KEGG   ENZYME: 2.7.7.31
Entry
EC 2.7.7.31                 Enzyme                                 
Name
DNA nucleotidylexotransferase;
terminal deoxyribonucleotidyltransferase;
terminal addition enzyme;
addase;
deoxynucleotidyl terminal transferase;
deoxyribonucleic acid nucleotidyltransferase;
deoxyribonucleic nucleotidyltransferase;
terminal deoxynucleotide transferase;
TdT
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
2'-deoxyribonucleoside-5'-triphosphate:DNA deoxynucleotidylexotransferase
Reaction(IUBMB)
2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 [RN:R00379]
Reaction(KEGG)
R00379
Substrate
2'-deoxyribonucleoside 5'-triphosphate [CPD:C00677];
DNAn [CPD:C00039]
Product
diphosphate [CPD:C00013];
DNAn+1 [CPD:C00039]
Comment
Catalyses template-independent extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Nucleoside may be ribo- or 2'-deoxyribo-.
History
EC 2.7.7.31 created 1972
Orthology
K00977  DNA nucleotidylexotransferase
Genes
HSA1791(DNTT)
PTR466167(DNTT)
PPS100976638(DNTT)
GGO101139353(DNTT)
PON100457001(DNTT)
NLE100579985(DNTT)
MCC704482(DNTT)
MCF102140598(DNTT)
CSAB103216324(DNTT)
CATY105581774(DNTT)
PANU101004822(DNTT)
TGE112631429(DNTT)
RRO104682828(DNTT)
RBB108534467(DNTT)
TFN117069302(DNTT)
PTEH111538742(DNTT)
CJC100397804(DNTT)
SBQ101034366(DNTT)
CSYR103261490(DNTT)
MMUR105872841(DNTT)
LCAT123649681(DNTT)
OGA100963608(DNTT)
MMU21673(Dntt)
MCAL110285762(Dntt)
MPAH110329145(Dntt)
RNO294051(Dntt)
MCOC116101174(Dntt)
MUN110546318(Dntt)
CGE100755735(Dntt)
MAUA101827000(Dntt)
PLEU114706872(Dntt)
MORG121454650(Dntt)
AAMP119801080(Dntt)
NGI103733214(Dntt)
HGL101718847(Dntt)
CPOC100717998(Dntt)
CCAN109693658(Dntt)
DORD105986669(Dntt)
DSP122115853(Dntt)
NCAR124985352
OCU100353958(DNTT)
OPI101522282(DNTT)
TUP102478219(DNTT)
CFA486815(DNTT)
CLUD112672117(DNTT)
VVP112917661(DNTT)
VLG121485315(DNTT)
AML100481079(DNTT)
UMR103672419(DNTT)
UAH113251768(DNTT)
UAR123783977(DNTT)
ELK111145199
LLV125085219
MPUF101678942(DNTT)
ORO101367975(DNTT)
EJU114205392(DNTT)
ZCA113923793(DNTT)
MLX118020756(DNTT)
FCA101097099(DNTT)
PYU121037047(DNTT)
PBG122493072(DNTT)
PTG102950975(DNTT)
PPAD109272695(DNTT)
AJU106984796(DNTT)
HHV120230554(DNTT)
BTA281120(DNTT)
BOM102272669(DNTT)
BIU109579068(DNTT)
BBUB102406379(DNTT)
CHX102168322(DNTT)
OAS101111504(DNTT)
ODA120873741(DNTT)
CCAD122445930(DNTT)
SSC100518694(DNTT)
CFR102504796(DNTT)
CBAI105081793(DNTT)
CDK105084270(DNTT)
VPC102525566(DNTT)
BACU103011471(DNTT)
LVE103081504(DNTT)
OOR101287627(DNTT)
DLE111172631(DNTT)
PCAD102994470(DNTT)
PSIU116741659(DNTT)
ECB100061113(DNTT)
EPZ103552065(DNTT)
EAI106842101(DNTT)
MYB102253082(DNTT)
MYD102751385(DNTT)
MMYO118669916(DNTT)
MLF102434921(DNTT)
MNA107542556(DNTT)
PKL118718954(DNTT)
HAI109380941(DNTT)
DRO112307104(DNTT)
SHON118990318(DNTT)
AJM119044488(DNTT)
PDIC114497769(DNTT)
PHAS123828914(DNTT)
MMF118632487(DNTT)
RFQ117035914(DNTT)
PALE102888799(DNTT)
PGIG120609697(DNTT)
PVP105301367(DNTT)
RAY107520451(DNTT)
MJV108409011(DNTT)
TOD119233784(DNTT)
SARA101551596(DNTT)
LAV100673573(DNTT)
TMU101349757
DNM101442590(DNTT)
MDO554183(DNTT)
GAS123236341(DNTT)
SHR100932555(DNTT)
PCW110215362(DNTT)
OAA100074260(DNTT)
GGA396351(DNTT)
PCOC116231747(DNTT)
MGP100541055(DNTT)
CJO107316113(DNTT)
NMEL110400293(DNTT)
APLA101802023(DNTT)
ACYG106039193(DNTT)
AFUL116491654(DNTT)
TGU100220809(DNTT)
LSR110473700(DNTT)
SCAN103813904(DNTT)
PMOA120501951(DNTT)
OTC121341879(DNTT)
PRUF121350267(DNTT)
GFR102044003(DNTT)
FAB101816703(DNTT)
PHI102109349(DNTT)
PMAJ107206803(DNTT)
CCAE111931212(DNTT)
CCW104696134(DNTT)
CBRC103624524(DNTT)
ETL114071228(DNTT)
ZAB102066525(DNTT)
FPG101919206(DNTT)
FCH102054379(DNTT)
CLV102094484(DNTT)
EGZ104129169(DNTT)
NNI104012889(DNTT)
PCRI104036506(DNTT)
ACUN113481618(DNTT)
TALA104361460(DNTT)
PADL103916289(DNTT)
ACHC115347985(DNTT)
HALD104320522(DNTT)
CCRI104157951(DNTT)
CSTI104559628(DNTT)
EHS104514514(DNTT)
FGA104069598(DNTT)
GSTE104257532(DNTT)
LDI104348038(DNTT)
MNB103782135(DNTT)
AAM106494703(DNTT)
AROW112964185(DNTT)
NPD112957371(DNTT)
DNE112979750(DNTT)
ASN102384458(DNTT)
AMJ102561518(DNTT)
CPOO109324044(DNTT)
GGN109287517(DNTT)
PSS102450678(DNTT)
CMY102947062(DNTT)
CPIC101934430(DNTT)
TST117880577(DNTT)
CABI116818963(DNTT)
MRV120369534(DNTT)
ACS100561065(dntt)
PVT110079723(DNTT)
SUND121926231(DNTT)
PBI103057405(DNTT)
PMUR107296133(DNTT)
PGUT117673154(DNTT)
VKO123018182(DNTT)
PMUA114596810(DNTT)
ZVI118096351(DNTT)
GJA107110244(DNTT)
STOW125438057(DNTT)
XLA378525(dntt.L)
XTR100495475(dntt)
NPR108788987(DNTT)
RTEM120910399(DNTT)
BBUF121005503(DNTT)
BGAR122942221(DNTT)
DRE544653(dntt)
SRX107750146
SANH107689364 107689760
SGH107562388 107565064(dntt)
CCAR109061132 109084734
CAUA113056613 113077836 113113209 113113212
PPRM120460955 120460956
MAMB125276495(dntt)
IPU108262831(dntt)
PHYP113539039(dntt)
SMEO124395153(dntt)
TFD113660969(dntt)
AMEX103039195(dntt)
EEE113579896(dntt)
TRU445927(dntt)
TNGGSTEN00031681G001
LCO104921904(dntt)
CGOB115020233(dntt)
ELY117248468(dntt)
EFO125903507(dntt)
PLEP121954928(dntt)
SLUC116047855(dntt)
ECRA117960944(dntt)
PFLV114572599(dntt)
GAT120820389(dntt)
PPUG119214495(dntt)
MSAM119917012(dntt)
CUD121511492(dntt)
ALAT119033118(dntt)
MZE101468990(dntt)
ONL100692116(dntt)
OAU116309670(dntt)
OLA101161827(dntt)
OML112161363(dntt)
XMA102220485(dntt)
XCO114137448(dntt)
XHE116712604(dntt)
PRET103477089(dntt)
PFOR103131300
PLAI106935023
PMEI106930456(dntt)
GAF122842235(dntt)
CVG107088395(dntt)
CTUL119782867(dntt)
GMU124859346(dntt)
KMR108246559(dntt)
ALIM106527857
NWH119420755(dntt)
AOCE111572840(dntt)
MCEP125018400(dntt)
POV109631607(dntt)
SSEN122781507(dntt)
HHIP117775488(dntt)
HSP118119090(dntt)
LCF108886302(dntt)
SDU111220725(dntt)
SLAL111669406(dntt)
XGL120796576(dntt)
HCQ109523082(dntt)
BPEC110166297
MALB109960959
BSPL114842095(dntt)
SASA106576788 106605322
OTW112252990 112253405
OMY100136754(tdt) 110526770
OGO124037185 124040812(dntt)
ONE115113350 115135271(dntt)
SALP111951682 111977656
SNH120017546 120045594
CCLU121553292 121569188
ELS105025934(dntt)
SFM108925807(dntt)
PKI111850348
AANG118218329(dntt)
LOC102690875(dntt)
PSPA121325345(dntt)
ARUT117418578(dntt)
LCM102353127(DNTT)
CMK103180497(dntt)
RTP109913711(dntt) 109929373
SPU591373
DPXDAPPUDRAFT_300508
DMK116921683
SPIS111336409
 » show all
Reference
1  [PMID:5543689]
  Authors
Chang LM, Bollum FJ.
  Title
Deoxynucleotide-polymerizing enzymes of calf thymus gland. V. Homogeneous terminal deoxynucleotidyl transferase.
  Journal
J Biol Chem 246:909-16 (1971)
Reference
2  [PMID:4288534]
  Authors
Gottesman ME, Canellakis ES.
  Title
The terminal nucleotidyltransferases of calf thymus nuclei.
  Journal
J Biol Chem 241:4339-52 (1966)
Reference
3  [PMID:14459258]
  Authors
KRAKOW JS, COUTSOGEORGOPOULOS C, CANELLAKIS ES.
  Title
Studies on the incorporation of deoxyribonucleic acid.
  Journal
Biochim Biophys Acta 55:639-50 (1962)
DOI:10.1016/0006-3002(62)90842-9
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.31
IUBMB Enzyme Nomenclature: 2.7.7.31
ExPASy - ENZYME nomenclature database: 2.7.7.31
BRENDA, the Enzyme Database: 2.7.7.31
CAS: 9027-67-2
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