KEGG   ENZYME: 2.6.1.111
Entry
EC 2.6.1.111                Enzyme                                 
Name
3-aminobutanoyl-CoA transaminase;
kat (gene name);
acyl-CoA beta-transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
3-aminobutanoyl-CoA:2-oxoglutarate aminotransferase
Reaction(IUBMB)
3-aminobutanoyl-CoA + 2-oxoglutarate = acetoacetyl-CoA + L-glutamate [RN:R11607]
Reaction(KEGG)
R11607
Substrate
3-aminobutanoyl-CoA [CPD:C05117];
2-oxoglutarate [CPD:C00026]
Product
acetoacetyl-CoA [CPD:C00332];
L-glutamate [CPD:C00025]
Comment
The enzyme, found in bacteria, is part of a L-lysine degradation pathway. The enzyme is also active with other beta-amino compounds such as 3-amino-5-methylhexanoyl-CoA and 3-amino-3-phenylpropanoyl-CoA.
History
EC 2.6.1.111 created 2017
Orthology
K21585  3-aminobutanoyl-CoA transaminase
Genes
DTI: Desti_1824
HALS: D7D81_18035
IFN: GM661_14600
SPLA: CP981_00370
SMOB: J7W19_02365
GGR: HKW67_04175
BEG: INE88_04059(kat)
CACI: CLOAM0809
Reference
1  [PMID:21826218]
  Authors
Perret A, Lechaplais C, Tricot S, Perchat N, Vergne C, Pelle C, Bastard K, Kreimeyer A, Vallenet D, Zaparucha A, Weissenbach J, Salanoubat M
  Title
A novel acyl-CoA beta-transaminase characterized from a metagenome.
  Journal
PLoS One 6:e22918 (2011)
DOI:10.1371/journal.pone.0022918
  Sequence
[caci:CLOAM0809]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.111
IUBMB Enzyme Nomenclature: 2.6.1.111
ExPASy - ENZYME nomenclature database: 2.6.1.111
BRENDA, the Enzyme Database: 2.6.1.111
LinkDB

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