KEGG   ENZYME: 2.7.8.42
Entry
EC 2.7.8.42                 Enzyme                                 
Name
Kdo2-lipid A phosphoethanolamine 7''-transferase;
eptB (gene name)
Class
Transferases;
Transferring phosphorus-containing groups;
Transferases for other substituted phosphate groups
Sysname
diacylphosphatidylethanolamine:alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid-A 7''-phosphoethanolaminetransferase
Reaction(IUBMB)
(1) diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A = diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [RN:R11204];
(2) diacylphosphatidylethanolamine + alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA = diacylglycerol + 7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA [RN:R11205]
Reaction(KEGG)
R11204 R11205
Substrate
diacylphosphatidylethanolamine [CPD:C00350];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD:C06026];
alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA [CPD:C06025]
Product
diacyglycerol [CPD:C00641];
7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid A [CPD:C21173];
7-O-[2-aminoethoxy(hydroxy)phosphoryl]-alpha-D-Kdo-(2->4)-alpha-D-Kdo-(2->6)-lipid IVA [CPD:C21174]
Comment
The enzyme has been characterized from the bacterium Escherichia coli. It is activated by Ca2+ ions and is silenced by the sRNA MgrR.
History
EC 2.7.8.42 created 2015
Pathway
ec00540  Lipopolysaccharide biosynthesis
Orthology
K12975  KDO II ethanolaminephosphotransferase
Genes
ECOb3546(eptB)
ECJJW5660(eptB)
ECDECDH10B_3725(eptB)
EBWBWG_3234(eptB)
ECOKECMDS42_2983(eptB)
ECEZ4964(yhjW)
ECSECs_4425(eptB)
ECFECH74115_4916
ETWECSP_4537(eptB)
ELXCDCO157_4163
EOIECO111_4361(eptB)
EOJECO26_5060(eptB)
EOHECO103_4693(eptB)
ECOOECRM13514_4536(yhjW)
ECOHECRM13516_4337(yhjW)
ESLO3K_01155
ESOO3O_24520
ESMO3M_01185
ECKEC55989_3997(eptB)
ECGE2348C_3793(eptB)
EOKG2583_4283(eptB)
ELRECO55CA74_20500
ELHETEC_3790
ECWEcE24377A_4041
EUNUMNK88_4329
ECPECP_3648
ENAECNA114_3697(yhjW)
ECOSEC958_3952(yhjW)
ECVAPECO1_2902(yhjW)
ECOAAPECO78_21540
ECXEcHS_A3747
ECMEcSMS35_3867
ECYECSE_3819
ECRECIAI1_3705(eptB)
ECQECED1_4224(eptB)
EUMECUMN_4058(eptB)
ECTECIAI39_4054(eptB)
EOCCE10_4098(eptB)
EBRECB_03396(yhjW)
EBLECD_03396(eptB)
EBEB21_03347(eptB)
EBDECBD_0191
ECIUTI89_C4086(yhjW)
EIHECOK1_3992
ECZECS88_3965(eptB)
ECCc4364(yhjW)
ELOEC042_3852(eptb)
ELNNRG857_17630
ESEECSF_3381
ECLEcolC_0170
EKOEKO11_0187
EKFKO11_05020(eptB)
EABECABU_c39880(yhjW)
EDHEcDH1_0166
EDJECDH1ME8569_3425(eptB)
ELUUM146_17900
ELWECW_m3813(eptB)
ELLWFL_18620(eptB)
ELCi14_4032(yhjW)
ELDi02_4032(yhjW)
ELPP12B_c3675(eptB)
ELFLF82_0575(eptB)
ECOLLY180_18190
ECOIECOPMV1_03884(eptB)
ECOJP423_19745
EFEEFER_3543(yhjW)
EALEAKF1_ch2402
EMAC1192_15755
ESZFEM44_08910(eptB)
STYSTY4162(yhjW)
STTt3879(yhjW)
SEXSTBHUCCB_40950
SENTTY21A_19715
STMSTM3635(yhjW)
SEOSTM14_4382(yhjW)
SEVSTMMW_36251
SEYSL1344_3600(yhjW)
SEMSTMDT12_C36920
SEJSTMUK_3622(yhjW)
SEBSTM474_3807(yhjW)
SEFUMN798_3946(yhjW)
SETUSTU288_18365
SETCCFSAN001921_22270
SENRSTMDT2_35201(yhjW)
SENDDT104_36201(yhjW)
SENICY43_18875
SEENSE451236_02740
SEKSSPA3259a(yhjW)
SPQSPAB_04518
SEISPC_3713(yhjW)
SECSCH_3567(yhjW)
SEHSeHA_C3957
SHBSU5_04111
SENHCFSAN002069_13865
SEEHSEEH1578_04260
SEESNSL254_A3913
SENNSN31241_2490
SEWSeSA_A3835
SEASeAg_B3848
SENSQ786_17755
SEDSeD_A4017
SEGSG3799(yhjW)
SELSPUL_3932
SEGASPUCDC_3918
SETSEN3458(yhjW)
SENAAU38_17655
SENOAU37_17845
SENVAU39_17850
SENQAU40_19880
SENLIY59_18290
SENJCFSAN001992_15455
SEECCFSAN002050_25145
SEEBSEEB0189_001705
SEEPI137_18860
SENBBN855_37170
SENEIA1_17640
SENCSEET0819_01905
SESSARI_03999
SBGSBG_3228(yhjW)
SBZA464_3716
SBVN643_16055
SALZEOS98_01105
SFLSF3580(yhjW)
SFXS4189(yhjW)
SFVSFV_3541(yhjW)
SFESFxv_3904(eptB)
SFNSFy_5102
SFSSFyv_5174
SFTNCTC1_03871(eptB)
SSNSSON_3844(yhjW)
SBOSBO_3545(yhjW)
SBCSbBS512_E3983
SHQA0259_21545
ENCECL_00228
ENLA3UG_01155
ECLGEC036_02190
ECLEECNIH2_01780
ECLNECNIH4_01100
ECLIECNIH5_01325
ECLXLI66_01170
ECLYLI62_01580
ECLZLI64_01305
ECLOENC_01530
EHMAB284_00935
EXFBFV63_01155
ECLAECNIH3_01320
ECLCECR091_01320
EAUDI57_17570
EKBBFV64_00845
ENOECENHK_01090
EECEcWSU1_00196(eptB)
ELGBH714_16125
ECANCWI88_01075
ERNBFV67_00910
ECLSLI67_001885
ECHGFY206_01050(eptB)
ESHC1N69_00965
ENTEnt638_0178
EASEntas_0201
ENRH650_14150
ENXNI40_000875
ENFAKI40_0189
LNICWR52_11575
EBGFAI37_05635(eptB)
ENDA4308_08080
ENZG0034_00875(eptB)
ENSHWQ15_09485(eptB)
ENKLOC22_11995(eptB)
EHUD5067_0022195(eptB)
EMORL6Y89_00990(eptB)
ESAESA_04188
CSKES15_0157(eptB)
CSZCSSP291_19410
CSJCSK29544_01109
CCONAFK62_19185
CDMAFK67_19820
CSIP262_00236
CMJAFK66_000815
CUIAFK65_18915
CMWAFK63_19435
CTUCTU_40480(yhjW)
KPNKPN_03904(yhjW)
KPUKP1_5249(yhjW)
KPMKPHS_50620
KPPA79E_0212
KPHKPNIH24_25225
KPZKPNIH27_24140
KPVKPNIH29_25070
KPWKPNIH30_25530
KPYKPNIH31_24575
KPGKPNIH32_26400
KPCKPNIH10_25190
KPQKPR0928_24710
KPTVK055_3565
KPOKPN2242_22545
KPRKPR_5012(eptB)
KPJN559_0247
KPID364_19960
KPAKPNJ1_00219
KPSKPNJ2_00219
KPXPMK1_01405(eptB)
KPBFH42_15855
KPNEKU54_001065
KPNULI86_01060
KPNKBN49_0212(eptB)
KVAKvar_0199
KPEKPK_0202
KVDKR75_07080
KVQSP68_13680
KOXKOX_05505
KOEA225_5571
KOYJ415_04250
KOMHR38_03985
KMIVW41_23140
KOKKONIH1_28035
KOCAB185_08365
KQUAVR78_03420
EAEEAE_06005
EARCCG32801
KQVB8P98_01140
KLLBJF97_27670
KLWDA718_01235(eptB)
KARLGL98_01070(eptB)
KGRJJJ10_01145(eptB)
RORRORB6_19810
RONTE10_01155
RPLNB1209_00990
RAODSD31_01130
RTGNCTC13098_00239(eptB)
REEelectrica_00201(eptB)
CROROD_42621(eptb)
CKOCKO_04996
CFDCFNIH1_05330
CBRAA6J81_18235
CWECO701_23085
CYOCD187_00945
CPOTFOB25_12295(eptB)
CFQC2U38_00155
CSEDJY391_00935(eptB)
CAMAF384_19225
CAFAL524_01985
CIFAL515_00270
CFARCI104_00950
CIRC2U53_08615
CIEAN232_05470
CPARCUC49_18285
CTELGBC03_03395(eptB)
CITZE4Z61_17995(eptB)
CARSE1B03_25180(eptB)
EBTEBL_c01360(yhjW)
CNTJT31_12840
CEMLH23_04870
CENLH86_04820
CLAPNCTC11466_04705(eptB)
PGELG71_01955
ESCEntcl_0198
KLEAO703_20430
KSAC813_25785
KORAWR26_00885(eptB)
KRDA3780_23840
KCOBWI95_08780
KOTEH164_00860
KPSEIP581_22230(eptB)
KIENCTC12125_04013(eptB)
KASKATP_02060
LAXAPT61_21300
LEIC2U54_05815
LEHC3F35_10775
LEEDVA44_00865
LERGNG29_00835(eptB)
LEAGNG26_00865(eptB)
LPNUKQ929_19665(eptB)
LAZA8A57_01095
LEFLJPFL01_0183
LEWDAI21_03420
BUFD8682_15850
BAGEBADSM9389_00370
BFTMNO13_00370(eptB)
SYMK6K13_20915(eptB)
METYMRY16398_02070
AHNNCTC12129_00150(yhjW)
ASUBNLZ15_00660(eptB)
YREHEC60_17050(eptB)
SGOEA8O29_001510(eptB)
KINAB182_26495
PDZHHA33_03205(eptB)
IZHFEM41_04390(eptB)
PSGCG163CM_37920(eptB)
EBFD782_0188
EBCC2U52_09295
EBUCUC76_16630
YPEYPO4013(yhjW)
YPKy4034
YPHYPC_4523(eptB)
YPAYPA_4101
YPNYPN_3661
YPMYP_3372
YPPYPDSF_3375
YPGYpAngola_A4133(eptB)
YPTA1122_05770
YPDYPD4_3531
YPXYPD8_3537
YPWCH59_1965
YPJCH55_2691
YPVBZ15_3693
YPLCH46_1041
YPSYPTB3848(yhjW)
YPOBZ17_2733
YPIYpsIP31758_4081(eptB)
YPYYPK_0080
YPBYPTS_4066
YPQDJ40_2543(eptB)
YPUBZ21_3206
YPRBZ20_2240
YPCBZ23_3481
YPFBZ19_3339
YENYE4090(yhjW)
YEPYE105_C3807
YEYY11_31061
YELLC20_00112
YEWCH47_3639(eptB)
YETCH48_1540(eptB)
YEFFORC2_0085
YEEYE5303_39451(yhjW)
YSIBF17_07105
YALAT01_2595
YFRAW19_3363(eptB)
YINCH53_1651
YKRCH54_2427
YROCH64_2488
YRUBD65_2069
YRBUGYR_10630
YAKACZ76_09365
YMADA391_22635
YHID5F51_21680
YCAF0T03_21300(eptB)
YMOHRD69_05090(eptB)
SMARSM39_4369(eptB)
SMACSMDB11_4239(eptB)
SMWSMWW4_v1c01400(eptB)
SPESpro_0131 Spro_1859
SRRSerAS9_0094 SerAS9_1801
SRLSOD_c00890(eptB1) SOD_c16840(eptB)
SRYM621_00445 M621_09315
SPLYQ5A_000535(eptB_1) Q5A_009195(eptB_2)
SRSSerAS12_0094 SerAS12_1801
SRASerAS13_0093 SerAS13_1802
SMAFD781_0097
SLQM495_00470 M495_08690
SERFL085_05075
SERSSERRSCBI_00565
SFWWN53_08990
SFGAV650_01935
SRZAXX16_0426
SERMCLM71_00580
SQUE4343_06865(eptB) E4343_15640(eptB)
SFJSAMEA4384070_0096(eptB_1) SAMEA4384070_1889(eptB_2)
SOFNCTC11214_01877(eptB)
SSURATE40_021380
SURIJ0X03_23380(eptB)
SRHZFO014_09425(eptB)
SENPKHA73_09315(eptB) KHA73_22625(eptB)
RAHRahaq_0082 Rahaq_1381
RACEJHW33_01365(eptB) JHW33_17020(eptB)
RAQRahaq2_0101 Rahaq2_1444
RAAQ7S_00400 Q7S_06665
ROXBV494_02230 BV494_16270
RVCJ9880_08185(eptB) J9880_14840(eptB)
GQUAWC35_10925
FSMCCS41_08475
EAMEGXP68_00380(eptB) GXP68_14165(eptB)
RBADH2866_07500(eptB) H2866_14260(eptB)
ECAECA0044
PATREV46_00225
PATOGZ59_00480
PCTPC1_4207
PCCPCC21_000290
PCVBCS7_21265
PWAPecwa_4490
PPARA8F97_19000
PECW5S_4672
PWSA7983_07985
PPOABJK05_16725
PBRAB5S52_21790
PPUJE2566_21345(eptB)
PARII2D83_21795(eptB)
PAQUDMB82_0020170(eptB)
PVZOA04_00480(eptB)
PPAVLOZ86_00935(eptB)
PQUIG609_019935(eptB)
DDDDda3937_01131(eptB)
DZEDd1591_4143
DSOA4U42_08590
CEDLH89_12850
DFNCVE23_22040
DDQDDI_4189
DAQDAQ1742_00044(eptB)
BGJAWC36_18150
BRBEH207_17530
BNGEH206_22250
BIZHC231_23185(eptB)
LBQCKQ53_04835
LPOPI6N93_16600(eptB)
SODSant_0121(eptB)
EAMEAMY_3617(yhjW)
EAYEAM_3396
ETAETA_34000
EPYEpC_36110
EPREPYR_03887(yhjW)
EBIEbC_22590 EbC_44110
ERJEJP617_10880
EGEEM595_3372(eptB)
EPECI789_19220
ERWIGN242_00420(eptB)
ETPLU633_12605(eptB)
PAMPANA_0120(yhjW)
PLFPANA5342_4307(yhjW)
PAJPAJ_3281(yhjW)
PAQPAGR_g4156
PVAPvag_3345(yhjW)
PAGGAL522_04865
PAOPat9b_0106
KLNLH22_01755
PANTPSNIH1_06140
PANPPSNIH2_17940
PAGCBEE12_07245
PSTWDSJ_22340
PALHB1H58_06880
PANSFCN45_00535(eptB) FCN45_20435(eptB)
PEYEE896_18590(eptB) EE896_19830(eptB)
PDISD8B20_00395 D8B20_20750
PERLAC65_00240(eptB)
PGZC2E15_00810
PCDC2E16_00950
MINTC7M51_03657(eptB)
MTHIC7M52_03366(eptB)
TPTYNCTC11468_03553(eptB)
PTTVY86_10840
PMRPMI3576
PMIBBB2000_0018
PVGCRN77_01920
PHAUPH4a_09265
PROTBTA34_00875
PCOLF1325_02195(eptB)
PCIBF9282_02065(eptB)
PPEEI6G31_07205(eptB)
PHEINCTC12003_02602(eptB)
MMKMU9_3457
MWIMNY66_00810(eptB)
HAVAT03_21265
HPARAL518_05505
OPODSM2777_04155
LPVHYN51_06725
PRAGEKN56_15365(eptB)
LRINCTC12151_02063(eptB)
CEKD0B88_17795
NELNELON_00405
ECORSAMEA4412678_0072(eptB)
LHKLHK_02964
AZAAZKH_0150
SUNSUN_1948
 » show all
Reference
1  [PMID:11042192]
  Authors
Kanipes MI, Lin S, Cotter RJ, Raetz CR
  Title
Ca2+-induced phosphoethanolamine transfer to the outer 3-deoxy-D-manno-octulosonic acid moiety of Escherichia coli lipopolysaccharide. A novel membrane enzyme dependent upon phosphatidylethanolamine.
  Journal
J Biol Chem 276:1156-63 (2001)
DOI:10.1074/jbc.M009019200
Reference
2  [PMID:15795227]
  Authors
Reynolds CM, Kalb SR, Cotter RJ, Raetz CR
  Title
A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant.
  Journal
J Biol Chem 280:21202-11 (2005)
DOI:10.1074/jbc.M500964200
  Sequence
[eco:b3546]
Reference
3  [PMID:23659637]
  Authors
Moon K, Six DA, Lee HJ, Raetz CR, Gottesman S
  Title
Complex transcriptional and post-transcriptional regulation of an enzyme for lipopolysaccharide modification.
  Journal
Mol Microbiol 89:52-64 (2013)
DOI:10.1111/mmi.12257
Other DBs
ExplorEnz - The Enzyme Database: 2.7.8.42
IUBMB Enzyme Nomenclature: 2.7.8.42
ExPASy - ENZYME nomenclature database: 2.7.8.42
BRENDA, the Enzyme Database: 2.7.8.42
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