KEGG   ENZYME: 2.6.1.103
Entry
EC 2.6.1.103                Enzyme                                 
Name
(S)-3,5-dihydroxyphenylglycine transaminase;
HpgT
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
(S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
(S)-3,5-dihydroxyphenylglycine + 2-oxoglutarate = 2-(3,5-dihydroxyphenyl)-2-oxoacetate + L-glutamate [RN:R06634]
Reaction(KEGG)
R06634;
(other) R06626
Substrate
(S)-3,5-dihydroxyphenylglycine [CPD:C12026];
2-oxoglutarate [CPD:C00026]
Product
2-(3,5-dihydroxyphenyl)-2-oxoacetate [CPD:C12325];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-5'-phosphate protein. The enzyme from the bacterium Amycolatopsis orientalis catalyses the reaction in the reverse direction as part of the biosynthesis of the (S)-3,5-dihydroxyphenylglycine constituent of the glycopeptide antibiotic chloroeremomycin.
History
EC 2.6.1.103 created 2013
Pathway
ec00261  Monobactam biosynthesis
ec01055  Biosynthesis of vancomycin group antibiotics
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K16423  (S)-3,5-dihydroxyphenylglycine transaminase
Genes
SMAFD781_2332
SERMCLM71_12105
SRHZFO014_21605
RBADH2866_19100
DDADd703_3064
PLUplu1105
PLUMA4R40_05450
XALXALC_1062
XTNFD63_09735 FD63_09805
XEUXSP_002199
XHDLMG31886_20750(hpgT)
XPRMUG10_21485
VEUIXK98_24045
PFEPSF113_4198
PBAPSEBR_a4101
PBCCD58_21635
PYMAK972_5188
PVKEPZ47_20770
PBZGN234_26590
PZAHU749_021600
PLZS4054249_22560
HCHHCH_01676
HAHEENC22_22240
HHHCLM76_06050
BGLbglu_1g22660
BGUKS03_3097
BGDbgla_1g16570
BGOBM43_2883
BGPBGL_1c14500
BPLAbpln_1g14050
PMEGFNZ07_11715
AGEAA314_04079
MBDMEBOL_005603
CFUSCYFUS_001036 CYFUS_002910
NTPCRH09_30900
NHUH0264_30790
SCOSCO3227(SCE63.06)
SVLStrvi_8790
SHYSHJG_1205
SHOSHJGH_1040
SRCM271_00255 M271_09150 M271_27675
SMALSMALA_7754
SSOII1A49_42605
SBHSBI_01124
SALSSLNWT_0925
SALUDC74_566
SALLSAZ_03325
SLVSLIV_21555
SVTSVTN_32170
STREGZL_08684
SLCSL103_26555
SXISXIM_47470
STRCAA958_31860
SAMBSAM23877_5650
SPRISPRI_0187 SPRI_7166
SPAVSpa2297_02905 Spa2297_26655 Spa2297_33005
SKYD0C37_02205 D0C37_28250
SALWCP975_31975 CP975_34470
SPHWNFX46_23640
SNRSNOUR_39370
SPLULK06_002720 LK06_031575
SSIAA7J05_04095
SLAUSLA_6886
STROSTRMOE7_29135
SFKKY5_6710c
SCYAEJ357_01675
SKACP970_03000 CP970_07095 CP970_09770
SGZC0216_32515
SRKFGW37_00525
SGALCP966_31745
SVRCP971_02380 CP971_08180
SFYGFH48_02900 GFH48_36335
SAQUEJC51_23020
SBYH7H31_03470
SRIMCP984_06495
SFUGCNQ36_25595
STSUB7R87_00125 B7R87_00860
SCHACP983_01440 CP983_10840
SGXH4W23_38365
SSPBCP982_06160
SATAC5746_00985 C5746_42250
SVDCP969_02975
SAUHSU9_002095
SROIIAG44_40620
SXNIAG42_36490
SANUK7396_35170
SGOBtest1122_04790
SINEKI385_01590
SDURM4V62_39100
KSKKSE_65200 KSE_67440
KAUB6264_25025 B6264_28335
KITCFP65_1243
STRHGXP74_22690 GXP74_26135
ABRYNYE86_02915
KFLKfla_4129 Kfla_6051
KQIF1D05_14900
NDANdas_1742
NALB005_2520
ACTWF7P10_10130
AGRAAGRA3207_002323
NOABKM31_54170
NCXNocox_13270(noc3)
NGNLCN96_07970
FRAFrancci3_2452
AOIAORI_1491 AORI_5327
AJAAJAP_32060
AMYBBKN51_28925 BKN51_41500
AORISD37_16615 SD37_33665
AROONQK81_15430
AMIAmir_4591
SSYIEKG83_29585 EKG83_30970
KALKALB_1757 KALB_6130
ACTIUA75_15375
ACADUA74_14805
ACTAC1701_23415
STPStrop_2477
SAQSare_2660
MAUMicau_3467
MILML5_4924
MICBMicB006_2521
MTUACSH63_07710
MICHFJK98_16510
MTEMGCE86_08080 GCE86_13305
MCABHXZ27_18280
MSAGGCM10017556_53940(avtA) GCM10017556_56510
VMAVAB18032_22225
PFLAPflav_007670
PSUUPsuf_064710
ATLAthai_14020
PRYPrubr_36830(avtA_2) Prubr_64980
CATICS0771_77040(avtA_3)
DVCDvina_13755
DFUDfulv_12395
DAURDaura_12880
CAICaci_3266
AEYCDG81_10665
SCORJ3U87_23940
COYHF329_09890
 » show all
Reference
1
  Authors
Sandercock, A.M., Charles, E.H., Scaife, W., Kirkpatrick, P.N., O'Brien, S.W., Papageorgiou, E.A., Spencer, J.B. and Williams, D.H.
  Title
Biosynthesis of the di-meta-hydroxyphenylglycine constituent of the vancomycin-group antibiotic chloroeremomycin.
  Journal
Chem Comm 1252-1253 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.103
IUBMB Enzyme Nomenclature: 2.6.1.103
ExPASy - ENZYME nomenclature database: 2.6.1.103
BRENDA, the Enzyme Database: 2.6.1.103
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