Entry
Name
alpha-N-acetylgalactosaminidase;
alpha-acetylgalactosaminidase;
N-acetyl-alpha-D-galactosaminidase;
N-acetyl-alpha-galactosaminidase;
alpha-NAGAL;
alpha-NAGA;
alpha-GalNAcase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
BRITE hierarchy
Sysname
alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase
Reaction(IUBMB)
Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids
Reaction(KEGG)
Comment
The human lysosomal enzyme is involved in the degradation of blood type A epitope.
History
EC 3.2.1.49 created 1972, modified 2011
Pathway
ec00603 Glycosphingolipid biosynthesis - globo and isoglobo series
Orthology
K01204 alpha-N-acetylgalactosaminidase
Genes
ANAN : 105733965(NAGA) 135268078 135271262
SETR : 126006265 126006909 126006910
PSS : 102457826 102463470(NAGA)
CMY : 102938681 102948025(NAGA)
CCAY : 125629944(NAGA) 125644183
DCC : 119843756(NAGA) 119862015
CPIC : 101940500 101949244(NAGA)
TST : 117879763(NAGA) 117884012
CABI : 116824402 116828655(NAGA)
MRV : 120372978 120388241(NAGA)
ACS : 100558544(naga) 100561397
PVT : 110076094(NAGA) 110087036
SUND : 121914721 121930837(NAGA)
PBI : 103050555(NAGA) 103062412
PMUR : 107284005 107285348(NAGA)
CTIG : 120304707(NAGA) 120319293
TSR : 106537803(NAGA) 106551524
PGUT : 117655846(NAGA) 117679480
APRI : 131185380 131202690(NAGA)
PTEX : 113434142(NAGA) 113438874
NSS : 113422414 113432676(NAGA)
VKO : 123024956 123036014(NAGA)
PMUA : 114584858 114605424(NAGA)
PRAF : 128401326 128422534(NAGA)
ZVI : 118090684(NAGA) 118092720
HCG : 128326235(NAGA) 128336771
GJA : 107109285 107124086(NAGA)
STOW : 125431786 125434385(NAGA)
EMC : 129335837(NAGA) 129340610
XLA : 443592(naga.S) 443753(naga.L)
CCAR : 109044975(naga) 109044979
CAUA : 113048520 113048521 113064738
CGIB : 127956248 127979701 128028905
AMEX : 103026015(naga) 103035758
CMAO : 118797201 118812294(naga)
CHAR : 105897611 105899535(naga)
TBEN : 117470771 117492290
CGOB : 115004066 115021387
PGEO : 117440179(naga) 117460966
GACU : 117538563 117555312
EMAC : 134861971 134876459
PLEP : 121946152 121955894
SLUC : 116064585 116066291
ECRA : 117946601 117961153
PFLV : 114557187 114572938
PPUG : 119194579 119197929
CLUM : 117727298(naga) 117728260
PSWI : 130202419 130206474
MSAM : 119887973 119898153 119909038
SCHU : 122863353 122881650
ALAT : 119005321 119012882
CSEM : 103380792 103388750
SSEN : 122775154 122783991(naga)
SLAL : 111664120 111672770
XGL : 120784719 120789171 120789172
BPEC : 110159082 110170156
MALB : 109973040 109973819
SASA : 100195244(nagab) 106605016(NAGAB)
STRU : 115174693 115175520
OKE : 118364173 118367570 118398576
SALP : 111954345 111965311
CCLU : 121542471 121552400 121585419
AANG : 118220561 118230805
PSPA : 121300536 121306145(naga) 121330809
PSEX : 120537041(naga) 120542618
RTP : 109912737 109918425(naga)
CPLA : 122542330(naga) 122560453
LERI : 129707010 129713764(naga)
SCLV : 120335584 120335840 120335841 120336669 120336670 120336671
LPIC : 129260745 129260747
APLC : 110979801 110983724 110983725 110983726
ARUN : 117293333 117293334 117293335 117305520
SKO : 100372870 100373018 100374673
DME : Dmel_CG5731(CG5731) Dmel_CG7997(CG7997)
DSI : Dsimw501_GD22296(Dsim_GD22296) Dsimw501_GD25544(Dsim_GD25544)
DYA : Dyak_GE14068 Dyak_GE26351
ECOE : 129948874 129950991
AMER : 121597641 121601729
AALB : 109409620 109413741
MGEN : 117220488 117228319
CFEL : 113377030 113387868 113387869 113388479 113388482
CCRN : 123291385 123297787 123299189
API : 100161159 100161679 100163871 100168844
DNX : 107163389 107166489 107170563 107171670
RMD : 113550049 113550417 113555041
ACOO : 126838058 126841779 126846159
DVT : 126896684 126902618 126908660 126909271
PHU : Phum_PHUM061380 Phum_PHUM476700 Phum_PHUM476710
CSEC : 111868046 111869442
SGRE : 126281182 126281183
BROR : 134534230 134534231
DPX : DAPPUDRAFT_309394 DAPPUDRAFT_309434
PCHN : 125044678 125044716
PMOO : 119582586 119582834
HAME : 121859550 121870400
PCLA : 123745643 123757610
PTRU : 123500089 123513846
MNZ : 135208396 135212602 135219552 135225671
HAZT : 108666989 108666993
PPOI : 119090892 119090896 119092962
DSV : 119448283 119449552 119449553 119449557 119449859
RSAN : 119382560 119382561 119382562 119382563 119382759
RMP : 119170107 119179705 119179714 119179725 119179740
CSCU : 111637616 111637617 111639968
PTEP : 107442827 107454496 107457045
ABRU : 129958128 129960516 129961831
UDV : 129218094 129224581 129231582
SDM : 118184115 118192968 118202592
LPOL : 106460381 106472165
PMEO : 129584925 129597038
CEL : CELE_R07B7.11(gana-1)
CBR : CBG_23373(Cbr-gana-1)
BMY : BM_BM5269(Bma-gana-1)
HRO : HELRODRAFT_111560 HELRODRAFT_182706
LGI : LOTGIDRAFT_158234 LOTGIDRAFT_178842 LOTGIDRAFT_209340 LOTGIDRAFT_235899
PVUL : 126828049 126829285 126830080 126830191 126830438 126830492
PCAN : 112559739 112560249 112560712 112560713 112560714 112560715
BGT : 106057326 106057369 106057370
GAE : 121374342 121374920 121376150 121376283 121376303
HRF : 124119945 124129757 124139615 124139616 124139617 124143661 124148129 124148132 124148942 124148995 124148997 124148998 125371717
HRJ : 124256424 124256433 124256435 124256437 124256447 124256448 124256450 124280219 124280221 124280222 124280223 124280224 124283107 124283108 124283138 124283487
CRG : 105326821 105331657 105339434
CANU : 128157076 128184593 128192440
CVN : 111104087 111104138 111125097 111125814
MYI : 110454106 110454114 110459235 110465170
PMAX : 117328990 117328994 117329669
MCAF : 127714304 127716492 127726257 127732872
MMER : 123556288 123556509 123556588 123557012 123557021 123557150 123557151 123557964
RPHI : 132717197 132717447 132721887 132721890 132722113 132729233 132731067 132731918 132738372 132753260
DPOL : 127842635 127878981
MAEA : 128225607 128226390 128227368 128227597 128228203 128228670
LJP : 135471010 135471544 135472197 135473091 135473408
SMM : Smp_170830 Smp_179260
NVE : 116608331 5498815 5501245 5508946 5513905
ATEN : 116299918 116299920 116299921
ADF : 107330554 107331315 107334325 107334332
AMIL : 114958680 114958713 114968339 114968344
PDAM : 113672638 113672725 113681613 113681615
SPIS : 111321754 111340747 111340767
EHX : EMIHUDRAFT_205415 EMIHUDRAFT_460708
» show all
Taxonomy
Reference
Authors
Asfaw B, Schindler D, Ledvinova J, Cerny B, Smid F, Conzelmann E
Title
Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.
Journal
J Lipid Res 39:1768-80 (1998)
Sequence
Reference
Authors
Zhu A, Monahan C, Wang ZK, Goldstein J
Title
Expression, purification, and characterization of recombinant alpha-N-acetylgalactosaminidase produced in the yeast Pichia pastoris.
Journal
Reference
Authors
Clark NE, Garman SC
Title
The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases.
Journal
Sequence
Reference
Authors
Hoskins LC, Boulding ET, Larson G
Title
Purification and characterization of blood group A-degrading isoforms of alpha-N-acetylgalactosaminidase from Ruminococcus torques strain IX-70.
Journal
Reference
Authors
Harun-Or-Rashid M, Matsuzawa T, Satoh Y, Shiraishi T, Ando M, Sadik G, Uda Y
Title
Purification and characterization of alpha-N-acetylgalactosaminidases I and II from the starfish Asterina amurensis.
Journal
Reference
Authors
Weignerova L, Filipi T, Manglova D, Kren V
Title
Induction, purification and characterization of alpha-N-acetylgalactosaminidase from Aspergillus Niger.
Journal
Reference
Authors
Ashida H, Tamaki H, Fujimoto T, Yamamoto K, Kumagai H
Title
Molecular cloning of cDNA encoding alpha-N-acetylgalactosaminidase from Acremonium sp. and its expression in yeast.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.49
ExPASy - ENZYME nomenclature database: 3.2.1.49
LinkDB
All DBs