| Entry |
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| Name |
phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase;
cyclic phosphate dihydrolase;
phnPP (gene name)
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| Class |
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
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| Sysname |
5-phospho-alpha-D-ribose 1,2-cyclic phosphate 1,2-diphosphophosphohydrolase
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| Reaction(IUBMB) |
(1) 5-phospho-alpha-D-ribose 1,2-cyclic phosphate + H2O = D-ribofuranose 2,5-bisphosphate [RN: R10972];
(2) D-ribofuranose 2,5-bisphosphate + H2O = D-ribofuranose 5-phosphate + phosphate [RN: R10973]
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| Reaction(KEGG) |
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| Substrate |
5-phospho-alpha-D-ribose 1,2-cyclic phosphate [CPD: C20440];
H2O [CPD: C00001];
D-ribofuranose 2,5-bisphosphate
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| Product |
D-ribofuranose 2,5-bisphosphate;
D-ribofuranose 5-phosphate;
phosphate [CPD: C00009]
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| Comment |
The enzyme, characterized from the bacterium Eggerthella lenta, is involed in degradation of methylphosphonate.
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| History |
EC 3.1.4.57 created 2014
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| Pathway |
| ec00440 | Phosphonate and phosphinate metabolism |
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| Orthology |
| K20859 | phosphoribosyl 1,2-cyclic phosphate 1,2-diphosphodiesterase |
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| Genes |
| CPAS: | Clopa_3535 Clopa_4267 |
| PDC: | CDIF630_03845(phnPP) |
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| Reference |
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| Authors |
Ghodge SV, Cummings JA, Williams HJ, Raushel FM |
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| Title |
Discovery of a cyclic phosphodiesterase that catalyzes the sequential hydrolysis of both ester bonds to phosphorus. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.4.57 |
| ExPASy - ENZYME nomenclature database: | 3.1.4.57 |
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| LinkDB |
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