| Entry |
|
| Name |
L-serine-phosphatidylethanolamine phosphatidyltransferase;
phosphatidylserine synthase 2;
serine-exchange enzyme II;
PTDSS2 (gene name)
|
| Class |
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
|
| Sysname |
L-1-phosphatidylethanolamine:L-serine phosphatidyltransferase
|
| Reaction(IUBMB) |
L-1-phosphatidylethanolamine + L-serine = L-1-phosphatidylserine + ethanolamine [RN: R07376]
|
| Reaction(KEGG) |
|
| Substrate |
L-1-phosphatidylethanolamine [CPD: C00350];
L-serine [CPD: C00065]
|
| Product |
L-1-phosphatidylserine [CPD: C02737];
ethanolamine [CPD: C00189]
|
| Comment |
This mammalian enzyme catalyses an exchange reaction in which the polar head group of phosphatidylethanolamine is replaced by L-serine.
|
| History |
EC 2.7.8.29 created 2010
|
| Pathway |
| ec00564 | Glycerophospholipid metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
|
| Orthology |
| K08730 | phosphatidylserine synthase 2 |
|
| Genes |
| CGE: | 100689448(Ptdss2) 100763873 |
| DMER: | 138813005 138818600 |
| PMUR: | 107291107(PTDSS2) 107300150 |
| XLA: | 100190774(ptdss2.L) 108715190(ptdss2.S) |
| SANH: | 107673288 107680136 |
| CCAR: | 109050607 109050615 |
| CAUA: | 113043717 113066680 113066696 113074843 |
| CGIB: | 127947305 128014602 |
| GRF: | 141301549(ptdss2) 141301678 |
| MASI: | 127436094 127437692 |
| PSPA: | 121294898 121330068 |
| ARUT: | 117431967 117435009 |
| PMRN: | 116939914(PTDSS2) 116945620 |
| BBEL: | 109481719 109486878 109486882 |
| AFRA: | 136041263 136041662 136042753 136043972 |
| LPOL: | 106461777 106466964 |
| PMAX: | 117336411 117339202 |
| AIRR: | 138330205 138334845 |
| OVI: | T265_08340 T265_08342 |
| PDAM: | 113667703 113667751 |
| OSA: | 4326076(PSS1) 4339554(OsJ_19482) 9271420 |
| DOSA: | Os01g0118300 Os05g0554400 |
| OBR: | 102705851 102712813 102722731 |
| OGL: | 127772534 127773095 127784371 |
| TDC: | 119274412 119291046 119349438 |
| TAES: | 123067183 123068290 123076842 123144567 123182994 |
| HVG: | 123425625 123442412 123449624 |
| LPER: | 127327485 127340803 |
| ZMA: | 100191625 100216715 100283193 103634768 103647622 |
| MFLO: | 136449672 136461887 136511632 |
| SITA: | 101767818 101772301 |
| PVIR: | 120664703 120675874 120697901 120706184 |
| PHAI: | 112885694 112891526 |
| PAUA: | 133885239 133895449 133905317 133929372 |
| TANG: | 140765284 140766036 140768737 |
| PDA: | 103696139 103705637 103719016 |
| EGU: | 105041133 105047235 105048470 |
| MUS: | 103979244 103987383 135619477 135625103 |
| ZOF: | 121992953 121996948 121999730 122018840 122023489 |
| PEQ: | 110033016 110036199 110039580 |
| CSAT: | 104755819 104773869 |
| BNA: | 106377066 106412180 106415915 106439980 |
| MINC: | 123214568 123215340 |
| GHI: | 107888495 107931303 107946209 121224155 |
| HSYR: | 120121952 120142060 120143821 120184248 120197936 120216107 |
| DZI: | 111283034 111288443 111317773 |
| LANG: | 109334974 109346371 109354405 |
| PCIN: | 129284648 129297095 129310938 |
| QSA: | O6P43_025781 O6P43_032673 |
| MSYL: | 126596505 126608483 |
| PCOX: | 137732477 137736851 |
| HLP: | 133779364 133821857 133822933 |
| MCHA: | 111018718 111020081 |
| CMAX: | 111467762 111478458 111487009 111489342 |
| CMOS: | 111445439 111449822 111458312 111464375 |
| CPEP: | 111784319 111784552 111801353 111805286 111808977 |
| MESC: | 110600004 110617268 |
| PALZ: | 118039880 118057890 |
| CILL: | 122309711 122313764 |
| SPEN: | 107015927 107018619 |
| SSTN: | 125852569 125856675 |
| SDUL: | 129870377 129879905 |
| SVER: | 125813371 125821526 |
| CANN: | 107854102 107870662 |
| NTA: | 107759508 107768420 107776034 107820856 |
| SIND: | 105156339 105160377 |
| OEU: | 111383017 111385100 111398987 |
| SSPL: | 121769493 121772476 121779774 121782458 |
| SHIS: | 125204320 125215583 |
| APAN: | 127261744 127264121 |
| HPUM: | 140874593 140881687 |
| PHUA: | 140979771 140981533 |
| PEBU: | 140810024 140830502 140834280 140841190 |
| PTAB: | 142543611 142554566 142555362 |
| CARB: | 113717254 113719358 |
| BHW: | 143546179 143579801 143590259 143607836 143619786 143631090 |
| ECAD: | 122584382 122609710 |
| CCAV: | 112525661 112527749 |
| MING: | 122080140 122082496 |
| PSOM: | 113275442 113282170 |
| ACAK: | 137936719 137941172 |
| NCOL: | 116246902 116264166 |
| SMO: | SELMODRAFT_121992 SELMODRAFT_92791 |
| ABP: | AGABI1DRAFT74777(AGABI1DRAFT_74777) |
| ABV: | AGABI2DRAFT224623(AGABI2DRAFT_224623) |
| SCM: | SCHCO_02570286(SCHCODRAFT_02570286) |
| EHI: | EHI_009800(4.t00097) |
| ACAN: | ACA1_280020 ACA1_295990 |
| PLAG: | 39743904(PADL01_1365700) |
| BBES: | BESB_007340 BESB_084670 |
| TET: | TTHERM_00046230 TTHERM_00190960 |
| PTM: | GSPATT00003378001 GSPATT00005991001 GSPATT00011949001 GSPATT00014709001 |
| PIF: | PITG_00570 PITG_14699 |
| PSOJ: | PHYSODRAFT_474455 PHYSODRAFT_509169 |
| BLAC: | 94347576(CCR75_003812) |
| SPAR: | SPRG_03478 SPRG_08668 |
» show all
|
| Reference |
|
| Authors |
Stone SJ, Vance JE |
| Title |
Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. |
| Journal |
Biochem J 342 ( Pt 1):57-64 (1999) |
| Sequence |
|
| Reference |
|
| Authors |
Tomohiro S, Kawaguti A, Kawabe Y, Kitada S, Kuge O |
| Title |
Purification and characterization of human phosphatidylserine synthases 1 and 2. |
| Journal |
|
| Sequence |
|
| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.7.8.29 |
| ExPASy - ENZYME nomenclature database: | 2.7.8.29 |
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| LinkDB |
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