KEGG   ENZYME: 2.7.1.222
Entry
EC 2.7.1.222                Enzyme                                 
Name
4-hydroxytryptamine kinase;
PsiK
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:4-hydroxytryptamine 4-phosphotransferase
Reaction(IUBMB)
ATP + 4-hydroxytryptamine = ADP + 4-hydroxytryptamine 4-phosphate [RN:R11933]
Reaction(KEGG)
R11933;
(other) R08480
Substrate
ATP [CPD:C00002];
4-hydroxytryptamine [CPD:C21762]
Product
ADP [CPD:C00008];
4-hydroxytryptamine 4-phosphate [CPD:C21778]
Comment
Also acts on 4-hydroxy-L-tryptophan in vitro. Isolated from the fungus Psilocybe cubensis. Involved in the biosynthesis of the psychoactive compound psilocybin.
History
EC 2.7.1.222 created 2017
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22435  4-hydroxytryptamine kinase
Genes
PCUB: JR316_0010785
Reference
1  [PMID:28763571]
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
  Sequence
[ag:ASU62237]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.222
IUBMB Enzyme Nomenclature: 2.7.1.222
ExPASy - ENZYME nomenclature database: 2.7.1.222
BRENDA, the Enzyme Database: 2.7.1.222
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