Entry
Name
isopentenyl phosphate kinase;
ATP:isopentenyl phosphate phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
BRITE hierarchy
Sysname
ATP:3-methylbut-3-en-1-yl-phosphate phosphotransferase
Reaction(IUBMB)
ATP + 3-methylbut-3-en-1-yl phosphate = ADP + 3-methylbut-3-en-1-yl diphosphate [RN:
R10093 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
3-methylbut-3-en-1-yl phosphate [CPD:
C20345 ]
Product
ADP [CPD:
C00008 ];
3-methylbut-3-en-1-yl diphosphate [CPD:
C00129 ]
Comment
The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin.
History
EC 2.7.4.26 created 2012
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K06981 isopentenyl phosphate kinase
Genes
RPHI : 132750498 132753777
CSAT : 104741189 104756878 104776619
BNA : 106360561(BNAC05G20190D) 125578013
HSYR : 120118198 120170909
PDUL : 117619058 117637975
PSOM : 113299878 113300252
TAES : 123062154 123070881 123079271
LPER : 127339871 127343703
LRD : 124660852 124663156 124667919 124690211
MFLO : 136453044 136453303
PVIR : 120672214 120708153
NCOL : 116257507 116268168
SMO : SELMODRAFT_136903 SELMODRAFT_92970
MAW : 19250312(J3458_020782)
EHX : EMIHUDRAFT_103456 EMIHUDRAFT_114408
THV : ADU37_CDS09070 ADU37_CDS09160
MEHF : MmiHf6_06660(argB_1)
MEES : MmiEs2_03450(argB_1)
MJK : N2V74_01035 N2V74_04825
HJT : DVR14_17930 DVR14_22060
TVO : TVG0187430(TVG0187430)
ACF : AciM339_0341 AciM339_0399 AciM339_0625
PSYT : DSAG12_01210 DSAG12_02985
» show all
Taxonomy
Reference
Authors
Grochowski LL, Xu H, White RH
Title
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
Journal
Sequence
Reference
Authors
Lange BM, Croteau R
Title
Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step.
Journal
Reference
Authors
Chen M, Poulter CD
Title
Characterization of thermophilic archaeal isopentenyl phosphate kinases.
Journal
Sequence
Reference
Authors
Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD
Title
X-ray structures of isopentenyl phosphate kinase.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.26
ExPASy - ENZYME nomenclature database: 2.7.4.26
LinkDB
All DBs