KEGG   ENZYME: 2.6.1.84
Entry
EC 2.6.1.84                 Enzyme                                 
Name
arginine---pyruvate transaminase;
arginine:pyruvate transaminase;
AruH;
ATase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-arginine:pyruvate aminotransferase
Reaction(IUBMB)
L-arginine + pyruvate = 5-guanidino-2-oxopentanoate + L-alanine [RN:R08197]
Reaction(KEGG)
R08197
Substrate
L-arginine [CPD:C00062];
pyruvate [CPD:C00022]
Product
5-guanidino-2-oxopentanoate [CPD:C03771];
L-alanine [CPD:C00041]
Comment
A pyridoxal-phosphate protein. While L-arginine is the best substrate, the enzyme exhibits broad substrate specificity, with L-lysine, L-methionine, L-leucine, L-ornithine and L-glutamine also able to act as substrates, but more slowly. Pyruvate cannot be replaced by 2-oxoglutarate as amino-group acceptor. This is the first catalytic enzyme of the arginine transaminase pathway for L-arginine utilization in Pseudomonas aeruginosa. This pathway is only used when the major route of arginine catabolism, i.e. the arginine succinyltransferase pathway, is blocked.
History
EC 2.6.1.84 created 2007
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K12252  arginine:pyruvate transaminase
Genes
VZIG5S32_08435
PAEPA4976(aruH)
PAEVN297_5148
PAEIN296_5148
PAUPA14_65770(aspC)
PAPPSPA7_5709(aspC)
PAGPLES_53641(aruH)
PAFPAM18_5087(aruH)
PNCNCGM2_0542(aspC)
PAEBNCGM1900_5724(aspC)
PDKPADK2_26370
PSGG655_26225
PRPM062_26235
PAEPPA1S_26990
PAERPA1R_gp2899
PAEMU769_27255
PAELT223_27450
PAESSCV20265_5639
PAEUBN889_05521(aruH)
PAEGAI22_07005
PAECM802_5146
PAEOM801_5013
PREPCA10_09720 PCA10_40340(aspC)
PFUWKF707C_9000
PCQPcP3B5_02230(aruH)
PMUIG4G71_03200 G4G71_27455
PPUPP_3721(aruH)
PPFPput_2042
PPGPputGB1_2185
PPWPputW619_2796
PPTPPS_3189
PPBPPUBIRD1_2041(aspC)
PPIYSA_09437
PPXT1E_1732(aspC)
PPUHB479_15825
PPUTL483_19365
PPUNPP4_21010(aspC)
PPUDDW66_3460
PMONX969_15335
PMOTX970_14980
PMOSO165_008755
PPJRK21_01449
PMOLCLJ08_24785
PFLPFL_2715(aruH) PFL_3354 PFL_5024
PPRCPFLCHA0_c27760(aspC2) PFLCHA0_c33840(aspC3)
PPROPPC_2762(aruH) PPC_3378
PFEPSF113_2328
PFOPfl01_2905
PFBVO64_0254
PMANOU5_0567 OU5_1090 OU5_1975
PTVAA957_00235
PAZOAYR47_22180
PMEDE3Z27_16900
PFWPF1751_v1c26370
PFXA7318_13560
PENPSEEN3003(aspC)
PBAPSEBR_a3399
PBCCD58_12060
PPUUPputUW4_02429 PputUW4_02748 PputUW4_03176
PDRH681_05055 H681_24930
PSVPVLB_11490
PSKU771_16930
PKCPKB_0124(aspc1) PKB_4718
PCHEY04_16645
PCZPCL1606_27200 PCL1606_34600
PCPJM49_14095
PALKPSAKL28_23960 PSAKL28_27660
PSEMTO66_13290 TO66_17300
PSECCCOS191_2783(aruH)
PSOSPOS17_2711(aruH) POS17_3331
PKRAYO71_17595
PFKPFAS1_25360
PANRA7J50_2814
PSETTHL1_1027 THL1_3997
PSILPMA3_15850
PYMAK972_2938
PKEDLD99_15205
PUMHGP31_15755 HGP31_15870 HGP31_16595
POJPtoMrB4_51000(aruH_2)
PGYAWU82_13100
PLALFXN65_04505 FXN65_08195
PVKEPZ47_11875
PEZHWQ56_12395
PBZGN234_06360
PMAOPMYSY11_3758(aruH)
PATAJWU58_12635
PDWBV82_3153 BV82_5127
PZEHU754_013580
PMOEHV782_014290
PSEPC4K39_2740 C4K39_4608 C4K39_5322
PVWHU752_013325
PTZHU718_014235
PQIKH389_11595
PSHHHU773_005780
PXNHU772_014345
PHVHU739_003585
PMUYKSS95_16865
PMAMKSS90_13625
PAZEKSS91_13350 KSS91_15425 KSS91_17540
PALVKSS97_11295
PORYEJA05_14670 EJA05_15310
PTKEXN22_14850 EXN22_15085
PTWTUM18999_04140(aruH)
PZAHU749_018240
PIEHU724_015855
PWYHU734_015260
PTAENCTC10697_02325(aspC_1)
PGFJ0G10_16910
PCAVD3880_08975
COLWA3Q33_05690
CBERB5D82_00655
AALEP13_17935
AAUSEP12_18740
SAGAM5M_04555
MTHDA3224_03285
MICCAUP74_01586(aruH_1) AUP74_02850(aruH_2)
MAGAMag101_09640 Mag101_13965
MIIBTJ40_03595
MICTFIU95_03540(aruH)
MHYDGTQ55_04695 GTQ55_10565
MCELLPW13_11100
MICZGL2_06580(aruH)
GAIIMCC3135_11970(aruH_1)
CSACsal_0536
HELHELO_2764(aruH)
HHUAR456_09240
HBEBEI_1553(aruH)
HAFC8233_03405
HTTHZS52_22740
CMAIBFX80_10085
CAMHLCW13_07820
CRZD1345_05740
CHAECH06BL_12510(aruH)
BCENDM39_3804
BCTGEM_4550
BPSLWS57_08055
BANNJFN94_23195
BUGBC1001_3734
BGFBC1003_3781
BUQAC233_20655
BUMAXG89_35180
BUIAX768_17330
BXEBxe_B1173
BXBDR64_6490
BGEBC1002_4015 BC1002_6946
BPXBUPH_00300
BPYBphyt_5434
BFNOI25_6931
PSPWBJG93_26095 BJG93_27760
PARBCJU94_23330
PGPCUJ91_22775
PCJCUJ87_22160
PTSCUJ90_29950
PCAFDSC91_001246
PTROG5S35_19210
PGISI6I06_23795
PACPFAZ97_15790
PACSFAZ98_20385
PDIOPDMSB3_1932.1(aruH)
CABASBC2_40600(aruH)
PACRFXN63_02030
LLUAKJ09_11325
MLOmlr1282
MLNA9174_20005
MCIMesci_3330
MOPMesop_3821
MAMMesau_03610
MAMOA6B35_21965
MESWA9K65_018015
MESMEJ066_25830
MESPC1M53_24215
MHUAMCHK_2912
MJREB229_19765
MERDEB233_17100
MESRFGU64_05435
MESOBSQ44_15810
MESMeso_1479
HOEIMCC20628_02962
AAKAA2016_2971
AMIHCO731_02952(aruH)
PHTBLM14_07955
NIYFQ775_22805
NKIKW403_01440
SMESMc02262(aspC)
SMKSinme_0209
SMQSinmeB_0186
SMXSM11_chr0192(aspC)
SMIBN406_00201
SMEGC770_GR4Chr0562
SMELSM2011_c02262(aspC)
SMERDU99_02980
SMDSmed_0178
RHINGR_c01980
SFHSFHH103_00217
SFDUSDA257_c01790(aspC2)
SIXBSY16_2654
SAMESAMCFNEI73_Ch0558(aspC)
SINOSS05631_c01920
EADOV14_1495
EAHFA04_01000
ESJSJ05684_c01780
EAKEKH55_0174
EMXFKV68_03275
ARUIG6M88_23055
NGLRG1141_CH32880(aruH)
NGGRG540_CH33690
NEOCYG48_12085
NENNCHU2750_30720(aruH)
RHTNT26_2963(aspC)
RFVRFYW14_03045
SHZshn_00815
SZOK8M09_01185
SOJK6301_01035
OINIAR37_19830
PSCQKHQ08_05840
LNEFZC33_23945
APOLK9D25_11640
MEYTM49_20655
MAADAZF01_01000
MMEDMame_04622(aruH)
MLUTJET14_02205
NOHG5V57_07020
LAPACP90_08715
LABRCHH27_11905
LABPFJ695_12295
LABTFIU93_14270(aruH)
LAGGB0E33_20790
ACUTMRB58_04725
SILSPO2132(aspC-3) SPOA0066
SITTM1040_3605
RUAD1823_04845 D1823_17940
RUTFIU92_08160(aruH1) FIU92_13435(aruH2)
JANJann_1956
RDERD1_3185(aspC)
RLIRLO149_c024100(aspC)
RPONG3256_07130
PGAPGA1_262p02330
PGLPGA2_239p2060
PGDGal_03952
PHPPhaeoP97_03759
PPICPhaeoP14_03656
PHQD1820_17525
OATOAN307_c22570(aspC)
OAROA238_c22200(aspC)
OTMOSB_16290(aruH)
OCTFTO60_08170
LMDMETH_14760
LEJETW24_15690
LAQUR2C4_03470
REDroselon_03069
MALGMALG_01400
YPACCEW88_06400 CEW88_20105
YANAYJ57_13545
SUAMBOO69_10325
SULZC1J03_09245
SULIC1J05_09180
SULDB5M07_09490
SPOTG6548_10720
SMEDJNX03_05665
SINLDSM14862_02675(aruH)
SPSESULPSESMR1_01753(aruH)
TOMBWR18_08205
RMMROSMUCSMR3_01198(aruH)
ROKRAK1035_0146
RIDRIdsm_02296(aruH)
ROMEI983_10800
ROHFIU89_08135(aruH)
AHTANTHELSMS3_03017(aruH)
SAGUCDO87_01160
THAACFI11_10485
ROTFIV09_08090(aruH)
RMHLVO79_06820
MALUKU6B_22800
TGLHFZ77_03005
PALXGQA70_08045
LSALKBK07_06510
RHPLPB142_08990
RBLB6K69_07060
PAMIJCM7686_2718
PARSDRW48_10140
PTPRCA23_c16670(aspC3)
RMBK529_019675
DAAAKL17_1923
LVSLOKVESSMR4R_02264(aruH)
GEHHYN69_13810
GFUKM031_13540
TAWEI545_07470
SALOEF888_12205
SEDIEBB79_11325
HMLHmaOT1_04045
BOOE2K80_07675
PPRUFDP22_01915
PAEDG5B38_10600
PAMOBAR1_07280
POZI0K15_16660
PALWPSAL_036520(aruH)
PPAFI8N54_08275
CACTHZ995_13435
THASC6Y53_09510
HDHG5B40_01995
CMAGCBW24_05150
GCEKYE46_11885
NSMJO391_11960
NDRHT578_17780
SECHB18_10965
SANDH3309_02615
ABSAZOBR_p250001
ABQABAZ39_26620
ABFAMK58_24180
AZTTSH58p_01790
SKTIGS68_24370
SMUCJL100_026235
SROEJL101_024340
HTQFRZ44_30830(aruH)
HADHFRZ61_16780(aruH)
TIIDY252_00675
PARHI5S86_15450
SPAVSpa2297_02970
SMOBJ7W19_27505
HRMK6T25_15350
 » show all
Reference
1  [PMID:17416668]
  Authors
Yang Z, Lu CD.
  Title
Characterization of an arginine:pyruvate transaminase in arginine catabolism of Pseudomonas aeruginosa PAO1.
  Journal
J Bacteriol 189:3954-9 (2007)
DOI:10.1128/JB.00262-07
  Sequence
[pae:PA4976]
Reference
2  [PMID:17416670]
  Authors
Yang Z, Lu CD
  Title
Functional genomics enables identification of genes of the arginine transaminase pathway in Pseudomonas aeruginosa.
  Journal
J Bacteriol 189:3945-53 (2007)
DOI:10.1128/JB.00261-07
  Sequence
[pae:PA4976]
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.84
IUBMB Enzyme Nomenclature: 2.6.1.84
ExPASy - ENZYME nomenclature database: 2.6.1.84
BRENDA, the Enzyme Database: 2.6.1.84
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