KEGG   ENZYME: 3.2.1.144
Entry
EC 3.2.1.144                Enzyme                                 
Name
3-deoxyoctulosonase;
alpha-Kdo-ase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
3-deoxyoctulosonyl-lipopolysaccharide hydrolase
Reaction(IUBMB)
3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide [RN:R06054]
Reaction(KEGG)
R06054;
(other) R12219
Substrate
3-deoxyoctulosonyl-lipopolysaccharide [CPD:C06744];
H2O [CPD:C00001]
Product
3-deoxyoctulosonic acid [CPD:C01187];
lipopolysaccharide [CPD:C00338]
Comment
Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic acid) from different lipopolysaccharides, including Re-LPS from Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is also a substrate.
History
EC 3.2.1.144 created 2000
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K23082  3-deoxy-D-manno-octulosonic acid-hydrolase
Genes
HPYHP_0579
HEOC694_02985
HPJjhp_0526
HPAHPAG1_0558
HPSHPSH_03980
HHPHPSH112_04135
HHQHPSH169_02980
HHRHPSH417_02780
HPGHPG27_538
HPPHPP12_0585
HPBHELPY_0797
HPLHPB8_775
HPCHPPC_02870
HCAHPPC18_02780
HPMHPSJM_02930
HPEHPELS_03675
HPOHMPREF4655_21022
HPIhp908_0586
HPQhp2017_0566
HPWhp2018_0568
HPUHPCU_03160
HEFHPF16_0780
HPFHPF30_0748
HEQHPF32_0554
HEXHPF57_0604
HPTHPSAT_03910
HPZHPKB_0765
HPVHPV225_0585
HPXHMPREF0462_0837
HENHPSNT_02975
HPHHPLT_02875
HEGHPGAM_02980
HPNHPIN_03980
HEPHPPN120_02850
HEUHPPN135_02855
HESHPSA_02680
HPYSHPSA20_0593
HCNHPB14_03795
HPDKHP_0739
HEYMWE_0938
HERC695_02990
HEIC730_02990
HPYAHPAKL117_02735
HPYKHPAKL86_01955
HPYOHPOK113_0595
HPYLHPOK310_0757
HPYBHPOKI102_04120
HPYCHPOKI112_04150
HPYDHPOKI128_02750
HPYEHPOKI154_02970
HPYFHPOKI422_04120
HPYGHPOKI673_02945
HPYHHPOKI828_02950
HPYJHPOKI898_04120
HPYRK747_06965
HPYIK750_05175
HPYUK751_03515
HPYMK749_01605
HEMK748_00100
HEBU063_0884
HEZU064_0888
HACHac_1433
HFEHFELIS_01180
HBIHBZC1_15940
HCEHCW_06240
HCMHCD_01360
HHMBN341_10740
FUVJR347_06145
 » show all
Reference
1  [PMID:9334217]
  Authors
Li YT, Wang LX, Pavlova NV, Li SC, Lee YC.
  Title
alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid.
  Journal
J Biol Chem 272:26419-24 (1997)
DOI:10.1074/jbc.272.42.26419
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.144
IUBMB Enzyme Nomenclature: 3.2.1.144
ExPASy - ENZYME nomenclature database: 3.2.1.144
BRENDA, the Enzyme Database: 3.2.1.144
CAS: 199128-67-1
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