Entry
Name
1,4-dihydroxy-2-naphthoyl-CoA hydrolase;
menI (gene name);
ydiL (gene name)
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
BRITE hierarchy
Sysname
1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Reaction(IUBMB)
1,4-dihydroxy-2-naphthoyl-CoA + H2O = 1,4-dihydroxy-2-naphthoate + CoA [RN:
R07262 ]
Reaction(KEGG)
Substrate
1,4-dihydroxy-2-naphthoyl-CoA [CPD:
C15547 ];
H2O [CPD:
C00001 ]
Product
Comment
This enzyme participates in the synthesis of menaquinones [4], phylloquinone [3], as well as several plant pigments [1,2]. The enzyme from the cyanobacterium Synechocystis sp. PCC 6803 does not accept benzoyl-CoA or phenylacetyl-CoA as substrates [3].
History
EC 3.1.2.28 created 2010
Pathway
ec00130 Ubiquinone and other terpenoid-quinone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K12073 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
K19222 1,4-dihydroxy-2-naphthoyl-CoA hydrolase
Genes
ATH : AT1G48320(DHNAT1) AT5G48950(DHNAT2)
CSAT : 104723224 104725379 104758130 104760877 104777747
EUS : EUTSA_v10005061mg EUTSA_v10011838mg EUTSA_v10011840mg EUTSA_v10023991mg EUTSA_v10024062mg
BRP : 103833017 103854251 103868682 103871476 103875007
BNA : 106345174 106355856 106359448 106359526 106374261 106374604 106401948 106411331 106422399 125580378 125589787
BOE : 106293805 106297220 106304592 106309710 106325619
RSZ : 108818698 108851832 108859325
THJ : 104802684 104818933 104821814
CIC : CICLE_v10006514mg CICLE_v10006547mg
MINC : 123209984 123221669
HSYR : 120152542 120155856 120191327 120219532
GMX : 100527403 100527631 100783241 100790693
GSJ : 114366900 114367353 114385692 114395096
PVU : PHAVU_008G037400g PHAVU_009G221000g
VRA : 106753762 106758875 106778343
VUM : 124828363 124828364 124843163 124843165
CCAJ : 109802355 109807485
APRC : 113852487 113863536
PSAT : 127115372 127138518
VVO : 131594683 131599028 131622644 131622651
AHF : 112738410 112790631 112797804
LANG : 109327275 109353050 109359258
PCIN : 129300592 129308506 129316413
QSA : O6P43_003756 O6P43_003757 O6P43_021954 O6P43_021955
PMUM : 103328910 103328913
PAVI : 110763357 110763360 110763362
PDUL : 117627082 117627083
MDM : 103421281 103452600 103452602
MSYL : 126596389 126596390 126607563
PXB : 103944707 103950342 108865307
CSAV : 115723432 115723433
MCHA : 111009343 111009390
CMAX : 111479482 111479487 111479492
CMOS : 111457607 111457608 111457609
CPEP : 111791095 111791096 111791417
PEU : 105107192 105107194 105107196 105107198
PALZ : 118057349 118057351
QLO : 115949591 115949975 115993535
SLY : 101245223 101250664 101259914
SPEN : 107009148 107013722
SSTN : 125846271 125859166
CANN : 107859398 107868340
NTA : 107776683 107776684 107808947 107822271 107822273
NSY : 104233309 104233310 104249539
NTO : 104086048 104120957 104120958
NAU : 109212083 109212084 109244104 109244111
SIND : 105159746 105162540
SSPL : 121751628 121794294 121801281
SHIS : 125188397 125208085
APAN : 127256556 127259659 127263823
ECAD : 122579364 122579758 122580007
LSV : 111877797 111877815 111877816
DCR : 108195854 108195855 108199431
CSIN : 114256747 114287347 114313687 114313950
CQI : 110717410 110717523 110738611 110738614
ATRI : 130804821 130804827
MING : 122057337 122063710 122073518
TSS : 122654283 122658875 122668669 122671771
PSOM : 113334874 113358030
BDI : 100821654 100826961 100846866
ATS : 109739334 109739581 109759559 109774910 109786370 109786371
TDC : 119266957 119274756 119287021 119287025 119289222 119294694 119294696 119296763 119318057 119323861 119336628 119340821 119349143 119364213
TAES : 123060136 123068611 123077142 123087233 123087235 123087805 123094283 123094284 123096523 123099407 123099408 123105615 123106266 123124847 123158988 123165528 123180170
TUA : 125539755 125542647 125542651 125547715 125550297 125550309
LPER : 127293382 127308396 127346814
LRD : 124646435 124649539 124685990 124686414 124700131 124703920
SBI : 8054144 8065258 8068200 8071292
ZMA : 100191529 100277871 100283760 100383169
MFLO : 136508202 136511060 136512852 136512853 136512863 136520158 136521464 136530766
SITA : 101756867 101769977 101771046 101772939
SVS : 117839759 117848862 117850650 117850651
PVIR : 120648289 120650132 120664197 120667158 120690363 120690364 120697385 120700271 120701206
PHAI : 112873916 112873918 112886480 112887472 112888076
PDA : 103697400 103698782 103714726
EGU : 105035507 105035778 105037062
MUS : 103985845 103994638 103997597
ZOF : 121980945 121984833 122000389 122003940 122043475 122043476 122048011
DCT : 110095853 110096732 110101193 110112243
PEQ : 110024777 110033794 110038785
MSIN : 131225262 131225798 131230821 131231217
SMO : SELMODRAFT_139210 SELMODRAFT_156340
PPP : 112275571 112276463 112282853
ECW : EcE24377A_1902(ydiL)
EDJ : ECDH1ME8569_1630(ydiI)
ECOI : ECOPMV1_01784(ydiI)
REE : electrica_02111(ydiI)
RTG : NCTC13098_03084(ydiI)
CLAP : NCTC11466_02620(ydiI)
KIE : NCTC12125_01154(ydiI)
AHN : NCTC12129_02315(ydiI)
METY : MRY16398_23240(menI)
PSHI : SAMEA2665130_1681(ydiI)
YPG : YpAngola_A2595(ydiI)
YPI : YpsIP31758_1740(ydiI)
SMW : SMWW4_v1c22060(ydiI)
SFJ : SAMEA4384070_2236(ydiI)
SOF : NCTC11214_04653(ydiI)
SSAR : SSARUM_002101(menI)
PAQU : DMB82_0009330(menI)
DDD : Dda3937_00002(ydiI) Dda3937_02430
DZE : Dd1591_1314 Dd1591_1692
DDC : Dd586_1653 Dd586_2821
DZC : W909_11750 W909_13810
DSO : A4U42_00640 A4U42_02270
CED : LH89_19390 LH89_21450
DFN : CVE23_13525 CVE23_15135
DAQ : DAQ1742_01255(entH) DAQ1742_02761(menI)
DIC : Dpoa569_001063 Dpoa569_001564
DLC : O1Q98_03990 O1Q98_05305
DDA : Dd703_1486 Dd703_1660
LBQ : CKQ53_12485 CKQ53_17125
LPOP : I6N93_06930 I6N93_11305
EPE : CI789_09025 CI789_21080
ERWI : GN242_02370 GN242_09125
ERP : LJN55_02630 LJN55_10470
TPTY : NCTC11468_00298(ydiI)
PHEI : NCTC12003_02316(ydiI)
PRJ : NCTC6933_01658(ydiI)
LRI : NCTC12151_01725(ydiI)
XAL : XALC_1531(albIII) XALC_3099
XPH : XppCFBP6546_10955(XppCFBP6546P_10955)
VPL : SA104470976_03345(ydiI)
PMUD : NCTC8068_03694(ydiI)
LCJ : NCTC11976_01833(ydiI)
LSS : NCTC12082_00920(ydiI)
LADL : NCTC12735_01247(ydiI)
TNI : TVNIR_1666(ydiI_[C])
HAAH : HALA3H3_910117(ydiI)
AEL : NCTC12917_02459(ydiI)
PLG : NCTC10937_03270(ydiI)
SCU : SCE1572_18320 SCE1572_34105
MRM : A7982_03736 A7982_05999
BAZ : BAMTA208_15740(yuxO)
BSON : S101395_04073(menI)
SALE : EPH95_02220 EPH95_15155
SCIB : HUG20_03575 HUG20_09715
SDP : NCTC12225_02125(ydiI)
SPIC : SAMEA4384060_2019(ydiI)
SSH : NCTC13712_00889(ydiI)
SSIM : SAMEA4384339_0802(ydiI)
SSTE : SAMEA4384403_1916(ydiI)
LMQ : LMM7_2430(ydiI_comA)
LOR : AYI71_14095 AYI71_15590
OEN : DSM07_05455 DSM07_06925
SSID : SPSIL_005180 SPSIL_016380
MPAG : C0J29_15660 C0J29_32430
MHAS : MHAS_01820 MHAS_03200
MHEV : MHEL_52700 MHEL_53310
MSAR : MSAR_16430 MSAR_39090
CLW : CLAC_01265 CLAC_06655
NCY : NOCYR_2612 NOCYR_2667
RPY : Y013_04410 Y013_11080 Y013_15200
RAV : AAT18_14025 AAT18_16940
RRZ : CS378_03695 CS378_06505
RFA : A3L23_04198 A3L23_04845
RHS : A3Q41_03420 A3Q41_04068
PDEF : P9209_11050 P9209_18310
GOQ : ACH46_01405 ACH46_11200
GOC : CXX93_01490 CXX93_11950
GSI : P5P27_00220 P5P27_10180
DTM : BJL86_1247 BJL86_1574
DIT : C3V38_13345 C3V38_13605
DIZ : CT688_07680 CT688_07765
DPC : A6048_07555 A6048_08025
DLU : A6035_07500 A6035_07630
DKN : NHB83_07245 NHB83_07340
SRK : FGW37_16490 FGW37_16495
NANO : G5V58_11525 G5V58_15035
BALA : DSM104299_02702(fcbC)
SYY : SYNGTS_2465(slr0204)
SYT : SYNGTI_2464(slr0204)
SYS : SYNPCCN_2463(slr0204)
SYQ : SYNPCCP_2463(slr0204)
TVN : NIES2134_103020(ycf83)
RSIN : B6N60_00214 B6N60_04566
DDR : Deide_00430 Deide_3p01440
DSW : QR90_04415 QR90_06080
DEIN : DAAJ005_06350 DAAJ005_09150
DTAE : LAJ19_13195 LAJ19_14510
SMIZ : 4412673_00403(ydiI)
SDJ : NCTC13534_00406(ydiI)
STHA : NCTC11429_01936(ydiI)
PSEZ : HME7025_00401(menI)
SPON : HME9304_02950(menI)
CGLE : NCTC11432_01977(ydiI)
CTAI : NCTC12078_03377(ydiI)
CTAK : 4412677_00883(ydiI)
CJG : NCTC13459_01283(ydiI)
CANT : NCTC13489_02905(ydiI)
» show all
Taxonomy
Reference
1
Authors
Muller W, Leistner E.
Title
1,4-Naphthoquinone, an intermediate in juglone (5-hydroxy-1,4-naphthoquinone) biosynthesis.
Journal
Phytochemistry 15:407-410 (1976)
Reference
2
Authors
Eichinger D, Bacher A, Zenk MH, Eisenreich W.
Title
Quantitative assessment of metabolic flux by 13C NMR analysis. Biosynthesis of anthraquinones in Rubia tinctorum.
Journal
J Am Chem Soc 121:7469-7475 (1999)
Reference
Authors
Widhalm JR, van Oostende C, Furt F, Basset GJ
Title
A dedicated thioesterase of the Hotdog-fold family is required for the biosynthesis of the naphthoquinone ring of vitamin K1.
Journal
Sequence
Reference
Authors
Chen M, Ma X, Chen X, Jiang M, Song H, Guo Z
Title
Identification of a hotdog fold thioesterase involved in the biosynthesis of menaquinone in Escherichia coli.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.28
ExPASy - ENZYME nomenclature database: 3.1.2.28
LinkDB
All DBs