KEGG   ENZYME: 3.2.1.184
Entry
EC 3.2.1.184                Enzyme                                 
Name
UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing);
UDP-Bac2Ac4Ac 2-epimerase;
NeuC
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
UDP-N,N'-diacetylbacillosamine hydrolase (2-epimerising)
Reaction(IUBMB)
UDP-N,N'-diacetylbacillosamine + H2O = UDP + 2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose [RN:R10187]
Reaction(KEGG)
R10187
Substrate
UDP-N,N'-diacetylbacillosamine [CPD:C20357];
H2O [CPD:C00001]
Product
UDP [CPD:C00015];
2,4-diacetamido-2,4,6-trideoxy-D-mannopyranose [CPD:C20424]
Comment
Requires Mg2+. Involved in biosynthesis of legionaminic acid, a nonulosonate derivative that is incorporated by some bacteria into assorted virulence-associated cell surface glycoconjugates. The initial product formed by the enzyme from Legionella pneumophila, which incorporates legionaminic acid into the O-antigen moiety of its lipopolysaccharide, is 2,4-diacetamido-2,4,6-trideoxy-alpha-D-mannopyranose, which rapidly mutarotates to a mixture of anomers [1]. The enzyme from Campylobacter jejuni, which incorporates legionaminic acid into flagellin, prefers GDP-N,N'-diacetylbacillosamine [2].
History
EC 3.2.1.184 created 2012
Pathway
ec00520  Amino sugar and nucleotide sugar metabolism
ec01100  Metabolic pathways
Orthology
K18429  GDP/UDP-N,N'-diacetylbacillosamine 2-epimerase (hydrolysing)
Genes
CITZE4Z61_12345(neuC)
MLQASQ50_04380
MARJMARI_04470(legG)
SLITJQC75_12035(neuC)
SEURFM038_016015(neuC)
PSYMJ1N51_14000(neuC)
LPNlpg0753
LPHLPV_0879(neuC)
LPOLPO_0834(neuC)
LPULPE509_02458
LPMLP6_0733(neuC)
LPFlpl0790(neuC)
LPPlpp0819(neuC)
LPCLPC_2539(neuC)
LPAlpa_01161
LPElp12_0763
LCDclem_09450
LWASAMEA4504053_1067(neuC)
LANTTUM19329_12810
MDNJT25_014980
MDHAYM39_17515
MKOMKLM6_3557
METLU737_04570(neuC)
MOZMoryE10_08780
FPHFphi_1168
FPIBF30_1412(neuC)
FPXKU46_146(neuC)
FHACDV26_09125(neuC)
FRCKX01_1746(neuC)
HTREPV75_07830(neuC)
TSETHMIRHAS_08940
TANIJ8380_09290(neuC)
GAIIMCC3135_22690 IMCC3135_24280
HAHEENC22_10855(neuC)
MARSA8C75_01305
OMEOLMES_5579
SUTRL0B52_04050(neuC)
TBNTBH_C0741
THINCRN91_03150(neuC)
THOSP60_02325
CARIFNU76_04760(neuC)
PIGEGT29_04945(neuC)
POSDT070_03540(neuC)
POOF7R28_05900(neuC)
RTEAHK414_20335(neuC)
JAJEKL02_02180(neuC)
TINTint_0496
THITHI_0582
METRBSY238_2010(neuC)
ARESIWH25_01420(neuC)
ACOMCEW83_19885(neuC)
HCPHCN_1150 HCN_1160
HCBHCBAA847_0808 HCBAA847_0810 HCBAA847_0821
TDNSuden_0597
SPALFM071_00630(neuC)
SSEIFJR45_04435(neuC)
SMASHUE87_09360(neuC)
SULRB649_08545
CJECj1328(neuC2)
CJBBN148_1328(neuC2)
CJICJSA_1264(neuC2)
CJSCJS3_1422(neuC)
CJPA911_06455
CJEJN564_02260
CJEUN565_02350
CJENN755_02410
CJEIN135_01416
CJERH730_07595
CJYQZ67_01464(legG)
CJQUC78_1271(legG)
CJLPJ17_07025
CJWPJ18_06825
CJRCJE1517(neuC)
CJDJJD26997_0381 JJD26997_0384
CJZM635_02335
CJXBN867_13130
CCOCCC13826_2302(legG)
CCOCCCON33237_1631(legG)
CLACLA_1234(legG)
CLLCONCH_0307
CCOLBN865_08090c
CCCG157_02180
CCQN149_1291(legG)
CCFYSQ_02210
CCYYSS_07205
CCOIYSU_02245
CCOFVC76_06665(legG)
CCOOATE51_00908(legG)
CAJCIG1485E_0030(legG) CIG1485E_0036 CIG1485E_0038
CISCINS_1193(legG)
CVOCVOL_1213(legG)
CSMCSUB8521_1416(legG)
CSFCSUB8523_1516(legG)
CHVCHELV3228_1654(legG)
CLXCLAN_1242(legG)
CAVICAV_1242(legG)
CAMZCVIC12175_0321(legG)
CAMYCSUIS_1329(legG)
COJCORN_1304(legG)
CUXCUP3940_0185(legG)
CARMCARM_1263(legG)
CMUCCMCT_0196(legG)
CNVCNZW441b_0375(legG)
ABTABED_0621
ATPATR_1812(legG)
ACIBACBT_0327
ACREACRYA_0151(legG)
ALANALANTH_0841(legG)
AELLAELL_2681
ACLOACLO_2505
APAIAPAC_2451(legG)
HBVABIV_2489(legG)
ARCABLL_0810
GSBGSUB_14710
GSUBKP001_19670(neuC)
GPLM1B72_03360(neuC)
RBSRHODOSMS8_01668
EMXFKV68_30695(neuC)
DEIC4375_03850(neuC)
DEAFPZ08_13225(neuC)
PSINCAK95_17685
RBMTEF_17310
BOOE2K80_11710(neuC)
PAEDG5B38_20055(neuC)
FAQG5B39_16695(neuC)
SALSala_1575
SLANGV829_10190(neuC)
PMASNCF86_12535(neuC)
PELSAR11G3_00117
GKAGK3126
GTHGeoth_0376
LYZDCE79_02890(neuC)
FPNABE65_018190
MEKUHUW50_13945(neuC)
BBEBBR47_53280(mnaA)
PPYPPE_04400
PTAHPL003_04490
PDUPDUR_25195
PPEOABE82_23140
PAIHASL14_14805
PALBEJC50_01640(neuC)
PRZGZH47_18505(neuC)
PLYCGXP70_28095(neuC)
PALOE6C60_3853
CCHLFPL14_11290(neuC)
TABCIG75_02425(neuC)
EFFskT53_28650
KEBGXN75_11655(neuC)
EFCEFAU004_01371
EFAUEFAU085_00959
EFUHMPREF0351_10917(neuC)
AUIAPT62_03105
CARCNY10_959
CNONT01CX_1785
CBLCLK_2100
CBKCLL_A1553
CBBCLD_1853
CBNCbC4_0997 CbC4_1108
CBTCLH_1463
CKLCKL_2470
CKRCKR_2184
CCBClocel_2386
CEUA7L45_12140
CTAEBGI42_06560(neuC)
CFMBJL90_06970 BJL90_21235
CCHVBTM20_03655
CGASJ1C67_16070(neuC)
CALEFDN13_00875(neuC)
CRSFQB35_02425(neuC)
CTHCthe_2640
CTXClo1313_0229
CCLClocl_4179
HSCHVS_09995(legG)
BPBbpr_I0429
CLEClole_3571
LBWC3V36_05585(neuC)
CSTCLOST_0368(neuC)
DDLDesdi_3208
DMTDESME_12775
DORDesor_0347
DAUDaud_0018
TFRBR63_12270(neuC)
FWADCMF_13710
TJRTherJR_2786
AWOAwo_c24830(neuC)
CBARPATL70BA_2644(legG)
THEPDYI95_003450(neuC)
CTHMCFE_2538
TITThit_0480
MTHOMOTHE_c06990(legG)
MTHZMOTHA_c07930(legG)
CCHAELD05_07920(neuC)
TXYThexy_1879
TSHTsac_2669
HORHore_16940
HPKHprae_0328
HALSD7D81_17930(neuC)
IFNGM661_06750(neuC) GM661_18115(neuC)
AFTBBF96_11095
SPOAEQM13_03520(neuC)
MANAMAMMFC1_02386(legG)
SYGsync_0169
SYWSYNW0449(neuC)
PRCEW14_1467
MPROBJP34_35235
FGIOP10G_3270
RLCK227x_18870(legG)
GMRGmarT_17250(legG)
GIMF1728_06155(neuC)
GPNPan110_17080(legG)
PCORKS4_35110
MCADPan265_27900
UAMUABAM_06152
SCDSpica_0511
LILLA_1610
LIELIF_A1297
LICLIC_12172
LSTLSS_16466
LAJA0128_07380
LMAYDPV73_15965(neuC)
LKMEFP84_17925(neuC)
FVAFV113G1_25410
FULC4N20_01275(neuC)
BVUBVU_4043
BDHGV66_21490
COPRCop2CBH44_22060
FLSGLV81_12315(neuC)
PSTYBFS30_06855
PEJFYC62_11655(neuC)
SCNSolca_4308
MMABHQ865_06380(neuC)
AGDFRZ59_07160(neuC)
ALMAO498_13845
DSNHWI92_21150(neuC)
PACTCA264_12445
ASWUHUW51_14160(neuC)
FUVJR347_14625(neuC)
FPALHYN49_06985(neuC)
FNKE1750_14010(neuC)
FENJ0383_14255(neuC)
COLAM608_07320
MARTBTR34_08475
MARBCJ263_08135(neuC)
MUTGVT53_17460(neuC)
NDODDD_3553
NOBCW736_09220(neuC)
NOJEJ995_10790(neuC)
POMMED152_05680
PCEAJ3359_01880(neuC)
TJETJEJU_1145
SEONBWZ22_01495
KOSKORDIASMS9_03608
CJGNCTC13459_02716(neuC)
CANTNCTC13489_01540(neuC)
PPHPpha_0528
PMXPERMA_1624(neuC)
TTKTST_1474(wecB)
TNPTnap_0418
DDFDEFDS_0375
TYETHEYE_A0480
NDENIDE2998(wecB)
NLIG3M70_01900(neuC)
PRFPeribacterA2_0945
MIBUY43_C0001G0708
MMQMmarC5_0504
MMAKMMKA1_03770
MAEMaeo_0423
MEWMSWAN_1356
MSJMSSAC_2016
MSWMSSIT_2301
MBUMbur_1587
MFOMetfor_1306
HPELHZS54_05945(neuC)
HALPDOS48_05295(neuC)
HAEhalTADL_2401
NMGNmag_0149
NINNADRNF5_2155(neuC)
NDVNDEV_0147(neuC)
AGWQT03_C0001G0657
 » show all
Reference
1  [PMID:18275154]
  Authors
Glaze PA, Watson DC, Young NM, Tanner ME
  Title
Biosynthesis of CMP-N,N'-diacetyllegionaminic acid from UDP-N,N'-diacetylbacillosamine in Legionella pneumophila.
  Journal
Biochemistry 47:3272-82 (2008)
DOI:10.1021/bi702364s
  Sequence
[lpn:lpg0753]
Reference
2  [PMID:19282391]
  Authors
Schoenhofen IC, Vinogradov E, Whitfield DM, Brisson JR, Logan SM
  Title
The CMP-legionaminic acid pathway in Campylobacter: biosynthesis involving novel GDP-linked precursors.
  Journal
Glycobiology 19:715-25 (2009)
DOI:10.1093/glycob/cwp039
  Sequence
[cje:Cj1328]
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.184
IUBMB Enzyme Nomenclature: 3.2.1.184
ExPASy - ENZYME nomenclature database: 3.2.1.184
BRENDA, the Enzyme Database: 3.2.1.184
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