KEGG   ENZYME: 2.7.1.225
Entry
EC 2.7.1.225                Enzyme                                 
Name
L-serine kinase (ATP);
sbnI (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-serine 3-phosphotransferase
Reaction(IUBMB)
ATP + L-serine = ADP + O-phospho-L-serine [RN:R12344]
Reaction(KEGG)
R12344
Substrate
ATP [CPD:C00002];
L-serine [CPD:C00065]
Product
ADP [CPD:C00008];
O-phospho-L-serine [CPD:C01005]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of L-2,3-diaminopropanoate, which is used by that organism as a precursor for the biosynthesis of the siderophore staphyloferrin B.
History
EC 2.7.1.225 created 2019
Pathway
ec00997  Biosynthesis of various other secondary metabolites
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23371  L-serine kinase (ATP) / ParB family transcriptional regulator, heme-responsive regulator
Genes
BTHRYBT1520_29789
BTHIBTK_29574
BTHTH175_233p021 H175_328p222 H175_328p225
BBYCY96_29570
BBADK7T73_21420
PCALBV455_03916
SAUSA0120(sbnI)
SAVSAV0124
SAWSAHV_0123
SAHSaurJH1_0115
SAJSaurJH9_0111
SAMMW0097(sbnI)
SASSAS0098
SARSAR0127
SACSACOL0108
SAXUSA300HOU_0135
SAASAUSA300_0126
SAOSAOUHSC_00083
SAENWMN_0068(sbnI)
SADSAAV_0092
SUUM013TW_0114(sbnI)
SUVSAVC_00360
SUESAOV_0071
SUJSAA6159_00107(sbnI)
SUKSAA6008_00102(sbnl)
SUCECTR2_80
SUTSAT0131_00110
SUQHMPREF0772_10373
SUZMS7_0116
SUDST398NM01_0136
SUXSAEMRSA15_00900
SUWSATW20_01360(sbnI)
SUGSAPIG0136
SUFSARLGA251_00990(sbnI)
SAUASAAG_00608
SAUERSAU_000078
SAUNSAKOR_00098
SAUSSA40_0091
SAUUSA957_0106
SAUGSA268_0103(sbnI)
SAUZSAZ172_0135(sbnI)
SAUTSAI1T1_2000800(sbnl)
SAUJSAI2T2_1000800(sbnl)
SAUKSAI3T3_1000800(sbnl)
SAUQSAI4T8_1000800(sbnl)
SAUVSAI7S6_1000800
SAUWSAI5S5_1000800
SAUXSAI6T6_1000800
SAUYSAI8T7_1000800
SAUFX998_0103
SABSAB0063
SUYSA2981_0125(sbnI)
SAUBC248_0112
SAUMBN843_1260
SAUCCA347_135
SAURSABB_01716(sbnI)
SAUIAZ30_00645
SAUDCH52_05100
SAMSNI36_00540
SUHSAMSHR1132_01000
SSDSPSINT_0342
SDTSPSE_2116
SDPNCTC12225_02333
SHUSHYC_00395(sbnI)
SSCHLH95_00395
SSCZRN70_00615
SAGQEP23_09730(sbnI)
SEQOSE1039_25030
SLZB5P37_07630
SARLSAP2_02110
SSHNCTC13712_00077
SRAILN051_00270(sbnI)
SFFFOB90_07395(sbnI)
BBEBBR47_31880
BLRBRLA_c008290
BFMBP422_11075
BAGRBA6348_15315
BRWGOP56_19895
BCHSJNE38_14390
PLVERIC2_c18230
ANXACH33_02530
ATHEK3F53_16420
TUMCBW65_11360
TABCIG75_02750 CIG75_02875
LFBC1X05_04270
KPULGXN76_14205
PABSJIR001_05160(sbnI)
PACPPA1292
PAVTIA2EST22_06440
PAXTIA2EST36_06410
PAZTIA2EST2_06345
PAWPAZ_c13530
PADTIIST44_08130
PCNTIB1ST10_06650
PACCPAC1_06780
RXYRxyl_0989
RRDRradSPS_0901
RUBGBA63_07300
RMARGBA65_09075
THUGKNN16_05245
PMETG4Y79_15610
 » show all
Reference
1  [PMID:29483190]
  Authors
Verstraete MM, Perez-Borrajero C, Brown KL, Heinrichs DE, Murphy MEP
  Title
SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
J Biol Chem 293:6147-6160 (2018)
DOI:10.1074/jbc.RA118.001875
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.225
IUBMB Enzyme Nomenclature: 2.7.1.225
ExPASy - ENZYME nomenclature database: 2.7.1.225
BRENDA, the Enzyme Database: 2.7.1.225
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