KEGG   ENZYME: 2.7.1.225
Entry
EC 2.7.1.225                Enzyme                                 
Name
L-serine kinase (ATP);
sbnI (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:L-serine 3-phosphotransferase
Reaction(IUBMB)
ATP + L-serine = ADP + O-phospho-L-serine [RN:R12344]
Reaction(KEGG)
R12344
Substrate
ATP [CPD:C00002];
L-serine [CPD:C00065]
Product
ADP [CPD:C00008];
O-phospho-L-serine [CPD:C01005]
Comment
The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of L-2,3-diaminopropanoate, which is used by that organism as a precursor for the biosynthesis of the siderophore staphyloferrin B.
History
EC 2.7.1.225 created 2019
Pathway
ec00975  Biosynthesis of various siderophores
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K23371  L-serine kinase (ATP) / ParB family transcriptional regulator, heme-responsive regulator
Genes
BTHR: YBT1520_29789
BTHI: BTK_29574
BTHT: H175_233p021 H175_328p222 H175_328p225
BBY: CY96_29570
BARD: QRY57_07165 QRY57_11930
BBAD: K7T73_21420
PCAL: BV455_03916
SAU: SA0120(sbnI)
SAV: SAV0124
SAW: SAHV_0123
SAH: SaurJH1_0115
SAJ: SaurJH9_0111
SAM: MW0097(sbnI)
SAS: SAS0098
SAR: SAR0127
SAC: SACOL0108
SAX: USA300HOU_0135
SAA: SAUSA300_0126
SAO: SAOUHSC_00083
SAE: NWMN_0068(sbnI)
SAD: SAAV_0092
SUU: M013TW_0114(sbnI)
SUV: SAVC_00360
SUE: SAOV_0071
SUJ: SAA6159_00107(sbnI)
SUK: SAA6008_00102(sbnl)
SUC: ECTR2_80
SUT: SAT0131_00110
SUQ: HMPREF0772_10373
SUZ: MS7_0116
SUD: ST398NM01_0136
SUX: SAEMRSA15_00900
SUW: SATW20_01360(sbnI)
SUG: SAPIG0136
SUF: SARLGA251_00990(sbnI)
SAUA: SAAG_00608
SAUE: RSAU_000078
SAUN: SAKOR_00098
SAUS: SA40_0091
SAUU: SA957_0106
SAUG: SA268_0103(sbnI)
SAUZ: SAZ172_0135(sbnI)
SAUT: SAI1T1_2000800(sbnl)
SAUJ: SAI2T2_1000800(sbnl)
SAUK: SAI3T3_1000800(sbnl)
SAUQ: SAI4T8_1000800(sbnl)
SAUV: SAI7S6_1000800
SAUW: SAI5S5_1000800
SAUX: SAI6T6_1000800
SAUY: SAI8T7_1000800
SAUF: X998_0103
SAB: SAB0063
SUY: SA2981_0125(sbnI)
SAUB: C248_0112
SAUM: BN843_1260
SAUC: CA347_135
SAUR: SABB_01716(sbnI)
SAUI: AZ30_00645
SAUD: CH52_05100
SAMS: NI36_00540
SUH: SAMSHR1132_01000
SSD: SPSINT_0342
SDT: SPSE_2116
SDP: NCTC12225_02333
SHU: SHYC_00395(sbnI)
SSCH: LH95_00395
SSCZ: RN70_00615
SAGQ: EP23_09730(sbnI)
SEQO: SE1039_25030
SLZ: B5P37_07630
SARL: SAP2_02110
SSH: NCTC13712_00077
SRAI: LN051_00270(sbnI)
SROT: ML435_00440(sbnI)
STAP: AOB58_1881
SFF: FOB90_07395(sbnI)
MBOC: QSV55_00200
BBE: BBR47_31880
BLR: BRLA_c008290
BFM: BP422_11075
BAGR: BA6348_15315
BRW: GOP56_19895
BCHS: JNE38_14390
BBOR: RFB14_00510
BREP: M655_013830
BGEL: AAFJ72_11125
PLV: ERIC2_c18230
ANX: ACH33_02530
ATHE: K3F53_16420
TUM: CBW65_11360
TAB: CIG75_02750 CIG75_02875
LFB: C1X05_04270
KPUL: GXN76_14205
PABS: JIR001_05160(sbnI)
PAC: PPA1292
PAV: TIA2EST22_06440
PAX: TIA2EST36_06410
PAZ: TIA2EST2_06345
PAW: PAZ_c13530
PAD: TIIST44_08130
PCN: TIB1ST10_06650
PACC: PAC1_06780
RXY: Rxyl_0989
RRD: RradSPS_0901
RUB: GBA63_07300
RMAR: GBA65_09075
THUG: KNN16_05245
PMET: G4Y79_15610
 » show all
Reference
1  [PMID:29483190]
  Authors
Verstraete MM, Perez-Borrajero C, Brown KL, Heinrichs DE, Murphy MEP
  Title
SbnI is a free serine kinase that generates O -phospho-l-serine for staphyloferrin B biosynthesis in Staphylococcus aureus.
  Journal
J Biol Chem 293:6147-6160 (2018)
DOI:10.1074/jbc.RA118.001875
  Sequence
[saa:SAUSA300_0126]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.225
IUBMB Enzyme Nomenclature: 2.7.1.225
ExPASy - ENZYME nomenclature database: 2.7.1.225
BRENDA, the Enzyme Database: 2.7.1.225
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