KEGG   ENZYME: 2.7.1.164
Entry
EC 2.7.1.164                Enzyme                                 
Name
O-phosphoseryl-tRNASec kinase;
PSTK;
phosphoseryl-tRNA[Ser]Sec kinase;
phosphoseryl-tRNASec kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-seryl-tRNASec O-phosphotransferase
Reaction(IUBMB)
ATP + L-seryl-tRNASec = ADP + O-phospho-L-seryl-tRNASec [RN:R08223]
Reaction(KEGG)
R08223
Substrate
ATP [CPD:C00002];
L-seryl-tRNA(Sec) [CPD:C06481]
Product
ADP [CPD:C00008];
O-phospho-L-seryl-tRNASec
Comment
In archaea and eukarya selenocysteine formation is achieved by a two-step process: O-phosphoseryl-tRNASec kinase (PSTK) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by EC 2.9.1.2 (Sep-tRNA:Sec-tRNA synthase).
History
EC 2.7.1.164 created 2009
Pathway
ec00450  Selenocompound metabolism
ec00970  Aminoacyl-tRNA biosynthesis
Orthology
K10837  O-phosphoseryl-tRNA(Sec) kinase
Genes
HSA118672(PSTK)
PTR466225(PSTK)
PPS100991616(PSTK)
GGO101132103(PSTK)
PON100444035(PSTK)
NLE100604256(PSTK)
MCC707601(PSTK)
MCF101864845(PSTK)
CSAB103216648(PSTK)
CATY105578001(PSTK)
PANU101014912(PSTK)
TGE112631225(PSTK)
RRO104657572(PSTK)
RBB108519575(PSTK)
TFN117065401(PSTK)
PTEH111550818(PSTK)
CJC100395731(PSTK)
SBQ101028456(PSTK)
CSYR103273230(PSTK)
MMUR105880342(PSTK)
LCAT123649971(PSTK)
OGA100954013(PSTK)
MMU214580(Pstk)
MCAL110298453(Pstk)
MPAH110330132(Pstk)
RNO361661(Pstk)
MCOC116103097(Pstk)
MUN110563206(Pstk)
CGE100766247(Pstk)
MAUA101837105(Pstk)
PLEU114692602(Pstk)
MORG121457578(Pstk)
AAMP119805958(Pstk)
NGI103729264(Pstk)
HGL101700708(Pstk)
CPOC100715100(Pstk)
CCAN109691653(Pstk)
DORD105989750(Pstk)
DSP122126798(Pstk)
NCAR124985279
OCU103345569(PSTK)
OPI101520728(PSTK)
TUP102495932(PSTK)
CFA477855(PSTK)
VVP112928833(PSTK)
VLG121484009(PSTK)
AML100469975(PSTK)
UMR103657947(PSTK)
UAH113252023(PSTK)
UAR123803903(PSTK)
ELK111145055
LLV125084474
MPUF101675082(PSTK)
ORO101374388(PSTK)
EJU114221856(PSTK)
ZCA113919316(PSTK)
MLX118027391(PSTK)
FCA101097176(PSTK)
PYU121037340(PSTK)
PBG122493343(PSTK)
PTG102952756(PSTK)
PPAD109252317(PSTK)
AJU106969408(PSTK)
HHV120235536(PSTK)
BTA511744(PSTK)
BOM102266938(PSTK)
BIU109579123(PSTK)
BBUB102398808(PSTK)
CHX102176662(PSTK)
OAS101113029(PSTK)
ODA120873890(PSTK)
CCAD122446717(PSTK)
SSC100517244(PSTK)
CFR102516976(PSTK)
CBAI105067409(PSTK)
CDK105085762(PSTK)
VPC102529762(PSTK)
BACU102998209
LVE103077611(PSTK)
OOR101290272(PSTK)
DLE111172228(PSTK)
PCAD102991683(PSTK)
PSIU116741949(PSTK)
ECB100050336(PSTK)
EPZ103560221(PSTK)
EAI106826682(PSTK)
MYB102256958(PSTK)
MYD102770046(PSTK)
MMYO118655620(PSTK)
MLF102426589(PSTK) 102442991
MNA107532660(PSTK)
PKL118719617(PSTK)
HAI109396918(PSTK)
DRO112300264(PSTK)
SHON118990531(PSTK)
AJM119059548(PSTK)
PDIC114497444(PSTK)
PHAS123828768(PSTK)
MMF118632357(PSTK)
RFQ117035901(PSTK)
PALE102883394(PSTK)
PGIG120608846(PSTK)
PVP105295677(PSTK)
RAY107515972(PSTK)
MJV108390574(PSTK)
TOD119234924(PSTK)
SARA101554345(PSTK)
LAV100658151(PSTK)
TMU101360573
DNM101443049(PSTK)
MDO100025338(PSTK)
GAS123238202(PSTK)
SHR100928232(PSTK)
PCW110192799(PSTK)
OAA100087684(PSTK)
GGA771778(PSTK)
PCOC116231553(PSTK)
MGP100541977(PSTK)
CJO107316259(PSTK)
NMEL110399567(PSTK)
APLA101795083(PSTK)
AFUL116491074(PSTK)
TGU105759382(PSTK)
LSR110468449(PSTK)
SCAN103814103(PSTK)
PMOA120500005(PSTK)
OTC121341686(PSTK)
PRUF121350051(PSTK)
GFR102040109(PSTK)
FAB101818121(PSTK)
PHI102100740(PSTK)
PMAJ107206823(PSTK)
CCAE111931385(PSTK)
CCW104694581(PSTK)
ETL114072597(PSTK)
ZAB102062086(PSTK)
FPG101917794(PSTK)
FCH102057982(PSTK)
CLV102096798(PSTK)
EGZ104128328(PSTK)
NNI104022113(PSTK)
PLET104614497(PSTK)
ACUN113481717(PSTK)
TALA104363955(PSTK)
PADL103918644(PSTK)
ACHC115348311(PSTK)
AAM106494196(PSTK)
AROW112965993(PSTK)
NPD112947817(PSTK)
DNE112994033(PSTK)
ASN102369560(PSTK)
AMJ102576845(PSTK)
CPOO109323793(PSTK)
GGN109287688(PSTK)
PSS102452198(PSTK)
CMY102937930(PSTK)
TST117880735(PSTK)
CABI116834434(PSTK)
MRV120368566(PSTK)
ACS100560637(pstk)
PVT110087226(PSTK)
PBI103065614(PSTK)
PMUR107285943(PSTK)
TSR106554070(PSTK)
PGUT117676699(PSTK)
VKO123031111(PSTK)
PMUA114597409(PSTK)
ZVI118096521(PSTK)
GJA107116290(PSTK)
STOW125438195(PSTK)
XLA444702(pstk.L)
XTR100158568(pstk)
NPR108784788(PSTK)
RTEM120910375(PSTK)
BBUF121005204(PSTK)
DRE101884223 103911967
SRX107736724
SANH107674413(pstk)
SGH107569516(pstk)
CCAR109073713(pstk)
CAUA113055819
PPRM120487124
MAMB125254956
IPU108273621
PHYP113527246(pstk)
SMEO124388487
TFD113652182
AMEX103029452(pstk)
EEE113588403(pstk)
TRU101079271(pstk)
TNGGSTEN00012528G001
LCO109143027(pstk)
NCC104954038(pstk)
CGOB115024466(pstk)
ELY117247574
PLEP121959129
SLUC116061443
ECRA117937066
PFLV114548101(pstk)
GAT120819197
PPUG119213164
MSAM119915475
CUD121528187
ALAT119009332
MZE101472959(pstk)
ONL100699733(pstk)
OAU116328845
OLA101163364(pstk)
OML112154113
XMA102231130(pstk)
XCO114151946(pstk)
XHE116727011(pstk)
PRET103481583(pstk)
PFOR103150622(pstk)
PLAI106951748(pstk)
PMEI106922411(pstk)
GAF122823773
CVG107090221(pstk)
CTUL119775961
GMU124874699
NFU107387803(pstk)
KMR108249255
ALIM106516589(pstk)
NWH119423719
AOCE111582231(pstk)
CSEM103381954(pstk)
POV109627125(pstk)
SSEN122759128
HHIP117753006
HSP118100964
LCF108899017(pstk)
SDU111219968 111219969 111240231
SLAL111660230(pstk)
XGL120793986
HCQ109523991(pstk)
BPEC110165471(pstk)
MALB109962967(pstk)
BSPL114845930
SASA106577432
OTW112236397
OMY110531859 110531886
OGO124018355
SALP112077272(pstk)
SNH120038504 120038513
ELS105009563(pstk)
SFM108939710(pstk)
PKI111853682(pstk)
AANG118217580
LOC102696251(pstk)
PSPA121326124
ARUT117417961
LCM102366882(PSTK)
CMK103185460
RTP109927462(pstk)
BBEL109462956
CIN100177473
SCLV120347537
SPU100888397
APLC110977115
DMEDmel_CG12788(Pstk)
DER6550434
DSE6615020
DSIDsimw501_GD24457(Dsim_GD24457)
DYADyak_GE17373
DSR110180106
DPODpse_GA22688
DPE6602902
DMN108152639
DGR6565872
DMODmoj_GI11009
DAZ108620194
DNV108656631
DHE111591998
CCAT105664496
BOD106616554
MDE101887591
SCAC106094461
LCQ111680183
LSQ119604949
ACOZ120949008
AARA120895200
ASTE118510276
AALB109416978
CQUCpipJ_CPIJ010839
CPII120418875
BCOO119076537
PPYR116172917
CLEC106668175
HHAL106684661
NLU111058942
PHUPhum_PHUM297960
FOC113208904
TPAL117649975
ZNE110833329
CSEC111863886
FCD110852207
DMK116917105
PVM113828387
PJA122261727
PCHN125032729
HAME121861227
PCLA123762143
PTRU123511902
HAZT108679572
EAF111701265
LSM121123181
PPOI119092525
ISCIscW_ISCW010109
DSV119461173
RSAN119379060
RMP119175959
VDE111254616
VJA111259397
TUT107360222
CSCU111632000
PTEP107449627
SDM118200870
CELCELE_Y49E10.22(pstk-1)
CBRCBG_11694(Cbr-pstk-1)
LOALOAG_18421
NAINECAME_03575
TSPTsp_10561
HROHELRODRAFT_163542
LGILOTGIDRAFT_232809
PCAN112564087
BGT106079838
GAE121384106
HRF124139376
HRJ124274370
CRG105325005
MYI110466484
PMAX117339566
MMER123546552
OBI106872979
OSN115230201
LAK106151138
SMMSmp_074770
SHXMS3_0015798
OVIT265_06161
NVE5508623
ATEN116291250
AMIL114962404
PDAM113670418
SPIS111334283
DGT114515894
XEN124444758
HMG105845147
TADTRIADDRAFT_58609
AQU100632695
CRECHLRE_06g296000v5
CSLCOCSUDRAFT_62949
CVRCHLNCDRAFT_140755
OLUOSTLU_16752
OTAOT_ostta09g01900
BPGBathy10g02680
MISMICPUN_64194
MPPMICPUCDRAFT_55939
GSLGasu_43110
SREPTSG_02035
DFADFA_05221
ACANACA1_074470
PTIPHATRDRAFT_41418
FCYFRACYDRAFT_238778
PIFPITG_05651
PSOJPHYSODRAFT_556252
SPARSPRG_22201
EHXEMIHUDRAFT_116308 EMIHUDRAFT_208254
GTTGUITHDRAFT_105125
NGRNAEGRDRAFT_78247(FM175)
CBLACBLAS_0018
MJAMJ_1538
MFEMefer_1539
MVUMetvu_0654
MFSMFS40622_0749
MIFMetin_1012
MJHJH146_0135
MESGMLAUSG7_0499(pstK)
MESAMLASG1_0010(pstK)
MIGMetig_0165
MMPMMP1490
MMQMmarC5_0087
MMXMmarC6_1184
MMZMmarC7_0734
MMDGYY_08290
MMAKMMKA1_17140(pstK)
MMAOMMOS7_15960(pstK)
MMADMMJJ_13480(mtaD_2)
MAEMaeo_0491
MVNMevan_0799
MVOMvol_1610
MOKMetok_1516
METFCFE53_04575(pstK)
MKAMK1679
LOKILokiarch_31880(pstK)
PSYTDSAG12_02520(pstK)
 » show all
Reference
1  [PMID:15317934]
  Authors
Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL
  Title
Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase.
  Journal
Proc Natl Acad Sci U S A 101:12848-53 (2004)
DOI:10.1073/pnas.0402636101
  Sequence
[hsa:118672] [mmu:214580]
Reference
2  [PMID:18174226]
  Authors
Sherrer RL, O'Donoghue P, Soll D
  Title
Characterization and evolutionary history of an archaeal kinase involved in selenocysteinyl-tRNA formation.
  Journal
Nucleic Acids Res 36:1247-59 (2008)
DOI:10.1093/nar/gkm1134
Reference
3  [PMID:9521673]
  Authors
Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC
  Title
Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer.
  Journal
Biochemistry 37:3518-28 (1998)
DOI:10.1021/bi972177k
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.164
IUBMB Enzyme Nomenclature: 2.7.1.164
ExPASy - ENZYME nomenclature database: 2.7.1.164
BRENDA, the Enzyme Database: 2.7.1.164
CAS: 91273-83-5
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