KEGG ENZYME: 3.4.21.43

ENZYME: 3.4.21.43

Entry

EC 3.4.21.43                Enzyme

Name

classical-complement-pathway C3/C5 convertase;
C3 convertase;
C_overbar_42_;
C4b,2a;
C5 convertase;
C_overbar_423_;
C4b,2a,3b;
C42;
C423;
complement C.hivin.4.hivin2;
complement C3 convertase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Selective cleavage of Arg!Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg! bond in complement component C5 alpha-chain to form C5a and C5b

Comment

A complex of complement fragments C4b, C2a and C2b. C2a contains the active site, C2b the site for C4b binding. C2a and C2b are formed by cleavage of proenzyme C2 by complement subcomponent C_overbar_1s_. Cleavage of C5 requires complement fragment C3b which binds C5 and renders it susceptible to cleavage by the C4b,2a complex. Includes former EC 3.4.21.44. Complement component C2a is in peptidase family S1 (trypsin family)

History

EC 3.4.21.43 created 1981 (EC 3.4.21.44 created 1981, incorporated 1984)

Orthology

K01332

complement component 2

Genes

HSA:

717(C2)

PTR:	100608992(C2)

PPS:	103783827(C2)

GGO:	101145799(C2)

PON:	100173033(C2)

NLE:	100606928(C2)

MCC:	106997899(C2)

MCF:	102137096(C2)

MTHB:

126953216

MNI:	105497597(C2)

CSAB:

103221735(C2)

CATY:

105583240(C2)

TGE:	112622243(C2)

RRO:	104678122(C2)

RBB:	108520263(C2)

TFN:	117086977(C2)

CANG:

105513812(C2)

CJC:	103792363(C2)

SBQ:	104650316(C2)

CSYR:

103271297(C2)

MMUR:

105858160(C2)

LCAT:

123631761(C2)

PCOQ:

105817869(C2)

OGA:	100948920(C2)

MMU:

12263(C2)

MCAL:

110312387(C2)

MPAH:

110336126(C2)

RNO:

24231(C2)

MCOC:

116075350(C2)

MUN:	110560138(C2)

CGE:	100759069(C2)

MAUA:

101829138(C2)

PLEU:

114705865(C2)

MORG:

121435235(C2)

MFOT:

126495378

AAMP:

119822469(C2)

NGI:	103724419(C2)

HGL:	101723809(C2)

CPOC:

100716184(C2)

CCAN:

109689592(C2)

DORD:

105999865(C2)

DSP:	122111495(C2)

NCAR:

124989526

OCU:

100355553

OPI:	101519169(C2)

TUP:	102480144(C2)

GVR:	103592349(C2)

CFA:	474853(C2)

CLUD:

112641335(C2)

VVP:	112913623(C2)

VLG:	121500782(C2)

AML:	100474163(C2)

UMR:	103682287(C2)

UAH:	113243740(C2)

UAR:	123790974(C2)

ELK:

111152312

LLV:

125101523

MPUF:

101692540(C2)

NVS:	122911435(C2)

ORO:	101377842(C2)

EJU:	114222260(C2)

ZCA:	113927723(C2)

MLX:	118027318(C2)

NSU:	110586911(C2)

LWW:	102735390(C2)

FCA:	101092434(C2)

PYU:	121022335(C2)

PBG:	122478264(C2)

LRUF:

124528942

PTG:	102969252(C2)

PPAD:

109260505(C2)

AJU:	106983482(C2)

HHV:	120221933(C2)

BTA:	515440(C2)

BOM:	102269155(C2)

BIU:	109576932(C2)

BBUB:

102406076(C2)

BBIS:

104983805(C2)

CHX:	102176085(C2)

OAS:	101115321(C2)

ODA:	120870574(C2)

CCAD:

122429826(C2)

SSC:	448981(C2)

CFR:	102518989(C2)

CDK:	105087440(C2)

VPC:	102528144(C2)

BACU:

103018276(C2)

LVE:	103071578(C2)

OOR:	101281566(C2)

DLE:	111170704(C2)

PCAD:

102992128(C2)

PSIU:

116762860(C2)

ECB:	100059162(C2)

EPZ:	103563291(C2)

EAI:	106831000(C2)

MYB:	102263362(C2)

MYD:	102766284(C2)

MMYO:

118679566(C2)

MLF:	102434614 102435622(C2)

MNA:	107538982(C2)

SHON:

118979560(C2)

AJM:	119053694(C2)

PDIC:

114494189(C2)

PHAS:

123810445(C2)

MMF:	118621434(C2)

RFQ:	117020467(C2)

PALE:

102889530(C2)

PGIG:

120618902(C2)

PVP:	105305295(C2)

RAY:	107498438(C2)

MJV:	108393991(C2)

TOD:	119252228(C2)

LAV:	100668309(C2)

TMU:

101350027

ETF:	101661223(C2)

MDO:	100025443(C2)

GAS:	123243666(C2)

SHR:	105750443(CFB)

PCW:	110199442(C2)

OAA:

100089242

GGA:	419574(C2)

PCOC:

116230112(C2)

MGP:

104914277

CJO:

107323905

NMEL:

110387356

ACHC:

115338421(CFB)

HLE:	104836577(C2)

ASN:	102381270(CFB)

AMJ:	102574290(C2)

CPIC:

101947880

CABI:

116829917

ACS:	100556178(c2)

PVT:	110088698(C2)

SUND:

121922133(C2)

PBI:

103049015

PMUR:

107295035

CTIG:

120309290

ZVI:

118080127

GJA:

107105482

XLA:	734198(c2.L)

XTR:	100491079(c2)

NPR:

108786508

RTEM:

120913253

BBUF:

120977489

BGAR:

122946772

DRE:	563828(si:ch1073-280e3.1)

SRX:

107720441

SANH:

107662575

SGH:

107567682

CCAR:

109055343

CAUA:

113115417

PPRM:

120466881(si:ch1073-280e3.1)

MAMB:

125248875(si:ch1073-280e3.1)

IPU:	100862743(si:ch1073-280e3.1)

PHYP:

113539139

SMEO:

124394571(si:ch1073-280e3.1)

TFD:	113643603(si:ch1073-280e3.1)

AMEX:

103046310

EEE:

113574701

TRU:

101064033

TNG:	GSTEN00026804G001

LCO:

104930441

NCC:

104962863

CGOB:

115017381

ELY:	117259163(si:ch1073-280e3.1)

EFO:	125888711(si:ch1073-280e3.1)

PLEP:

121942912(si:ch1073-280e3.1)

SLUC:

116039027(si:ch1073-280e3.1)

ECRA:

117942570(si:ch1073-280e3.1)

ESP:

116685960

PFLV:

114549828

GAT:	120816446(si:ch1073-280e3.1)

PPUG:

119223014(si:ch1073-280e3.1)

MSAM:

119882756(si:ch1073-280e3.1)

CUD:	121523692(si:ch1073-280e3.1)

ALAT:

119031698(si:ch1073-280e3.1)

MZE:

101480328

ONL:

100697699

OAU:	116323697(si:ch1073-280e3.1)

OLA:

101167637

OML:	112136450(si:ch1073-280e3.1)

XMA:

102229083

XCO:

114161640

XHE:

116737354

PRET:

103474842

PFOR:

103154630

PLAI:

106965101

PMEI:

106914174

GAF:	122832266(si:ch1073-280e3.1)

CVG:

107102499

CTUL:

119775419(si:ch1073-280e3.1)

GMU:	124883852(si:ch1073-280e3.1)

NFU:

107397014

KMR:	108244431(si:ch1073-280e3.1)

ALIM:

106530408

NWH:	119411148(si:ch1073-280e3.1)

AOCE:

111574507

MCEP:

125013111(si:ch1073-280e3.1)

POV:

109642964

SSEN:

122772936(si:ch1073-280e3.1)

HHIP:

117772604(si:ch1073-280e3.1)

HSP:	118106051(si:ch1073-280e3.1)

LCF:	108890635(si:ch1073-280e3.1)

XGL:	120792530(si:ch1073-280e3.1)

BPEC:

110162865

BSPL:

114867603(si:ch1073-280e3.1)

SASA:

106580826

STRU:

115163141

OTW:	112265208(si:ch1073-280e3.1)

OMY:	100135805(si:ch1073-280e3.1)

OGO:	123992917(si:ch1073-280e3.1)

ONE:

115136963

SALP:

111982534

SNH:	120018329(si:ch1073-280e3.1)

CCLU:

121563694(si:ch1073-280e3.1)

ELS:

105011227

SFM:

108928780

PKI:

111854971

AANG:

118209021(si:ch1073-280e3.1)

LOC:	102694189 107079953

PSPA:

121304122

ARUT:

117433872(si:ch1073-280e3.1) 117971245

PSEX:

120539046(si:ch1073-280e3.1)

RTP:

109921429

BFO:

118420754

CIN:	497243(bf-1) 619241(bf-2)

SPU:	754422 756500 756883

APLC:

110983861

SKO:

100368814

PTEP:

107450490

LAK:	106177660 106178727

NVE:	5501707 5502106 5515331

EPA:	110235255 110235277 110235590 110242877 110244509 110253640

ATEN:

116298611 116308431 116308433

ADF:	107349284 107355215

AMIL:

114946777 114954057 114977272

PDAM:

113668202 113675686

SPIS:

111328750 111343603 111345231

» show all

Reference

Authors

Kerr, M.A.

Title

The second component of human complement.

Journal

Method Enzymol 80:54-64 (1981)

Reference

2 [PMID:3052276]

Authors

Muller-Eberhard HJ.

Title

Molecular organization and function of the complement system.

Journal

Annu Rev Biochem 57:321-47 (1988)
DOI:10.1146/annurev.bi.57.070188.001541

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.43

IUBMB Enzyme Nomenclature:

3.4.21.43

ExPASy - ENZYME nomenclature database:

3.4.21.43

BRENDA, the Enzyme Database:

3.4.21.43

CAS:	56626-15-4

LinkDB

DBGET integrated database retrieval system