Entry
Name
taurine---pyruvate aminotransferase;
Tpa
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
BRITE hierarchy
Sysname
taurine:pyruvate aminotransferase
Reaction(IUBMB)
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:
R05652 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC
2.6.1.55 , taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
History
EC 2.6.1.77 created 2003
Pathway
ec00430 Taurine and hypotaurine metabolism
Orthology
K03851 taurine-pyruvate aminotransferase
Genes
PMAO : PMYSY11_0934(hpa_tpa)
NJP : NEJAP_1517 NEJAP_3251
MAQU : Maq22A_c21465(bioA)
RFU : ROLI_002810(hpa_tpa)
KVL : KVU_0494(yhxA) KVU_0941(tpa)
PPIC : PhaeoP14_02649(tpa)
SINL : DSM14862_03101(tpa)
SPSE : SULPSESMR1_03483(tpa)
RMM : ROSMUCSMR3_02376(tpa)
LALG : LentiSH36_00033(tpa)
LVS : LOKVESSMR4R_02315(tpa)
PALW : PSAL_028160(hpa_tpa)
PSHQ : F3W81_15520 F3W81_16595
FAP : GR316_08615 GR316_12565
BAZ : BAMTA208_04320(yhxA)
BWE : BcerKBAB4_1524 BcerKBAB4_3172
BWW : bwei_1477(tpa) bwei_3380(tpa)
BMYO : BG05_2542 BG05_4284
BTY : Btoyo_0519 Btoyo_4240
BNT : GSN03_08150 GSN03_16365
BFD : NCTC4823_01351(tpa_5) NCTC4823_02711(tpa_6)
BBAD : K7T73_04730 K7T73_07315
BACA : FAY30_14100 FAY30_25625
BARD : QRY57_09800 QRY57_17265
BCOH : BC6307_05660 BC6307_15990
OJD : NP439_03395 NP439_09765
OON : NP440_05060 NP440_09745
PARG : PspKH34_24170(bioA_2)
LSP : Bsph_0922 Bsph_2005 Bsph_2223
LFU : HR49_15100 HR49_16385 HR49_21455
LYS : LBYS11_02380 LBYS11_07100 LBYS11_07965
LCAP : ICJ70_16250 ICJ70_17135 ICJ70_22085
LIU : OU989_02170 OU989_07000 OU989_07925
HNZ : P9989_04280 P9989_17480
HSHI : MUO14_09665 MUO14_15240 MUO14_17615
VIL : CFK37_09915 CFK37_10510
VNE : CFK40_05260 CFK40_05890
VIK : KFZ58_06130 KFZ58_15090
LAO : AOX59_17185 AOX59_17360
BSJ : UP17_09745 UP17_13145 UP17_14580
BMUR : ABE28_010400 ABE28_012275
PBUT : DTO10_00525 DTO10_23550 DTO10_26010
PFRI : L8956_10770 L8956_13440
PERI : RE409_11825 RE409_15765
GSM : MUN87_17480 MUN87_19815 MUN87_19825
NMK : CHR53_13300 CHR53_16990
BLEN : NCTC4824_02911(tpa)
SFOR : QNH23_02720 QNH23_09105
DOM : RRU94_03670 RRU94_03695
PBD : PBOR_26460 PBOR_34365
ANX : ACH33_08470 ACH33_09925
ATHE : K3F53_09095 K3F53_10350
FFE : LSG31_01440 LSG31_18475
SPSY : AZE41_14385 AZE41_20715
SOW : QWT69_01185 QWT69_03160 QWT69_06175
SSPH : SPSPH_029660(hpa_tpa)
» show all
Taxonomy
Reference
Authors
Laue H, Cook AM.
Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
Journal
Sequence
Reference
Authors
Cook AM, Denger K.
Title
Dissimilation of the C2 sulfonates.
Journal
Reference
Authors
Masepohl B, Fuhrer F, Klipp W.
Title
Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.
Journal
Reference
Authors
Felux AK, Denger K, Weiss M, Cook AM, Schleheck D
Title
Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.77
ExPASy - ENZYME nomenclature database: 2.6.1.77
LinkDB
All DBs