| Entry |
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| Name |
juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
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| Class |
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
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| Sysname |
methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
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| Reaction(IUBMB) |
(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN: R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN: R08149]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
juvenile hormone I acid [CPD: C20992];
methanol [CPD: C00132];
juvenile hormone III acid [CPD: C16504]
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| Comment |
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
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| History |
EC 3.1.1.59 created 1989, modified 2015
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| Pathway |
| ec00981 | Insect hormone biosynthesis |
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| Orthology |
| K01063 | juvenile-hormone esterase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
de Kort, C.A.D. and Granger, N.A. |
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| Title |
Regulation of the juvenile hormone titer. |
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| Journal |
Annu Rev Entomol 26:1-28 (1981) |
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| Reference |
2 |
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| Authors |
Mitsui, T., Riddiford, L.M. and Bellamy, G. |
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| Title |
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta). |
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| Journal |
Insect Biochem 9:637-643 (1979) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.1.59 |
| ExPASy - ENZYME nomenclature database: | 3.1.1.59 |
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| LinkDB |
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