KEGG   ENZYME: 3.1.1.34
Entry
EC 3.1.1.34                 Enzyme                                 
Name
lipoprotein lipase;
clearing factor lipase;
diacylglycerol lipase;
postheparin esterase;
diglyceride lipase;
postheparin lipase;
diacylglycerol hydrolase;
lipemia-clearing factor;
hepatic triacylglycerol lipase;
LIPC (gene name);
LPL (gene name);
triacylglycero-protein acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
triacylglycerol acylhydrolase (lipoprotein-dependent)
Reaction(IUBMB)
triacylglycerol + H2O = diacylglycerol + a carboxylate [RN:R01369]
Reaction(KEGG)
R01369;
(other) R01350
Substrate
triacylglycerol [CPD:C00422];
H2O [CPD:C00001]
Product
diacylglycerol [CPD:C00165];
carboxylate [CPD:C00060]
Comment
Hydrolyses triacylglycerols and diacylglycerol in chylomicrons and low-density lipoprotein particles. Human protein purified from post-heparin plasma (LPL) shows no activity against triglyceride in the absence of added lipoprotein. The principal reaction sequence of that enzyme is triglyceride -> 1,2-diglyceride -> 2-monoglyceride. The hepatic enzyme (LIPC) also hydrolyses triglycerides and phospholipids present in circulating plasma lipoproteins.
History
EC 3.1.1.34 created 1972, modified 1976
Pathway
ec00561  Glycerolipid metabolism
Orthology
K01059  lipoprotein lipase
Genes
HSA4023(LPL)
PTR464031(LPL)
PPS100986925(LPL)
GGO101124245(LPL)
PON100443394(LPL)
NLE100584438(LPL)
MCC712887(LPL)
MCF102129758(LPL)
MTHB126961448
CSAB103215415(LPL)
CATY105579258(LPL)
PANU100126663(LPL)
TGE112629737(LPL)
RRO104662456(LPL)
RBB108526485(LPL)
TFN117092871(LPL)
PTEH111545664(LPL)
CJC100409187(LPL)
SBQ101050033(LPL)
CSYR103276581(LPL)
MMUR105882558(LPL)
LCAT123626511(LPL)
OGA100948213(LPL)
MMU16956(Lpl)
MCAL110299545(Lpl)
MPAH110336613(Lpl)
RNO24539(Lpl)
MCOC116069412(Lpl)
MUN110541256(Lpl)
CGE100689191(Lpl)
MAUA101841994(Lpl)
PLEU114703117(Lpl)
MORG121463009(Lpl)
MFOT126491343
AAMP119812456(Lpl)
NGI103747648(Lpl)
HGL101703016(Lpl)
CPOC100135570(Lpl)
CCAN109695324(Lpl)
DORD105992597(Lpl)
DSP122125612(Lpl)
NCAR124983295
OCU100340171(LPL)
OPI101522573(LPL)
TUP102492328(LPL)
CFA403626(LPL)
CLUD112669794(LPL)
VVP112925544(LPL)
VLG121496978(LPL)
AML100482804(LPL)
UMR103676703(LPL)
UAH113270022(LPL)
UAR123789904(LPL)
ELK111154450
LLV125092832
MPUF101692638(LPL)
ORO101380450(LPL)
EJU114200797(LPL)
ZCA113924410(LPL)
MLX118022060(LPL)
NSU110588669(LPL)
FCA727696(LPL)
PYU121039907(LPL)
PBG122472697(LPL)
LRUF124520965
PTG102967736(LPL)
PPAD109261142(LPL)
AJU106971857(LPL)
HHV120234031(LPL)
BTA280843(LPL)
BOM102266770(LPL)
BIU109563092(LPL)
BBUB102412415(LPL)
CHX100860750(LPL)
OAS443408(LPL)
ODA120862953(LPL)
CCAD122431880(LPL)
SSC397537(LPL)
CFR102520179(LPL)
CBAI105069002(LPL)
CDK105094532(LPL)
VPC102528503(LPL)
BACU103005101
LVE103083746(LPL)
OOR101284828(LPL)
DLE111169014(LPL)
PCAD102976943(LPL)
PSIU116755997(LPL)
ECB100055358(LPL)
EPZ103559571(LPL)
EAI106831205(LPL)
MYB102247387(LPL)
MYD102759852(LPL)
MMYO118658325(LPL)
MLF102421203(LPL)
MNA107535437(LPL)
PKL118726095(LPL)
HAI109382488(LPL)
DRO112305220(LPL)
SHON118975028(LPL)
AJM119054698(LPL)
PDIC114503561(LPL)
PHAS123828359(LPL)
MMF118616087(LPL)
RFQ117037818(LPL)
PALE102892638(LPL)
PGIG120606606(LPL)
PVP105296666(LPL)
RAY107503749(LPL)
MJV108384237(LPL)
TOD119233676(LPL)
SARA101555281(LPL)
LAV100667686(LPL)
TMU101345905
DNM101424109(LPL)
MDO100033067(LPL)
GAS123236970(LPL)
SHR100933361(LPL)
PCW110196400(LPL)
OAA100077350(LPL)
GGA396219(LPL)
PCOC116238184(LPL)
MGP100544844(LPL)
CJO107306443(LPL)
NMEL110389877(LPL)
APLA101796218(LPL)
ACYG106040417
AFUL116501160(LPL)
TGU100223817(LPL)
LSR110472801(LPL)
SCAN103821279(LPL)
PMOA120509453(LPL)
OTC121331469(LPL)
PRUF121355346(LPL)
GFR102041807(LPL)
FAB101814126(LPL)
PHI102111905(LPL)
PMAJ107216453(LPL)
CCAE111941733(LPL)
CCW104689737(LPL)
CBRC103619200(LPL)
ETL114063704(LPL)
ZAB102074097(LPL)
ACHL103804513(LPL)
FPG101913413(LPL)
FCH102046454(LPL)
CLV102097018(LPL)
EGZ104123360(LPL)
NNI104011947(LPL)
PLET104625055(LPL)
PCRI104029655(LPL)
ACUN113490034(LPL)
TALA104365755(LPL)
PADL103925585(LPL)
AFOR103904825(LPL)
ACHC115336420(LPL)
HALD104311533(LPL)
CCRI104155615(LPL)
CSTI104561210(LPL)
EHS104506628(LPL)
CMAC104474269(LPL)
MUI104544121(LPL)
FGA104078246(LPL)
GSTE104251577(LPL)
LDI104345916(LPL)
MNB103770188(LPL)
OHA104330190(LPL)
NNT104404799(LPL)
DPUB104305775(LPL)
PGUU104461649(LPL)
ACAR104528854(LPL)
AVIT104270889(LPL)
CVF104288407(LPL)
AAM106482500 106495445
AROW112972260(LPL)
NPD112956429(LPL)
TGT104572791(LPL)
DNE112982387(LPL)
SCAM104152300(LPL)
ASN102368909(LPL)
AMJ102573889(LPL)
CPOO109323269(LPL)
GGN109297392(LPL)
PSS102456906(LPL)
CMY102941095(LPL)
CPIC101932991(LPL)
TST117879105(LPL)
CABI116815306(LPL)
MRV120408560(LPL)
ACS100556298(lpl)
PVT110083190(LPL)
SUND121920775(LPL)
PBI103057093(LPL)
PMUR107286300(LPL)
CTIG120311460(LPL)
TSR106547738(LPL)
PGUT117661632(LPL)
VKO123030216(LPL)
PMUA114587743(LPL)
ZVI118097826(LPL)
GJA107118995(LPL)
STOW125437057
XLA108706825(lpl.S) 108712233(lpl.L)
XTR100127862(lpl)
NPR108804916(LPL)
RTEM120914637(LPL)
BBUF120989657(LPL)
BGAR122945880(LPL)
DRE100331214 101884800 30354(lpl)
SRX107715086 107715087 107750918 107754598 107757476
SANH107653621 107665504 107665505 107687910 107696683
SGH107552720 107561901 107561902 107588077 107588078 107596239
CCAR109046620 109046622 109046956 109090420
CAUA113040150 113040152 113040163 113040164 113045264 113064829
PPRM120474930 120486228 120486532(lpl)
MAMB125251126(lpl) 125251135 125251306
IPU108271131 108280930
PHYP113533484 113536621 113536692
SMEO124391426 124391471(lpl) 124403364
TFD113645101 113650786 113650790(lpl)
AMEX103021581 103042854 103043174
EEE113574503 113574524 113582888
TRU101062428(lpl) 101068642
TNGGSTEN00028798G001 GSTEN00028799G001
LCO104923638 104923639
NCC104943575 104948086
CGOB115006849(lpl) 115007104
ELY117254214 117254432(lpl)
EFO125895494(lpl) 125895495
PLEP121937831(lpl) 121937842
SLUC116055229 116055317(lpl)
ECRA117951001(lpl) 117951002
ESP116695129(lpl) 116695130
PFLV114561073 114561172
GAT120824060(lpl) 120824184
PPUG119216356(lpl) 119216357
MSAM119900751 119900754(lpl)
CUD121512160 121512162(lpl)
ALAT119028769 119028900(lpl)
MZE101478316 101478598
ONL100534504(lpl) 100689908
OAU116309207(lpl) 116309219
OLA101160309(lpl) 101160547
OML112150410(lpl) 112150654
XMA102225809 102226072
XCO114150801 114151199(lpl)
XHE116725568 116726198
PRET103463532 103463534(lpl)
PFOR103156884(lpl) 103156885
PLAI106955285(lpl) 106955287
PMEI106928981(lpl) 106929061
GAF122838476(lpl) 122838503
CVG107097308 107097322
CTUL119780851(lpl) 119780853
GMU124873925 124874261(lpl)
NFU107393172 107393174(lpl)
KMR108230795(lpl) 108230848
ALIM106521565(lpl) 106521567
NWH119407848 119430661(lpl)
AOCE111585084 111586565 111586568
MCEP125009575(lpl) 125009766
CSEM103397050 103397060(lpl)
POV109625830(lpl) 109625897
SSEN122780908 122781182(lpl)
HHIP117760249(lpl) 117760400
HSP118121010(lpl) 118121083
LCF108881396 108881397
SDU111232066(lpl) 111232091
SLAL111654280(lpl) 111654288
XGL120790626(lpl) 120790802
HCQ109532054 109532313
BPEC110160148
MALB109967464
BSPL114853517(lpl) 114853518
SASA106569629 106573544 106573546 106613694 106613695
STRU115151752 115151753 115157543 115158162 115158163
OTW112224719 112250798 112250799 112252199
OMY100136622(lpl) 110501773 110501969 110524209 110530805
OGO123989645 123997140 123997141 123998873 124009783
ONE115108237 115108239 115109211 115109213 115117068
SALP111952856 111952857 111975751 111975815
SNH120053767(lpl) 120054726 120054727 120056135
CCLU121533603 121533604 121535425 121576808 121577139
ELS105011471 105011473(lpl) 105022495
SFM108919920 108919924(lpl)
PKI111847582 111860378 111860417
AANG118225833 118226535(lpl) 118228878 118228901
LOC102692780 102692977
PSPA121300697 121300855 121301421 121301562
ARUT117401417 117401443 117963032 117966368
LCM102349247(LPL) 102362907
CMK103183498 103183499
RTP109922304(lpl) 109922306
BBEL109473436
AAG5567092
CQUCpipJ_CPIJ015386 CpipJ_CPIJ015387 CpipJ_CPIJ016050 CpipJ_CPIJ016051
CPII120413210
AGB108905840
APLN108744937 112905182
PTRU123520348
DSV119434676
 » show all
Reference
1  [PMID:4703566]
  Authors
Egelrud T, Olivecrona T.
  Title
Purified bovine milk (lipoprotein) lipase: activity against lipid substrates in the absence of exogenous serum factors.
  Journal
Biochim Biophys Acta 306:115-27 (1973)
DOI:10.1016/0005-2760(73)90215-4
Reference
2  [PMID:5441398]
  Authors
Fielding CJ.
  Title
Human lipoprotein lipase. I. Purification and substrate specificity.
  Journal
Biochim Biophys Acta 206:109-17 (1970)
DOI:10.1016/0005-2744(70)90087-2
Reference
3  [PMID:5466051]
  Authors
Greten H, Levy RI, Fales H, Fredrickson DS.
  Title
Hydrolysis of diglyceride and glyceryl monoester diethers with "lipoprotein lipase".
  Journal
Biochim Biophys Acta 210:39-45 (1970)
DOI:10.1016/0005-2760(70)90059-7
Reference
4  [PMID:5076762]
  Authors
Morley N, Kuksis A.
  Title
Positional specificity of lipoprotein lipase.
  Journal
J Biol Chem 247:6389-93 (1972)
Reference
5  [PMID:5168777]
  Authors
Nilsson-Ehle P, Belfrage P, Borgstrom B.
  Title
Purified human lipoprotein lipase: positional specificity.
  Journal
Biochim Biophys Acta 248:114-20 (1971)
DOI:10.1016/0005-2760(71)90081-6
Reference
6  [PMID:15284087]
  Authors
Santamarina-Fojo S, Gonzalez-Navarro H, Freeman L, Wagner E, Nong Z
  Title
Hepatic lipase, lipoprotein metabolism, and atherogenesis.
  Journal
Arterioscler Thromb Vasc Biol 24:1750-4 (2004)
DOI:10.1161/01.ATV.0000140818.00570.2d
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.34
IUBMB Enzyme Nomenclature: 3.1.1.34
ExPASy - ENZYME nomenclature database: 3.1.1.34
BRENDA, the Enzyme Database: 3.1.1.34
CAS: 9004-02-8
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