KEGG ENZYME: 3.1.1.103

ENZYME: 3.1.1.103

Entry

EC 3.1.1.103                Enzyme

Name

teichoic acid D-alanine hydrolase;
fmtA (gene name)

Class

Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases

Sysname

teichoic acid D-alanylhydrolase

Reaction(IUBMB)

[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n H2O = [(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan + n D-alanine [RN:R11965]

Reaction(KEGG)

R11965

Substrate

[(4-D-Ala)-(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
H2O [CPD:C00001]

Product

[(2-GlcNAc)-Rib-ol-P]n-[Gro-P]m-beta-D-ManNAc-(1->4)-alpha-D-GlcNAc-P-peptidoglycan;
D-alanine [CPD:C00133]

Comment

The enzyme, characterized from the bacterium Staphylococcus aureus, removes D-alanine groups from the teichoic acid produced by this organism, thus modulating the electrical charge of the bacterial surface. The activity greatly increases methicillin resistance in MRSA strains.

History

EC 3.1.1.103 created 2018

Orthology

K22580

teichoic acid D-alanine hydrolase

Genes

SDO:	SD1155_07555

SRD:	SD10_11505

BCB:	BCB4264_A3498

BCY:	Bcer98_2742

BTB:	BMB171_C3163 BMB171_P0160

BTT:

HD73_3735

BTHR:

YBT1520_18415

BTHI:

BTK_18405

BTC:	CT43_CH4049

BTM:

MC28_2645

BTG:	BTB_c41780(pbpX3)

BTHT:

H175_ch4115

BTHU:

YBT1518_22395

BTHY:

AQ980_12640

BWE:	BcerKBAB4_3210

BWW:

bwei_1441

BMYO:

BG05_2505

BTY:	Btoyo_0712

BBY:	CY96_19305

BMOB:

MLA2C4_18155

SAU:	SA0909(fmtA)

SAV:	SAV1057(fmt)

SAW:	SAHV_1049(fmt)

SAH:	SaurJH1_1139

SAJ:	SaurJH9_1116

SAM:	MW0940(fmt)

SAS:

SAS0992

SAR:	SAR1030(fmt)

SAC:

SACOL1066

SAX:	USA300HOU_1001(fmt1)

SAA:	SAUSA300_0959(fmt)

SAO:	SAOUHSC_00998

SAE:

NWMN_0926

SAD:

SAAV_1021

SUU:	M013TW_0988(fmtA)

SUV:	SAVC_04450

SUE:

SAOV_1003

SUJ:	SAA6159_00913(fmtA)

SUK:	SAA6008_01012

SUC:

ECTR2_912

SUT:	SAT0131_01092

SUQ:	HMPREF0772_12177

SUZ:	MS7_1014(fmtA)

SUD:	ST398NM01_1054

SUX:	SAEMRSA15_08880(fmt)

SUW:	SATW20_10530(fmt)

SUG:

SAPIG1054

SUF:	SARLGA251_09710(fmt)

SAUA:

SAAG_02168

SAUE:

RSAU_000944(fmtA)

SAUN:

SAKOR_00978

SAUS:

SA40_0927(fmt)

SAUU:

SA957_0942(fmt)

SAUG:

SA268_0945(fmt)

SAUZ:

SAZ172_0997(fmtA)

SAUT:

SAI1T1_2007480

SAUJ:

SAI2T2_1007500

SAUK:

SAI3T3_1007490

SAUQ:

SAI4T8_1007480

SAUV:

SAI7S6_1007490(fmtA)

SAUW:

SAI5S5_1007450(fmtA)

SAUX:

SAI6T6_1007460(fmtA)

SAUY:

SAI8T7_1007490(fmtA)

SAUF:

X998_1056

SAB:	SAB0923(fmt)

SUY:	SA2981_1011(fmtA)

SAUB:

C248_1082(fmt)

SAUM:

BN843_9630

SAUC:

CA347_973(fmtA)

SAUR:

SABB_01023(fmtA)

SAUI:

AZ30_05045

SAUD:

CH52_00600

SAMS:

NI36_05060

SUH:	SAMSHR1132_09050

SER:

SERP0641

SEP:

SE_0754

SEPP:

SEB_00730

SEPS:

DP17_2087(fmtA)

SHA:	SH1907(fmt)

SHH:	ShL2_01771

SSP:

SSP1736

SCA:

SCA_0665

SLG:	SLGD_01819

SLN:	SLUG_18150(fmt)

SSD:	SPSINT_0518

SDT:	SPSE_1942(fmtA)

SDP:	NCTC12225_02173(fmtA)

SWA:	A284_08550

SPAS:

STP1_2114

SXY:	BE24_02600

SXL:	SXYLSMQ121_1737

SXO:	SXYL_01880(fmtA)

SHU:	SHYC_01895

SCAP:

AYP1020_0379(pbpX)

SSCH:

LH95_09295

SSCZ:

RN70_10070

SAGQ:

EP23_08225

SEQO:

SE1039_08140

SSIF:

AL483_06610 AL483_06615

SCV:	A4G25_04610

SLZ:	B5P37_08435

SCOH:

BZ166_00595

SURY:

MUA21_03785

SNL:	BJD96_09640

SKL:	C7J89_10440

SHOM:

EGX58_01415

SCAR:

DWB96_09410

SCHR:

DWB92_01740

SARL:

SAP2_17690

SPIC:

SAMEA4384060_1899(fmtA_2)

SSH:	NCTC13712_01002(fmtA_1)

SSIM:

SAMEA4384339_0968(fmtA_1)

SLLO:

ISP08_08725

SAUL:

I6G39_08025

SSAC:

I6I31_07495

SPSD:

JMB28_09405

STAS:

HYI43_08930

SEDA:

MNY58_09315

SCAQ:

QMO72_09345

SROT:

ML435_04800(fmtA)

STAP:

AOB58_946

SGAI:

K3U27_02865

SSUC:

ACSSAF_09260

SSCU:

CEP64_08355

SFF:	FOB90_10230

SSTE:

SAMEA4384403_1803(fmtA)

MLEN:

H3V22_13610

MVT:	I6J10_02355

MARY:

LAU42_03235 LAU42_03240

MPSH:

QA539_03075

MAEQ:

ACMGE4_07365

MCL:	MCCL_0555 MCCL_0556

MCAK:

MCCS_07680(pbpX_2)

SAG:

SAG0658

SAN:

gbs0640

SAK:

SAK_0786

SGC:

A964_0654

SAGS:

SaSA20_0551

SAGL:

GBS222_0540

SAGM:

BSA_7450

SAGP:

V193_03115

SAGC:

DN94_03115

SAGT:

GBSCOH1_0580

SAGE:

EN72_04025

SAGG:

EN73_03725

SAGN:

W903_0749

SAGJ:

ID870_05980

LJF:	FI9785_1472(pbpX) FI9785_1730

LJH:

LJP_1717c

LJN:	T285_07215 T285_08775

LAC:	LBA1605(pbpX)

LAF:	SD55_1605(pbpX2)

LGA:

LGAS_1459

LHE:

lhv_1192

LHL:

LBHH_0974

LHR:	R0052_05750

LHV:

lhe_1083

LHD:

HUO_06210

LCR:	LCRIS_00552(pbp1)

LKE:

WANG_0789

LGL:	AO203_08705

LTA:	H1A07_08850

LCL:	LOCK919_2316

LPI:	LBPG_02057

LCX:	LCA12A_0680

LRH:

LGG_02141

LRG:

LRHM_2058

LRO:	LOCK900_2102

LRU:	HMPREF0538_21124

LRT:

LRI_1866

LRR:	N134_10195

LVA:	LV515_05195

LFN:	LF145_07135

LPOR:

PRK60_03620

LZY:	LZ3411_1809

LSA:

LCA_0648

LCV:	FBA2_03350

LHB:	D1010_12850

LCI:

LCK_00771

EHR:

EHR_00080

EDU:

LIU_05530

ETH:	CK496_08425

» show all

Reference

1 [PMID:9371333]

Authors

Komatsuzawa H, Sugai M, Ohta K, Fujiwara T, Nakashima S, Suzuki J, Lee CY, Suginaka H

Title

Cloning and characterization of the fmt gene which affects the methicillin resistance level and autolysis in the presence of triton X-100 in methicillin-resistant Staphylococcus aureus.

Journal

Antimicrob Agents Chemother 41:2355-61 (1997)
DOI:10.1128/AAC.41.11.2355

Sequence

[sau:SA0909]

Reference

2 [PMID:22564846]

Authors

Qamar A, Golemi-Kotra D

Title

Dual roles of FmtA in Staphylococcus aureus cell wall biosynthesis and autolysis.

Journal

Antimicrob Agents Chemother 56:3797-805 (2012)
DOI:10.1128/AAC.00187-12