Entry
Name
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
L-fucono-1,5-lactone lactonohydrolase
Reaction(IUBMB)
L-fucono-1,5-lactone + H2O = L-fuconate [RN:
R10689 ]
Reaction(KEGG)
Substrate
Product
Comment
The enzyme, characterized from the bacterium Burkholderia multivorans, participates in an L-fucose degradation pathway. The enzyme exhibits catalytic activity for the hydrolysis of several lactones, including L-fucono-1,4-lactone, D-arabinono-1,4-lactone, L-xylono-1,4-lactone, and L-galactono-1,4-lactone, but L-fucono-1,5-lactone is the best substrate.
History
EC 3.1.1.120 created 2022
Pathway
ec00051 Fructose and mannose metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
Genes
XPH : XppCFBP6546_13445(XppCFBP6546P_13445)
PYM : AK972_2744 AK972_3692
ABER : BSR55_00535 BSR55_03495
TFT : RI844_02485 RI844_09665
BPSO : X996_3971 X996_4020
BCM : Bcenmc03_5248 Bcenmc03_6311
BCH : Bcen2424_5036 Bcen2424_6705
BCEN : DM39_6875 DM39_6886
BAC : BamMC406_1250 BamMC406_4964
BCEP : APZ15_27720 APZ15_34705
BPYR : ABD05_24190 ABD05_33340
BCON : NL30_01165 NL30_32625
BDF : WI26_24080 WI26_30385
BTEI : WS51_08415 WS51_30155
BSEM : WJ12_20135 WJ12_31285
BSER : R0290_18000 R0290_31940
BURK : DM992_22820 DM992_34240
BPY : Bphyt_5475 Bphyt_6914
RSB : RS694_10705 RS694_15370
VPD : VAPA_2c00510 VAPA_2c06680
HSE : Hsero_1052 Hsero_4499
HSZ : ACP92_05265 ACP92_22465
HRB : Hrubri_0851 Hrubri_4450
HHF : E2K99_04915 E2K99_23690
HFR : G5S34_05240 G5S34_15450
HEW : HBDW_08600 HBDW_46480
ARUI : G6M88_17860 G6M88_21110
AVV : RvVAT039_35510 RvVAT039_42730
AVF : RvVAR031_35310 RvVAR031_38370
LABR : CHH27_01475 CHH27_24305
RPOP : K1718_07145 K1718_19575
LIZ : LGH83_17665 LGH83_19150
MALG : MALG_00069 MALG_00240
PTP : RCA23_c06460 RCA23_c24760
PPSO : QPJ95_12220 QPJ95_22415
MEKU : HUW50_14585 HUW50_16165
PUK : PU629_12970 PU629_16515
PJD : Pjdr2_3214 Pjdr2_3571
PMS : KNP414_04452 KNP414_05169
PMQ : PM3016_3864 PM3016_4569
PYG : AWM70_07785 AWM70_07910
PDH : B9T62_23435 B9T62_26555
PPSC : EHS13_07375 EHS13_09085 EHS13_10490 EHS13_15130
PBK : Back11_05590 Back11_08400 Back11_27700
PCEL : HUB94_09650 HUB94_25510
PSPN : L1F29_24150 L1F29_30115
PAUN : MJA45_05920 MJA45_11435 MJA45_25430
PKP : SK3146_00338 SK3146_01732
CHEB : HH215_08265 HH215_29165
COHL : J4772_02390 J4772_13345 J4772_15475 J4772_31995
SCO : SCO0350(SCF41.09) SCO7160(SC9A4.22c)
SMA : SAVERM_1405 SAVERM_7286
SGRF : SGFS_031900 SGFS_100440 SGFS_100670
SCB : SCAB_6521 SCAB_84361 SCAB_89131
SBH : SBI_01307 SBI_08461 SBI_09929
SDV : BN159_1443 BN159_1629 BN159_1649
SLV : SLIV_03475 SLIV_36185
SCX : AS200_02070 AS200_07860
SLE : sle_17790(sle_17790)
SCAD : DN051_06955 DN051_38570
SNZ : DC008_00265 DC008_34880
SGE : DWG14_01186 DWG14_07246 DWG14_08169
SCYA : EJ357_04740 EJ357_06155 EJ357_45940
SFY : GFH48_01625 GFH48_07510
SAQU : EJC51_03530 EJC51_40300
SBRO : GQF42_36405 GQF42_38670 GQF42_41810
SROI : IAG44_35140 IAG44_41900
SDEC : L3078_03130 L3078_40125 L3078_40375
SCAE : IHE65_04520 IHE65_42205
STUD : STRTU_005764 STRTU_006436
SCYN : N8I84_05695 N8I84_33090 N8I84_38915
SLAI : P8A22_00710 P8A22_02640 P8A22_02985
SPRF : K4G22_09730 K4G22_25535
SCAJ : O1G22_03485 O1G22_03565 O1G22_06105 O1G22_40965
SRPZ : HEP85_34050 HEP85_36915
AGLA : OIE69_01075 OIE69_02070 OIE69_02095 OIE69_32795
LEIF : HF024_00330 HF024_17285
LEIZ : IT072_00265 IT072_17185
MRG : SM116_01975 SM116_15380
MVD : AWU67_10145 AWU67_13945
ASOI : MTP13_05115 MTP13_12170
CPHY : B5808_04420 B5808_14300
HUM : DVJ78_06380 DVJ78_16480
AOG : LH407_04215 LH407_07410
HALT : IM660_18090 IM660_18525
MICG : GJV80_12495 GJV80_17195 GJV80_17530
KSL : OG809_10440 OG809_20045 OG809_22170
ACTQ : OG417_08775 OG417_25835 OG417_33260
NOW : GBF35_12995 GBF35_32550
NFS : OIE67_12885 OIE67_32835
MHAI : OHB01_32265 OHB01_32410
SACG : FDZ84_14260 FDZ84_22375
ARHD : VSH64_07560 VSH64_47145
ACYN : ORV05_13670 ORV05_16875
PSDS : K1T35_14660 K1T35_46910
LED : BBK82_12085 BBK82_39265
MICH : FJK98_13415 FJK98_13580 FJK98_14915
MCAB : HXZ27_11885 HXZ27_13780
VMA : VAB18032_18200 VAB18032_19470
VER : HUT12_14385 HUT12_15630
MCAY : PVK37_15785 PVK37_20850
MICF : QQG74_15540 QQG74_17490
ACTN : L083_5663 L083_5673
ACTL : L3i22_042690 L3i22_053580
AOU : ACTOB_004515 ACTOB_004792
CATI : CS0771_27800 CS0771_59290 CS0771_59300
DFU : Dfulv_11535 Dfulv_32145
DAUR : Daura_18940 Daura_30715
DACT : KZZ52_11525 KZZ52_34155 KZZ52_42215
PPHT : GA004_03195 GA004_11300
MTAR : DF168_01458 DF168_01831
ROL : CA51_05860 CA51_40510
RCF : Poly24_10320 Poly24_40400
AHEL : Q31a_32080 Q31a_38130
LCRE : Pla8534_12820 Pla8534_63030 Pla8534_66190
AAGG : ETAA8_24430 ETAA8_44280
SMAM : Mal15_12870 Mal15_16150
SNEP : Enr13x_50580 Enr13x_62290
PBS : Plabr_3082 Plabr_3926
FMR : Fuma_01117 Fuma_04504
CHYA : V22_21860 V22_27370
TIM : GMBLW1_13240 GMBLW1_16020
TSA : AciPR4_1051 AciPR4_2237 AciPR4_2654
ABAS : ACPOL_3974 ACPOL_5701
EPL : P4G45_03580 P4G45_07965
ORP : MOP44_01310 MOP44_27350
TPSC : RBB77_04465 RBB77_14040
SUS : Acid_0697 Acid_1511 Acid_2255
PFER : IRI77_05220 IRI77_18045
CHOR : MKQ68_10650 MKQ68_15635
NKO : Niako_3628 Niako_6702
NIA : A8C56_03960 A8C56_18695
NYN : U0035_03830 U0035_06145
NDF : KRR40_31355 KRR40_43505
FLS : GLV81_12890 GLV81_12920
LACS : H4075_05545 H4075_11690
SPHE : GFH32_05870 GFH32_14235
EVI : Echvi_1688 Echvi_2938
ECHI : FKX85_08100 FKX85_13895
SMON : AWR27_01290 AWR27_16160
SPIK : EXU85_08950 EXU85_24885
SPIB : G8759_11310 G8759_12750
SFOL : H3H32_01590 H3H32_16225
SENF : GJR95_12190 GJR95_13765
DSN : HWI92_07345 HWI92_24915
RTI : DC20_02265 DC20_21545
REK : N6H18_01420 N6H18_16685
FPLU : NLG42_17925 NLG42_18515
MARM : YQ22_01950 YQ22_02025
CBAL : M667_00135 M667_09840
CBAT : M666_00135 M666_09830
WFU : AXE80_06970 AXE80_11855
SAHN : JRG66_03540 JRG66_07435
» show all
Taxonomy
Reference
Authors
Hobbs ME, Vetting M, Williams HJ, Narindoshvili T, Kebodeaux DM, Hillerich B, Seidel RD, Almo SC, Raushel FM
Title
Discovery of an L-fucono-1,5-lactonase from cog3618 of the amidohydrolase superfamily.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.1.1.120
LinkDB
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