KEGG   ENZYME: 2.7.4.26
Entry
EC 2.7.4.26                 Enzyme                                 
Name
isopentenyl phosphate kinase;
ATP:isopentenyl phosphate phosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with a phosphate group as acceptor
Sysname
ATP:3-methylbut-3-en-1-yl-phosphate phosphotransferase
Reaction(IUBMB)
ATP + 3-methylbut-3-en-1-yl phosphate = ADP + 3-methylbut-3-en-1-yl diphosphate [RN:R10093]
Reaction(KEGG)
R10093
Substrate
ATP [CPD:C00002];
3-methylbut-3-en-1-yl phosphate [CPD:C20345]
Product
ADP [CPD:C00008];
3-methylbut-3-en-1-yl diphosphate [CPD:C00129]
Comment
The enzyme is involved in the mevalonate pathway in Archaea [1]. The activity has also been identified in the plant Mentha piperita (peppermint) [2]. It is strictly specific for ATP but can use other phosphate acceptors such as prenyl phosphate, geranyl phosphate, or fosfomycin.
History
EC 2.7.4.26 created 2012
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K06981  isopentenyl phosphate kinase
Genes
ASN106723108
AMJ106737678
CPOO109317576
TST117877258
MRV120404739
ACS103278744
PVT110073401
SUND121928951
PBI103049702
PMUR107287790
TSR106539195
PGUT117663776
VKO123032206
PMUA114599410
ZVI118089509
GJA107107948
CMK103179096
BFO118413305
BBEL109475511
SPU100890155
APLC110979072
HAME121862232
LGILOTGIDRAFT_238298
PCAN112564276
BGT106074055
GAE121380859
HRF124128643 124131008
HRJ124287065
MYI110461970
PMAX117343856
MMER123531596 123543974
LAK106152890
NVE5515104
EPA110242649
ATEN116300256
ADF107347187
AMIL114966446
PDAM113684719
SPIS111323292
TADTRIADDRAFT_51825
ATHAT1G26640
ALY9329452
CRB17899902
CSAT104741189 104756878 104776619
EUSEUTSA_v10008165mg
BRP103840631
BNA106360561
BOE106343097
RSZ108813718 108813740
THJ104808621
CPAP110824151
CIT102621982
CICCICLE_v10031995mg
PVY116120596 116121375
MINC123213209
TCC18610326
GRA105783960
GHI107893867
GAB108461668
DZI111281867
EGR104433419
GMX100792453
GSJ114386983
PVUPHAVU_002G091000g
VRA106755265
VAR108336004
VUN114169739
CCAJ109803037
APRC113869974
MTRMTR_5g042980
CAM101491500(288)
LJALj2g3v1277250.1(Lj2g3v1277250.1)
ADU107489266
AIP107643569
AHF112750238 112801549
LANG109359013
FVE101295219
RCN112197842
PPER18789342
PMUM103321523
PAVI110751257
PDUL117619058 117637975
MDM103423801
PXB103947215
ZJU107429028
MNT21398807
CSV101216243
CMO103503361
BHJ120079784
MCHA111025262
CMAX111493614
CMOS111450692
CPEP111783871
RCU8289160
JCU105630501
HBR110643207
MESC110625733
POP7492908
PEU105116803
PALZ118042996
JRE109019800
QSU112009069
QLO115978810
TWL120001932
VVI100247979
VRI117912870
SLY101250107
SPEN107017971
SOT102588327
CANN107871289
NTA107793526 107805486
NSY104225818
NTO104108659
NAU109240151
INI109162071
ITR116015368
SIND105160005
OEU111398337 111398921
EGT105967535
SSPL121768346
HAN110871873
ECAD122606880
LSV111902634
CCAV112525640
DCR108200374
CSIN114280717
BVG104897837
SOE110777852
CQI110706388 110713255
NNU104598036
MING122077143
TSS122654270
PSOM113299878 113300252
NCOL116257507 116268168
OSA4326891
DOSAOs01t0764600-01(Os01g0764600)
OBR102707821
BDI100832959
ATS109753727
TDC119269101 119277091
TAES123062154 123070881 123079271
TUA125544869
SBI8079244
ZMA100191244 103652468
SITA101785538
SVS117856785
PVIR120672214 120708153
PHAI112892982
PDA103700858
EGU105057791
MUS103975627
DCT110099259 110099419
PEQ110029254
AOF109849095
ATR18434727
SMOSELMODRAFT_136903 SELMODRAFT_92970
PPP112280543 112285657
CRECHLRE_13g579800v5
VCNVOLCADRAFT_89200
MNGMNEG_4828
CVRCHLNCDRAFT_12639
OLUOSTLU_92808
OTAOT_ostta05g04420
BPGBathy03g05220
MISMICPUN_76277
MPPMICPUCDRAFT_70280
MAWMAC_06001
MAJMAA_09148
CMTCCM_06064
DDIDDB_G0288029
DPPDICPUDRAFT_152394
DFADFA_09969
SMINv1.2.021279.t1(symbB.v1.2.021279.t1)
FCYFRACYDRAFT_235467
TPSTHAPSDRAFT_11228
EHXEMIHUDRAFT_103456 EMIHUDRAFT_114408
NGRNAEGRDRAFT_61783
SDNSden_1166
CVICV_3960
CVCBKX93_17520
CHRIDK842_11805
CHRBDK843_17240
BRYM0696_19620
PAUSNCTC13651_00687
NSHGXM_10396
RRSRoseRS_2247
RCARcas_4059
CAUCaur_0506
CHLChy400_0542
CAGCagg_3216
HAUHaur_2285
ATMANT_15950
ABATCFX1CAM_1693
PSUBPelsub_P1567
ABAOBEQ56_06645
CAPCLDAP_05580
PBFCFX0092_A0137
THUGKNN16_12765
PMETG4Y79_16160
MJAMJ_0044
MFEMefer_0425
MVUMetvu_0307
MFSMFS40622_0936
MIFMetin_0190
MJHJH146_1549
MESGMLAUSG7_0754
MESAMLASG1_0439
MIGMetig_0202
MMPMMP1645
MMQMmarC5_1763
MMXMmarC6_1026
MMZMmarC7_0918
MMDGYY_09080
MMAKMMKA1_18770
MMAOMMOS7_17590
MMADMMJJ_11920
MAEMaeo_1031
MVNMevan_0950
MVOMvol_1261
MOKMetok_0924
METFCFE53_02940
MTHMTH_47
MMGMTBMA_c05360
MWOMWSIV6_0501
MTEEMTTB_10950
METCMTCT_0046
METEtca_00047(proB)
METZMETMT2_0295
METKFVF72_01865
MTHMFZP57_02375
METJFZP68_07395
MSTMsp_0857
METBAW729_01825
MRUmru_0921
MSIMsm_1440
MEBAbm4_1229
MMILsm9_1640
MEYETL18_07255
MOLYLM1_0486
MAROMarbSA_06150
METVK4897_08025
MELMetbo_0819
MEWMSWAN_1426
METHMBMB1_0812
MFCBRM9_0362
MFIDSM1535_0289
MCUBMCBB_1337
MSUBBK009_04660
METNBK008_00135
METTCIT01_08910
METOCIT02_00415
MEMEHYG87_09360
MFVMfer_0896
MKAMK0777
AFUAF_2288
APOArcpr_1564
AVEArcve_0600
ASTAsulf_00536
FPLFerp_1382
GACGACE_1301
GAHGAH_00188
PFUPF1636
PFIPFC_10425
PHOPH1623(PH1623)
PABPAB0373(argB-like)
PYNPNA2_0206
PYAPYCH_02620
PYSPy04_1517
PYCTQ32_08705
TKOTK1473
TONTON_0134
TGATGAM_1729(fomA)
TSITSIB_1230
TBATERMP_00144
THEGQS_04565
THATAM4_1700
THMCL1_0568
TLTOCC_01024
THSTES1_0236
TNUBD01_2227
TEUTEU_05465
TGYX802_01560
THVADU37_CDS09070 ADU37_CDS09160
TCHCHITON_1859
TPEPA0127_07835
TPIEA7C91_06635
TGGA3K92_01380
TCEA3L02_00085
TBSA3L01_01380
THHCDI07_01360
TSLA3L11_05130
TTDA3L14_02860
TPRFA3L09_04260
TRLA3L10_05185
TPAFA3L08_04390
THYA3L12_00935
TICFH039_03260
TCQTIRI35C_0496
THEMFPV09_05955
THEIK1720_09230
PPACPAP_01960
MBAMbar_A1420
MBYMSBRM_0484
MBWMSBRW_3307
MBARMSBR2_1898
MBAKMSBR3_2037
MACMA_0603
MMAMM_1763
MMJMSMAS_2915
MMACMSMAC_1518
MVCMSVAZ_0528
MEKMSKOL_0507
MLSMSLAZ_0337
METMMSMTP_2866
MEFMSWH1_2735
MEQMSWHS_2303
MSJMSSAC_0532
MSZMSSIH_0494
MSWMSSIT_0517
MTHRMSTHT_2118
MTHEMSTHC_1166
MHORMSHOH_3625
MFZAOB57_005355
MBUMbur_2396
MMETMCMEM_0542
MELOJ7W08_00740
MMHMmah_1550
MHAZBHR79_05975
MEVMetev_0322
MZHMzhil_1008
MPYMpsy_0884
MZIHWN40_04230
MHZMetho_1634
MTPMthe_0475
MCJMCON_2558
MHIMhar_0984
MHUMhun_2889
MRTJKHC33_02505
MLAMlab_0682
MEMMemar_1813
MBGBN140_0575
MEMAMMAB1_0740
MCHKMchiMG62_20760
MPIMpet_0760
MBNMboo_2212
MFOMetfor_0496
MPLMpal_2375
MPDMCP_1638
MEZMtc_2284
RCILRC398
HALVNG_1148G(argB)
HSLOE_2647F
HDLHALDL1_11700
HHBHhub_2771
HAGSJT689_06000
HABOJRZ79_04465
HNOLT974_10940
HLULT972_04630
HANRLJ422_04695
HJEHacjB3_08705
HALHHTSR_0764
HHSRHSR6_0790
HSUHLASF_1451
HSFHLASA_1438
SALRFQU85_08325
HALREFA46_008415
HARAAArcS_1353
HAADMW046_02225
HALXM0R89_16920
HAXZM0R88_17205
HMArrnAC0078(argB1)
HHIHAH_0835(argB1)
HHNHISP_04320
HABSG26_12035
HTABVU17_04105
HALJG9465_13460
HSINKDQ40_09330
NPHNP_2852A
NMONmlp_2741
NHOHWV23_00010
NSALHWV07_02360
HUTHuta_2046
HTIHTIA_1633
HALAHrd1104_07350
HMUHmuk_2605
HALZE5139_00310
HALLLC1Hm_1949(ipk)
HAZPGBQ70_00310
HALIBV210_01175
HSNDV733_03775
HDSHSR122_2117
HRRHZS55_19070
HPELHZS54_23245
HLTI7X12_16320
HARCHARCEL1_05835
HDOMUK72_12110
HWAHQ_2926A
HWCHqrw_3337
HVOHVO_2762
HMEHFX_2774
HGIABY42_13835
HALEG3A49_17500
HBOHbor_12300
HAQDU484_10955
HAJDU500_11220
HAERDU502_08605
HRAEI982_17310
HLMDV707_05560
HALMFCF25_05055
HLAHlac_1830
HALPDOS48_08835
HALBEKH57_00675
HEZZEO776_10605
HALQHrr1229_013105
HSSJ7656_05985
HSAIHPS36_11195
HAZZKI388_08785
SRUBC2R22_12520
HAEhalTADL_0076
HALNB4589_004970
HALGHUG10_04465
HALUHUG12_12495
HMPK6T50_02540
HREK6T36_02375
HRMK6T25_14045
HACBHbl1158_09415
HDFAArcSl_2732(ipk)
HAHHalar_1546
HTUHtur_2540
HDABB347_07640
HSALJMJ58_16130
HLOJ0X27_14645
HAKZJ0X25_00010
NMGNmag_0440
HXAHalxa_0730
NATNJ7G_1104
NPENatpe_1689
NVRFEJ81_08690
NPLFGF80_03245
NAYHYG81_01025
HALYHYG82_04865
HJTDVR14_17930 DVR14_22060
NGENatgr_2566
HRUHalru_1739
NOUNatoc_1801
SALIL593_01905
SAIMK0C01_08360
HLRHALLA_13925
HLCCHINAEXTREME11300
NAJB1756_02530
NAGAArcMg_2526
NANAArc1_1200
NBGDV706_11915
NASGCU68_00165
SAWLNGM29_07780
MELUMTLP_11460
MEAMMU439_02995
TACTa0103
TVOTVG0187430(TVG0187430)
PTOPTO0497
FACFACI_IFERC01G0945
FAIFAD_1830
CDIVCPM_0049
TARTALC_01359
MAXMMALV_14490
MERMMINT_05450
MEARMpt1_c00630
MEUZKRP56_07065
MARCAR505_0192
ABIAboo_0423 Aboo_0725
ACFAciM339_0341 AciM339_0399 AciM339_0625
APEAPE_1768.1
ACJACAM_1109
SMRSmar_0511
SHCShell_0286
IHOIgni_0566
IISEYM_04880
DKADKAM_1442
DFDDesfe_0065
DMUDesmu_1042
TAGTagg_1081
IAGIgag_0200
THGTCELL_0752
HBUHbut_0538
PFMPyrfu_0915
PDLPyrde_2023
SSOSSO0064
SOLSsol_1044
SSOASULA_1081
SSOLSULB_1082
SSOFSULC_1081
SSHIJ5U23_00184
SCASSACC_32480
SISLS215_2221
SIAM1425_2056
SIMM1627_2136
SIDM164_2063
SIYYG5714_2182
SINYN1551_0737
SIILD85_2323
SIHSiH_2002
SIRSiRe_1929
SICSiL_1909
SULABFU36_05525
SULEGFS03_11240
SULOGFS33_03055
MSEMsed_2137
MCNMcup_0152
MHKDFR87_07785
MPRUDFR88_07455
MTENGWK48_04365
MJNMjAS7_0448
MEMJMJ1HA_2411
AHOAhos_0653
AMANB6F84_06685
ABRIDFR85_08930
ASULDFR86_05745
AAMBD1866_11040
ACIHHS5_20280
STEPIC006_1979
PAIPAE1012
PISPisl_1207
PCLPcal_0149
PASPars_0180
PYRP186_2438
POGPogu_2299
TNETneu_0164
PYWPYWP30_00187
CMACmaq_1001
TTNTTX_2050
TUZTUZN_1437
VDIVdis_1766
VMOVMUT_0213
TPETpen_0607
THBN186_04380
TCBTCARB_1903
THELIG193_04520
ASCASAC_0904
ACIASE86_05200
CLGCalag_0846
FFOFFONT_0456
NMRNmar_0314
NIRNSED_01515
NKRNKOR_01425
NIDNPIRD3C_0716
NINNADRNF5_1938
NIWNisw_03345
NCLC5F47_01680
NOXC5F49_01675
NUEC5F50_02280
NIPNsoK4_07205
NCTNMSP_1394
NICDSQ20_01830
CSYCENSYa_1615
NGANgar_c21610
NVNNVIE_008070
NEVNTE_02263
TAANMY3_02132
NFNNFRAN_2921
NCVNCAV_1517
CSUCSUB_C0425
NBVT478_0246
TAHSU86_004395
NIUDSQ19_01720
NDVNDEV_0280
CCAINAS2_0355
KCRKcr_1595
BARCAOA65_2113
BARBAOA66_1068
MARHMia14_0599
FLTSv326_0061
MIYMicr_00463
LOKILokiarch_22770
PSYTDSAG12_01210 DSAG12_02985
 » show all
Reference
1  [PMID:16621811]
  Authors
Grochowski LL, Xu H, White RH
  Title
Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate.
  Journal
J Bacteriol 188:3192-8 (2006)
DOI:10.1128/JB.188.9.3192-3198.2006
  Sequence
[mja:MJ_0044]
Reference
2  [PMID:10570138]
  Authors
Lange BM, Croteau R
  Title
Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step.
  Journal
Proc Natl Acad Sci U S A 96:13714-9 (1999)
DOI:10.1073/pnas.96.24.13714
Reference
3  [PMID:19928876]
  Authors
Chen M, Poulter CD
  Title
Characterization of thermophilic archaeal isopentenyl phosphate kinases.
  Journal
Biochemistry 49:207-17 (2010)
DOI:10.1021/bi9017957
  Sequence
[mth:MTH_47] [tac:Ta0103]
Reference
4  [PMID:20402538]
  Authors
Mabanglo MF, Schubert HL, Chen M, Hill CP, Poulter CD
  Title
X-ray structures of isopentenyl phosphate kinase.
  Journal
ACS Chem Biol 5:517-27 (2010)
DOI:10.1021/cb100032g
  Sequence
[mth:MTH_47] [tac:Ta0103]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.4.26
IUBMB Enzyme Nomenclature: 2.7.4.26
ExPASy - ENZYME nomenclature database: 2.7.4.26
BRENDA, the Enzyme Database: 2.7.4.26
LinkDB

DBGET integrated database retrieval system