KEGG   ENZYME: 3.1.2.17
Entry
EC 3.1.2.17                 Enzyme                                 
Name
(S)-methylmalonyl-CoA hydrolase;
D-methylmalonyl-coenzyme A hydrolase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
(S)-methylmalonyl-CoA hydrolase
Reaction(IUBMB)
(S)-methylmalonyl-CoA + H2O = methylmalonate + CoA [RN:R02764]
Reaction(KEGG)
R02764
Substrate
(S)-methylmalonyl-CoA [CPD:C00683];
H2O [CPD:C00001]
Product
methylmalonate [CPD:C02170];
CoA [CPD:C00010]
History
EC 3.1.2.17 created 1989
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
Reference
1  [PMID:6885824]
  Authors
Kovachy RJ, Copley SD, Allen RH.
  Title
Recognition, isolation, and characterization of rat liver D-methylmalonyl coenzyme A hydrolase.
  Journal
J Biol Chem 258:11415-21 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.17
IUBMB Enzyme Nomenclature: 3.1.2.17
ExPASy - ENZYME nomenclature database: 3.1.2.17
BRENDA, the Enzyme Database: 3.1.2.17
CAS: 87928-03-8
LinkDB

KEGG   REACTION: R02764
Entry
R02764                      Reaction                               
Name
(S)-methylmalonyl-CoA hydrolase
Definition
(S)-Methylmalonyl-CoA + H2O <=> Methylmalonate + CoA
Equation
C00683 + C00001 <=> C02170 + C00010
Reaction class
RC00004  C00010_C00683
RC00137  C00683_C02170
Enzyme
3.1.2.17
Pathway
rn00280  Valine, leucine and isoleucine degradation
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.17
     R02764  (S)-Methylmalonyl-CoA + H2O <=> Methylmalonate + CoA
Other DBs
RHEA: 17348
LinkDB

DBGET integrated database retrieval system