KEGG   ENZYME: 3.1.7.5
Entry
EC 3.1.7.5                  Enzyme                                 
Name
geranylgeranyl diphosphate diphosphatase;
geranylgeranyl diphosphate phosphatase
Class
Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases
Sysname
geranyl-diphosphate diphosphohydrolase
Reaction(IUBMB)
geranylgeranyl diphosphate + H2O = geranylgeraniol + diphosphate [RN:R08993]
Reaction(KEGG)
R08993
Substrate
geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]
Product
geranylgeraniol [CPD:C09094];
diphosphate [CPD:C00013]
Comment
Involved in the biosynthesis of plaunotol. There are two isoenzymes with different ion requirements. Neither require Mg2+ but in addition PII is inhibited by Zn2+, Mn2+ and Co2+. It is not known which isoenzyme is involved in plaunotol biosynthesis.
History
EC 3.1.7.5 created 2009
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Reference
1  [PMID:16445953]
  Authors
Nualkaew N, De-Eknamkul W, Kutchan TM, Zenk MH
  Title
Membrane-bound geranylgeranyl diphosphate phosphatases: purification and characterization from Croton stellatopilosus leaves.
  Journal
Phytochemistry 67:1613-20 (2006)
DOI:10.1016/j.phytochem.2005.12.014
Other DBs
ExplorEnz - The Enzyme Database: 3.1.7.5
IUBMB Enzyme Nomenclature: 3.1.7.5
ExPASy - ENZYME nomenclature database: 3.1.7.5
BRENDA, the Enzyme Database: 3.1.7.5
LinkDB

KEGG   REACTION: R08993
Entry
R08993                      Reaction                               
Name
geranyl-diphosphate diphosphohydrolase
Definition
Geranylgeranyl diphosphate + H2O <=> Geranylgeraniol + Diphosphate
Equation
C00353 + C00001 <=> C09094 + C00013
Reaction class
RC00017  C00353_C09094
Enzyme
3.1.7.5
Pathway
rn00904  Diterpenoid biosynthesis
rn01110  Biosynthesis of secondary metabolites
Brite
Enzymatic reactions [BR:br08201]
 3. Hydrolase reactions
  3.1  Acting on ester bonds
   3.1.7  Diphosphoric-monoester hydrolases
    3.1.7.5
     R08993  Geranylgeranyl diphosphate + H2O <=> Geranylgeraniol + Diphosphate
Other DBs
RHEA: 26240
LinkDB

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