KEGG   ENZYME: 3.1.1.59
Entry
EC 3.1.1.59                 Enzyme                                 
Name
juvenile-hormone esterase;
JH-esterase;
juvenile hormone analog esterase;
juvenile hormone carboxyesterase;
methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
methyl-(2E,6E,10R)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase
Reaction(IUBMB)
(1) juvenile hormone I + H2O = juvenile hormone I acid + methanol [RN:R10983];
(2) juvenile hormone III + H2O = juvenile hormone III acid + methanol [RN:R08149]
Reaction(KEGG)
R08149 R10983;
(other) R04608 R08150
Substrate
juvenile hormone I [CPD:C19613];
H2O [CPD:C00001];
juvenile hormone III [CPD:C09694]
Product
juvenile hormone I acid [CPD:C20992];
methanol [CPD:C00132];
juvenile hormone III acid [CPD:C16504]
Comment
Demethylates the insect juvenile hormones JH1 and JH3, but does not hydrolyse the analogous ethyl or isopropyl esters.
History
EC 3.1.1.59 created 1989, modified 2015
Pathway
ec00981  Insect hormone biosynthesis
Orthology
K01063  juvenile-hormone esterase
Genes
DMEDmel_CG8425(Jhe)
DER113564355 6548853
DSE6609376
DSIDsimw501_GD11160(Dsim_GD11160) Dsimw501_GD11161(Dsim_GD11161)
DYADyak_GE11753
DAN6494157
DSR110188938
DPODpse_GA25124
DPE6601344 6601345
DMN108158080 108160294 108160295
DWI26529390 26529790 26529934 6640104 6640209 6640210 6640211 6640534 6640536 6640538 6642291 6642292 6652305
DGR6560824
DMODmoj_GI19153 Dmoj_GI19154
DAZ108614905
DNV108652754
DHE111594015 111594041
DVI116650991
CCAT101455422 101455709 101459506(Jhedup2)
MDE101898361
SCAC106095748 106095759 106096357 106096366
LCQ111684795 111684803 111689840 111689841 111689842 111689843 111689844 111689879 111689880
LSQ119614830 119614831 119614832 119614893 119615303
HIS119659715
AGAAgaP_AGAP005833(COEJHE1F) AgaP_AGAP005834 AgaP_AGAP005835(COEJHE3F) AgaP_AGAP005836(COEJHE4F) AgaP_AGAP005837
ACOZ120947906 120947907 120952446 120953460 120961449
AARA120895609 120895877 120895976 120895977
ASTE118511476 118511478
AAG5564561 5566107 5566114 5566115 5566144
AALB109409689 109409690 109409691 109409692
CQUCpipJ_CPIJ002073 CpipJ_CPIJ002074 CpipJ_CPIJ002075 CpipJ_CPIJ007135 CpipJ_CPIJ007140 CpipJ_CPIJ013026 CpipJ_CPIJ013027 CpipJ_CPIJ013028 CpipJ_CPIJ013029 CpipJ_CPIJ013175 CpipJ_CPIJ014154 CpipJ_CPIJ020045
CPII120415174 120421623 120424078 120424083 120428123 120428686 120430980 120430983
CNS116339894 116343186 116345269 116346537
BCOO119067276 119073846 119074399 119081748 119083194
ACER107994233 107998239
ALAB122712419
BIM100747687
BBIF117207348 117215610
BVK117239627 117239629
BVAN117160201 117165772 117165823
BTER100644683
BPYO122565904 122565905
MGEN117223177
NMEA116430565 116430566
CGIG122398420 122398537
SOC105204452
ACEP105624427
CFO105253145
FEX115244260 115244603
PFUC122521421 122526321
VPS122626934
NVI100116956
TPRE106648476 106648477 106648642 106649960 106651086 106654859
CGLO123264594 123265768
FAS105268394 105268604 105271909 105272368
DAM107036668 107037809 107037811 107037825 107041165 107044435
AGIF122849067 122852485 122857263
CCIN107268776 107270792
TCA658208(Tcjhe)
DPA109544202
SOY115874432 115879484 115880324 115891782 115891956
ATD109604357 109604377
CSET123320239
AGB108914511 108914512 108917334 108917359 108917459 108917768 111692882
LDC111503335 111503338 111508437 111509916
NVL108559512 108567338
APLN108736917 108739450 108739452 108739470 108739568 108739585
PPYR116162493 116166887 116167223 116170992 116174771 116174863 116174864 116175126 116177944 116179631
OTU111413493 111427441
MSEX115449770
PPOT106101078 106102269
PXU106120154
ZCE119831887
HAW110376310 110380678
TNL113499569
OFU114356558 114361122 114361124 114363330 114365528 114365529 114365530 114365531 114365535 114365536
API100167473
DNX107163695
AGS114125584
RMD113560686 113560695 113560932
BTAB109044387
DCI103521191
HHAL106678779 106678781 106678785 106680444 106680448 106684895 106684907 106686619 106691387
NLU111060276
FOC113202308 113204778 113216791
TPAL117639564 117643349 117651814 117652006 117653369
ZNE110830303
CSEC111861666 111862711 111868484 111871333 111871335
DMK116931876
PCHN125027212 125027534 125033407 125038500 125040048 125040087 125043095
HAME121856955
PCLA123755654 123767619
PTRU123500966 123503046 123514018 123514097 123514098 123514181
HAZT108676749
LSM121123268 121125935
PPOI119089278 119089382 119089461 119090585 119090667 119092189 119094471 119099705 119099707 119099708 119100042 119100043 119100047 119100048 119100049 119100050 119100051 119100052 119101124 119101382 119101651 119101665 119101794 119101795 119102518 119103911 119104892 119112110 119112220 119114728
DSV119441975
RSAN119387580
VDE111247698
VJA111273776
DFR124496656 124498270
SDM118198391
HRJ124285713
 » show all
Reference
1
  Authors
de Kort, C.A.D. and Granger, N.A.
  Title
Regulation of the juvenile hormone titer.
  Journal
Annu Rev Entomol 26:1-28 (1981)
Reference
2
  Authors
Mitsui, T., Riddiford, L.M. and Bellamy, G.
  Title
Metabolism of juvenile hormone by the epidermis of the tobacco hornworm (Manduca sexta).
  Journal
Insect Biochem 9:637-643 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.59
IUBMB Enzyme Nomenclature: 3.1.1.59
ExPASy - ENZYME nomenclature database: 3.1.1.59
BRENDA, the Enzyme Database: 3.1.1.59
CAS: 50812-15-2
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