KEGG   ENZYME: 3.1.8.1
Entry
EC 3.1.8.1                  Enzyme                                 
Name
aryldialkylphosphatase;
organophosphate hydrolase;
paraoxonase;
A-esterase;
aryltriphosphatase;
organophosphate esterase;
esterase B1;
esterase E4;
paraoxon esterase;
pirimiphos-methyloxon esterase;
OPA anhydrase (ambiguous);
organophosphorus hydrolase;
phosphotriesterase;
paraoxon hydrolase;
OPH;
organophosphorus acid anhydrase
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-triester hydrolases
Sysname
aryltriphosphate dialkylphosphohydrolase
Reaction(IUBMB)
an aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol [RN:R03979]
Reaction(KEGG)
R03979 > R05548;
(other) R05421
Substrate
aryl dialkyl phosphate [CPD:C03254];
H2O [CPD:C00001]
Product
dialkyl phosphate [CPD:C02534];
phenol [CPD:C15584]
Comment
Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids. Inhibited by chelating agents; requires divalent cations for activity. Previously regarded as identical with EC 3.1.1.2 arylesterase.
History
EC 3.1.8.1 created 1989
Pathway
ec00627  Aminobenzoate degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K01045  arylesterase / paraoxonase
Genes
HSA5444(PON1) 5445(PON2) 5446(PON3)
PTR463547(PON1) 463548(PON3) 463549(PON2)
PPS100971627(PON1) 100971959(PON3) 100972315(PON2)
GGO101146649(PON1) 101147009(PON3) 101147360(PON2)
PON100436262(PON3) 100436640(PON1) 100437018(PON2)
NLE100602768(PON1) 100603110(PON3) 100603799(PON2)
MCC699107(PON2) 699236(PON3) 699355(PON1)
MCF102119827(PON2) 102120476(PON3) 102121098(PON1)
CSAB103226525(PON3) 103226526(PON2) 103226528(PON1)
CATY105592193(PON1) 105592194(PON3) 105592195(PON2)
PANU101002432(PON2) 101003014(PON3) 101003347(PON1)
TGE112620240(PON3) 112620241(PON2) 112620242(PON1)
RRO104656585(PON1) 104656587(PON3) 104656588(PON2)
RBB108513529(PON2) 108513530(PON3) 108513531(PON1)
TFN117073771(PON1) 117073773(PON3) 117073774(PON2)
PTEH111552394(PON2) 111552395(PON3) 111552396(PON1)
CJC100407939(PON2) 100408549(PON3) 100408915(PON1)
SBQ101047829(PON3) 101048148(PON2) 101048681(PON1)
CSYR103254947(PON1) 103260954(PON2) 103265877(PON3)
MMUR105867256(PON1) 105867257(PON2) 105867258(PON3)
OGA100957793(PON1) 100958123(PON3) 100958437(PON2)
MMU18979(Pon1) 269823(Pon3) 330260(Pon2)
MCAL110296021(Pon2) 110296115(Pon3) 110296505(Pon1)
MPAH110315074(Pon2) 110315089(Pon3) 110316677(Pon1)
RNO296851(Pon2) 312086(Pon3) 84024(Pon1)
MCOC116098550(Pon2) 116098551(Pon1) 116098552(Pon3)
MUN110559637(Pon3) 110559638(Pon1) 110559640(Pon2)
CGE100762244(Pon1) 100762539(Pon2) 100762826(Pon3)
PLEU114693449(Pon1) 114693450(Pon3) 114693451(Pon2)
NGI103725227(Pon3) 103725228(Pon2) 103725260(Pon1)
HGL101696947(Pon1) 101697319(Pon3) 101697694(Pon2)
CPOC100721268(Pon1) 100721546(Pon3) 100721821(Pon2)
CCAN109693468 109693469
DORD106000573(Pon3) 106000583(Pon1) 106000589(Pon2)
DSP122111835(Pon3) 122111836(Pon2) 122111944(Pon1)
OCU100008754(PON3) 100009133(PON1) 100340152(PON2)
OPI101520084(PON2) 101534294(PON1) 101534535(PON3)
TUP102467949(PON3) 102482718(PON2) 102503295(PON1)
CFA403855(PON2) 475234(PON1) 475235(PON3)
VVP112923903(PON1) 112923904(PON3) 112923905(PON2)
VLG121474827(PON1) 121475134(PON3) 121475135(PON2)
AML100466658 100467410(PON1) 100467660
UMR103658742(PON1) 103658743(PON3) 103658801(PON2)
UAH113260313(PON1) 113260329 113260347(PON2)
UAR123789264 123789267 123789268(PON1)
ELK111147270 111147301 111147332
LLV125080885 125081037 125081038
MPUF101686418(PON2) 101687088(PON3) 101687383(PON1)
ORO101371249(PON2) 101371749(PON3) 101372042(PON1)
EJU114220533(PON3) 114220612(PON2) 114221028(PON1)
ZCA113911198(PON1) 113911674 113911779
MLX118020783(PON3) 118020784(PON2) 118021328(PON1)
FCA101091522(PON1) 101091774(PON3) 101094492(PON2)
PYU121028717(PON2) 121028718(PON3) 121028719(PON1)
PBG122487897(PON1) 122487898(PON3) 122487899(PON2)
PTG102965359(PON2) 102969631(PON3) 102969909(PON1)
PPAD109263711(PON1) 109263712(PON3) 109263714(PON2)
AJU106969955(PON3) 106969956(PON2) 106970003(PON1)
HHV120234396(PON1) 120234408(PON2) 120234432(PON3)
BTA281417(PON2) 510953(PON3) 523798(PON1)
BOM102268223(PON1) 102268513(PON3) 102269334(PON2)
BIU109558220(PON1) 109558221(PON3) 109558222(PON2)
BBUB102413831(PON2) 102414943(PON1) 102415937(PON3)
CHX102183658(PON2) 102189091(PON1) 102189455(PON3)
OAS100145861(PON2) 100337686(PON3) 101116983(PON1)
ODA120877965(PON1) 120877966(PON3) 120877967(PON2)
CCAD122438107(PON1) 122438108(PON2) 122438109(PON3)
SSC100048952(PON1) 100142663(PON2) 733674(PON3)
CFR102519221(PON3) 102519463(PON1) 102521631(PON2)
CBAI105082825(PON3) 105082858(PON1) 105083086(PON2)
CDK105088724(PON2) 105088725(PON3) 105088728(PON1)
VPC102534353(PON2) 102534760(PON3) 102535006(PON1)
BACU103002002(PON2) 103002453(PON3) 103004502(PON1)
LVE103072098(PON3) 103072365(PON2) 103075141(PON1) 103079171
OOR101286851(PON2) 101287293(PON3)
DLE111181194(PON3) 111181203(PON1) 111181316(PON2)
PCAD102985460(PON3) 102985745(PON2) 102986866
PSIU116759151 116759268(PON2) 116759341(PON3)
ECB100051896(PON1) 100051959(PON3) 100062686(PON2)
EPZ103541442(PON1) 103542649(PON3) 103542650(PON2) 103566405
EAI106838926(PON2) 106838927(PON3) 106838928(PON1)
MYB102249558(PON3) 102250151(PON1) 102251833(PON2)
MYD102757128(PON2) 102772860(PON1) 102775231(PON3)
MMYO118666202(PON2) 118666203(PON3) 118666205(PON1)
MLF102439191(PON1) 102440037(PON2) 102441484(PON3)
MNA107541647(PON3) 107541664 107541732(PON2)
PKL118714277(PON2) 118714279(PON3) 118714280(PON1)
HAI109393132 109393133(PON1)
DRO112319802(PON3) 112319857(PON1) 112319862(PON2)
SHON118987342(PON2) 118987343(PON3) 118987344(PON1)
AJM119047359(PON1) 119047361 119047362
PDIC114507714(PON3) 114507779(PON2) 114507858(PON1)
PHAS123811678(PON1) 123811716(PON3) 123812142(PON2)
MMF118619863(PON3) 118619864(PON1) 118620127(PON2)
RFQ117012450 117012551(PON1)
PALE102878821(PON1) 102879084 102879651
PGIG120615003 120615004 120615005(PON1)
PVP105294270(PON3) 105294284(PON1) 105295118(PON2)
RAY107507375 107507376 107518816(PON1) 107518821(PON3)
MJV108406224(PON2) 108406225(PON1) 108406229(PON3)
TOD119242392(PON1) 119242403(PON3) 119242426(PON2)
SARA101538771(PON1) 101539038(PON3) 101539298(PON2)
LAV100667197(PON2) 100675274(PON3) 100675554(PON1)
TMU101344330 101360527 101360792
DNM101418552(PON3) 101444818(PON1) 101447198(PON2)
MDO100017970(PON2) 100018559(PON3) 100028798
GAS123248682 123248979 123250414
SHR100922843 100929514 116419648
PCW110217569 110217570(PON3) 110217612
OAA103168141
GGA395830(PON2)
PCOC116243321(PON2)
MGP100303695
CJO107309112
NMEL110393402
APLA101800414
ACYG106037501(PON2)
AFUL116485706
TGU100218152
LSR110474732
SCAN103812828
PMOA120503471
OTC121338205
PRUF121353189
GFR102033037(PON2)
FAB101812552(PON2)
PHI102101075(PON2)
PMAJ107200070
CCAE111924234
CCW104689162
ETL114072935(PON2)
ZAB102066636
FPG101913744(PON2)
FCH102055053
CLV102089494
EGZ104128625
NNI104012814(PON2)
ACUN113477127
TALA104364705
PADL103922433(PON2)
ACHC115338749
AAM106483521(PON2)
AROW112976477
NPD112951101
DNE112982366
ASN102370400
AMJ102569523(PON2)
CPOO109309008
GGN109291426
PSS102457846
CMY102930790
CPIC101938475
TST117872230
CABI116829229
MRV120397939
ACS100551677(pon2)
PVT110074724
SUND121933587
PBI103052672
PMUR107283648
TSR106543984(PON2)
PGUT117655292
VKO123022598
PMUA114607242
ZVI118092011
GJA107118000(PON2)
XLA108718843 380341(pon2.L) 432039(pon2.S)
XTR448598(pon2)
NPR108790495 108790498 108790499
RTEM120939888 120939889 120939890 120939892
BBUF121000644 121000645
BGAR122938922(PON2) 122939265
DRE335176(pon2) 447803(pon1) 554122(pon3.1) 568655(pon3.2)
SRX107714733 107714734 107723437
SANH107657594 107657661 107699523 107699524
SGH107570834 107595282 107595292
CCAR109074161
CAUA113059725 113079744 113116720 113116721
IPU108271509
PHYP113526829
SMEO124385111
AMEX103046166
EEE113575646
TRU101062836
TNGGSTEN00034170G001 GSTEN00034171G001
LCO104925500 104925501
NCC104965579 104965581
CGOB115021251 115021843
ELY117265303 117266421 117266422
PLEP121945606 121946211
SLUC116049365 116049366
ECRA117946428 117946429
PFLV114556724 114556725
GAT120810607 120810756
PPUG119197756 119198029
MSAM119897783 119897784
CUD121513158 121513774
MZE101475101 101475704
ONL100710431 100710697
OAU116319793 116319798
OLA101174858 101175104
OML112144065 112144107
XMA102228189 102233391
XCO114141748
XHE116717115 116717116
PRET103478535 103478537
PFOR103143082 103143083
PLAI106937744 106937746
PMEI106904286 106904294
GAF122831396 122831397
CVG107102526 107102544
CTUL119772840 119772885
GMU124865883 124865905
NFU107378667 107378669
KMR108241913 108241982
ALIM106517722 106517725
NWH119410128 119410129
AOCE111577043 111577055 111577060 111577061 111577062 111577063
CSEM103388494
POV109633519
SSEN122774224
HHIP117776690
LCF108891018 108891027
SDU111234043 111234052
SLAL111664937 111664938
XGL120783577 120784784
HCQ109517591 109517598
BPEC110171411
MALB109971674 109971685
SASA100196477(pon2) 106573659 106598067 106598982 106605980
OTW112225380 112243792
OMY110506763 110506813 110520730 118937655
OGO124019519 124019520 124023552 124023554 124025810
ONE115115597 115117856
SALP112073006 112073012
SNH120036654 120036656 120039601 120039605
ELS105018843 105018844
SFM108940718
PKI111844496
AANG118216015
LOC102695084(pon2)
PSPA121315035
ARUT117394733
LCM102361851
CMK103176917
RTP109914992
BFO118403687 118405499 118406237 118409877 118417337 118426551 118429226 118431508
BBEL109464907 109469948 109476840 109476852
SPU100889706 105443412 115918103 589937 752021
APLC110985577 110988044
SKO100378655 102801568
EAF111714354
LOALOAG_02638
NAINECAME_03451 NECAME_03452
HROHELRODRAFT_97933
LGILOTGIDRAFT_174719
PCAN112556722 112556723 112556724
BGT106058217 106058218 106058221 106060320
GAE121387696
HRF124149810 124149839 124149840 124149841
HRJ124291138 124291142 124291143 124291144 124291145
CRG105322421 105346951
MYI110446029 110446051 110450177 110450178 110460254
PMAX117317753 117318409 117320909 117326122 117326556 117328280 117328281 117328506
MMER123523547 123523548 123523549 123523551 123524988 123524989 123524990 123525017 123539285
OBI106873488
OSN115223773
LAK106158780 106181365
NVE5510365 5512864
EPA110240777 110240778 110246487
ATEN116292657
ADF107327691 107348033
AMIL114964441 114977442
PDAM113678921
DGT114526900 114526961 114526962
XEN124449788 124454067 124454083
HMG100211341
AQU105316431
QSU112021952
YLIYALI0C00110g YALI0C21516g
MGRMGG_13116
SSCKSPSK_02462
FGRFGSG_07918
FPUFPSE_04455 FPSE_05302
FVRFVEG_10110 FVEG_12110
FOXFOXG_11704 FOXG_18645
NHENECHADRAFT_81096 NECHADRAFT_88077
MAWMAC_03353
VDAVDAG_03638
SAPOSAPIO_CDS10289
ELAUCREL1_4757
PFYPFICI_02441 PFICI_15218
SSLSS1G_00419
BFUBCIN_03g04340
MBEMBM_03697
PSCOLY89DRAFT_716256
GLZGLAREA_12824
TMFPMAA_018810 PMAA_082640
TRGTRUGW13939_06818 TRUGW13939_08383
PBLPAAG_03299
PBNPADG_03170
BGHBDBG_00600
PNOSNOG_00401
PTEPTT_18852
BORCOCMIDRAFT_3353
AALTCC77DRAFT_1056035
ZTRMYCGRDRAFT_66874
PFJMYCFIDRAFT_130988
TMLGSTUM_00011823001
SHSSTEHIDRAFT_149114
PSQPUNSTDRAFT_62101
ADLAURDEDRAFT_111322 AURDEDRAFT_145403
FMEFOMMEDRAFT_134301 FOMMEDRAFT_20360
GTRGLOTRDRAFT_105028 GLOTRDRAFT_93268
LBCLACBIDRAFT_313942
MRRMoror_6312 Moror_6313
CCICC1G_03270
SCMSCHCODRAFT_58362
ABPAGABI1DRAFT119181(AGABI1DRAFT_119181)
ABVAGABI2DRAFT185052(AGABI2DRAFT_185052)
CPUTCONPUDRAFT_121628
SLASERLADRAFT_465370
UMAUMAG_11303
PFPPFL1_04110
PGRPGTG_02508 PGTG_10976 PGTG_16097
MLRMELLADRAFT_118260
SREPTSG_06241
TETTTHERM_000470733
PTMGSPATT00019259001
EHXEMIHUDRAFT_110098
ENLA3UG_02300
LNICWR52_10215
SRRSerAS9_1139
SRLSOD_c10360
SRYM621_05845
SPLYQ5A_005815
SRSSerAS12_1139
SRASerAS13_1139
PRRAT705_03985
OSGBST96_17895
PSPIPS2015_622
DWDDSCW_42750
MSDMYSTI_07768
MFBMFUL124B02_41330
PCAYFRD00_16850
PLAPlav_2097
PMOBHG718_01910 HG718_01915
RBSRHODOSMS8_00055 RHODOSMS8_00093 RHODOSMS8_02237
PGLPGA2_c23710
LEJETW24_04710
GAKX907_2580
HBCAEM38_12870
SKTIGS68_13665
FERFNB15_11845
PBRPB2503_06702
ALMAO498_04375
LBYLbys_0674
EOLEmtol_0692
ALSDJ013_02390
FBCFB2170_09436
TENLPB136_07215
AQBD1818_19420
AQAD1815_12040
AQDD1816_22030
 » show all
Reference
1  [PMID:13032041]
  Authors
ALDRIDGE WN.
  Title
Serum esterases.  I.  Two types of esterase (A and B) hydrolysing p-nitrophenyl acetate, propionate and butyrate, and a method for their determination.
  Journal
Biochem J 53:110-7 (1953)
DOI:10.1042/bj0530110
Reference
2  [PMID:5047702]
  Authors
Bosmann HB.
  Title
Membrane marker enzymes. Characterization of an arylesterase of guinea pig cerebral cortex utilizing p-nitrophenyl acetate as substrate.
  Journal
Biochim Biophys Acta 276:180-91 (1972)
DOI:10.1016/0005-2744(72)90019-8
Reference
3  [PMID:2822017]
  Authors
Mackness MI, Thompson HM, Hardy AR, Walker CH.
  Title
Distinction between 'A'-esterases and arylesterases. Implications for esterase classification.
  Journal
Biochem J 245:293-6 (1987)
DOI:10.1042/bj2450293
Reference
4  [PMID:14420012]
  Authors
MAIN AR.
  Title
The differentiation of the A-type esterases in sheep serum.
  Journal
Biochem J 75:188-95 (1960)
DOI:10.1042/bj0750188
Reference
5
  Authors
In: Reiner, E., Aldridge, W.N. and Hoskin, C.G. (Eds.), Enzymes Hydrolysing Organophosphorus Compounds, Ellis Horwood, Chichester, UK, 1989
Other DBs
ExplorEnz - The Enzyme Database: 3.1.8.1
IUBMB Enzyme Nomenclature: 3.1.8.1
ExPASy - ENZYME nomenclature database: 3.1.8.1
UM-BBD (Biocatalysis/Biodegradation Database): 3.1.8.1
BRENDA, the Enzyme Database: 3.1.8.1
CAS: 117698-12-1
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