KEGG   ENZYME: 2.7.7.44
Entry
EC 2.7.7.44                 Enzyme                                 
Name
glucuronate-1-phosphate uridylyltransferase;
UDP-glucuronate pyrophosphorylase;
UDP-D-glucuronic acid pyrophosphorylase;
UDP-glucuronic acid pyrophosphorylase;
uridine diphosphoglucuronic pyrophosphorylase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
Reaction(IUBMB)
UTP + 1-phospho-alpha-D-glucuronate = diphosphate + UDP-alpha-D-glucuronate [RN:R01381]
Reaction(KEGG)
R01381
Substrate
UTP [CPD:C00075];
1-phospho-alpha-D-glucuronate [CPD:C05385]
Product
diphosphate [CPD:C00013];
UDP-alpha-D-glucuronate [CPD:C00167]
Comment
Also acts slowly with CTP.
History
EC 2.7.7.44 created 1976
Pathway
ec00040  Pentose and glucuronate interconversions
ec00053  Ascorbate and aldarate metabolism
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:5570433]
  Authors
Roberts RM.
  Title
The formation of uridine diphosphate-glucuronic acid in plants. Uridine diphosphate-glucuronic acid pyrophosphorylase from barley seedlings.
  Journal
J Biol Chem 246:4995-5002 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.44
IUBMB Enzyme Nomenclature: 2.7.7.44
ExPASy - ENZYME nomenclature database: 2.7.7.44
BRENDA, the Enzyme Database: 2.7.7.44
CAS: 52228-05-4
LinkDB

KEGG   REACTION: R01381
Entry
R01381                      Reaction                               
Name
UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
Definition
UTP + D-Glucuronate 1-phosphate <=> Diphosphate + UDP-glucuronate
Equation
C00075 + C05385 <=> C00013 + C00167
Reaction class
RC00002  C00167_C05385
Enzyme
2.7.7.44        2.7.7.64
Pathway
rn00040  Pentose and glucuronate interconversions
rn00053  Ascorbate and aldarate metabolism
rn00520  Amino sugar and nucleotide sugar metabolism
rn01100  Metabolic pathways
rn01250  Biosynthesis of nucleotide sugars
Module
M00014  Glucuronate pathway (uronate pathway)
M00994  UDP-GlcA biosynthesis, myo-inositol => GlcA => UDP-GlcA
Brite
Enzymatic reactions [BR:br08201]
 2. Transferase reactions
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.44
     R01381  UTP + D-Glucuronate 1-phosphate <=> Diphosphate + UDP-glucuronate
    2.7.7.64
     R01381  UTP + D-Glucuronate 1-phosphate <=> Diphosphate + UDP-glucuronate
IUBMB reaction hierarchy [BR:br08202]
 2. Transferase reactions
  2.7.7.64
   R08845  alpha-D-Aldose 1-phosphate <=> UDP-sugar
    R01381  D-Glucuronate 1-phosphate <=> UDP-glucuronate
Orthology
K12447  UDP-sugar pyrophosphorylase [EC:2.7.7.64]
Other DBs
RHEA: 16328
LinkDB

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