KEGG   ENZYME: 3.1.3.99
Entry
EC 3.1.3.99                 Enzyme                                 
Name
IMP-specific 5'-nucleotidase;
ISN1 (gene name)
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-monoester hydrolases
Sysname
inosine 5'-phosphate phosphohydrolase
Reaction(IUBMB)
IMP + H2O = inosine + phosphate [RN:R01126]
Reaction(KEGG)
R01126
Substrate
IMP [CPD:C00130];
H2O [CPD:C00001]
Product
inosine [CPD:C00294];
phosphate [CPD:C00009]
Comment
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+.
History
EC 3.1.3.99 created 2016
Pathway
ec00230  Purine metabolism
ec01100  Metabolic pathways
Orthology
K18550  IMP and pyridine-specific 5'-nucleotidase
Genes
QSU111990697 112019689
SMOSELMODRAFT_103387 SELMODRAFT_413967 SELMODRAFT_415743 SELMODRAFT_99737
PPP112282666 112283810 112286598 112287728 112291556 112292774
CRECHLRE_04g225750v5
VCNVOLCADRAFT_105288
MNGMNEG_6875
CSLCOCSUDRAFT_59997
CVRCHLNCDRAFT_52757
APROF751_2896
OLUOSTLU_4044
OTAOT_ostta06g01180
BPGBathy05g01210
MISMICPUN_107875
MPPMICPUCDRAFT_27168
SCEYOR155C(ISN1)
SEUBDI49_4989
SPAOSPAR_O02840
AGOAGOS_AAR112C
ERCEcym_5451
KLAKLLA0_A02365g
KMXKLMA_30643(ISN1)
LTHKLTH0G03036g
VPOKpol_363p1
ZROZYRO0D11902g
CGRCAGL0L04268g
NCSNCAS_0H02430(NCAS0H02430)
NDINDAI_0C01230(NDAI0C01230)
TPFTPHA_0J02930(TPHA0J02930)
TBLTBLA_0D01760(TBLA0D01760)
TDLTDEL_0A03650(TDEL0A03650)
TGBHG536_0A05190
KAFKAFR_0C05230(KAFR0C05230)
KNGKNAG_0B03860(KNAG0B03860)
ZMKHG535_0D04680
DHADEHA2G07414g
PICPICST_38342(ISN1)
PGUPGUG_02836
SPAASPAPADRAFT_57719
LELLELG_01436
CALCAALFM_C101650WA(ISN1)
CTPCTRG_04462
COTCORT_0B10510
CDUCD36_01520
CTENCANTEDRAFT_124335
YLIYALI0E11913g
CLUCLUG_00750
CLUSA9F13_17g01364
CAURCJI97_002349
BNNFOA43_001352
BBRXBRETT_002508
OPAHPODL_03887
SLUDSCDLUD_003278
NCRNCU01945
NTENEUTE1DRAFT55104(NEUTE1DRAFT_55104)
SMPSMAC_05391
PANPODANSg040
TTTTHITE_2111481
MTMMYCTH_2137468
CTHRCTHT_0011740
MGRMGG_02955
PPEIPpBr36_09354
SSCKSPSK_06243
FGRFGSG_11629
FPUFPSE_08202
FVRFVEG_02510
FOXFOXG_03639
NHENECHADRAFT_35271
TRETRIREDRAFT_3372
TRRM419DRAFT_140832
MAWMAC_05366
MAJMAA_03704
CMTCCM_06504
PLJVFPFJ_00549
VDAVDAG_10339
CFJCFIO01_08488
CHIGCH63R_09956
SAPOSAPIO_CDS5219
PFYPFICI_09724
SSLSS1G_11331
BFUBCIN_08g04420(Bcisn1)
MBEMBM_07528
PSCOLY89DRAFT_724295
GLZGLAREA_02834
ANIAN3222.2
AFMAFUA_4G00970
ACTACLA_078090
NFINFIA_044530
AORAO090003001389
ANGANI_1_1120164(An18g01690)
AFVAFLA_000289
ALUCAKAW2_31395S(ISN1)
ACHEACHE_51268S(ISN1)
APUUAPUU_80935A(ISN1)
PCSPc12g13510
PDPPDIP_77910
TMFPMAA_006560
TRGTRUGW13939_07393
CIMCIMG_08882
CPWCPC735_063960
UREUREG_02795
PBLPAAG_11311(PAAG_01584)
PBNPADG_00190
ABEARB_05991
TVETRV_06351
AJEHCAG_07493
BGHBDBG_08713
PNOSNOG_02535
PTEPTT_12382
BZECOCCADRAFT_2013
BSCCOCSADRAFT_149090
BORCOCMIDRAFT_1067
AALTCC77DRAFT_611878
ZTRMYCGRDRAFT_56200
PFJMYCFIDRAFT_35210
FFUCLAFUR5_09838
BCOMBAUCODRAFT_151081
NPAUCRNP2_275
TMLGSTUM_00004490001
SPOSPBC30D10.03c
PFAPF3D7_1206100
PFDPFDG_02232
PFHPFHG_03990
PREIPRSY57_1205400
PGABPGSY75_1206100
PKNPKNH_1305800
PVXPVX_084340
PCYPCYB_131470
TGOTGME49_222710
PTIPHATRDRAFT_13606
FCYFRACYDRAFT_263138
TPSTHAPSDRAFT_34077
AAFAURANDRAFT_18663
PIFPITG_13347
PSOJPHYSODRAFT_502616
SPARSPRG_11168 SPRG_14401
EHXEMIHUDRAFT_231552 EMIHUDRAFT_455795
GTTGUITHDRAFT_163029 GUITHDRAFT_89259
 » show all
Reference
1  [PMID:8141771]
  Authors
Itoh R
  Title
Purification and some properties of an IMP-specific 5'-nucleotidase from yeast.
  Journal
Biochem J 298 Pt 3:593-8 (1994)
DOI:10.1042/bj2980593
Reference
2  [PMID:12735798]
  Authors
Itoh R, Saint-Marc C, Chaignepain S, Katahira R, Schmitter JM, Daignan-Fornier B
  Title
The yeast ISN1 (YOR155c) gene encodes a new type of IMP-specific 5'-nucleotidase.
  Journal
BMC Biochem 4:4 (2003)
DOI:10.1186/1471-2091-4-4
  Sequence
[sce:YOR155C]
Other DBs
ExplorEnz - The Enzyme Database: 3.1.3.99
IUBMB Enzyme Nomenclature: 3.1.3.99
ExPASy - ENZYME nomenclature database: 3.1.3.99
BRENDA, the Enzyme Database: 3.1.3.99
CAS: 9027-73-0
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