KEGG   ENZYME: 2.7.7.92
Entry
EC 2.7.7.92                 Enzyme                                 
Name
3-deoxy-D-glycero-D-galacto-nonulopyranosonate cytidylyltransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases
Sysname
CTP:3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate cytidylyltransferase
Reaction(IUBMB)
CTP + 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate = diphosphate + CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [RN:R11441]
Reaction(KEGG)
R11441
Substrate
CTP [CPD:C00063];
3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:C20934]
Product
diphosphate [CPD:C00013];
CMP-3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate [CPD:C21384]
Comment
The enzyme is part of the biosynthesis pathway of the sialic acid 3-deoxy-D-glycero-D-galacto-non-2-ulopyranosonate (Kdn). Kdn is abundant in extracellular glycoconjugates of lower vertebrates such as fish and amphibians, but is also found in the capsular polysaccharides of bacteria that belong to the Bacteroides genus.
History
EC 2.7.7.92 created 2016
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K21749  N-acylneuraminate/3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
K21750  3-deoxy-D-glycero-D-galacto-nononate cytidylyltransferase
Genes
HSA55907(CMAS)
PTR465340(CMAS)
PPS100970394(CMAS)
GGO101134064(CMAS)
PON100173476(CMAS)
NLE100588502(CMAS)
MCC706604(CMAS)
MCF102117955(CMAS)
MTHB126930523
CSAB103218742(CMAS)
CATY105585058(CMAS)
PANU101009685(CMAS)
TGE112634866(CMAS)
RRO104660755(CMAS)
RBB108541109(CMAS)
TFN117090398(CMAS)
PTEH111540639(CMAS)
CANG105521099(CMAS)
CJC100406904(CMAS)
SBQ101042258(CMAS)
CSYR103255168
MMUR105882803(CMAS)
LCAT123639935(CMAS)
PCOQ105807556(CMAS)
OGA100950112(CMAS)
MMU12764(Cmas)
MCAL110296030(Cmas)
MPAH110316174(Cmas)
RNO312826(Cmas)
MCOC116099768(Cmas)
MUN110560537(Cmas)
CGE100773134(Cmas)
MAUA101834722(Cmas)
PLEU114700283(Cmas)
MORG121439415(Cmas)
MFOT126497321
AAMP119806711(Cmas)
NGI103736727(Cmas)
HGL101697716(Cmas)
CPOC100715137(Cmas)
CCAN109684205(Cmas) 109700116
DORD105992240(Cmas)
DSP122102254(Cmas)
NCAR124984040
OCU100351910
OPI101531831(CMAS)
TUP102484781(CMAS)
GVR103599360(CMAS)
CFA477673(CMAS)
CLUD112665512(CMAS)
VVP112917221(CMAS)
VLG121480099(CMAS)
AML100464890(CMAS)
UMR103665267(CMAS)
UAH113257802(CMAS)
UAR123801662(CMAS)
ELK111161354
LLV125107288
MPUF101692809(CMAS)
ORO101367176(CMAS)
EJU114216635(CMAS)
ZCA113922763(CMAS)
MLX118025583(CMAS)
NSU110580831(CMAS)
LWW102734020(CMAS)
FCA101096901(CMAS)
PYU121038821(CMAS)
PBG122474063(CMAS)
LRUF124501645
PTG102968672(CMAS)
PPAD109268728(CMAS)
AJU106967979(CMAS)
HHV120236000(CMAS)
BTA100336710(CMAS)
BOM102265983(CMAS)
BIU109558556(CMAS)
BBUB102410777(CMAS)
BBIS105000215(CMAS)
CHX102171581(CMAS)
OAS101115615(CMAS)
ODA120858933(CMAS)
CCAD122423658(CMAS)
SSC100520022(CMAS)
CFR102512611(CMAS)
CBAI105062286(CMAS)
CDK105096480(CMAS)
VPC102526239(CMAS)
BACU103009004(CMAS)
LVE103076237(CMAS)
OOR101286195(CMAS)
DLE111176838 111176839
PCAD102986559(CMAS)
PSIU116760945(CMAS)
ECB100064384(CMAS) 111767497 111772031 111772222
EPZ103554940(CMAS)
EAI106825570(CMAS)
MYB102249530(CMAS)
MYD102769445(CMAS)
MMYO118651200(CMAS)
MLF102437190(CMAS)
MNA107525267(CMAS)
PKL118729455(CMAS)
HAI109375147(CMAS)
DRO112318410(CMAS)
SHON118978367(CMAS)
AJM119048977(CMAS)
PDIC114513143(CMAS)
PHAS123813106(CMAS)
MMF118624507(CMAS)
RFQ117029190(CMAS)
PALE102891934(CMAS)
PGIG120618364(CMAS)
PVP105306531(CMAS)
RAY107508579(CMAS)
MJV108398365(CMAS)
TOD119247641(CMAS)
SARA101537210(CMAS)
LAV100659502(CMAS)
TMU101358724
ETF101660094(CMAS)
DNM101445069(CMAS)
MDO100010366(CMAS)
GAS123249156(CMAS)
SHR100916925(CMAS)
PCW110213797(CMAS)
OAA100079158(CMAS)
GGA418199(CMAS)
PCOC116231408(CMAS)
MGP100547771(CMAS)
CJO107317124(CMAS)
NMEL110396222(CMAS)
APLA101797002(CMAS)
ACYG106038290(CMAS)
AFUL116493389(CMAS)
TGU100225966(CMAS)
LSR110475217(CMAS)
SCAN103819571(CMAS)
PMOA120507577(CMAS)
OTC121332067(CMAS)
PRUF121352112(CMAS)
GFR102039209(CMAS)
FAB101808069(CMAS)
PHI102099665(CMAS)
PMAJ107205108(CMAS)
CCAE111929504(CMAS)
CCW104696139(CMAS)
CBRC103623398(CMAS)
ETL114068941(CMAS)
ZAB102069251(CMAS)
ACHL103809183(CMAS)
FPG101922260(CMAS)
FCH102056814(CMAS)
CLV102093680(CMAS)
EGZ104135092(CMAS)
NNI104012728(CMAS)
PLET104614354(CMAS)
PCRI104029073(CMAS)
PCAO104043592(CMAS)
ACUN113488254(CMAS)
TALA104360103(CMAS)
PADL103924479(CMAS)
AFOR103898736(CMAS)
ACHC115352604(CMAS)
HALD104319173(CMAS)
HLE104836710(CMAS)
AGEN126047784
GCL127017251
CCRI104165180(CMAS)
CSTI104562286(CMAS)
EHS104510454(CMAS)
CMAC104480002(CMAS)
MUI104534845(CMAS)
FGA104070353(CMAS)
GSTE104262592(CMAS)
LDI104346311(CMAS)
MNB103773097(CMAS)
OHA104327195(CMAS)
NNT104399858(CMAS)
DPUB104299428(CMAS)
PGUU104464829(CMAS)
ACAR104521373(CMAS)
CPEA104393512(CMAS)
AVIT104270825(CMAS)
CVF104281727(CMAS)
CUCA104059292(CMAS)
TEO104383582(CMAS)
BRHI104490738(CMAS)
AAM106488296(CMAS)
AROW112966587(CMAS)
NPD112944383(CMAS)
TGT104578996(CMAS)
DNE112978899(CMAS)
SCAM104154120(CMAS)
ASN102377821(CMAS)
AMJ102572771(CMAS)
CPOO109316393(CMAS)
GGN109296300(CMAS)
PSS102462348(CMAS)
CMY102944186(CMAS)
CPIC101937923(CMAS)
TST117883383(CMAS)
CABI116835473(CMAS)
MRV120391308(CMAS)
ACS100560058(cmas)
PVT110091200(CMAS)
SUND121931412(CMAS)
PBI103057127(CMAS)
PMUR107295787(CMAS)
CTIG120309795(CMAS)
TSR106553370(CMAS)
PGUT117679859(CMAS)
VKO123034669(CMAS)
PMUA114605172(CMAS)
ZVI118091426(CMAS)
GJA107106355(CMAS)
STOW125434317(CMAS)
XLA108710695(cmas.L)
XTR100036739(cmas)
NPR108789878(CMAS)
RTEM120932767(CMAS)
BBUF121005137(CMAS)
DRE100885772(cmasb) 561018(cmasa)
SRX107725656 107729858 107754376
SANH107676932 107686963 107686964 107690429
SGH107561146 107566237 107583561 107587160
CCAR109050865 109055284 109078903 109079913 109087566
CAUA113060713 113063685 113066549 113066552 113066554 113066638 113085421
PPRM120475374(cmasb) 120475382 120475383 120476870(cmasa)
MAMB125246406(cmasa) 125247715 125247764 125247863 125247900 125247934 125251691
IPU108260153 108279965(cmasa)
PHYP113531521 113532112
SMEO124378729 124400965 124401283 124401284 124401666
TFD113647288(cmasa)
AMEX103032957(cmas)
EEE113569165 113569273 113571272 113587611
TRU777966(cmas)
TNGGSTEN00036152G001
LCO104933596(cmas)
CGOB115024037(cmas)
ELY117246230(cmasa)
EFO125884435(cmasa)
PLEP121962198 121966280
SLUC116053150(cmasa)
ECRA117935047(cmasa)
ESP116669510(cmas)
PFLV114573918(cmas)
GAT120823098(cmasa)
PPUG119222965(cmasa)
MSAM119912402
CUD121504755(cmasa)
ALAT119027006(cmasa)
MZE106676701 111501613
ONL100690888 100691152 100691690
OAU116317091 116329280 116334504
OLA101175534(cmas)
OML112156064(cmasa)
XMA102216878 102216980 111610925 111610926
XCO114157354(cmas)
XHE116733436 116733437 116733438
PRET103480600 103480601
PFOR103156678 103156685(cmas) 103156781
PLAI106956934 106956935 106956936
PMEI106907823 106907824
GAF122820263 122820265
CVG107083409 107095092 107104871 107104876
CTUL119779748 119787166
GMU124880206 124880382 124880383 124880384 124880385 124880456
NFU107376910 107376911
KMR108228449 108250897
ALIM106519069 106519070
NWH119411792 119411887
AOCE111584516(cmas)
MCEP125020788(cmasa)
CSEM103386081(cmas)
POV109642938(cmas)
SSEN122765919(cmasa)
HHIP117751875(cmasa)
HSP118102620(cmasa)
LCF108891965(cmasa)
SDU111233310(cmas)
SLAL111657238(cmas)
XGL120797656(cmasa)
HCQ109506960(cmas)
BPEC110172765 110174880
MALB109974198 109974201
BSPL114847429(cmasa)
SASA100194895(neua) 106576595 106578766 106590764 106590838 106593487 106596479(NEUA) 106597166 106597185 106597441 106597467 106597528 106597536
STRU115180552 115180553 115199177 115199178 115202177
OTW112240998 112241039 112245012 121845714
OMY100135794(cmas) 110490643 110497426 118936248 118942883
OGO124002066 124017676(cmasa) 124027201 124028462 124028543
ONE115146547(cmas)
SALP112068284(cmas) 112077130
SNH120031773 120031774 120035099 120035151 120049417 120050104
CCLU121535763 121557235 121557236 121561191
ELS105009720(cmas)
SFM108935968(cmas)
PKI111837183(cmas)
AANG118219286(cmasa)
LOC102697163(cmas)
PSPA121318009 121320279
ARUT117414820 117419575
PSEX120539540(cmasa)
LCM102354669(CMAS)
CMK103181066(cmasa)
RTP109936007(cmas)
BFO118406623 118406756 118407224 118421524
BBEL109463567 109463577 109471768 109471775
CIN100101814(cmas)
SCLV120331504 120331505
SPU115923639 588508(cmas)
APLC110980233
AJC117120586 117120616
SKO100378063 100378406 102808000
DMEDmel_CG32220(Csas)
DER6545780
DSE6619433
DSIDsimw501_GD12235(Dsim_GD12235)
DYADyak_GE22447
DAN6493701
DSR110190055
DPO6900890
DPE6603364
DMN108152106
DWI6643060
DGR6557117
DMODmoj_GI13380
DAZ108614625
DNV108651686
DHE111605622
DVI6622652
CCAT101454971
BOD106617956
RZE108362028
SCAC106080898
LCQ111687698
LSQ119612161
HIS119649316
AGAAgaP_AGAP004527
ACOZ120948298
AARA120903006
ASTE118503037
AAG5576920
AALB109411850 115259468 115268775
CQUCpipJ_CPIJ000558
CPII120417068
CNS116349105
BCOO119074977
NVL108564803
APLN108741878
PPYR116178086
OTU111417161
DPLKGM_200278
BANY112056558
PMAC106718036
PPOT106107405
ZCE119832208
TNL113508728
OFU114363071
PXY105388536
API100161457
DNX107172003
AGS114128368
RMD113556369
BTAB109035092
DCI103508411
CLEC106667611
HHAL106687600
PHUPhum_PHUM094730
TPAL117649570
ZNE110839122
CSEC111868098
FCD110861915
DPXDAPPUDRAFT_310334
DMK116924342
DPZ124337543
PVM113806787
PJA122263570
PCHN125039821
HAME121855760
PCLA123763938
PTRU123503078
EAF111713760
LSM121121214 121121454 121130036
PPOI119095530
ISCIscW_ISCW021121
DSV119453111 119453112
RSAN119400028
RMP119179616
VDE111252968
VJA111260555
TUT107359229
CSCU111618601
PTEP107440108
SDM118183334
MMER123529943 123530395 123530487
AAFAURANDRAFT_22362
EHXEMIHUDRAFT_442878(NANT1) EMIHUDRAFT_445636
BPAAK7I13_00550
BTHBT_1715
BTHOBtheta7330_01301
BEGINE88_01920
BSTEK6V31_10260
FAZM0M57_00285
AICJK629_04880
SINHLS482_08955
 » show all
Reference
1  [PMID:8381411]
  Authors
Terada T, Kitazume S, Kitajima K, Inoue S, Ito F, Troy FA, Inoue Y
  Title
Synthesis of CMP-deaminoneuraminic acid (CMP-KDN) using the CTP:CMP-3-deoxynonulosonate cytidylyltransferase from rainbow trout testis. Identification and characterization of a CMP-KDN synthetase.
  Journal
J Biol Chem 268:2640-8 (1993)
Reference
2  [PMID:8665905]
  Authors
Terada T, Kitajima K, Inoue S, Koppert K, Brossmer R, Inoue Y
  Title
Substrate specificity of rainbow trout testis CMP-3-deoxy-D-glycero-D-galacto-nonulosonic acid (CMP-Kdn) synthetase: kinetic studies of the reaction of natural and synthetic analogues of nonulosonic acid catalyzed by CMP-Kdn synthetase.
  Journal
Eur J Biochem 236:852-5 (1996)
DOI:10.1111/j.1432-1033.1996.00852.x
Reference
3  [PMID:11479279]
  Authors
Nakata D, Munster AK, Gerardy-Schahn R, Aoki N, Matsuda T, Kitajima K
  Title
Molecular cloning of a unique CMP-sialic acid synthetase that effectively utilizes both deaminoneuraminic acid (KDN) and N-acetylneuraminic acid (Neu5Ac) as substrates.
  Journal
Glycobiology 11:685-92 (2001)
DOI:10.1093/glycob/11.8.685
  Sequence
Reference
4  [PMID:17580313]
  Authors
Tiralongo J, Fujita A, Sato C, Kitajima K, Lehmann F, Oschlies M, Gerardy-Schahn R, Munster-Kuhnel AK
  Title
The rainbow trout CMP-sialic acid synthetase utilises a nuclear localization signal different from that identified in the mouse enzyme.
  Journal
Glycobiology 17:945-54 (2007)
DOI:10.1093/glycob/cwm064
  Sequence
[mmu:12764]
Reference
5  [PMID:18804026]
  Authors
Wang L, Lu Z, Allen KN, Mariano PS, Dunaway-Mariano D
  Title
Human symbiont Bacteroides thetaiotaomicron synthesizes 2-keto-3-deoxy-D-glycero-D- galacto-nononic acid (KDN).
  Journal
Chem Biol 15:893-7 (2008)
DOI:10.1016/j.chembiol.2008.08.005
  Sequence
[bth:BT_1715]
Other DBs
ExplorEnz - The Enzyme Database: 2.7.7.92
IUBMB Enzyme Nomenclature: 2.7.7.92
ExPASy - ENZYME nomenclature database: 2.7.7.92
BRENDA, the Enzyme Database: 2.7.7.92
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