KEGG   ENZYME: 2.8.2.2
Entry
EC 2.8.2.2                  Enzyme                                 

Name
alcohol sulfotransferase;
hydroxysteroid sulfotransferase;
3beta-hydroxy steroid sulfotransferase;
Delta5-3beta-hydroxysteroid sulfokinase;
3-hydroxysteroid sulfotransferase;
HST;
5alpha-androstenol sulfotransferase;
cholesterol sulfotransferase;
dehydroepiandrosterone sulfotransferase;
estrogen sulfokinase;
estrogen sulfotransferase;
steroid alcohol sulfotransferase;
steroid sulfokinase;
steroid sulfotransferase;
sterol sulfokinase;
sterol sulfotransferase;
alcohol/hydroxysteroid sulfotransferase;
3beta-hydroxysteroid sulfotransferase;
3'-phosphoadenylyl-sulfate:alcohol sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
Sysname
3'-phosphoadenylyl-sulfate:alcohol sulfonotransferase
Reaction(IUBMB)
3'-phosphoadenylyl sulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate [RN:R00629]
Reaction(KEGG)
Substrate
3'-phosphoadenylyl sulfate [CPD:C00053];
alcohol [CPD:C00069]
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
alkyl sulfate [CPD:C02000]
Comment
Primary and secondary alcohols, including aliphatic alcohols, ascorbic acid, chloramphenicol, ephedrine and hydroxysteroids, but not phenolic steroids, can act as acceptors (cf. EC 2.8.2.15 steroid sulfotransferase).
History
EC 2.8.2.2 created 1961, modified 1980
Pathway
ec00140  Steroid hormone biosynthesis
ec01100  Metabolic pathways
Orthology
K01015  alcohol sulfotransferase
Genes
HSA: 6820(SULT2B1)
PTR: 747360(SULT2B1)
PPS: 100993458(SULT2B1)
GGO: 101129679(SULT2B1)
PON: 100441770(SULT2B1)
NLE: 100587860(SULT2B1)
MCC: 718739(SULT2B1)
MCF: 102147126(SULT2B1)
CSAB: 103234980(SULT2B1)
CATY: 105595444(SULT2B1)
PANU: 101012116(SULT2B1)
RRO: 104666566(SULT2B1)
RBB: 108523626(SULT2B1)
TFN: 117091512(SULT2B1)
PTEH: 111520064(SULT2B1)
CJC: 100402576(SULT2B1)
SBQ: 101043923(SULT2B1)
MMUR: 105865660(SULT2B1)
MMU: 54200(Sult2b1)
MCAL: 110298618(Sult2b1)
MPAH: 110316585(Sult2b1)
RNO: 292915(Sult2b1)
MCOC: 116102233(Sult2b1)
MUN: 110550470(Sult2b1)
CGE: 100774216(Sult2b1)
PLEU: 114684722(Sult2b1)
NGI: 103743615(Sult2b1)
HGL: 101723933(Sult2b1)
CPOC: 100730889(Sult2b1)
CCAN: 109682673(Sult2b1)
OCU: 100008957(SULT2B1)
OPI: 101529733(SULT2B1)
TUP: 102477821(SULT2B1)
CFA: 484403(SULT2B1)
VVP: 112931439(SULT2B1)
VLG: 121485128(SULT2B1)
AML: 100480162(SULT2B1)
UMR: 103657236(SULT2B1)
UAH: 113243345(SULT2B1)
ORO: 101377746(SULT2B1)
ELK: 111160811
MPUF: 101676565(SULT2B1)
EJU: 114199480(SULT2B1)
MLX: 117998223(SULT2B1)
FCA: 101086863(SULT2B1)
PYU: 121018885(SULT2B1)
PBG: 122494875(SULT2B1)
PTG: 107180097(SULT2B1)
PPAD: 109253129(SULT2B1)
AJU: 106988649(SULT2B1)
HHV: 120240271(SULT2B1)
BTA: 531192(SULT2B1)
BOM: 102284976(SULT2B1)
BBUB: 102413917(SULT2B1)
CHX: 102183905(SULT2B1)
OAS: 101122543(SULT2B1)
ODA: 120872190(SULT2B1)
CCAD: 122421679(SULT2B1)
SSC: 100626471(SULT2B1)
CFR: 102503575(SULT2B1)
CBAI: 105062751(SULT2B1)
CDK: 105102909(SULT2B1)
BACU: 103009833(SULT2B1)
LVE: 103078205(SULT2B1)
OOR: 101269222(SULT2B1)
DLE: 111180462(SULT2B1)
PCAD: 102993424(SULT2B1) 114484129
PSIU: 116744199(SULT2B1)
ECB: 100147584(SULT2B1)
EPZ: 103540017(SULT2B1)
EAI: 106838308(SULT2B1)
MYB: 102258569(SULT2B1)
MYD: 102766101(SULT2B1)
MMYO: 118655351(SULT2B1)
MNA: 107531856(SULT2B1)
PKL: 118721088(SULT2B1)
HAI: 109391113(SULT2B1)
DRO: 112310043(SULT2B1)
AJM: 119061853(SULT2B1)
PDIC: 114511521(SULT2B1)
MMF: 118638877(SULT2B1)
RFQ: 117034349(SULT2B1)
PALE: 102887796(SULT2B1)
PGIG: 120606972(SULT2B1)
PVP: 105301808(SULT2B1)
RAY: 107498807(SULT2B1)
MJV: 108393142(SULT2B1)
TOD: 119249517(SULT2B1)
LAV: 100677254(SULT2B1)
TMU: 101357729
MDO: 100015166 100032213(SULT2B1)
GAS: 123239818(SULT2B1) 123240896
SHR: 100933402(SULT2B1)
PCW: 110219960(SULT2B1)
OAA: 100091264(SULT2B1)
GGA: 426825(SULT2B1) 769841(SULT2B1L2)
NMEL: 110390406
APLA: 101803633
ACYG: 106049358(SULT2B1)
PHI: 102107518
CCAE: 111944211
NNI: 104022627
PADL: 103922156(SULT2B1)
AAM: 106482022(SULT2B1)
AROW: 112967833 112977344(SULT2A1)
DNE: 112993757
PBI: 103055981 103057086(SULT2B1) 103065422(SULT2A1)
PMUR: 107283076 107283091(SULT2B1)
TSR: 106538457 106538474(SULT2B1)
PGUT: 117666712 117666715(SULT2B1)
XLA: 100036899(sult2b1.L) 100037047(XB5850668.L) 108695914 108695915 108697829(sult2a1.S) 432283(sult2b1.S) 447414(XB986081.L) 496246(sult2a1.L)
XTR: 100144919 100144988(sult2a1) 100497264 100498051 493303(sult2b1)
DRE: 777792(sult2st3) 777793(sult2st2)
AMEX: 103022604
PLEP: 121945665 121946290(sult2st3) 121959155
GAT: 120810920(sult2st3)
PPUG: 119198079(sult2st3)
MSAM: 119896296 119897946(sult2st3) 119915713
CUD: 121513279 121513280 121528421(sult2st2)
OML: 112143258(sult2st3) 112154309
GAF: 122822830(sult2st2) 122831532(sult2st3) 122831533
CTUL: 119786505(sult2st3) 119796021
CSEM: 103382275
SSEN: 122758785 122775271(sult2st3)
HHIP: 117753415 117777521(sult2st3)
SASA: 100196439(st2b1) 106577720
OTW: 112224376(sult2st2) 112227238(sult2st3)
OMY: 110498876 110519921(sult2st3)
LCM: 102363673 102365349(SULT2B1)
RTP: 109934135
BFO: 118426989
PTEP: 107439587
LAK: 106175170
MESQ: C7H62_1064
 » show all
Reference
1  [PMID:6935986]
  Authors
Lyon ES, Jakoby WB.
  Title
The identity of alcohol sulfotransferases with hydroxysteroid sulfotransferases.
  Journal
Arch Biochem Biophys 202:474-81 (1980)
DOI:10.1016/0003-9861(80)90452-X
Reference
2  [PMID:6173569]
  Authors
Lyon ES, Marcus CJ, Wang JL, Jakoby WB.
  Title
Hydroxysteroid sulfotransferase.
  Journal
Methods Enzymol 77:206-13 (1981)
DOI:10.1016/s0076-6879(81)77027-7
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.2
IUBMB Enzyme Nomenclature: 2.8.2.2
ExPASy - ENZYME nomenclature database: 2.8.2.2
BRENDA, the Enzyme Database: 2.8.2.2
CAS: 9032-76-2
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