KEGG ENZYME: 3.4.22.27

ENZYME: 3.4.22.27

Entry

EC 3.4.22.27                Enzyme

Name

cathepsin S

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Similar to cathepsin L, but with much less activity on Z-Phe-Arg!NHMec, and more activity on the Z-Val-Val-Arg! compound

Comment

A lysosomal cysteine endopeptidase that is unusual amongst such enzymes for its stability to neutral pH. In peptidase family C1 (papain family)

History

EC 3.4.22.27 created 1992

Orthology

K01368

cathepsin S

Genes

HSA:	1520(CTSS)

PTR:	457277(CTSS)

PPS:	100975000(CTSS)

GGO:	101141942(CTSS)

PON:	100432810(CTSS)

NLE:	100579205(CTSS)

MCC:	708080(CTSS)

MCF:	102120796(CTSS)

CSAB:

103247206(CTSS)

CATY:

105590202(CTSS)

PANU:

101021545(CTSS)

TGE:	112620366(CTSS)

RRO:	104681069(CTSS)

RBB:	108533262(CTSS)

TFN:	117075084(CTSS)

PTEH:

111543624(CTSS)

CJC:	100409214(CTSS)

SBQ:	101044698(CTSS)

CSYR:

103251385(CTSS)

MMUR:

105873003(CTSS)

OGA:	100950667(CTSS)

MMU:	13040(Ctss)

MCAL:

110290972(Ctss)

MPAH:

110320470(Ctss)

RNO:	50654(Ctss)

MCOC:

116093415(Ctss)

MUN:	110543431(Ctss)

CGE:	100751823(Ctss)

PLEU:

114682396(Ctss)

NGI:	103729103(Ctss)

HGL:	101697008(Ctss)

CPOC:

100722492(Ctss)

CCAN:

109681200(Ctss)

DORD:

105984724(Ctss)

DSP:	122109432(Ctss)

NCAR:

124959416

OCU:	100101598(CTSS)

OPI:	101532461(CTSS)

TUP:	102469586(CTSS)

CFA:	403400(CTSS)

VVP:	112907699(CTSS)

VLG:	121492130(CTSS)

AML:	100483259(CTSS)

UMR:	103667539(CTSS)

UAH:	113246210(CTSS)

UAR:	123787738(CTSS)

ELK:

111162017

LLV:

125096876

MPUF:

101683261(CTSS)

ORO:	101370623(CTSS)

EJU:	114197270(CTSS)

ZCA:	113912803(CTSS)

MLX:	118000310(CTSS)

FCA:	101083283(CTSS)

PYU:	121021050(CTSS)

PBG:	122481131(CTSS)

PTG:	102967913(CTSS)

PPAD:

109257065(CTSS)

AJU:	106979853(CTSS)

HHV:	120241248(CTSS)

BTA:	327711(CTSS)

BOM:	102287237(CTSS)

BIU:	109555340(CTSS)

BBUB:

102408311(CTSS)

CHX:	102183747(CTSS)

OAS:	780472(CTSS)

ODA:	120855927(CTSS)

CCAD:

122434353(CTSS)

SSC:	100153090(CTSS)

CFR:	102510939(CTSS)

CBAI:

105071741(CTSS)

VPC:	102544736(CTSS)

BACU:

103007667(CTSS)

LVE:	103074342(CTSS)

OOR:	101269523(CTSS)

DLE:	111169766(CTSS)

PCAD:

102979785(CTSS)

PSIU:

116738968(CTSS)

ECB:	100054948(CTSS)

EPZ:	103547636(CTSS)

EAI:	106846535(CTSS)

MYB:	102259811(CTSS)

MYD:	102771016(CTSS)

MMYO:

118672753(CTSS)

MLF:	102439661(CTSS)

MNA:	107539106(CTSS)

PKL:	118727473(CTSS)

HAI:	109372254(CTSS)

DRO:	112313687(CTSS)

AJM:	119034681(CTSS)

PDIC:

114489220(CTSS)

PHAS:

123804406(CTSS)

MMF:	118637207 118637209 118637210

RFQ:	117015222(CTSS)

PALE:

102884940(CTSS)

PGIG:

120585211(CTSS)

PVP:	105303820(CTSS)

RAY:	107498990(CTSS)

MJV:	108404026(CTSS)

TOD:	119236327(CTSS)

SARA:

101543601(CTSS)

LAV:	100674232(CTSS)

TMU:

101340786

DNM:	101441455(CTSS)

MDO:	100017406(CTSS)

GAS:	123247280(CTSS)

SHR:	100917184(CTSS)

PCW:	110220556(CTSS)

OAA:	100088270(CTSS)

GGA:	425657(CTSS)

PCOC:

116238445(CTSS)

MGP:	104914438(CTSS)

CJO:	107324540(CTSS)

NMEL:

110387850

APLA:

101794564(CTSS)

ACYG:

106049275(CTSS)

AFUL:

116499813(CTSS)

TGU:	100223082(CTSS)

LSR:

110476808

SCAN:

103824795

PMOA:

120502604(CTSS)

OTC:	121335620(CTSS)

PRUF:

121353497

GFR:

102032358

FAB:	101815635(CTSS)

PHI:	102107924(CTSS)

PMAJ:

107214698

CCAE:

111939529

ETL:	114072354 114072744

FPG:	101911722(CTSS)

FCH:	102055558(CTSS)

CLV:	102094330(CTSS)

EGZ:

104126881

NNI:	104014433 104014434

ACUN:

113490571(CTSS)

TALA:

104366166 122152486 122152489 122152527

PADL:

103919476 103919480

ACHC:

115345557 115345558

AAM:	106495149(CTSS)

AROW:

112972481 112972517

NPD:	112953003(CTSS)

DNE:	112990058 112990083

ASN:	102373459 102384087(CTSS)

AMJ:	102562033(CTSS) 109283982

PSS:

102458936

CMY:	102947704 102947924 119564251

CPIC:

101931018 101934688 101940635 101944372 101944639 101949655

TST:

117869840

CABI:

116817621 116817622 116817623 116817624

MRV:	120390630 120390631 120390632 120390633

ACS:	100560943(ctss)

PVT:	110081451(CTSS)

SUND:

121916254(CTSS)

PBI:	103053841(CTSS)

PMUR:

107292919(CTSS)

TSR:	106546304(CTSS)

PGUT:

117670137(CTSS)

VKO:	123032984(CTSS)

PMUA:

114586295(CTSS) 114588654

ZVI:	118076374(CTSS)

GJA:	107120549(CTSS)

STOW:

125438579

XLA:	100036949(ctsh.L) 108699062 108699063 108699333 108699334 108699410 108700331 108700332 108700335 108700336 380516(ctss.L) 398927 443661(XB5914295.S) 443722 446505(ctss.S)

XTR:	100124852 100494325 100498084 100498238 105945585 105948322 116406662 116406764 448203(ctss) 496647(ctss.2) 496748(ctsh) 594890

NPR:	108789799(CTSS) 108800693

RTEM:

120920090 120920158 120920159 120920357

BBUF:

120982070 120982478

BGAR:

122923217 122923219

DRE:	337572(ctss2.2) 393398(ctss1) 554157(ctss2.1)

SRX:	107714774 107741752 107741753 107741774

SANH:

107663319 107663331 107689850 107689852 107689853 107691368

SGH:	107571626 107587832 107587833 107597985 107597987

CCAR:

109051923 109056426 109058805 109089990 109096260 109099830

CAUA:

113059153 113059154 113062485 113116109 113116110 113116111 113116112 113116113 113119713 113119760

PPRM:

120475234(ctss1) 120484669(ctss2.1) 120484670

MAMB:

125243015(ctss2.1) 125243016 125275994(ctss1)

IPU:	100305010(ctss2.1) 108274831

PHYP:

113525243 113533916

SMEO:

124383789

TFD:	113634015 113642169 113644583 113647392(ctss1) 125145725

AMEX:

103044830 103045424

EEE:	113575272 113590155

TRU:	101066490 101073909

TNG:	GSTEN00011685G001

LCO:	104923937 104931628 104931629

NCC:

104957237

CGOB:

115015608 115021677

ELY:	117263943 117265981(ctss2.1)

PLEP:

121945417

SLUC:

116047397 116049093

ECRA:

117946034(ctss2.1)

PFLV:

114556853 114556913 114567831

GAT:	120810481(ctss2.1)

PPUG:

119197582(ctss2.1) 119219161

MSAM:

119882210 119897015(ctss2.1) 119906692(ctss1)

CUD:	121513325 121523314

MZE:	101485929 105940410

ONL:	100690368 100690911 100695758 100705431

OAU:	116333435 116333436

OLA:	100049247(ctss) 101165175

OML:	112136685(ctss2.1) 112137547

XMA:	102230330 102235885

XCO:	114142240 114156396

XHE:	116717363 116731587

PRET:

103472454 103477641

PFOR:

103156712

PLAI:

106949136

PMEI:

106920372

GAF:	122831313(ctss2.1)

CVG:	107086772 107088360

CTUL:

119781874(ctss2.1) 119784819

GMU:	124865441(ctss2.1)

NFU:	107379223 107394690

KMR:	108243190(ctss2.1)

ALIM:

106518088 106524065

NWH:	119409270(ctss2.1)

AOCE:

111571630

CSEM:

103388697 103394262 103394264

POV:	109633509 109638767 109638800

SSEN:

122774431(ctss2.1) 122786334

HHIP:

117770319 117776444(ctss2.1)

LCF:	108883175 108898158

SDU:	111222413 111222981

SLAL:

111659220 111669221

XGL:	120784605(ctss2.1) 120786191(ctss1) 120786192

HCQ:	109512113 109514600

BPEC:

110162666 110162667 110162671 110168875 110168941

MALB:

109968960

SASA:

100196462(cats) 106605328(CATS)

OTW:	112222947(ctss2.1) 112229276

OMY:	100136261 110487241

OGO:	123997753 124006231

ONE:	115103957 115141062

SALP:

111958812 112081015

SNH:	120022490 120031296 120048417

ELS:	105031242 105031251 114829684

SFM:	108930364 108930365 108930367 108930412 108930417 108941877 108941910 114909387

PKI:	111838382 111838421

AANG:

118220535 118233653 118233655 118233657

LOC:	102686501 102694713 107075469

PSPA:

121307010 121309884

ARUT:

117395491 117395567 117965122 117965129 117965168 117971317

LCM:	102351684(CTSS) 102365039

LCQ:

111684259

CNS:

116343293

TCA:

660428

CSET:

123316307

AGB:	108903191 108903193 108909798 108914557 108915519

LDC:

111506937

BMAN:

114253569

TNL:

113498261

DPX:	DAPPUDRAFT_216612 DAPPUDRAFT_315499 DAPPUDRAFT_315500

DMK:

116926832

VDE:

111251592

DFR:

124497903

HRF:	124126641 124126648 124135997

SMM:	Smp_187140

NTO:

104097067

EGT:

105971619

NCOL:

116244932

PTM:	GSPATT00038477001

SPAR:

SPRG_10279

» show all

Reference

1 [PMID:1182153]

Authors

Turnsek T, Kregar I, Lebez D.

Title

Acid sulphydryl protease from calf lymph nodes.

Journal

Biochim Biophys Acta 403:514-20 (1975)
DOI:10.1016/0005-2744(75)90079-0

Reference

2 [PMID:2604727]

Authors

Bromme D, Steinert A, Friebe S, Fittkau S, Wiederanders B, Kirschke H

Title

The specificity of bovine spleen cathepsin S. A comparison with rat liver cathepsins L and B.

Journal

Biochem J 264:475-81 (1989)
DOI:10.1042/bj2640475

Sequence

[bta:327711]

Reference

3 [PMID:2690828]

Authors

Kirschke H, Wiederanders B, Bromme D, Rinne A.

Title

Cathepsin S from bovine spleen. Purification, distribution, intracellular localization and action on proteins.

Journal

Biochem J 264:467-73 (1989)
DOI:10.1042/bj2640467

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.27

IUBMB Enzyme Nomenclature:

3.4.22.27

ExPASy - ENZYME nomenclature database:

3.4.22.27

BRENDA, the Enzyme Database:

3.4.22.27

CAS:	71965-46-3

LinkDB

DBGET integrated database retrieval system