KEGG   ENZYME: 3.3.2.2
Entry
EC 3.3.2.2                  Enzyme                                 
Name
lysoplasmalogenase;
alkenylglycerophosphocholine hydrolase;
alkenylglycerophosphoethanolamine hydrolase;
1-(1-alkenyl)-sn-glycero-3-phosphocholine aldehydohydrolase
Class
Hydrolases;
Acting on ether bonds;
Ether hydrolases
Sysname
lysoplasmalogen aldehydohydrolase
Reaction(IUBMB)
(1) 1-(1-alkenyl)-sn-glycero-3-phosphocholine + H2O = an aldehyde + sn-glycero-3-phosphocholine [RN:R02745];
(2) 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine + H2O = an aldehyde + sn-glycero-3-phosphoethanolamine [RN:R03415]
Reaction(KEGG)
R02745 R03415
Substrate
1-(1-alkenyl)-sn-glycero-3-phosphocholine [CPD:C04517];
H2O [CPD:C00001];
1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine [CPD:C04635]
Product
aldehyde [CPD:C00071];
sn-glycero-3-phosphocholine [CPD:C00670];
sn-glycero-3-phosphoethanolamine [CPD:C01233]
Comment
Lysoplasmalogenase is specific for the sn-2-deacylated (lyso) form of plasmalogen and catalyses hydrolytic cleavage of the vinyl ether bond, releasing a fatty aldehyde and sn-glycero-3-phosphocholine or sn-glycero-3-phosphoethanolamine.
History
EC 3.3.2.2 created 1972, modified 1976, (EC 3.3.2.5 created 1984, incorporated 2016), modified 2016
Pathway
ec00565  Ether lipid metabolism
ec01100  Metabolic pathways
Orthology
K18575  alkenylglycerophosphocholine hydrolase
Genes
HSA255043(TMEM86B)
PTR456297(TMEM86B)
PPS100985350(TMEM86B)
GGO101134478(TMEM86B)
PON100448045(TMEM86B)
NLE100597527(TMEM86B)
MCC699222(TMEM86B)
MCF102126102(TMEM86B)
CSAB103235296(TMEM86B)
CATY105582748(TMEM86B)
PANU101016665(TMEM86B)
TGE112613172(TMEM86B)
RRO104674761(TMEM86B)
RBB108542528(TMEM86B)
TFN117091731(TMEM86B)
PTEH111521208(TMEM86B)
CJC100388681(TMEM86B)
SBQ101047356(TMEM86B)
CSYR103267499(TMEM86B)
MMUR105877200(TMEM86B)
LCAT123624694(TMEM86B)
OGA100940373(TMEM86B)
MMU68255(Tmem86b)
MCAL110297428(Tmem86b)
MPAH110336976(Tmem86b)
RNO690610(Tmem86b)
MCOC116101553(Tmem86b)
MUN110561057(Tmem86b)
CGE100771800(Tmem86b)
MAUA101829923(Tmem86b)
PLEU114687716(Tmem86b)
MORG121449985(Tmem86b)
NGI103744859(Tmem86b)
HGL101720540(Tmem86b)
CPOC100713815(Tmem86b)
CCAN109696265(Tmem86b)
DORD105999526(Tmem86b)
DSP122110566(Tmem86b)
NCAR124966927
OCU100354255(TMEM86B)
OPI101532485(TMEM86B)
TUP102498612(TMEM86B)
CFA611345(TMEM86B)
VVP112909324(TMEM86B)
VLG121484888(TMEM86B)
AML100477670(TMEM86B)
UMR103680265(TMEM86B)
UAH113247424(TMEM86B)
UAR123786947(TMEM86B)
ELK111139581
LLV125089168
MPUF101675822(TMEM86B)
ORO101385614(TMEM86B)
EJU114202041(TMEM86B)
ZCA113935875(TMEM86B)
MLX117998002(TMEM86B)
FCA101092067(TMEM86B)
PYU121023434(TMEM86B)
PBG122493738(TMEM86B)
PTG102961296(TMEM86B)
PPAD109259907(TMEM86B)
AJU106980918(TMEM86B)
HHV120239689(TMEM86B)
BTA518466(TMEM86B)
BOM102265175(TMEM86B)
BIU109571855(TMEM86B)
BBUB102415924(TMEM86B)
CHX102186626(TMEM86B)
OAS101121701(TMEM86B)
ODA120871905(TMEM86B)
CCAD122420328(TMEM86B)
SSC100514582(TMEM86B)
CFR102512804(TMEM86B)
CBAI105074357(TMEM86B)
CDK105098739(TMEM86B)
VPC102545779(TMEM86B)
BACU103006787(TMEM86B)
LVE103082812(TMEM86B)
OOR101275562(TMEM86B)
DLE111181022(TMEM86B)
PCAD102985211(TMEM86B)
PSIU116743851(TMEM86B)
ECB100055488(TMEM86B)
EPZ103562865(TMEM86B)
EAI106840930(TMEM86B)
MYB102239470 102239989
MYD102757075(TMEM86B)
MMYO118655176 118655183(TMEM86B)
MNA107541331(TMEM86B)
PKL118715920 118715921
HAI109373772(TMEM86B)
DRO112313458(TMEM86B)
SHON118981342(TMEM86B)
AJM119059981(TMEM86B)
PDIC114510568(TMEM86B)
PHAS123813339(TMEM86B)
MMF118639534(TMEM86B)
RFQ117035309(TMEM86B)
PALE102878082(TMEM86B)
PGIG120598353(TMEM86B)
PVP105304915(TMEM86B)
RAY107515388(TMEM86B)
MJV108388698(TMEM86B)
TOD119250477(TMEM86B)
SARA101537235(TMEM86B)
LAV100671261(TMEM86B)
TMU101361536
DNM101418852(TMEM86B)
MDO103100945(TMEM86B)
GAS123255783(TMEM86B)
PCW110192255 110220258(TMEM86B)
ASN102387730(TMEM86B)
AMJ102558009(TMEM86B)
CPIC101933306 103307009
ACS103280322
PVT110078564(TMEM86B)
DRE751651(tmem86b)
SRX107731175 107755106
SANH107653546 107690344
SGH107560751 107567558
CCAR109048083
CAUA113043434 113047635
PPRM120489067(tmem86b)
MAMB125279474(tmem86b)
IPU108256452(tmem86b)
PHYP113528449
SMEO124397009(tmem86b)
TFD113641176(tmem86b)
AMEX103023220
EEE113589869
TRU105416426
TNGGSTEN00021889G001
LCO109142467
NCC104942715
CGOB115011617
ELY117268781(tmem86b)
PLEP121956671(tmem86b)
SLUC116065319(tmem86b)
ECRA117957504(tmem86b)
PFLV114568966
GAT120827240(tmem86b)
PPUG119220139(tmem86b)
MSAM119886628(tmem86b)
CUD121504018(tmem86b)
ALAT119013377(tmem86b)
MZE101486306
ONL100694713
OAU116314611(tmem86b)
OLA101155934
OML112141805(tmem86b)
XMA102233773
XCO114160008
XHE116735652
PRET103469090
PFOR103145416(tmem86b)
PLAI106951624(tmem86b)
PMEI106931192(tmem86b)
GAF122822357(tmem86b)
CVG107095140(tmem86b)
CTUL119781684(tmem86b)
GMU124863035 124864057(tmem86b)
NFU107376661(tmem86b)
KMR108242939(tmem86b)
ALIM106528140(tmem86b)
NWH119422206(tmem86b)
AOCE111565373
CSEM103392979
SSEN122785101(tmem86b)
HHIP117766761(tmem86b)
HSP118123978(tmem86b)
LCF108881012
SDU111230304
SLAL111649096
XGL120807594(tmem86b)
HCQ109514858
MALB109958883
BSPL114860841(tmem86b)
SASA106606413
OTW112237781(tmem86b)
OMY110487446 118937787
OGO124020630(tmem86b)
ONE115127895
SNH120043783(tmem86b)
ELS109614544
SFM108941811
PKI111836845
AANG118216524(tmem86b)
PSPA121306009(tmem86b)
MSEX115442432
DPLKGM_204626B
PPOT106107730
TNL113500329
SLIU111354585
OFU114358899
PMYPmen_1483
PMKMDS_1539
PPSEBN5_2891
PALCA0T30_08600
PCQPcP3B5_48920
PPGPputGB1_3690
PPTPPS_3515
PPUHB479_17505
PPUNPP4_16380
PPUDDW66_3961
PMONX969_16805
PMOTX970_16455
PFLPFL_4925
PPRCPFLCHA0_c49080
PFEPSF113_1051
PFNHZ99_11670
PFOPfl01_4581
PFSPFLU_1068
PFCPflA506_1051
PFBVO64_4195
PMANOU5_4684
PTVAA957_08645
PVRPverR02_05605
PAZOAYR47_12640
PRXHRH33_06185
PFWPF1751_v1c10260
PFFPFLUOLIPICF703005
PFXA7318_04670
PBAPSEBR_a983
PBCCD58_05615
PPUUPputUW4_00986
PSVPVLB_15595
PSKU771_06495
PKCPKB_1429
PCHEY04_25080
PCPJM49_06605
PPSYAOC04_01555
PSOSPOS17_4904
PANRA7J50_1075
PSILPMA3_24060
PYMAK972_4922
PALLUYA_07770
PUMHGP31_05480
POJPtoMrB4_16110
PPSHG5J76_07630
PSEJHNQ25_17010
PVKEPZ47_05365
PBZGN234_13020
PKHJLK41_07675
PTYJWV26_18070
PMAOPMYSY11_1452
PTRTHU722_0006555
PSAMHU731_021450
PSHHHU773_022575
PASGKSS96_06030
PWZJ7655_14285
PTAENCTC10697_00944
OSGBST96_19045
SHDSUTH_02011
BDAFSZ17_22675
VIRX953_18400
VHLBME96_17885
VPNA21D_01725
BSJUP17_24770
BMURABE28_023510
PBUTDTO10_11405
PPSRI6J18_14935
BVQFHE72_05150
BVJI5776_05090
BBEVBBEV_0249
GYMGYMC10_4649
PVOPVOR_25011
PLWD5F53_06940
PRZGZH47_23895
PLYCGXP70_22650
PLAYDNR44_011900
ACITHPK19_17355
AOKA3BBH6_28030
 » show all
Reference
1  [PMID:13783189]
  Authors
WARNER HR, LANDS WE.
  Title
The metabolism of plasmalogen: enzymatic hydrolysis of the vinyl ether.
  Journal
J Biol Chem 236:2404-9 (1961)
Reference
2  [PMID:17805898]
  Authors
Ellingson JS, Lands WE
  Title
Phospholipid reactivation of plasmalogen metabolism.
  Journal
Lipids 3:111-20 (1968)
DOI:10.1007/BF02531727
Reference
3  [PMID:7239443]
  Authors
Gunawan J, Debuch H.
  Title
Liberation of free aldehyde from 1-(1-alkenyl)-sn-glycero-3-phosphoethanolamine (lysoplasmalogen) by rat liver microsomes.
  Journal
Hoppe Seylers Z Physiol Chem 362:445-52 (1981)
DOI:10.1515/bchm2.1981.362.1.445
Reference
4  [PMID:3753461]
  Authors
Arthur G, Page L, Mock T, Choy PC.
  Title
The catabolism of plasmenylcholine in the guinea pig heart.
  Journal
Biochem J 236:475-80 (1986)
DOI:10.1042/bj2360475
Reference
5  [PMID:21515882]
  Authors
Wu LC, Pfeiffer DR, Calhoon EA, Madiai F, Marcucci G, Liu S, Jurkowitz MS
  Title
Purification, identification, and cloning of lysoplasmalogenase, the enzyme that catalyzes hydrolysis of the vinyl ether bond of lysoplasmalogen.
  Journal
J Biol Chem 286:24916-30 (2011)
DOI:10.1074/jbc.M111.247163
  Sequence
[hsa:255043]
Other DBs
ExplorEnz - The Enzyme Database: 3.3.2.2
IUBMB Enzyme Nomenclature: 3.3.2.2
ExPASy - ENZYME nomenclature database: 3.3.2.2
BRENDA, the Enzyme Database: 3.3.2.2
CAS: 37288-65-6
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