Entry
Name
coenzyme-B sulfoethylthiotransferase;
methyl-CoM reductase;
methyl coenzyme M reductase
Class
Transferases;
Transferring sulfur-containing groups;
Transferring alkylthio groups
BRITE hierarchy
Sysname
methyl-CoM:CoB S-(2-sulfoethyl)thiotransferase
Reaction(IUBMB)
methyl-CoM + CoB = CoM-S-S-CoB + methane [RN:
R04541 ]
Reaction(KEGG)
Substrate
Product
Comment
This enzyme catalyses the final step in methanogenesis, the biological production of methane. This important anaerobic process is carried out only by methanogenic archaea. The enzyme can also function in reverse, for anaerobic oxidation of methane.The enzyme requires the hydroporphinoid nickel complex coenzyme F430. Highly specific for coenzyme B with a heptanoyl chain; ethyl CoM and difluoromethyl CoM are poor substrates. The sulfide sulfur can be replaced by selenium but not by oxygen.
History
EC 2.8.4.1 created 2001, modified 2011
Pathway
ec01120 Microbial metabolism in diverse environments
Orthology
K00399 methyl-coenzyme M reductase alpha subunit
K00401 methyl-coenzyme M reductase beta subunit
K00402 methyl-coenzyme M reductase gamma subunit
Genes
MJA : MJ_0081 MJ_0082 MJ_0083 MJ_0842 MJ_0845 MJ_0846
MFE : Mefer_0934 Mefer_0937 Mefer_0938
MVU : Metvu_0145 Metvu_0148 Metvu_0149 Metvu_1192 Metvu_1193 Metvu_1194
MFS : MFS40622_0424 MFS40622_0425 MFS40622_0426 MFS40622_1315 MFS40622_1316 MFS40622_1319
MIF : Metin_0281 Metin_0282 Metin_0285
MJH : JH146_0503 JH146_0504 JH146_0505 JH146_1056 JH146_1057 JH146_1060
MESG : MLAUSG7_0353(mcrA) MLAUSG7_0354(mcrG) MLAUSG7_0357(mcrB)
MESA : MLASG1_1532(mcrA) MLASG1_1533(mcrG) MLASG1_1536(mcrB)
MIG : Metig_0442 Metig_0444 Metig_0445 Metig_1233 Metig_1236 Metig_1237
MMP : MMP1555(mcrB) MMP1558(mcrG) MMP1559(mcrA)
MMQ : MmarC5_0017 MmarC5_0018 MmarC5_0021
MMX : MmarC6_1111 MmarC6_1112 MmarC6_1115
MMZ : MmarC7_0802 MmarC7_0805 MmarC7_0806
MMD : GYY_08625 GYY_08640 GYY_08645
MMAK : MMKA1_17850(mcrB) MMKA1_17880(mcrG) MMKA1_17890(mcrA)
MMAO : MMOS7_16670(mcrB) MMOS7_16700(mcrG) MMOS7_16710(mcrA)
MMAD : MMJJ_12770(mcrA) MMJJ_12780(mcrG) MMJJ_12810(mcB)
MAE : Maeo_1264 Maeo_1267 Maeo_1268
MVN : Mevan_0868 Mevan_0871 Mevan_0872
MVO : Mvol_1124 Mvol_1127 Mvol_1128
MOK : Metok_0956 Metok_0957 Metok_0960
METF : CFE53_01190(mcrA) CFE53_01195(mcrG) CFE53_01210(mcrB)
MTH : MTH_1129 MTH_1130 MTH_1132 MTH_1164 MTH_1165 MTH_1168
MMG : MTBMA_c15120(mrtA) MTBMA_c15130(mrtG) MTBMA_c15150(mrtB) MTBMA_c15480(mcrA) MTBMA_c15490(mcrG) MTBMA_c15520(mcrB)
MWO : MWSIV6_1521(mrtA) MWSIV6_1522(mrtG) MWSIV6_1524(mrtB) MWSIV6_1556(mcrA) MWSIV6_1557(mcrG) MWSIV6_1560(mcrB)
MTEE : MTTB_02540(mcrB) MTTB_02570(mcrG) MTTB_02580(mcrA)
METC : MTCT_1022 MTCT_1023 MTCT_1025 MTCT_1058 MTCT_1059 MTCT_1062
METE : tca_01085 tca_01086 tca_01088 tca_01121 tca_01122 tca_01125
METZ : METMT2_1172 METMT2_1173 METMT2_1176
METK : FVF72_05745(mcrB) FVF72_05760(mcrG) FVF72_05765(mcrA) FVF72_05925(mcrB) FVF72_05935(mcrG) FVF72_05940(mcrA)
MTHM : FZP57_07280(mcrA) FZP57_07285(mcrG) FZP57_07295(mcrB) FZP57_07455(mcrA) FZP57_07460(mcrG) FZP57_07475(mcrB)
METJ : FZP68_03200(mcrB) FZP68_03215(mcrG) FZP68_03220(mcrA) FZP68_03380(mcrB) FZP68_03390(mcrG) FZP68_03395(mcrA)
MST : Msp_0318(mrtB) Msp_0320(mrtG) Msp_0321(mrtA)
METB : AW729_05480 AW729_05485 AW729_05495
MEIS : PXD04_05390(mcrB) PXD04_05400(mcrG) PXD04_05405(mcrA)
MRU : mru_1924(mcrA) mru_1925(mcrG) mru_1928(mcrB)
MSI : Msm_0902 Msm_0903 Msm_0905 Msm_1015 Msm_1016 Msm_1019
MEB : Abm4_1526(mcrA) Abm4_1527(mcrG) Abm4_1530(mcrB)
MMIL : sm9_1353(mrtA) sm9_1354(mrtG) sm9_1356(mrtB) sm9_2027(mcrA) sm9_2028(mcrG) sm9_2031(mcrB)
MEYE : TL18_09320 TL18_09325 TL18_09340
MOL : YLM1_1108 YLM1_1110 YLM1_1111 YLM1_1379 YLM1_1380 YLM1_1383
MARO : MarbSA_15380 MarbSA_15410 MarbSA_15420
METV : K4897_06370(mcrB) K4897_06385(mcrG) K4897_06390(mcrA)
MEL : Metbo_0349 Metbo_0352 Metbo_0353 Metbo_2278 Metbo_2280 Metbo_2281
MEW : MSWAN_2056 MSWAN_2057 MSWAN_2060
METH : MBMB1_1682(mcrA) MBMB1_1683(mcrG) MBMB1_1686(mcrB) MBMB1_1822(mrtB) MBMB1_1824(mrtG) MBMB1_1825(mrtA)
MFC : BRM9_0935(mcrA) BRM9_0936(mcrG) BRM9_0939(mcrB) BRM9_2153(mrtB) BRM9_2155(mrtG) BRM9_2156(mrtA)
MFI : DSM1535_0905(mcrA) DSM1535_0906(mcrG) DSM1535_0909(mcrB) DSM1535_1092(mrtB) DSM1535_1094(mrtG) DSM1535_1095(mrtA)
MCUB : MCBB_1985(mcrA) MCBB_1986(mcrG) MCBB_1989(mcrB)
MSUB : BK009_07405 BK009_07410 BK009_07425 BK009_08280 BK009_08290 BK009_08295
METN : BK008_03060 BK008_03065 BK008_03080 BK008_03955 BK008_03965 BK008_03970
METT : CIT01_01100(mcrB) CIT01_01110(mcrG) CIT01_01115(mcrA) CIT01_03630(mcrA) CIT01_03635(mcrG) CIT01_03650(mcrB)
METO : CIT02_08450(mcrA) CIT02_08455(mcrG) CIT02_08465(mcrB) CIT02_09460(mcrB) CIT02_09475(mcrG) CIT02_09480(mcrA)
MEME : HYG87_00765(mcrB) HYG87_00775(mcrG) HYG87_00780(mcrA) HYG87_04985(mcrA) HYG87_04990(mcrG) HYG87_05005(mcrB)
MFEG : GCM10025860_02820 GCM10025860_02830 GCM10025860_02860 GCM10025860_04430 GCM10025860_04450 GCM10025860_04460
MEER : NKF70_05230(mcrA) NKF70_05235(mcrG) NKF70_05250(mcrB) NKF70_08695(mcrA) NKF70_08700(mcrG) NKF70_08710(mcrB)
MFV : Mfer_0731 Mfer_0733 Mfer_0734 Mfer_0784 Mfer_0785 Mfer_0788
MKA : MK0651(mcrB) MK0654(mcrG) MK0655(mcrA)
MBA : Mbar_A0893 Mbar_A0894 Mbar_A0897
MBY : MSBRM_0097 MSBRM_0100 MSBRM_0101
MBW : MSBRW_0101 MSBRW_0104 MSBRW_0105
MBAR : MSBR2_2279 MSBR2_2280 MSBR2_2283
MBAK : MSBR3_2340 MSBR3_2341 MSBR3_2344
MAC : MA_4546 MA_4547 MA_4550
MMA : MM_1240 MM_1241 MM_1244
MMAZ : MmTuc01_1281 MmTuc01_1282 MmTuc01_1285
MMJ : MSMAS_0069 MSMAS_0072 MSMAS_0073
MMAC : MSMAC_0068 MSMAC_0071 MSMAC_0072
MVC : MSVAZ_3413 MSVAZ_3414 MSVAZ_3417
MEK : MSKOL_3374 MSKOL_3375 MSKOL_3378
MLS : MSLAZ_0156 MSLAZ_0157 MSLAZ_0160
METM : MSMTP_0096 MSMTP_0099 MSMTP_0100
MEF : MSWH1_0085 MSWH1_0088 MSWH1_0089
MEQ : MSWHS_0088 MSWHS_0091 MSWHS_0092
MSJ : MSSAC_4251 MSSAC_4254 MSSAC_4255
MSZ : MSSIH_3755 MSSIH_3758 MSSIH_3759
MSW : MSSIT_3834 MSSIT_3837 MSSIT_3838
MTHR : MSTHT_1640 MSTHT_1643 MSTHT_1644
MTHE : MSTHC_1645 MSTHC_1646 MSTHC_1649
MHOR : MSHOH_0080 MSHOH_0083 MSHOH_0084
MFZ : AOB57_007315(mcrB) AOB57_007330(mcrG) AOB57_007335(mcrA)
MBU : Mbur_2417(mcrA) Mbur_2418(mcrG) Mbur_2421(mcrB)
MMET : MCMEM_0559 MCMEM_0560 MCMEM_0563
MELO : J7W08_00830(mcrA) J7W08_00835(mcrG) J7W08_00850(mcrB)
MMH : Mmah_0612 Mmah_0613 Mmah_0616
MHAZ : BHR79_00290 BHR79_00305 BHR79_00310
MPOT : BKM01_08085 BKM01_08090 BKM01_08105
MEV : Metev_0902 Metev_0903 Metev_0906
MZH : Mzhil_0853 Mzhil_0856 Mzhil_0857
MPY : Mpsy_0828 Mpsy_0829 Mpsy_0832
MZI : HWN40_04500(mcrB) HWN40_04515(mcrG) HWN40_04520(mcrA)
MMAV : RE476_05650(mcrA) RE476_05655(mcrG) RE476_05670(mcrB)
MSEB : RE474_02885(mcrB) RE474_02900(mcrG) RE474_02905(mcrA)
MHZ : Metho_1666 Metho_1669 Metho_1670
MEHF : MmiHf6_13310 MmiHf6_13340 MmiHf6_13350
MEES : MmiEs2_15730 MmiEs2_15760 MmiEs2_15770
MTP : Mthe_0569 Mthe_0570 Mthe_0572
MCJ : MCON_0759(mcrA) MCON_0760(mcrG) MCON_0762(mcrB)
MHI : Mhar_0495 Mhar_0497 Mhar_0498
MHU : Mhun_2144 Mhun_2147 Mhun_2148
MRTJ : KHC33_15110(mcrB) KHC33_15125(mcrG) KHC33_15130(mcrA)
MLA : Mlab_1066 Mlab_1067 Mlab_1068 Mlab_1561 Mlab_1562 Mlab_1565
MEM : Memar_0375 Memar_0377 Memar_0378 Memar_0613 Memar_0614 Memar_0617
MBG : BN140_1521(mcrA1) BN140_1522(mcrG1) BN140_1524(mcrB1) BN140_1734(mcrB3) BN140_1737(mcrG3) BN140_1738(mcrA3)
MEMA : MMAB1_1952(mcrA) MMAB1_1953(mcrG) MMAB1_1956 MMAB1_2231(mcrB) MMAB1_2234(mcrG) MMAB1_2235(mcrA)
MCHK : MchiMG62_05000(mcrB_1) MchiMG62_05020 MchiMG62_05030 MchiMG62_07420 MchiMG62_07430 MchiMG62_07460(mcrB_2)
MSUM : OH143_08575(mcrB) OH143_08585(mcrG) OH143_08590(mcrA) OH143_09785(mcrA) OH143_09790(mcrG) OH143_09805(mcrB)
MRC : R6Y96_02630(mcrB) R6Y96_02645(mcrG) R6Y96_02650(mcrA) R6Y96_02980(mcrB) R6Y96_02990(mcrG) R6Y96_02995(mcrA)
MPI : Mpet_1991 Mpet_1992 Mpet_1993 Mpet_2415 Mpet_2416 Mpet_2419
MEND : L6E24_09485(mcrB) L6E24_09500(mcrG) L6E24_09505(mcrA)
MEFW : F1737_00880(mcrB) F1737_00895(mcrG) F1737_00900(mcrA)
MAQE : RJ40_03765(mcrB) RJ40_03775(mcrG) RJ40_03780(mcrA) RJ40_06075(mcrB) RJ40_06090(mcrG) RJ40_06095(mcrA)
MFK : E2N92_03830(mcrB) E2N92_03840(mcrG) E2N92_03845(mcrA) E2N92_06205(mcrB) E2N92_06220(mcrG) E2N92_06225(mcrA)
MOU : OU421_03055(mcrB) OU421_03065(mcrG) OU421_03070(mcrA) OU421_03510(mcrA) OU421_03515(mcrG) OU421_03530(mcrB)
MESB : L1S32_07110(mcrA) L1S32_07115(mcrG) L1S32_07130(mcrB)
MANQ : L1994_01300(mcrB) L1994_01315(mcrG) L1994_01320(mcrA)
MBN : Mboo_0582 Mboo_0583 Mboo_0586
MFO : Metfor_0871 Metfor_0873 Metfor_0874 Metfor_2605 Metfor_2608 Metfor_2609
MESK : METHP_00384 METHP_00387 METHP_00388
MPL : Mpal_2305 Mpal_2308 Mpal_2309
MPD : MCP_0512(mcrB) MCP_0515(mcrG) MCP_0516(mcrA)
MEZ : Mtc_0904(mcrB) Mtc_0907(mcrG) Mtc_0908(mcrA)
RCI : RCIX2059(mcrB) RCIX2062(mcrG) RCIX2063(mcrA)
MJK : N2V74_07320(mcrA) N2V74_07325(mcrG) N2V74_07335(mcrB)
MELU : MTLP_00200 MTLP_00210 MTLP_00220 MTLP_01260(mcrB) MTLP_01290 MTLP_01300
MEAM : MU439_05980(mcrA) MU439_05985(mcrG) MU439_05995(mcrB)
MEAE : QEN48_04150(mcrB) QEN48_04160(mcrG) QEN48_04165(mcrA) QEN48_04170(mcrA)
TAR : TALC_00469 TALC_00471 TALC_00472
MAX : MMALV_03970 MMALV_03990 MMALV_04000
MER : MMINT_15640 MMINT_15650 MMINT_15670
MEAR : Mpt1_c01980(mcrB) Mpt1_c02000(mrtG) Mpt1_c02010(mcrA)
MEUZ : KRP56_02075(mcrB) KRP56_02085(mcrG) KRP56_02090(mcrA)
MARC : AR505_1396 AR505_1397 AR505_1399
BARC : AOA65_0406(mrtB) AOA65_0407(mcrG) AOA65_0408(mcrA)
BARB : AOA66_1761(mcrA) AOA66_1769(mrtB) AOA66_1770(mcrG)
» show all
Taxonomy
Reference
Authors
Bobik TA, Olson KD, Noll KM, Wolfe RS.
Title
Evidence that the heterodisulfide of coenzyme M and 7-mercaptoheptanoylthreonine phosphate is a product of the methylreductase reaction in Methanobacterium.
Journal
Reference
2
Authors
Ellermann J, Hedderich R, Boecher R, Thauer RK.
Title
The final step in methane formation: investigations with highly purified methyl coenzyme M reductase component C from Methanobacterium thermoautotrophicum (strain Marburg).
Journal
Eur J Biochem 184:63-68 (1988)
Reference
Authors
Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK
Title
Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation.
Journal
Sequence
Reference
Authors
Signor L, Knuppe C, Hug R, Schweizer B, Pfaltz A, Jaun B.
Title
Methane formation by reaction of a methyl thioether with a photo-excited nickel thiolate--a process mimicking methanogenesis in archaea.
Journal
Reference
Authors
Scheller S, Goenrich M, Boecher R, Thauer RK, Jaun B
Title
The key nickel enzyme of methanogenesis catalyses the anaerobic oxidation of methane.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.8.4.1
ExPASy - ENZYME nomenclature database: 2.8.4.1
UM-BBD (Biocatalysis/Biodegradation Database): 2.8.4.1
BRENDA, the Enzyme Database: 2.8.4.1
LinkDB
All DBs