: UA75_15375
ACAD: UA74_14805
SAQ: Sare_2660
MIL: ML5_4924
PRY: Prubr_36830(avtA_2) Prubr_64980
CATI: CS0771_77040(avtA_3)
CAI: Caci_3266
 » show all
Reference
1
  Authors
Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H.
  Title
Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin.
  Journal
Chem Comm 1252-1253 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.103
IUBMB Enzyme Nomenclature: 2.6.1.103
ExPASy - ENZYME nomenclature database: 2.6.1.103
BRENDA, the Enzyme Database: 2.6.1.103
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