KEGG   ENZYME: 3.4.21.34
Entry
EC 3.4.21.34                Enzyme                                 
Name
plasma kallikrein;
serum kallikrein;
kininogenin;
kallikrein I;
kallikrein II;
kininogenase;
kallikrein;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
panceatic kallikrein;
onokrein P;
dilminal D;
depot-Padutin;
urokallikrein;
urinary kallikrein
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of some Arg! and Lys! bonds, including Lys!Arg and Arg!Ser in (human) kininogen to release bradykinin
Comment
Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.
History
EC 3.4.21.34 created 1965 as EC 3.4.4.21, transferred 1972 to EC 3.4.21.8, part transferred 1981 to EC 3.4.21.34
Orthology
K01324  plasma kallikrein
Genes
HSA3818(KLKB1)
PTR471375(KLKB1)
PPS100985593(KLKB1)
GGO101142617(KLKB1)
PON100172926(KLKB1)
NLE100594044 115835879
MCC696639(KLKB1)
MCF102142369(KLKB1)
CSAB103236637(KLKB1)
CATY105594265(KLKB1)
PANU101004320(KLKB1)
TGE112624825(KLKB1)
RRO104673817(KLKB1)
RBB108522428(KLKB1)
TFN117086226(KLKB1)
PTEH111548503(KLKB1)
CJC100409572(KLKB1)
SBQ101048983(KLKB1)
CSYR103271965(KLKB1)
MMUR105882474(KLKB1)
OGA100950732(KLKB1)
MMU16621(Klkb1)
MCAL110299702(Klkb1)
MPAH110336817(Klkb1)
RNO25048(Klkb1)
MCOC116071383(Klkb1)
MUN110558008(Klkb1)
CGE100767873(Klkb1)
PLEU114701164(Klkb1)
NGI103750509(Klkb1)
HGL101719264(Klkb1)
CPOC100715794(Klkb1)
CCAN109684302(Klkb1)
DORD105991332(Klkb1)
DSP122127383(Klkb1)
NCAR124983746
OCU100356267(KLKB1)
OPI101523823(KLKB1)
TUP102485674(KLKB1)
CFA475624(KLKB1)
VVP112934777(KLKB1)
AML100468355(KLKB1)
UMR103680968(KLKB1)
UAH113262285(KLKB1)
UAR123784492(KLKB1)
ELK111144530
LLV125093973
MPUF101689429(KLKB1)
ORO101379313(KLKB1)
EJU114206167(KLKB1)
ZCA113924887(KLKB1)
MLX118010046(KLKB1)
FCA101094092(KLKB1)
PYU121039709(KLKB1)
PBG122470993(KLKB1)
PTG102971874(KLKB1)
PPAD109250991(KLKB1)
AJU106982221(KLKB1)
HHV120237791(KLKB1)
BTA533547(KLKB1)
BOM102270694(KLKB1)
BIU109553560(KLKB1)
BBUB102396882(KLKB1)
CHX102184030(KLKB1)
OAS101116376(KLKB1)
ODA120865743(KLKB1)
CCAD122432375(KLKB1)
SSC397144(KLKB1)
CFR102512343(KLKB1)
CBAI105067666(KLKB1)
CDK105102384(KLKB1)
VPC102526079(KLKB1)
PCAD112063073
ECB100056650(KLKB1)
EAI106840366(KLKB1)
MYB102247445(KLKB1)
MYD102764838(KLKB1)
MMYO118652088(KLKB1)
MLF102426918(KLKB1)
MNA107534033(KLKB1)
PKL118730055(KLKB1)
HAI109395838(KLKB1)
DRO112306752(KLKB1)
SHON118993096(KLKB1)
AJM119036873(KLKB1)
PDIC114508386(KLKB1)
PHAS123807510(KLKB1)
RFQ117021760(KLKB1)
PALE102883484(KLKB1)
PGIG120618463(KLKB1)
PVP105294687(KLKB1)
RAY107510433(KLKB1)
MJV108396405(KLKB1)
TOD119230348 119257004(KLKB1)
SARA101551391(KLKB1)
LAV100660779
TMU101358166
DNM101423717(KLKB1)
MDO100013981(KLKB1)
GAS123253136(KLKB1)
SHR100917450(KLKB1)
PCW110204309 110204628
OAA100086786
GGA422723(F11)
PCOC116238902
MGP100549617
CJO107313680
NMEL110397297
APLA101805242
ACYG106035178
AFUL116488670
TGU100228027
LSR110474988
SCAN103826205
PMOA120498052
OTC121348392
PRUF121360367
GFR102045543(F11)
FAB101814154(KLKB1)
PHI102108065(F11)
PMAJ107203558
CCAE111927976
CCW104690592(KLKB1)
ETL114067778
ZAB102073697(KLKB1)
FPG101918416(F11)
FCH102054661
CLV102094577
EGZ104129485
NNI104021299
ACUN113479233
TALA104364370
PADL103922514
ACHC115341152
AAM106484024
AROW112965854
NPD112949925
DNE112986089
ASN102385242(KLKB1)
AMJ102566272(KLKB1)
CPOO109322021
GGN109303759(KLKB1)
PSS102455335
CPIC101952530(KLKB1)
TST117878095(KLKB1)
CABI116835912
MRV120406388
ACS100557428(klkb1)
PVT110077890(KLKB1)
SUND121931138(KLKB1)
PBI103051995(KLKB1)
PMUR107302682
TSR106542021(KLKB1)
PGUT117680187(KLKB1)
VKO123036510(KLKB1)
PMUA114604642(KLKB1)
ZVI118084140(KLKB1)
GJA107121980(KLKB1)
XLA446603(klkb1.L)
XTR100486524(klkb1)
NPR108784940
RTEM120921901
BBUF120990165(KLKB1)
BGAR122934952(KLKB1)
IPU108257413
PHYP113536237
SMEO124376377
TFD113661525
TNGGSTEN00017543G001
PFLV114568223
MZE101476310
ONL100691143 100711845 100712382
OLA101167304
OML112136310
XMA102235514 102236020 111610402
XCO114155410 114155689 114156653
XHE116730704 116731571
PRET103472119 103472120 103472122
GAF122843703
CVG107092604
CTUL119784643
GMU124878882 124879615
NFU107374492
AOCE111572227
HHIP117770686
LCF108893005 108893006 108900438
SDU111223201
SLAL111673270
XGL120786050
HCQ109519192
ELS105027740
SFM108938912
PKI111854240
LOC102685657 107077276
LCM102361209(KLKB1)
RTP109919186
BBEL109472036 109485493
CIN100176588 100182205
SCLV120327917 120334500 120338190 120342435 120342461 120342776 120344424 120344858
APLC110973868 110984589
SKO100375116
MDE101900180
LCQ111686343
AAG5563617 5570931 5575054 5575060
AALB109416028 109426188
CQUCpipJ_CPIJ016225
CPII120419921
CNS116347624
BIM100740887
BTER100644527
SOC105193897 105196026 105196044 105196739 105200420
MPHA105831007 105832984 114253741
AEC105151207 105151375
ACEP105617847 105619958
PBAR105422311 105424748
VEM105568413
HST105186338 109503706
CFO105249589 105251050 105251056 105255493 105257558
LHU105671298
PGC109852197 109853791
NVI100114471(SP16) 103318165
CSOL105362138 105366751
ATD109602881
NVL108559693 108563022 108565242
BMOR100862834 101740247
BMAN114246163 114251826
MSEX115446368 115455935
BANY112047014
HAW110374025
TNL113499223 113500559 113505544 113505545
PXY105385426
API100160497
AGS114121009
RMD113548576
BTAB109030011 109044184
CLEC106664815 106664816
HHAL106681226 106690899
ZNE110835922
FCD110842752 110853210 110853426 110858603
DPXDAPPUDRAFT_241460
PVM113802726 113803371 113807483 113811742 113811866 113819716 113821989 113827133
PJA122246632 122248640
PCHN125025792 125038135
HAME121870979
PCLA123760876 123765977
PTRU123513882
EAF111700653 111707120 111715548
ISCIscW_ISCW011206
RSAN119393437
VDE111249763
VJA111266457
TUT107359274 107364976 107370370 107371275
DPTE113796590 113797445 113798611
DFR124490111 124493637 124498460
CSCU111614124 111620528 111638398
PTEP107440325 107442445 107456184
SDM118195904
HROHELRODRAFT_180736
LGILOTGIDRAFT_153888
PCAN112554714 112571496
HRF124116279
HRJ124289327 124291123
CRG105348511
MYI110443096
PMAX117329014
OBI106870435 106877341
OSN115217699
LAK106151350
OVIT265_14457
NVE5502645
AMIL114955798
PDAM113669975 113670584 113685551
SPIS111344747
HMG105847477
TGOTGME49_286150
GTTGUITHDRAFT_151304
NGRNAEGRDRAFT_65585
 » show all
Reference
1  [PMID:6918767]
  Authors
Heimark RL, Davie EW.
  Title
Bovine and human plasma prekallikrein.
  Journal
Methods Enzymol 80 Pt C:157-72 (1981)
DOI:10.1016/s0076-6879(81)80016-x
Reference
2  [PMID:6976185]
  Authors
McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC.
  Title
Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates.
  Journal
Biochemistry 20:7196-206 (1981)
DOI:10.1021/bi00528a022
Reference
3  [PMID:3237096]
  Authors
Silverberg M, Kaplan AP.
  Title
Prekallikrein.
  Journal
Methods Enzymol 163:85-95 (1988)
DOI:10.1016/0076-6879(88)63010-2
Reference
4  [PMID:2598771]
  Authors
Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chretien M.
  Title
The cDNA structure of rat plasma kallikrein.
  Journal
DNA 8:563-74 (1989)
DOI:10.1089/dna.1989.8.563
  Sequence
[rno:25048]
Reference
5  [PMID:2534361]
  Authors
Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S.
  Title
Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein.
  Journal
Chem Pharm Bull (Tokyo) 37:3108-11 (1989)
DOI:10.1248/cpb.37.3108
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.34
IUBMB Enzyme Nomenclature: 3.4.21.34
ExPASy - ENZYME nomenclature database: 3.4.21.34
BRENDA, the Enzyme Database: 3.4.21.34
CAS: 410538-33-9
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