Entry
Name
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase;
MMPSepSecS;
SepSecS;
SLA/LP;
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase;
O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
Class
Transferases;
Transferring selenium-containing groups;
Selenotransferases
BRITE hierarchy
Sysname
selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase
Reaction(IUBMB)
O-phospho-L-seryl-tRNASec + selenophosphate + H2O = L-selenocysteinyl-tRNASec + 2 phosphate [RN:
R08224 ]
Reaction(KEGG)
Substrate
O-phospho-L-seryl-tRNASec;
selenophosphate [CPD:
C05172 ];
H2O [CPD:
C00001 ]
Product
L-selenocysteinyl-tRNA(Sec) [CPD:
C06482 ];
phosphate [CPD:
C00009 ]
Comment
A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC
2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.
History
EC 2.9.1.2 created 2009, modified 2014
Pathway
ec00970 Aminoacyl-tRNA biosynthesis
Orthology
K03341 O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase
Genes
XLA : 100101304(sepsecs.L)
SRX : 107709093(sepsecs) 107728650
SANH : 107675416 107691835
MASI : 127419823 127450929
SNH : 120030201 120049829(sepsecs)
DSI : Dsimw501_GD29559(Dsim_GD29559)
AGA : AgaP_AGAP003527 AgaP_AGAP012869
CEL : CELE_D1054.13(secs-1)
CBR : CBG_09712(Cbr-secs-1)
BMY : BM_BM14816(Bma-secs-1)
MIS : MICPUN_56124(SEPSECS)
DDI : DDB_G0280197(sepsecs)
PMAL : PMUG01_13015100(SEPSECS)
PREL : PRELSG_1303900(SEPSECS)
SMIN : v1.2.006611.t1(symbB.v1.2.006611.t1)
EHX : EMIHUDRAFT_365767 EMIHUDRAFT_428330(SLA1) EMIHUDRAFT_452696
LOKI : Lokiarch_10080(spcS)
» show all
Taxonomy
Reference
Authors
Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M
Title
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.
Journal
Sequence
Reference
Authors
Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Soll D, Nureki O
Title
Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation.
Journal
Sequence
Reference
Authors
Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Soll D, Schneider A
Title
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes.
Journal
Reference
Authors
Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D
Title
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.9.1.2
ExPASy - ENZYME nomenclature database: 2.9.1.2
BRENDA, the Enzyme Database: 2.9.1.2
LinkDB
All DBs