KEGG   ENZYME: 2.7.8.14
Entry
EC 2.7.8.14                 Enzyme                                 
Name
CDP-ribitol ribitolphosphotransferase;
teichoic-acid synthase (ambiguous);
polyribitol phosphate synthetase (ambiguous);
teichoate synthetase (ambiguous);
poly(ribitol phosphate) synthetase (ambiguous);
polyribitol phosphate polymerase (ambiguous);
teichoate synthase (ambiguous);
CDP-ribitol:poly(ribitol phosphate) ribitolphosphotransferase
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
CDP-ribitol:4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol ribitolphosphotransferase
Reaction(IUBMB)
n CDP-ribitol + 4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol = n CMP + 4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [RN:R11621 R12869]
Reaction(KEGG)
R11621 R12869(G)
Substrate
CDP-ribitol [CPD:C00789];
4-O-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21502]
Product
CMP [CPD:C00055];
4-O-(D-ribitylphospho)n-di[(2R)-1-glycerophospho]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl-diphospho-ditrans,octacis-undecaprenol [CPD:C21508]
Comment
Involved in the biosynthesis of poly ribitol phosphate teichoic acids in the cell wall of the bacterium Staphylococcus aureus. This enzyme adds around 40 ribitol units to the linker molecule.
History
EC 2.7.8.14 created 1972 as EC 2.4.1.55, transferred 1982 to EC 2.7.8.14, modified 2017
Pathway
ec00552  Teichoic acid biosynthesis
Orthology
K18704  CDP-ribitol ribitolphosphotransferase / teichoic acid ribitol-phosphate polymerase
Genes
CCON: AFK62_03185
ESC: Entcl_3738
YMA: DA391_06385
BSUN: A4G13_01115
APJ: APJL_1614(cps3A)
VAQ: FIV01_00150(tagB)
PPR: PBPRA2702
ALJ: G8D99_14940
PTN: PTRA_a0500
PPHE: PP2015_409
AAL: EP13_00240
AAUS: EP12_00250
ASP: AOR13_2475
ASQ: AVL57_11050
ALE: AV939_10070
ALZ: AV940_09840
TTI: THITH_00255
HAHE: ENC22_06700
CHAE: CH06BL_44160
CKE: B5M06_15315
HAD: CDV25_02490
CJS: CJS3_1521
CJY: QZ67_01572
CJQ: UC78_1376(tagB)
CJL: PJ17_07560
CJR: CJE1613
CCY: YSS_07705
CCOF: VC76_07105(epsJ_2)
CCOO: ATE51_00688(epsJ_1)
CAVI: CAV_0458
NAM: NAMH_1605
DMA: DMR_40290
DHY: DESAM_20301
DLM: DPPLL_12590
BSL: A7A1_1140
BSY: I653_17460
BSX: C663_3471(tarL)
BSS: BSUW23_17580(tarL)
BST: GYO_3936(tarL)
BIT: BIS30_07550
BHT: DIC78_13170
BMOJ: HC660_34700(tagB)
BTEQ: G4P54_18355 G4P54_18385
BIQ: AN935_18040
BRY: M0696_18145
BJS: MY9_3633
BACY: QF06_16305
BCO: Bcell_3613
BCIR: C2I06_13960
BGI: BGM20_12060
TAID: KS242_14075
VHL: BME96_16450
VIG: BKP57_07895 BKP57_07900
VSS: PD280_09995
FEC: QNH15_21935
PPSR: I6J18_16025
PRD: F7984_17505 F7984_17510
GAJ: MY490_02505 MY490_02510
FAF: OE104_14490
TEI: QS257_16340
PUK: PU629_01935
SAU: SA0243 SA0247
SAV: SAV0253 SAV0257
SAW: SAHV_0252 SAHV_0256
SAH: SaurJH1_0244 SaurJH1_0248
SAJ: SaurJH9_0238 SaurJH9_0242
SAM: MW0229 MW0233
SAS: SAS0229 SAS0234
SAR: SAR0248 SAR0254
SAC: SACOL0238 SACOL0242
SAX: USA300HOU_0264(tagB1) USA300HOU_0268(tagB2)
SAA: SAUSA300_0247 SAUSA300_0251
SAO: SAOUHSC_00222 SAOUHSC_00227
SAE: NWMN_0187 NWMN_0191
SAD: SAAV_0221 SAAV_0225
SUU: M013TW_0234 M013TW_0238
SUV: SAVC_01005 SAVC_01025
SUE: SAOV_0192 SAOV_0196
SUJ: SAA6159_00230 SAA6159_00234
SUK: SAA6008_00226 SAA6008_00231
SUC: ECTR2_214 ECTR2_218
SUT: SAT0131_00245 SAT0131_00250
SUQ: HMPREF0772_10245 HMPREF0772_10250
SUZ: MS7_0241 MS7_0247
SUD: ST398NM01_0265 ST398NM01_0270
SUX: SAEMRSA15_02120 SAEMRSA15_02160
SUW: SATW20_02550(tarK) SATW20_02590(tarL)
SUG: SAPIG0265 SAPIG0270
SUF: SARLGA251_02170(tarK) SARLGA251_02210(tarL)
SAUA: SAAG_00734 SAAG_00738
SAUE: RSAU_000197 RSAU_000201
SAUN: SAKOR_00230 SAKOR_00236
SAUS: SA40_0211 SA40_0215
SAUU: SA957_0226 SA957_0230
SAUG: SA268_0223 SA268_0227
SAUZ: SAZ172_0255 SAZ172_0260
SAUT: SAI1T1_2001940 SAI1T1_2001980
SAUJ: SAI2T2_1001940 SAI2T2_1001980
SAUK: SAI3T3_1001940 SAI3T3_1001980
SAUQ: SAI4T8_1001940 SAI4T8_1001980
SAUV: SAI7S6_1001940 SAI7S6_1001980
SAUW: SAI5S5_1001930 SAI5S5_1001970
SAUX: SAI6T6_1001940 SAI6T6_1001980
SAUY: SAI8T7_1001940 SAI8T7_1001980
SAUF: X998_0229 X998_0233
SAB: SAB0192 SAB0196
SUY: SA2981_0253 SA2981_0257
SAUB: C248_0240 C248_0245
SAUM: BN843_2520 BN843_2560
SAUC: CA347_260 CA347_264
SAUR: SABB_01595 SABB_01600
SAUI: AZ30_01270 AZ30_01290
SAUD: CH52_04440 CH52_04460
SAMS: NI36_01165 NI36_01185
SUH: SAMSHR1132_02210 SAMSHR1132_02250
SER: SERP0198
SEP: SE_0321
SEPP: SEB_00243
SEPS: DP17_1631
SSP: SSP0356
SCA: SCA_2404
SXY: BE24_10200
SXL: SXYLSMQ121_0384
SXO: SXYL_00387
SSCH: LH95_01800
SEQO: SE1039_21950
SCV: A4G25_08200 A4G25_08205 A4G25_09305
SPET: CEP67_06495 CEP67_08275
SKL: C7J89_03595
SARL: SAP2_04720
SPIC: SAMEA4384060_0081
SSH: NCTC13712_00199(tagF_1) NCTC13712_00203(tagF_3)
SSIM: SAMEA4384339_0090(tagF_1)
SDB: CNQ82_01380
SLLO: ISP08_02340
SPSD: JMB28_02430 JMB28_13565
SCAQ: QMO72_02030(tarL)
SROT: ML435_01080 ML435_01100
STAP: AOB58_2216
SGAI: K3U27_08165
SFF: FOB90_06000
NMY: CJ229_008685
LMO: lmo1077 lmo1085
LMN: LM5578_1160 LM5578_1168
LMY: LM5923_1114 LM5923_1122
LMT: LMRG_00539 LMRG_00547
LMOC: LMOSLCC5850_1083 LMOSLCC5850_1091
LMOE: BN418_1295 BN418_1303
LMOB: BN419_1292 BN419_1300
LMOD: LMON_1087 LMON_1095
LMOW: AX10_13965 AX10_14005
LMOQ: LM6179_01397 LM6179_01405
LMR: LMR479A_1105 LMR479A_1113
LMOM: IJ09_04860 IJ09_04900
LMF: LMOf2365_1097
LMC: Lm4b_01096
LMOG: BN389_11100(tarL)
LMP: MUO_05655
LMOL: LMOL312_1077
LMOJ: LM220_05507
LMOZ: LM1816_14202
LMOX: AX24_02805
LMH: LMHCC_1548
LMQ: LMM7_1109
LML: lmo4a_1087
LMG: LMKG_01835 LMKG_01843
LMS: LMLG_2308 LMLG_2568
LMJ: LMOG_00633 LMOG_03302
LMW: LMOSLCC2755_1075 LMOSLCC2755_1083
LMX: LMOSLCC2372_1091 LMOSLCC2372_1099
LMZ: LMOSLCC2482_1120 LMOSLCC2482_1129
LMON: LMOSLCC2376_1050
LMOS: LMOSLCC7179_1058 LMOSLCC7179_1066
LMOO: LMOSLCC2378_1094
LMOY: LMOSLCC2479_1090 LMOSLCC2479_1099
LMOT: LMOSLCC2540_1073 LMOSLCC2540_1082
LMOA: LMOATCC19117_1099
LMOK: CQ02_05615
LMV: Y193_10350
LIN: lin1068
LWE: lwe1060
LSG: lse_0967 lse_0975
LIV: LIV_1026
LII: JL52_05455
LIW: AX25_05545
LIA: JL58_05675
LIO: JL53_06130
LWI: UE46_11760
LGZ: NCTC10812_01040(tagF_3) NCTC10812_01812(tagF_6) NCTC10812_01814(tagF_7) NCTC10812_02004(kfoC_3)
LMAR: LAX80_004980
LNW: OTR81_10215
ESI: Exig_0188
EAN: Eab7_0180(tarL)
EXU: ESP131_03390
EACE: KKI46_01210
EXI: A0126_00975
EXH: HNY42_02435
PCX: LPB68_14190
ALIC: GI364_00580 GI364_00650
PLN: Plano_2232
PDG: BCM40_04090
PHC: BBI08_08415
PGQ: FK545_05100
KUR: ASO14_2499
SPOR: SporoP33_05625
SPOP: SporoP37_06115
RST: ATY39_17025
PANC: E2636_12615
LLK: LLKF_0947(ggaB)
LLX: NCDO2118_0939(ggaB)
LLJ: LG36_1406(ggaB)
LCAR: BHS00_06080
LPL: lp_1819(tarL)
LPJ: JDM1_1532(tagB2)
LPT: zj316_1807(tarL)
LPS: LPST_C1461(tagB2)
LPR: LBP_cg1415
LPZ: Lp16_1408
LPB: SH83_07570
LPX: ASU28_07570
LPG: BB562_08390
LARG: LPA65_07290
PCE: PECL_1837
PIO: PI20285_08410
LEC: LGMK_03545
WCE: WS08_0699
WTR: KHQ32_03755
WCT: WS74_0701
WCI: WS105_0761
WCB: AO080_09205
WJO: FOL01_0725
WHE: EFA59_03560
WVR: IE337_04450
TEY: GLW17_02095
VTE: BHY08_07870
VPI: BW732_01925
CBT: CLH_2994
CLS: CXIVA_01260
CBV: U729_1133
RAL: Rumal_1248
RUS: RBI_I00537 RBI_I01994
ALKA: J0B03_04345
EUU: ADJ67_05825
RIX: RO1_35060
RIM: ROI_04730
RRK: H8S51_015580
BLAB: EYS05_02830
BLAR: LC508_26875
BCOC: BLCOC_40530
LACY: A4V08_21485
HSD: SD1D_2042
EHL: EHLA_1018 EHLA_2957 EHLA_2962 EHLA_3127 EHLA_3144
ERE: EUBREC_2652
LBX: lbkm_2929 lbkm_2930 lbkm_2931
PSOR: RSJ16_02160
KPAR: JL105_07995
AARG: Aargi30884_26940(tagB)
ABSI: A9CBEGH2_00110(tagB)
EBM: SG0102_21250 SG0102_21290
LCG: L3BBH23_26570
ERM: EYR00_06710
CMIT: NQ499_09020
SHI: Shel_14500 Shel_14640
AEQ: AEQU_0651
AHAT: ADCFC_17250
DDT: AAY81_07475
SCYE: R2B67_11495
LXL: KDY119_02610(tarL)
MOO: BWL13_02197(tarL)
MELY: L2X98_21170
MEST: PTQ19_14610
MHOT: PU630_11635 PU630_11655
ARN: CGK93_08975
ACIT: HPK19_20705
JDE: Jden_1795
XCE: Xcel_2590
IDO: I598_2371(tagF_2)
PHW: G7075_10605
TEJ: KDB89_01275
TLS: QH948_12825
AEZ: C3E78_05610
AEF: GEV26_05360
MGG: MPLG2_2612(tagB)
BBP: BBPR_0698 BBPR_0699(tagB)
BBI: BBIF_0729 BBIF_0730
BBF: BBB_0690(tarK) BBB_0691
SNG: SNE_A00880
FMO: C4N19_12415
POC: NCTC13071_01724
TRQ: TRQ2_0300
MRU: mru_1079
MSI: Msm_1327
MEB: Abm4_1699
MMIL: sm9_2259
MEYE: TL18_00335
MOL: YLM1_0599
MARO: MarbSA_12200
METV: K4897_04690
MCUB: MCBB_1531(tarL)
HALJ: G9465_17790
 » show all
Reference
1  [PMID:5908130]
  Authors
Ishimoto N, Strominger JL.
  Title
Polyribitol phosphate synthetase of Staphylococcus aureus.
  Journal
J Biol Chem 241:639-50 (1966)
Reference
2  [PMID:18215769]
  Authors
Brown S, Zhang YH, Walker S
  Title
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps.
  Journal
Chem Biol 15:12-21 (2008)
DOI:10.1016/j.chembiol.2007.11.011
  Sequence
[sao:SAOUHSC_00227]
Reference
3  [PMID:18556787]
  Authors
Pereira MP, D'Elia MA, Troczynska J, Brown ED
  Title
Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases.
  Journal
J Bacteriol 190:5642-9 (2008)
DOI:10.1128/JB.00526-08
Reference
4  [PMID:21035733]
  Authors
Brown S, Meredith T, Swoboda J, Walker S
  Title
Staphylococcus aureus and Bacillus subtilis W23 make polyribitol wall teichoic acids using different enzymatic pathways.
  Journal
Chem Biol 17:1101-10 (2010)
DOI:10.1016/j.chembiol.2010.07.017
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.14
IUBMB Enzyme Nomenclature: 2.7.8.14
ExPASy - ENZYME nomenclature database: 2.7.8.14
BRENDA, the Enzyme Database: 2.7.8.14
CAS: 9076-71-5
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