KEGG   ENZYME: 3.1.1.101
Entry
EC 3.1.1.101                Enzyme                                 
Name
poly(ethylene terephthalate) hydrolase;
PETase;
PET hydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
poly(ethylene terephthalate) hydrolase
Reaction(IUBMB)
(ethylene terephthalate)n + H2O = (ethylene terephthalate)n-1 + 4-[(2-hydroxyethoxy)carbonyl]benzoate [RN:R11540]
Reaction(KEGG)
R11540
Substrate
(ethylene terephthalate)n [CPD:C21451];
H2O [CPD:C00001]
Product
(ethylene terephthalate)n-1;
4-[(2-hydroxyethoxy)carbonyl]benzoate [CPD:C21450]
Comment
The enzyme, isolated from the bacterium Ideonella sakaiensis, also produces small amounts of terephthalate (cf. EC 3.1.1.102, mono(ethylene terephthalate) hydrolase). The reaction takes place on PET-film placed in solution.
History
EC 3.1.1.101 created 2016
Pathway
ec00624  Polycyclic aromatic hydrocarbon degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K21104  poly(ethylene terephthalate) hydrolase
Reference
1  [PMID:26965627]
  Authors
Yoshida S, Hiraga K, Takehana T, Taniguchi I, Yamaji H, Maeda Y, Toyohara K, Miyamoto K, Kimura Y, Oda K
  Title
A bacterium that degrades and assimilates poly(ethylene terephthalate).
  Journal
Science 351:1196-9 (2016)
DOI:10.1126/science.aad6359
  Sequence
[ag:GAP38373]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.101
IUBMB Enzyme Nomenclature: 3.1.1.101
ExPASy - ENZYME nomenclature database: 3.1.1.101
BRENDA, the Enzyme Database: 3.1.1.101
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