KEGG ENZYME: 2.8.2.34

ENZYME: 2.8.2.34

Entry

EC 2.8.2.34                 Enzyme

Name

glycochenodeoxycholate sulfotransferase;
bile acid:3'-phosphoadenosine-5'-phosphosulfate sulfotransferase;
bile acid:PAPS:sulfotransferase;
BAST;
3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

3'-phosphoadenylyl-sulfate:glycochenodeoxycholate 7-sulfonotransferase

Reaction(IUBMB)

3'-phosphoadenylyl sulfate + glycochenodeoxycholate = adenosine 3',5'-bisphosphate + glycochenodeoxycholate 7-sulfate [RN:R07289]

Reaction(KEGG)

R07289

Substrate

3'-phosphoadenylyl sulfate [CPD:C00053];
glycochenodeoxycholate [CPD:C05466]

Product

adenosine 3',5'-bisphosphate [CPD:C00054];
glycochenodeoxycholate 7-sulfate [CPD:C15559]

Comment

The enzyme specifically sulfates glycochenodeoxycholate at the 7alpha-position (see also EC 2.8.2.14 bile-salt sulfotransferase). The monohydroxy bile acids glycolithocholate, chenodeoxycholate and ursodeoxycholate act as inhibitors.

History

EC 2.8.2.34 created 2005

Reference

1 [PMID:533830]

Authors

Barnes S, Burhol PG, Zander R, Haggstrom G, Settine RL, Hirschowitz BI.

Title

Enzymatic sulfation of glycochenodeoxycholic acid by tissue fractions from adult hamsters.

Journal

J Lipid Res 20:952-9 (1979)

Reference

2 [PMID:12543708]