KEGG   ENZYME: 3.13.1.8
Entry
EC 3.13.1.8                 Enzyme                                 
Name
S-adenosyl-L-methionine hydrolase (adenosine-forming);
SAM hydroxide adenosyltransferase
Class
Hydrolases;
Acting on carbon-sulfur bonds;
Acting on carbon-sulfur bonds (only sub-subclass identified to date)
Sysname
S-adenosyl-L-methionine hydrolase (adenosine-forming)
Reaction(IUBMB)
S-adenosyl-L-methionine + H2O = adenosine + L-methionine [RN:R12098]
Reaction(KEGG)
R12098
Substrate
S-adenosyl-L-methionine [CPD:C00019];
H2O [CPD:C00001]
Product
adenosine [CPD:C00212];
L-methionine [CPD:C00073]
Comment
The enzyme, found in bacteria and archaea, catalyses a nucleophilic attack of water at the C5' carbon of S-adenosyl-L-methionine to generate adenosine and L-methionine. May be involved in regulating SAM levels in the cell. cf. EC 3.3.1.2, S-adenosyl-L-methionine hydrolase (L-homoserine-forming).
History
EC 3.13.1.8 created 2018
Orthology
K22205  S-adenosyl-L-methionine hydrolase (adenosine-forming)
Genes
CTELGBC03_01375
KASKATP_46070
MCAMCA1485
METUGNH96_09230
MAHMEALZ_2621
MBUREQU24_09675
MMAIsS8_2685
MOZMoryE10_19890
MISZMishRS11D_38450
NOCNoc_2298
NHLNhal_2412
NWANwat_2131
NWRE3U44_09300
ALVAlvin_2336
ATEPAtep_13340
TVIThivi_4228
TMBThimo_2832
MPURMARPU_03850
TEETel_04170
TSYTHSYN_23625
TTPE6P07_07145
THIPN838_21740
CJAPGWK36_03635
THIMKFB96_09670
TBOGLT988_20585
AEHMlg_0485
HHAHhal_0831
HHKHH1059_22000
HHCM911_11715
TGRTgr7_2297
NAXHC341_14945
WOCBA177_05740
TTCFOKN1_2682
SDFACG33_07595
SLIMSCL_2271
SVASVA_3333
ACIIC4901_13975
ATYA9R16_002890
TBNTBH_C0327
SEDSAAY24_14615
REVHUE57_07275
ENMEBS_0210
BGEBC1002_5960
TBDTbd_0432
SPLBSFPGR_07420
SLACSKTS_05690
APPCAP2UW1_3654
DVUDVU_0915
DVLDvul_2069
DVMDvMF_1391
DVGDeval_0845
DFLDFE_2901
DSDGD606_13215
DMADMR_42120
DCBC3Y92_02060
DGGDGI_1504
DDEDde_2703
DMSE8L03_14640
DSADesal_3688
DHYDESAM_20859
DAFDesaf_1066
DASDaes_0690
DPIBN4_12778
DEJAWY79_05395
PPRFDPRO_2631
PSELGM415_07695
DDNDND132_1725
DSXGD604_00485
PBIZLWC08_12425
DBADbac_2246
DOAAXF15_07045
DRTDret_2108
DPRDespr_2413
DEOCAY53_05015
DOGHP555_00015
DBKDGMP_24920
DMLDmul_27170
DALDalk_3152
DTOTOL2_C17720
DOVDSCO28_22160
DWDDSCW_66030
DALKDSCA_63640
DLIdnl_28060
DMMdnm_078870
ADEAdeh_2362
ACPA2cp1_1597
AFWAnae109_1507
ANKAnaeK_1502
AGEAA314_08396
AVMJQX13_26780
MBDMEBOL_001507
CFUSCYFUS_001287
HOHHoch_3689
SATSYN_00195
DAODesac_0040
DTIDesti_3034
SFUSfum_1405
DAXFDQ92_07105
DBRDeba_1487
PCAYFRD00_21915
BBAEFRD01_21460
EMXFKV68_12450
BICLMTR13_14270
PHBHYN04_12505
AZLAZL_000290
ALIAZOLI_3003
ABSAZOBR_10223
ABQABAZ39_00235
ABFAMK58_01135
ATIAL072_04405
AHUA6A40_12030
AZTTSH58p_11780
AZMDM194_11585
AZZDEW08_18125
AOZHUE56_10260
NAOY958_12680
SKTIGS68_25170
SMUCJL100_027040
SROEJL101_025160
RRURru_A1812
RRFF11_09320
RCERC1_2458
RPMRSPPHO_00358
MAGamb2335
MGYMGMSRv2__1010
MGRYMSR1_12520(salL)
MAGXXM1_3319
MAGNWV31_06690
HJOAY555_08235
DEXHWD60_12185
DVNHQ394_07675
TXITH3_08100
THACCSC3H3_07755
TIIDY252_10975
MAGQMGMAQ_1507
ACHTbsdcttw_37640
ADGAdeg_0614
LPILLIP_0181
RKOJWS14_02790
SPINKV203_10045
SSUBCP968_28770
YIALO772_15445
MIKFOE78_13420
TFUTfu_0222
THAONI17_021485
NGVCDO52_15480
TCUTcur_0792
ACTWF7P10_33605
AGRAAGRA3207_006239
SROSros_8926
NOABKM31_48895
NCXNocox_39130(salL)
NGNLCN96_52605
TBITbis_3306
FRAFrancci3_0478 Francci3_1909
FREFranean1_2242 Franean1_6138
FRIFraEuI1c_4802 FraEuI1c_6318
FALFRAAL0976 FRAAL4509
FSYFsymDg_1781
ACEAcel_0608
AMDAMED_9061
AMNRAM_46470
AMMAMES_8924
AMZB737_8925
AJAAJAP_40705
KPHYAOZ06_51750
ALOCRK60454
SACEGIY23_10650
STPStrop_1405
SAQSare_1364
MAUMicau_1511
MILML5_1773
MICBMicB006_1541
MTUACSH63_16690
MICHFJK98_08010
MTEMGCE86_01735
MCABHXZ27_08850
MSAGGCM10017556_40720
VMAVAB18032_12150
MCRAID554_04475
ASEACPL_7181
AMSAMIS_69190
ACTNL083_6773
AFSAFR_35760
ACTSACWT_7050
AIHAiant_30120
PLKCIK06_07715
PLABC6361_15650
PLATC6W10_14710
PFLAPflav_087710
PSUUPsuf_050690
VERHUT12_08485
ATLAthai_24050
ASERAsera_50810
PRYPrubr_41110
CATICS0771_24490
DVCDvina_08810
NHYJQS43_17835
CCAZCOUCH_08640
AEYCDG81_10300
ABAIIMCC26256_112229
RXYRxyl_0791
RRDRradSPS_0665
RUBGBA63_06150
RMARGBA65_14385
BSOLFSW04_03255
AYMYM304_37870
ATQGH723_00915
AQZKSP35_17495
IAMHC251_22045
ERZER308_12585
SYCsyc0828_c
SYUM744_13280
SYFSynpcc7942_0702
SYPSYNPCC7002_A0264
CYACYA_1889
CYBCYB_0252
SYNESyn6312_0011
SYVAWQ23_01475
SYLAWQ21_01325
SYNCCB0101_01485
DSLDacsa_2611
AMRAM1_3630
TVNNIES2134_121000
SLWBRW62_05710
TELtll2177
THNNK55_07525
THECFFX45_04300
LEPLepto7376_0942
LENLEP3755_60140
LETO77CONTIG1_02834(salL)
LBOLBWT_280
KOVK9N68_23590
LSCKIK02_16520
LSKJ5X98_20930
HHGXM38_042990(salL)
PSEUPse7367_1008
THEUHPC62_17005
GLPGlo7428_3342
GENGM3709_1956
GEEGM3708_1405
CHONNIES4102_28580
MARMAE_18580
MPKVL20_4732
MIQB5D77_21160
MVZmyaer102_51790
CANCyan10605_1507
HAOPCC7418_0839
ENNFRE64_13200
CYTcce_4491
CWACwatDRAFT_5042
CYPPCC8801_1293
CYHCyan8802_1320
CYCPCC7424_2641
CYJCyan7822_5553
TERTery_4783
ARPNIES39_K04630
OXYHCG48_00950
MVAGD0A34_08510
LFSHFV01_02320
MICMic7113_4245
GEIGEI7407_2330
OACOscil6304_2016
ONIOsc7112_1181
MPROBJP34_03480
PHORJWS08_03940
CEPCri9333_1250
GVIglr2922
GLJGKIL_2664
GMLISF26_20505
ANAall1327
NPUNpun_F3461
NOSNos7107_3543
NOPNos7524_2571
NONNOS3756_24700
NFLCOO91_05267
NOECLI64_15815
NSHGXM_04521
NEDHUN01_14090
AVAAva_3794
NAZAazo_4209
ANNEH233_28230
CSGCylst_0135
RSINB6N60_04044
CALOCal7507_2264
RIVRiv7116_5785
FISFIS3754_32570
NSPHBDGGKGIB_04083(salL)
TOQHCG51_17575
NCNBZZ01_05720
CTHEChro_0605
PLPPle7327_2185
SCSSta7437_1251
STANSTA3757_06270
CEOETSB_0615
CERRGRSB_0578
DETDET1548
DEHcbdbA1640
DEVDhcVS_1438
DEGDehalGT_1355
DMCbtf_1499
DMDdcmb_1446
DMGGY50_1445
DMXX792_07795
DMYX793_07165
DMZX794_07055
DUCUCH007_14300
DLYDehly_1474
DEWDGWBC_1649
DFODform_02081
RRSRoseRS_3530
RCARcas_1378
HAUHaur_3652
TROtrd_0357
STISthe_1017
ATMANT_15610
PSUBPelsub_P0175
KBSEPA93_25150
THUGKNN16_13165
TTRTter_0566
PMETG4Y79_14720
TTHTT_C1645
TTJTTHA0338(TTHA0338)
TTSThthe16_0039
TTLTtJL18_0043
THCTCCBUS3UF1_340
TOSTheos_2180
TAQTO73_0017
TPARAV541_00675
TBCA0O31_01125(salL)
TANTKNN15_04305
MRBMrub_0668
MREK649_02990
MTAIMtai_v1c23990
OPROcepr_0136
MHDMarky_0091
CCZCCALI_01385
RUFIK0V07_01625
MINMinf_1432
MKCkam1_1448
MEAPMTHMO_0588
PSLPsta_4032
PIRVN12_15475(salL)
ROLCA51_03440(salL)
AHELQ31a_63130(salL)
LCREPla8534_09140(salL)
AAGGETAA8_25090(salL)
BVOPan97_10440(salL)
TTFTHTE_3276
LPAVPLANPX_3187
AMUCPan181_26400(salL)
PNDPla175_20410(salL)
PLHVT85_21115(salL)
PLONPla110_03500(salL)
FTJFTUN_1644
IPAIsop_1473
SACISinac_6581
PBORBSF38_04985(salL)
AGVOJF2_68470(salL)
KSTKSMBR1_0390
BROCIPI25_03680
BPITBPIT_18470
JETL3J17_13920
PCORKS4_11500(salL)
HBSIPV69_00340
UAMUABAM_03393
ABAAcid345_3529
TALBFTW19_09615
ABASACPOL_1591
SUSAcid_0601
PFERIRI77_06235
CTMCabther_A1393
CVLJ8C06_08745
CHLOJ8C02_06745
THYDTTHT_1091(flA)
SCORJ3U87_10630
TLITlie_0715
GAUGAU_2446
GPHGEMMAAP_12335
GGRHKW67_02255
GBAJ421_3913
TTZFHG85_09110
MBASALGA_3540
SRUSRU_1824
SRMSRM_02032
RMRRmar_1448
RMGRhom172_1506
RBARAWN76_006805
CBAECOR50_18490
CHITFW415_15080
CHIHGWR21_01500
FGGFSB75_04490
ARKD6B99_05570
AGIFSB73_00990
ARACE0W69_011360
FLNFLA_1599
PSEGD3H65_08225
PGINFRZ67_08140
PGOFSB84_20460
FLSGLV81_11285
LACSH4075_04865
PGSCPT03_09595
PEJFYC62_07505
PEKFFJ24_011365
PROEH9L23_11035
SMIZ4412673_00462
SPSCE2P86_02375
SPHZE3D81_01715
SPHEGFH32_02100
SPDRG6053_03570
SDJNCTC13534_00471
STHANCTC11429_00892
MGOTMgSA37_02994(salL_2)
MUHHYN43_010755
MGINFRZ54_17405
MGKFSB76_31485
MRUBDEO27_012635
MGOSDIU38_007445
MMABHQ865_09465
MGIKGO620_006950
AGDFRZ59_13990
OLIFKG96_09690
SBXCA265_09020
ESTDN752_08280
ECHIFKX85_01700
HNVDDQ68_22035
HYHD3Y59_07925
HYJFHG12_02880
HRSHER32_16910
HBNGUY19_07595
PACTCA264_01945
NIBGU926_05490
ADDHUW48_15885
ASWUHUW51_16620
FPFDCC35_17025
CHKD4L85_16555
FUVJR347_10845
GRSC7S20_16650
CGHCGC50_06975
CLKCGC53_10950
CSPUCGC55_02105
CCYNCGC48_00570
CAPHCGC49_01600
CSTOCGC58_00560
CAPQCGC52_01565
CAPFFOC45_05215
MAREEJ994_06405
DODDCS32_10335
LACICW733_06240
MUTGVT53_11605
SPONHME9304_02892
AEVEI546_05445
NOBCW736_12630
NOJEJ995_08760
POACW731_05120
PHALH9I45_16060
TMARMARIT_1978
TMPF9Y86_14760
FOPFNB79_16105
OLLCW732_14735
OAQDZC78_03710
FEKC1H87_04140
TAJC1A40_13610
AUEC5O00_11845
KOSKORDIASMS9_03322(flA)
KANIMCC3317_06320(flA)
MARFCJ739_3838
AQBD1818_23770
AQAD1815_08440
AQDD1816_07270
EMARD1013_13850
MUREQY75_04790
PSYNE9099_14470
AFLAFHG64_02515
ANPFK178_02905
OCIFEZ18_00065
MGELG5B37_01575
MESQC7H62_2207
GAAHX109_14340
CAGGHYG79_15645
ALTIALE3EI_2387
FBEFF125_12180
CHRSEAG08_19580
CHRZCO230_05480
CARHEGY05_10305
CSHAEG350_09380
CNKEG343_02705
CJTEG359_04110
CILEG358_13190
CCAUEG346_18180
CBENEG339_19145
CGLENCTC11432_00965
CTAINCTC12078_01100
CLACEG342_19135
CTAK4412677_00443
CJGNCTC13459_00186
CCASEIB73_01085
CANTNCTC13489_00276
KDAEIB71_00455
EVAEIB75_04610
CNREB819_02970
EBVF0358_01725
EFALFH779_02440
ESTEHNV03_00800
BCADDBX24_08445
APIBG8C43_00035
CIVIMZ16_02145
CHYDH4K34_03705
CTECT1550
CPCCpar_0408
CLZBIU88_02940
CPHCpha266_2027
CPBCphamn1_2034
CLIClim_0408
PLTPlut_0388
PPHPpha_2370
PAAPaes_1832
PROCPtc2401_01923
PRSB9H02_09205
PROSCHL67_09755
CTSCtha_1710
CPRVCYPRO_1072
AAEaq_2196
PMXPERMA_1166
TMATM0660
TMMTmari_0660
TMITHEMA_01365
TMWTHMA_0675
TMQTHMB_0675
TMXTHMC_0675
TPTTpet_0271
TRQTRQ2_0269
TNACTN_1926
TNPTnap_0456
THQT2812B_01360
THZCELL2_01410
THRTRQ7_01375
TLETlet_1715
TTATheth_0315
PHYAJ81_06600
TMETmel_1901
TAFTHA_195
THPBG95_01045
THERY592_01050
TFEJYK00_09595
FNOFnod_0080
FPEFerpe_0318
FIANA23_01885
PMOPmob_1412
MPZMarpi_1215
MARNLN42_06625
KOLKole_1594
KPFIX53_03220
MPGTheba_0401
MINFMESINF_1703
ASACATHSA_0596 ATHSA_0655
CABYCabys_2327
TYETHEYE_A0544
DTPJZK55_13390
NDENIDE2547
NMVNITMOv2_3319
NIONITINOP_2876
NJANSJP_3986
NKFNkreftii_002452
LFCLFE_1538
LFILFML04_1089
LFPY981_04995
LEGABH19_08225
TIDThein_2162
TOPTOPB45_0928
THETF1847_03685
CTHITHC_0805
TAVG4V39_06400
TMAIFVE67_07780
NLIG3M70_00790
ALAMRT761_00218(salL)
MOXDAMO_2067
MKAMK0807
AFUAF_0461
AFGAFULGI_00004670
APOArcpr_0319
AVEArcve_1625
ASTAsulf_02234
FPLFerp_0945
GACGACE_1742
GAHGAH_00892
PFUPF0459
PFIPFC_01410
PHOPH0463(PH0463)
PABPAB1317
PYNPNA2_1094
PYAPYCH_18740
PYSPy04_0645
PYCTQ32_02225
TKOTK0062
TONTON_1165
TGATGAM_1163
TSITSIB_1083
TBATERMP_01230
THEGQS_09750
THATAM4_1913
THMCL1_1538
TLTOCC_07631
THSTES1_1269
TNUBD01_1128
TEUTEU_11530
TGYX802_07945
THVADU37_CDS08870
TCHCHITON_1286
TPEPA0127_03580
TPIEA7C91_01265
TGGA3K92_02415
TCEA3L02_08780
TBSA3L01_06485
THHCDI07_06465
TSLA3L11_10735
TTDA3L14_08915
TPRFA3L09_04030
TRLA3L10_00055
TPAFA3L08_09695
THYA3L12_03580
TICFH039_09530
TCQTIRI35C_1624
THEMFPV09_00190
PPACPAP_07245
MBAMbar_A0603
MBYMSBRM_3167
MBWMSBRW_0400
MBARMSBR2_3127
MBAKMSBR3_3124
MACMA_4318
MMAMM_1017
MMAZMmTuc01_1042
MMJMSMAS_0283
MMACMSMAC_0289
MVCMSVAZ_3179
MEKMSKOL_3149
MLSMSLAZ_2826
METMMSMTP_0315
MEFMSWH1_2915
MEQMSWHS_2077
MSJMSSAC_4011
MSZMSSIH_3537
MSWMSSIT_3597
MTHRMSTHT_1602
MTHEMSTHC_1687
MHORMSHOH_0379
MFZAOB57_007105
MMHMmah_0186
MHAZBHR79_02555
MEVMetev_2118
MZHMzhil_1992
MPYMpsy_1513
MZIHWN40_13400
MHZMetho_2344
MTPMthe_0204
MCJMCON_2393
MHIMhar_0855
MEZMtc_1958
RCIRRC488
HALVNG_0300C
HSLOE_1461R
HDLHALDL1_05680
HHBHhub_1446
HAGSJT689_02600
HABOJRZ79_01105
HNOLT974_02265
HLULT972_11290
HANRLJ422_01315
HJEHacjB3_14270
HALHHTSR_1447
HHSRHSR6_1519
HSUHLASF_0615
HSFHLASA_0611
SALRFQU85_03410
HALREFA46_006100
HARAAArcS_2612
HAADMW046_10620
HALXM0R89_11295
HMArrnAC1911
HHIHAH_2423
HHNHISP_12335
HABSG26_04650
HTABVU17_11785
HALJG9465_07430
HSINKDQ40_01315
NPHNP_0906A
NMONmlp_3854
NHOHWV23_12085
NSALHWV07_14120
HUTHuta_2899
HTIHTIA_0578
HALAHrd1104_09525
HMUHmuk_3201
HALZE5139_03235
HALLLC1Hm_2545
HAZPGBQ70_03235
HALIBV210_04595
HSNDV733_04140
HDSHSR122_0698
HRRHZS55_15165
HPELHZS54_18215
HLTI7X12_20435
HARCHARCEL1_11580
HDOMUK72_05065
HWAHQ_1165A
HWCHqrw_1202
HVOHVO_0781
HMEHFX_0740
HGIABY42_03720
HALEG3A49_03930
HBOHbor_18120
HAQDU484_08585
HAJDU500_08625
HAERDU502_05925
HRAEI982_07870
HLMDV707_12055
HALMFCF25_10610
HLAHlac_1036
HALPDOS48_05515
HALBEKH57_07040
HEZZEO776_05390
HALQHrr1229_000895
HSSJ7656_11320
HSAIHPS36_01595
HAZZKI388_02855
SRUBC2R22_04690
HAEhalTADL_0584
HALNB4589_013175
HALGHUG10_01050
HALUHUG12_16545
HMPK6T50_14070
HREK6T36_14015
HRMK6T25_02760
HACBHbl1158_05960
HDFAArcSl_1190(flA)
HAHHalar_3280
HTUHtur_0862
HDABB347_01200
HJTDVR14_06155
HALYHYG82_16315
HSALJMJ58_04665
HLOJ0X27_07340
HAKZJ0X25_11370
NMGNmag_2825
HXAHalxa_4023
NATNJ7G_4034
NPENatpe_3204
NVRFEJ81_15375
NPLFGF80_14735
NAYHYG81_12895
NGENatgr_0770
HRUHalru_1241
NOUNatoc_0646
SALIL593_01875
SAIMK0C01_00845
HLRHALLA_07755
HLCCHINAEXTREME00310
NAJB1756_11650
NAGAArcMg_0905
NANAArc1_2816
NBGDV706_03200
NASGCU68_10315
MELUMTLP_09800
MEAMMU439_00435
ABIAboo_1168
ACFAciM339_1492
APEAPE_2338
ACJACAM_1470
SMRSmar_1196
SHCShell_1272
IHOIgni_0947
IISEYM_03095
DKADKAM_0978
DFDDesfe_1096
DMUDesmu_0098
TAGTagg_0102
IAGIgag_1551
THGTCELL_0597
HBUHbut_0160
PFMPyrfu_0209
PDLPyrde_1414
STOSTK_03010
SOHD1869_01045
SSOSSO0254
SOLSsol_1230
SSOASULA_1270
SSOLSULB_1271
SSOFSULC_1269
SSHIJ5U23_00004
SCASSACC_01650
SAISaci_0719
SACNSacN8_03470
SACRSacRon12I_03460
SACSSUSAZ_03240
SISLS215_1995
SIAM1425_1886
SIMM1627_1963
SIDM164_1893
SIYYG5714_1962
SINYN1551_0958
SIILD85_2107
SIHSiH_1823
SIRSiRe_1743
SICSiL_1736
SULABFU36_04690
SULEGFS03_10345
SULOGFS33_02160
SULLEWF20_02510
MSEMsed_0005
MCNMcup_0005
MHKDFR87_06995
MPRUDFR88_06670
MTENGWK48_05170
MJNMjAS7_0592
AHOAhos_0776
AMANB6F84_07330
ABRIDFR85_07595
ASULDFR86_06390
AAMBD1866_11700
ACIHHS5_21500
SACDHS1genome_2327
SAZOD1868_01840
CSTYKN1_18630
STEPIC006_1800
SAHSHS7_07880
PAIPAE3627
PISPisl_0002
PCLPcal_2013
PASPars_2209
PYRP186_0791
POGPogu_2657
TNETneu_0919
PYWPYWP30_01041
CMACmaq_1067
TTNTTX_1655
TUZTUZN_1856
VDIVdis_2530
VMOVMUT_0875
TPETpen_0216
THBN186_01930
TCBTCARB_1471
THFMA03_00440
THELIG193_06525
ASCASAC_0826
ACIASE86_05665
CLGCalag_0787
FFOFFONT_0760
CSUCSUB_C1506
CCAINAS2_1237
BARCAOA65_0887
BARBAOA66_0233
PSYTDSAG12_00120
 » show all
Reference
1  [PMID:18720493]
  Authors
Eustaquio AS, Harle J, Noel JP, Moore BS
  Title
S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.
  Journal
Chembiochem 9:2215-9 (2008)
DOI:10.1002/cbic.200800341
  Sequence
[saq:Sare_1364]
Reference
2  [PMID:19739191]
  Authors
Deng H, McMahon SA, Eustaquio AS, Moore BS, Naismith JH, O'Hagan D
  Title
Mechanistic insights into water activation in SAM hydroxide adenosyltransferase (duf-62).
  Journal
Chembiochem 10:2455-9 (2009)
DOI:10.1002/cbic.200900369
  Sequence
[pho:PH0463]
Other DBs
ExplorEnz - The Enzyme Database: 3.13.1.8
IUBMB Enzyme Nomenclature: 3.13.1.8
ExPASy - ENZYME nomenclature database: 3.13.1.8
BRENDA, the Enzyme Database: 3.13.1.8
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