KEGG   ENZYME: 2.6.1.6
Entry
EC 2.6.1.6                  Enzyme                                 
Name
leucine transaminase;
L-leucine aminotransferase;
leucine 2-oxoglutarate transaminase;
leucine aminotransferase;
leucine-alpha-ketoglutarate transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-leucine:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate [RN:R01090]
Reaction(KEGG)
R01090;
(other) R01214
Substrate
L-leucine [CPD:C00123];
2-oxoglutarate [CPD:C00026]
Product
4-methyl-2-oxopentanoate [CPD:C00233];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. This enzyme differs from EC 2.6.1.42, branched-chain-amino-acid transaminase, in that it does not act on L-valine or L-isoleucine, although it does act on L-methionine. The mitochondrial form from rat liver differs in physical characteristics from the cytoplasmic form.
History
EC 2.6.1.6 created 1961, modified 1982
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00290  Valine, leucine and isoleucine biosynthesis
ec00770  Pantothenate and CoA biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:4968655]
  Authors
Aki K, Ogawa K, Ichihara A.
  Title
Transaminases of branched chain amino acids. IV. Purification and properties of two enzymes from rat liver.
  Journal
Biochim Biophys Acta 159:276-84 (1968)
DOI:10.1016/0005-2744(68)90076-4
Reference
2  [PMID:974100]
  Authors
Ikeda T, Konishi Y, Ichihara A.
  Title
Transaminase of branched chain amino acids. XI. Leucine (methionine) transaminase of rat liver mitochondria.
  Journal
Biochim Biophys Acta 445:622-31 (1976)
DOI:10.1016/0005-2744(76)90115-7
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.6
IUBMB Enzyme Nomenclature: 2.6.1.6
ExPASy - ENZYME nomenclature database: 2.6.1.6
BRENDA, the Enzyme Database: 2.6.1.6
CAS: 9030-37-9
LinkDB

KEGG   REACTION: R01090
Entry
R01090                      Reaction                               
Name
L-leucine:2-oxoglutarate aminotransferase
Definition
L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
Equation
C00123 + C00026 <=> C00233 + C00025
Reaction class
RC00006  C00025_C00026  C00123_C00233
Enzyme
2.6.1.6         2.6.1.42        2.6.1.67
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00290  Valine, leucine and isoleucine biosynthesis
rn00966  Glucosinolate biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00036  Leucine degradation, leucine => acetoacetate + acetyl-CoA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.6
     R01090  L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
    2.6.1.42
     R01090  L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
    2.6.1.67
     R01090  L-Leucine + 2-Oxoglutarate <=> 4-Methyl-2-oxopentanoate + L-Glutamate
Orthology
K00826  branched-chain amino acid aminotransferase [EC:2.6.1.42]
Other DBs
RHEA: 18324
LinkDB

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