KEGG   ENZYME: 2.7.1.187
Entry
EC 2.7.1.187                Enzyme                                 
Name
acarbose 7IV-phosphotransferase;
acarbose 7-kinase;
AcbK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:acarbose 7IV-phosphotransferase
Reaction(IUBMB)
ATP + acarbose = ADP + acarbose 7IV-phosphate [RN:R11184]
Reaction(KEGG)
R11184
Substrate
ATP [CPD:C00002];
acarbose [CPD:C06802]
Product
ADP [CPD:C00008];
acarbose 7IV-phosphate [CPD:C21156]
Comment
The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is specific for acarbose.
History
EC 2.7.1.187 created 2015
Pathway
ec00525  Acarbose and validamycin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K19978  acarbose 7IV-phosphotransferase
Genes
MSXAU14_17890
PAEWKIH87_05050
AGZM0C34_15270
CJACJA_3262
HCHHCH_06560
HAHEENC22_28710
RFOREIFOR_01851
JAZYQ44_16480
JALBZG29_11390
JSVCNX70_11820
JASFJQ89_00455
JLVG3257_11880
NIVJY500_14630
SURSTAUR_1373(gacK)
MBDMEBOL_002883
JANJann_1951
NMKCHR53_26640
PSTEPSTEL_21445
CCHLFPL14_14950
CBEILF65_05135
HORHore_09710
TSGHLK68_06310
TBKHF295_05705
SMASAVERM_1511
SCBSCAB_20401
SHYSHJG_7630
SHOSHJGH_7391
SFASfla_0297
SVESVEN_7113
SDVBN159_1685
STRPF750_6718
SCIB446_30730
SALUDC74_6799
SALLSAZ_35315
SGUSGLAU_01020(gacK)
STREGZL_01972
SCWTU94_03345
SLCSL103_23555
SXISXIM_46650
STRCAA958_14090
SPRISPRI_1871
SCXAS200_09110
SRWTUE45_07278(kdgK_4)
SLEsle_62240(sle_62240)
SRNA4G23_05299(kdgK_4)
SGSAVL59_15010
SGMGCM10017557_11810
SCADDN051_08635
SPHWNFX46_12550
SLSSLINC_7169
SNRSNOUR_08805
SPLULK06_028515
SNWBBN63_04345
SSIAA7J05_03525
SPUNBFF78_06550
SLAUSLA_7384
SNZDC008_29530
SRJSRO_6633
SLKSLUN_34265
SDXC4B68_04950
SCYAEJ357_02025
SASTCD934_07730
SNQCP978_28840
STIRDDW44_27335
SGZC0216_15315
SNKCP967_21885
SHAWCEB94_30720
SSPODDQ41_28600 DDQ41_30790
SVRCP971_12025
SPADDVK44_30925
SAQUEJC51_30905
SGFHEP81_06976
SSEOD0Z67_24690
SPHVF9278_37950
SFUGCNQ36_29320
SPACB1H29_04410
SCHACP983_06555
SGXH4W23_04800
SCOECP976_32185
SPLACP981_32500
SBROGQF42_37495
STUIGCM10017668_53800(rbsK)
SATAC5746_04060
SCHFIPT68_31575
SHUNDWB77_06929(acbK)
SHARHUT13_23360
SCYGS1361_33170(ydjH3)
SFEUIM697_28610
SLIAHA039_04205
SDWK7C20_31055
SAUHSU9_029475
SFBCP974_28220
SPEUCGZ69_28305
SROIIAG44_06300
SGJIAG43_01740
SANUK7396_06165
SACTDMT42_32350
SINEKI385_36860
SDECL3078_35440
SDURM4V62_03095
KSKKSE_21730
KAUB6264_07090
KITCFP65_4944
STRHGXP74_26555
ABRYNYE86_13595
LXLKDY119_02177(rbsK)
PSICJ4E96_10105
MIMAKG07_06940
MIXAB663_003197
MIPAXH82_00785
MICRBMW26_11490
MPRTET475_07120
MOYCVS54_01240(acbK)
MRNK8F61_08185
MVDAWU67_13150
AGYATC03_17930
AGMDCE93_00270
AGFET445_02195
AMAUDSM26151_00790(acbK)
CRYB7495_16990
GARAOZ07_07750
GLUF0M17_07565
GMYXH9_01250
BRRC1N80_07505
JDEJden_1355
LMOIVV02_02970
XCEXcel_1009
IVAIsova_0272
CETB8281_01830
CCEUCBR64_10150
CFICelf_2318
CGACelgi_1262
CEZCBP52_06665
CEJGC089_07075
CELHGXP71_08500
CPALF1D97_13725
OEKFFI11_019090
TFLRPIT_10095
KQIF1D05_22850
NDANdas_3511
NALB005_4335
SAIUJ4H86_24555
ACTWF7P10_40580
SROSros_3352
NOABKM31_26065
NOWGBF35_20075
NCXNocox_24910(kdgK4)
NGNLCN96_20515
FALFRAAL2349
NMLNamu_1114
SESPBN6_77270
SSYIEKG83_24095
KALKALB_6123
ALOCRK60158
STPStrop_4175
MAUMicau_4674
MILML5_3626
MICBMicB006_3678
MTUACSH63_01235
MICHFJK98_24800
MTEMGCE86_17735
MSAGGCM10017556_09000
VMAVAB18032_27656
MCRAID554_23100
ASEACPL_1792 ACPL_3675(acbK)
AMSAMIS_22030
AFSAFR_34385
ACTSACWT_1670 ACWT_3547
AIHAiant_61270
ACTRAsp14428_14100(rbsK_2)
VERHUT12_25325
ATLAthai_20450(rbsK_2)
PRYPrubr_33530
CATICS0771_35390 CS0771_63340(rbsK_3)
DVCDvina_39925
DFUDfulv_30315
DAURDaura_15825
CAICaci_2113
SNASnas_4369
NAVJQS30_11260
GLYK3N28_04365
HAUHaur_0148
ABATCFX1CAM_1639
ABAOBEQ56_01045
DABAUC44_13735
SCDSpica_0068
LTEJMUB4039_1104
FLSGLV81_14135
FLPLK994_07100
FLVKJS94_14640
HRSHER32_18960
LUTLupro_02010
KPFIX53_06335
MPGTheba_2034
MINFMESINF_1227
HSNDV733_07275
HDSHSR122_2987(rbsK4)
 » show all
Reference
1  [PMID:8784428]
  Authors
Drepper A, Pape H
  Title
Acarbose 7-phosphotransferase from Actinoplanes sp.: purification, properties, and possible physiological function.
  Journal
J Antibiot (Tokyo) 49:664-8 (1996)
DOI:10.7164/antibiotics.49.664
Reference
2  [PMID:8784426]
  Authors
Goeke K, Drepper A, Pape H
  Title
Formation of acarbose phosphate by a cell-free extract from the acarbose producer Actinoplanes sp.
  Journal
J Antibiot (Tokyo) 49:661-3 (1996)
DOI:10.7164/antibiotics.49.661
Reference
3  [PMID:11937512]
  Authors
Zhang CS, Stratmann A, Block O, Bruckner R, Podeschwa M, Altenbach HJ, Wehmeier UF, Piepersberg W
  Title
Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.
  Journal
J Biol Chem 277:22853-62 (2002)
DOI:10.1074/jbc.M202375200
  Sequence
[ase:ACPL_3675]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.187
IUBMB Enzyme Nomenclature: 2.7.1.187
ExPASy - ENZYME nomenclature database: 2.7.1.187
BRENDA, the Enzyme Database: 2.7.1.187
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