KEGG   ENZYME: 2.7.7.71
Entry
EC 2.7.7.71                 Enzyme                                 
Name
D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase;
hddC (gene name);
gmhD (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
GTP:D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Reaction(IUBMB)
D-glycero-alpha-D-manno-heptose 1-phosphate + GTP = GDP-D-glycero-alpha-D-manno-heptose + diphosphate [RN:R09772]
Reaction(KEGG)
R09772
Substrate
D-glycero-alpha-D-manno-heptose 1-phosphate [CPD:C19880];
GTP [CPD:C00044]
Product
GDP-D-glycero-alpha-D-manno-heptose [CPD:C19881];
diphosphate [CPD:C00013]
Comment
The enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein in some Gram-positive bacteria.
History
EC 2.7.7.71 created 2010
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K15669  D-glycero-alpha-D-manno-heptose 1-phosphate guanylyltransferase
Genes
YPB: YPTS_1057
YPQ: DJ40_1346
YPU: BZ21_256
YPR: BZ20_1033
YPC: BZ23_532
YAS: N0H69_17355
PLU: plu4824(wblY)
PLUM: A4R40_23995
LSOL: GOY17_03460
LHX: LYSHEL_08780(hddC)
LCAS: LYSCAS_08780(hddC)
THES: FHQ07_06195
TCN: H9L16_07625
TBV: H9L17_06855
VAF: D1115_23000
VSR: Vspart_00205(rfbF_2)
VZI: G5S32_14895
VJP: NP165_18360
VRU: RND59_05065
PGB: H744_2c2396
PGH: FH974_09830
PPB: PPUBIRD1_1474
PEN: PSEEN2466
PALL: UYA_23035
PBZ: GN234_10455
PKH: JLK41_16275
PMUY: KSS95_17175
PORY: EJA05_20070
PWZ: J7655_08605
PSIH: LOY51_19415
PASI: LG197_25605
PSKP: KU43P_15430(hddC)
PAGR: E2H98_17305
SBB: Sbal175_1479
PSHO: KQ246_01930
AMAG: I533_13330
CEB: B0D95_15710
ASIP: AQUSIP_18120(hddC_2)
METL: U737_03410
MEEP: JWZ98_02700
MMOB: F6R98_01285
MEIN: methR_P2383
MESL: KKZ03_15205
HTR: EPV75_08905
TVI: Thivi_4047
HCH: HCH_06180
HAHE: ENC22_26650
HAHH: O5O45_29345
TOL: TOL_2195
TOR: R615_06680
ENW: MJO57_17215
REU: Reut_A0722
CUP: BKK80_17030
CUU: BKK79_15325
BMA: BMA2294(hddC)
BMV: BMASAVP1_A0534(hddC)
BML: BMA10229_A1066(wcbM)
BMN: BMA10247_2172(wcbM)
BMAL: DM55_1490
BMAE: DM78_2664
BMAQ: DM76_1468
BMAI: DM57_1069
BMAF: DM51_1935
BMAZ: BM44_1069
BMAB: BM45_2460
BPS: BPSL2794(wcbM)
BPM: BURPS1710b_3290(wcbM)
BPL: BURPS1106A_3276(wcbM)
BPD: BURPS668_3241(wcbM)
BPR: GBP346_A3419
BPSE: BDL_2651
BPSM: BBQ_515
BPSU: BBN_643
BPSD: BBX_1049
BPZ: BP1026B_I0516(wcbM)
BPQ: BPC006_I3324
BPK: BBK_2136
BPSH: DR55_1724
BPSA: BBU_2768
BPSO: X996_1364
BUT: X994_3362
BTD: BTI_922
BTHA: DR62_527
BCEW: DM40_4221
BLAT: WK25_23470
BSTL: BBJ41_08330
BARI: NLX30_31955
BAEN: L3V59_19735
BPLA: bpln_1g18360
BUZ: AYM40_03130 AYM40_03410
BCAI: K788_0007829
PHS: C2L64_13955
PMEG: FNZ07_18190
PACS: FAZ98_02535
PCOS: C2747_01705
TVL: FAZ95_17365
TCAR: U0034_03655
RSB: RS694_17780
ATER: MW290_21690
HSE: Hsero_4416
HSZ: ACP92_22055
HFR: G5S34_23460
HEW: HBDW_45220
MASS: CR152_19315
AON: DEH84_17470
NET: Neut_0159
MEH: M301_2250
MBAT: BN1208_0915
MEU: ACJ67_08020
ARES: IWH25_01540
REN: EF513_03800
BRN: D1F64_11925
CSE: Cseg_1878
CMB: CSW64_13085
BND: KWG56_04320
AZS: E6C72_17750
MAGX: XM1_1801
MAGN: WV31_16780
FER: FNB15_03140
MAG: amb0798
APB: SAR116_0975
HWI: A0Z60_06595
HPUL: NCTC13154_01557(rmlA1)
CJE: Cj1423c(hddC)
CJB: BN148_1423c(hddC)
CJJ: CJJ81176_1422
CJN: ICDCCJ07001_1353
CJS: CJS3_1516
CJEJ: N564_02350
CJEU: N565_02430
CJEN: N755_02485
CJEI: N135_01513
CJER: H730_08135
CJY: QZ67_01562(hddC_2)
CJQ: UC78_1364(hddC_2)
CJW: PJ18_07290
CJR: CJE1608
CJD: JJD26997_1755
CJZ: M635_02840
CJX: BN867_14000
CLR: UPTC16701_0318
CLM: UPTC16712_0316
CLN: UPTC3659_0328
CCF: YSQ_01745
CIS: CINS_0294
CAMR: CAQ16704_0317
CSM: CSUB8521_0329
CHV: CHELV3228_0219
CCUN: CCUN_1150
CLX: CLAN_0154
CHW: A2J15_004895
CAMZ: CVIC12175_0186
COJ: CORN_0315
CUX: CUP3940_1431
CARM: CARM_0283
CNV: CNZW441b_0370
CVU: CVULP_1505
CDEV: CIGN_0114
ANT: Arnit_2924
ALK: ALEK_0997
AMYT: AMYT_0705
HMR: Hipma_1691
GLO: Glov_0792
DMA: DMR_p1_00350
DOV: DSCO28_03320
TCM: HL41_06280
APAU: AMPC_02940(hddC)
PPSC: EHS13_28190
PRZ: GZH47_12300
ASOC: CB4_00634(hddC)
ACUR: JZ785_20285
CAC: CA_C3056
CAE: SMB_G3092
CAY: CEA_G3062
CFER: D4Z93_01725
CRW: CROST_039040(hddC)
CFB: CLFE_008780(hddC)
CAUN: CLAUR_036220(hddC)
DEC: DCF50_p1136
CSH: Closa_3799
LXA: OW255_03125
CASP: NQ535_04230
HHJ: NQ487_27320
PBIF: KXZ80_16775
AOC: Aocu_04610(hddC)
SYN: slr0007
SYZ: MYO_122470
SYY: SYNGTS_2223(slr0007)
SYT: SYNGTI_2222(slr0007)
SYS: SYNPCCN_2221(slr0007)
SYQ: SYNPCCP_2221(slr0007)
SYJ: D082_33180
SYO: C7I86_11615
SYNH: HTZ78_02885
PMH: P9215_14341
GEN: GM3709_95
GEE: GM3708_2173
CAN: Cyan10605_0114
MAR: MAE_55660
MPK: VL20_391
MIQ: B5D77_10620
MVZ: myaer102_27900
CYU: UCYN_11560
CYT: cce_0965
CWA: CwatDRAFT_2259
CYP: PCC8801_1636
CYH: Cyan8802_1663
CEO: ETSB_0017
CER: RGRSB_1051
CEEC: P3F56_10000
SNG: SNE_A16750(mpg1)
GAW: V144x_54480(hddC_2)
ULI: ETAA1_11120(hddC)
KST: KSMBR1_2292
BPIT: BPIT_11880 BPIT_20160
TPSC: RBB77_18785
MSIL: METEAL_02450(hddC)
FVA: FV113G1_09570(hddC)
HABY: HLVA_19740(hddC)
ACO: Amico_1360
AMIZ: RBH88_03095
TLI: Tlie_1237
AMO: Anamo_1480
BTH: BT_0476
BTHO: Btheta7330_02886(hddC_2)
BFG: BF638R_1446
PCLR: PC1C4_23770
ALD: GFH31_01605
AIT: AI2BBH_01750
AIU: NQ491_03840
CPI: Cpin_3113
CHIH: GWR21_07435
COY: HF329_02880
CFIL: MYF79_22185
CHF: KTO58_06615
CSAC: SIO70_23820
CHIM: CK934_22445
NKO: Niako_2549
NSO: NIASO_09040
NIA: A8C56_12860
NYN: U0035_05275
NDF: KRR40_00670
FLA: SY85_01480
ARK: D6B99_15400
FLN: FLA_2279
PSEG: D3H65_10795
PGIN: FRZ67_05020
PGO: FSB84_23210
FLS: GLV81_14345
FEI: K9M53_08230
FLP: LK994_12850
THEO: IMW88_11155
CHRW: KA713_13915
PAA: Paes_1744
NDE: NIDE3423
NALL: PP769_09065
NNEO: PQG83_20300
LFI: LFML04_1776
NVA: G3M78_07675
MPI: Mpet_1391
 » show all
Reference
1  [PMID:11279237]
  Authors
Kneidinger B, Graninger M, Puchberger M, Kosma P, Messner P
  Title
Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose.
  Journal
J Biol Chem 276:20935-44 (2001)
DOI:10.1074/jbc.M100378200
  Sequence
[ag:AAK27852]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.71
IUBMB Enzyme Nomenclature: 2.7.7.71
ExPASy - ENZYME nomenclature database: 2.7.7.71
BRENDA, the Enzyme Database: 2.7.7.71
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