Entry
Name
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase;
MEP cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
BRITE hierarchy
Sysname
CTP:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Reaction(IUBMB)
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [RN:
R05633 ]
Reaction(KEGG)
Substrate
CTP [CPD:
C00063 ];
2-C-methyl-D-erythritol 4-phosphate [CPD:
C11434 ]
Product
diphosphate [CPD:
C00013 ];
4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol [CPD:
C11435 ]
Comment
The enzyme from Escherichia coli requires Mg2+ or Mn2+. ATP or UTP can replace CTP, but both are less effective. GTP and TTP are not substrates. Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis (for diagram, click here).
History
EC 2.7.7.60 created 2001
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K00991 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
K12506 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase / 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Genes
CSAT : 104710168 104779591 104790032
LJA : Lj4g3v0016480.1(Lj4g3v0016480.1)
AHF : 112706805 112722754 112722760
MESC : 110600407 110630951
SSPL : 121805771 121808317
DOSA : Os01t0887100-01(Os01g0887100)
TAES : 123062915 123071780 123080105
PVIR : 120672828 120708918
SMO : SELMODRAFT_117940 SELMODRAFT_73567
CVR : CHLNCDRAFT_141910(CMS)
SMIN : v1.2.028096.t1(symbB.v1.2.028096.t1)
FCY : FRACYDRAFT_205256(CMS)
ECOO : ECRM13514_3599(ispD)
ECOH : ECRM13516_3464(ispD)
ELR : ECO55CA74_16165(ispD)
ECW : EcE24377A_3048(ispD)
ECOA : APECO78_17325(ispD)
EBR : ECB_02597(ispD) ECB_02825
EBL : ECD_02597(ispD) ECD_02825
EBE : B21_02562(ispD) B21_02774(ybl129)
EDJ : ECDH1ME8569_2657(ispD)
ECOI : ECOPMV1_03007(ispD)
SEM : STMDT12_C29790(ispD)
SEEH : SEEH1578_00655(ispD)
SENJ : CFSAN001992_18890(ispD)
RTG : NCTC13098_01436(ispD_1)
REE : electrica_00950(ispD)
CLAP : NCTC11466_00748(ispD)
KIE : NCTC12125_04938(ispD)
METY : MRY16398_10520(ispD)
AHN : NCTC12129_03948(ispD)
PTF : PROFFT_A_03000(ispD)
PSHI : SAMEA2665130_2347(ispD)
YPG : YpAngola_A0964(ispD)
YPI : YpsIP31758_3299(ispD)
SMW : SMWW4_v1c08050(ispD)
SFJ : SAMEA4384070_0854(ispD)
SOF : NCTC11214_00674(ispD)
PAQU : DMB82_0004630(ispD)
DIC : Dpoa569_000801(ispD)
EHD : ERCIPSTX3056_610(ispD)
BAPF : BUMPF009_CDS00179(ispd)
BAPG : BUMPG002_CDS00179(ispd)
BAPU : BUMPUSDA_CDS00179(ispd)
BAPW : BUMPW106_CDS00179(ispd)
TPTY : NCTC11468_00920(ispD)
PHEI : NCTC12003_00950(ispD)
PRJ : NCTC6933_03101(ispD)
LRI : NCTC12151_01111(ispD)
HIC : NTHIC486_00323(ispD)
HPIT : NCTC13334_00824(ispD)
HHZ : NCTC10839_00533(ispD)
HAEG : NCTC8502_00532(ispD)
HSEM : L3077_02415(ispD) L3077_03420
PDAG : 4362423_01685(ispD)
ADP : NCTC12871_00380(ispD)
ALIG : NCTC10568_00553(ispD_1)
AAZ : ADJ80_02385 ADJ80_07400
ASEG : NCTC10977_00426(ispD)
AVT : NCTC3438_00935(ispD)
RPNE : NCTC8284_00489(ispD)
PAET : NCTC13378_01738(ispD_2)
XFU : XFF4834R_chr27900(ispD)
XPH : XppCFBP6546_18890(XppCFBP6546P_18890)
XHD : LMG31886_25880(ispD)
THES : FHQ07_04175 FHQ07_10575
TCN : H9L16_02765 H9L16_09940
XBA : C7S18_13520 C7S18_22720
VAU : VANGNB10_cI0434(ispD)
PAEB : NCGM1900_2643(ispD)
PPUD : DW66_1159 DW66_1493
PVD : CFBP1590__4023(ispD)
PPRC : PFLCHA0_c12190(ispD)
PFW : PF1751_v1c12390(ispD)
PFF : PFLUOLIPICF701915(ispD)
PPUU : PputUW4_01110(ispD)
PTRT : HU722_0007520(ispD)
PTK : EXN22_07520 EXN22_16535
PTW : TUM18999_46050(ispD)
PTAE : NCTC10697_03436(ispD)
PSYC : DABAL43B_2149(ispD)
MCAT : MC25239_01279(ispD)
MCUN : NCTC10297_01059(ispD)
SCAA : TUM17387_12440(ispD)
SALH : HMF8227_00533(ispD)
MISZ : MishRS11D_13490(ispD)
TNI : TVNIR_1886(ispD_[H])
GAI : IMCC3135_23790(ispD)
HAXI : HAALTHF_22260n(ispD)
AEL : NCTC12917_03571(ispD)
CDIZ : CEDIAZO_01110(ispD)
NMM : NMBM01240149_0655(ispD)
NMS : NMBM01240355_1435(ispD)
NMQ : NMBM04240196_0707(ispD)
NMZ : NMBNZ0533_1488(ispD)
NMX : NMA510612_1926(ispD)
NWE : SAMEA3174300_1165(ispD)
NZO : SAMEA4504057_0803(ispD)
NCI : NCTC10296_00017(ispD)
NCZ : NCTC10294_00990(ispD)
NANI : NCTC12227_01187(ispD)
ECOR : SAMEA4412678_0286(ispD)
REH : H16_A1456(h16_A1456)
BMV : BMASAVP1_A1987(ispD)
BML : BMA10229_A3319(ispD)
BPM : BURPS1710b_2512(ispD)
BPL : BURPS1106A_2401(ispD)
BUE : BRPE67_ACDS12410(ispD)
PLG : NCTC10937_01489(ispD)
LMIR : NCTC12852_01843(ispD)
BUO : BRPE64_ACDS13440(ispD)
VTR : MYVALT_F_02800(ispD)
BTRM : SAMEA390648702504(ispD)
AXX : ERS451415_01390(ispD)
PACR : FXN63_10495 FXN63_24555
LIM : L103DPR2_02079(ispD)
LIH : L63ED372_01100(ispD)
SUTT : SUTMEG_07090(ispDF)
URU : DSM104443_02592(ispD)
UPL : DSM104440_02323(ispD)
FPHO : SHINM1_010300(ispD)
HHP : HPSH112_02410(ispDF)
HHQ : HPSH169_02330(ispDF)
HHR : HPSH417_02135(ispDF)
HPO : HMPREF4655_20672(ispD)
HPX : HMPREF0462_0488(ispD)
HEP : HPPN120_02170(ispDF)
HEU : HPPN135_02190(ispDF)
HPYA : HPAKL117_02085(ispDF)
HPYK : HPAKL86_03210(ispDF)
HPYO : HPOK113_0435(ispDF)
HPYL : HPOK310_0430(ispDF)
HCB : HCBAA847_1800(ispD_ispF)
HCL : NCTC13205_00024(ispDF)
HSH : NHP194022_15370(ispDF)
CJV : MTVDSCj20_1564(ispDF)
CFT : CFF04554_0408(ispDF)
CFV : CFVI03293_0407(ispDF)
CFX : CFV97608_0410(ispDF)
CAMP : CFT03427_0418(ispDF)
CCV : CCV52592_0202(ispDF)
CCO : CCC13826_1467(ispDF)
CCOC : CCON33237_1231(ispDF)
CLR : UPTC16701_0252(ispDF)
CLM : UPTC16712_0256(ispDF)
CLQ : UPTC4110_0247(ispDF)
CLN : UPTC3659_0264(ispDF)
CAJ : CIG1485E_0468(ispDF)
CAMR : CAQ16704_0254(ispDF)
CSM : CSUB8521_0256(ispDF)
CSF : CSUB8523_0250(ispDF)
CHV : CHELV3228_1535(ispDF)
CPIN : CPIN18020_0977(ispDF)
CLX : CLAN_0125(ispD) CLAN_1607(ispDF)
CAMZ : CVIC12175_1628(ispDF)
CINF : CINF_1118(ispDF) CINF_1601(ispD)
CNV : CNZW441b_0294(ispDF)
GBN : GEOBRER4_36880(ispD)
DMA : DMR_23150(ispD_ispF)
ERU : Erum1030(probable_ispD)
ERW : ERWE_CDS_01000(ispD)
ERG : ERGA_CDS_00960(ispD)
MESW : A9K65_019910(ispDF)
RBS : RHODOSMS8_00938(ispF)
SMEL : SM2011_c01040(ispDF)
SFD : USDA257_c34930(ispDF)
SAME : SAMCFNEI73_Ch1586(ispD)
AGR : AGROH133_05946(ispF)
REC : RHECIAT_CH0002043(ispDF)
REL : REMIM1_CH02004(ispDF)
REP : IE4803_CH02004(ispDF)
REI : IE4771_CH02079(ispDF)
RGA : RGR602_CH01839(ispDF)
RHN : AMJ98_CH02008(ispDF)
RPHA : AMC79_CH02126(ispDF)
RHX : AMK02_CH02016(ispDF)
REZ : AMJ99_CH02086(ispDF)
NEN : NCHU2750_19860(ispD)
BSV : BSVBI22_A1116(ispDF)
BVL : BF3285c1_1932(ispDF)
BIO : BR141012304_11720(ispDF)
BRC : BCCGELA001_18915(ispDF)
BVZ : BRAD3257_4530(ispDF)
VGO : GJW-30_1_02992(ispDF)
BHS : BM1374165_00568(ispDF)
BBK : BARBAKC583_0540(ispDF)
BTX : BM1374166_00809(ispDF)
BEZ : NCTC12898_00518(ispDF)
APOL : K9D25_01265 K9D25_15235
MDI : METDI3585(ispDF) METDI4485(ispF)
MAQU : Maq22A_c17520(ispF)
MTUN : MTUNDRAET4_1116(ispDF)
FIL : BN1229_v1_2799(ispDF)
FIY : BN1229_v1_3114(ispDF)
BVY : NCTC9239_01631(ispDF)
TSV : DSM104635_01993(ispDF)
RLI : RLO149_c017900(ispD)
KVL : KVU_0798(ispDF) KVU_1312(ispD)
KVU : EIO_1299 EIO_1847(ispD)
PHP : PhaeoP97_01473(ispDF)
PPIC : PhaeoP14_01380(ispDF)
SINL : DSM14862_01391(ispF)
SPSE : SULPSESMR1_01634(ispD)
RMM : ROSMUCSMR3_00179(ispF)
AHT : ANTHELSMS3_02797(ispDF)
RCP : RCAP_rcc01795(ispDF)
LVS : LOKVESSMR4R_01530(ispDF)
SDH : H9L15_10550 H9L15_10555(ispF)
SSY : SLG_18000(ispD_ispF)
SFLA : SPHFLASMR4Y_00766(ispDF)
EBLA : JGUZn3_17530(ispDF)
SHUM : STHU_25830(ispDF) STHU_41050(ispD)
STEL : STAQ_23660(ispDF) STAQ_25520(ispD)
ABS : AZOBR_p110006(ispDF)
MGY : MGMSRv2__1153(ispDF)
THAC : CSC3H3_09655(ispDF)
BAZ : BAMTA208_00455(ispD)
BAE : BATR1942_19060(ispD)
BSON : S101395_00123(ispD)
BTHR : YBT1520_00400(ispD)
BTHU : YBT1518_00410(ispD)
BACI : B1NLA3E_00410(ispD)
BFD : NCTC4823_04122(ispD)
BLEN : NCTC4824_00113(ispD_1)
SDP : NCTC12225_02467(ispD)
SSTE : SAMEA4384403_2332(ispD)
LMOC : LMOSLCC5850_0230(ispD)
LMW : LMOSLCC2755_0233(ispD)
LMX : LMOSLCC2372_0237(ispD)
LMZ : LMOSLCC2482_0235(ispD)
LMON : LMOSLCC2376_0205(ispD)
LMOS : LMOSLCC7179_0230(ispD)
LMOO : LMOSLCC2378_0248(ispD)
LMOY : LMOSLCC2479_0236(ispD)
LMOT : LMOSLCC2540_0241(ispD)
LMOA : LMOATCC19117_0243(ispD)
LGZ : NCTC10812_00244(ispD)
PPQ : PPSQR21_045600(ispD)
PCHI : PC41400_29275(ispD)
PCEL : HUB94_26540(ispD) HUB94_26930
LCAR : BHS00_02030 BHS00_06070
SPSU : NCTC13786_02012(ispD2)
SPOC : NCTC10925_01126(ispD2)
FPEN : KIW23_01595 KIW23_09530(ispD)
CLOS : DMR38_02305 DMR38_20465(ispD)
CLO : HMPREF0868_0720(ispD)
RUK : A4V00_01745 A4V00_12725
VFA : MM35RIKEN_10370(ispD)
CEV : LK421_05845 LK421_10540(ispD)
BLAU : DQQ01_03195(ispD) DQQ01_13315
BPRO : PMF13cell1_05312(tarI)
CSCI : HDCHBGLK_00450(ispD) HDCHBGLK_03643(tarI)
ACEL : acsn021_05200 acsn021_41650(ispD)
ACHT : bsdcttw_04360(ispD)
DLO : K5I24_03870(ispD) K5I24_06515(ispD)
SINT : K5I26_00040(ispD) K5I26_14320
WCP : H9Q76_00890 H9Q76_01745(ispD) H9Q76_02880
PDF : CD630DERM_00470(ispD)
EAC : EAL2_c01300(ispD1) EAL2_c19020(ispD2) EAL2_c19040(ispD3)
PHX : KGNDJEFE_00084(ispD)
TEM : JW646_04335 JW646_08920(ispD) JW646_10250
CBAR : PATL70BA_0999(ispD)
ABUT : Ami103574_01960 Ami103574_13585
ETM : CE91St48_38370(ispDF)
CDIA : CaldiYA01_09890(ispD)
PHAR : NCTC13077_00828(ispD)
PIV : NCTC13079_00837(ispD2)
VRM : 44547418_01030(ispDF)
VDN : NCTC11831_00878(ispDF)
DHO : Dia5BBH33_08250(ispDF)
MANA : MAMMFC1_02003(ispDF)
AFN : Acfer_0719 Acfer_0744
PFAC : PFJ30894_01028(ispD)
AARG : Aargi30884_18580(ispD)
ABSI : A9CBEGH2_16640(ispD)
FIT : Fi14EGH31_28230(ispD)
SCR : SCHRY_v1c00230(ispD)
SSYR : SSYRP_v1c00230(ispD)
SDI : SDIMI_v3c00200(ispD)
SAPI : SAPIS_v1c00210(ispD)
SCQ : SCULI_v1c00210(ispD)
SSAB : SSABA_v1c00200(ispD)
SATR : SATRI_v1c00320(ispD)
SERI : SERIO_v1c00420(ispD)
SCOU : SCORR_v1c00190(ispD)
SPRN : S100390_v1c00210(ispD)
SPIT : STU14_v1c00210(ispD)
STAB : STABA_v1c00200(ispD)
SALX : SALLE_v1c00200(ispD)
SGQ : SGLAD_v1c00200(ispD)
SCHI : SCHIN_v1c00220(ispD)
MBO : BQ2027_MB3613C(ispD)
MSA : Mycsm_04433 Mycsm_04434
MMAE : MMARE11_48970(ispD)
MGRO : FZ046_24050 FZ046_24055
MBAI : MB901379_04472(ispD)
MHEK : JMUB5695_00455(ispD)
MGAU : MGALJ_24990(ispD) MGALJ_25000
MDF : K0O62_20305 K0O62_20310
MHOL : K3U96_08825 K3U96_08830
MRF : MJO55_18645 MJO55_18650
MSP : Mspyr1_19550 Mspyr1_19560
MYN : MyAD_19495 MyAD_19500
MPHL : MPHLCCUG_03694(ispD_1) MPHLCCUG_03695(ispD_2)
MVQ : MYVA_3923(ispD) MYVA_3924
MRH : MycrhN_4057 MycrhN_4058
MTHN : 4412656_02984(ispD_1) 4412656_02985(ispD_2)
MHAS : MHAS_01075(ispD_1) MHAS_01076(ispD_2)
MDU : MDUV_05490(ispD_1) MDUV_05500(ispD_2)
MAUU : NCTC10437_03863(ispD_1) NCTC10437_03864(ispD_2)
MMAG : MMAD_38800(ispD) MMAD_38810
MMOR : MMOR_24360 MMOR_24370(ispD)
MPSC : MPSYJ_26830 MPSYJ_26840(ispD)
MARZ : MARA_58590 MARA_58600(ispD)
MGAD : MGAD_57550 MGAD_57560(ispD)
MAUB : MAUB_47580 MAUB_47590(ispD)
MPOF : MPOR_42490(ispD) MPOR_42500
MPHU : MPHO_21480(ispD) MPHO_21490
MMUC : C1S78_007475 C1S78_007565
MSEI : MSEDJ_50070(ispD) MSEDJ_50080
MFLV : NCTC10271_01609(ispD) NCTC10271_01610(ispD2)
MCEE : MCEL_00610 MCEL_00620(ispD)
MSAL : DSM43276_00485(ispD)
MTER : 4434518_03750(ispD)
CDIP : ERS451417_01976(ispD)
CUN : Cul210932_1960(ispD)
CUQ : Cul210931_1905(ispD)
CUJ : CUL131002_1872c(ispD)
CMIN : NCTC10288_00357(ispD)
CRL : NCTC7448_00434(ispD)
CCYS : SAMEA4530656_0199(ispD)
NFR : ERS450000_03801(ispD)
NAD : NCTC11293_01203(ispD)
NWL : NWFMUON74_04560(ispD)
RCR : NCTC10994_02178(ispD)