Entry
Name
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
All bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage
Comment
In both budding yeast and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis. Budding yeast separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19. Type example of peptidase family C50.
History
EC 3.4.22.49 created 2003
Orthology
Genes
MORG : 121444236(Espl1) 121459432
XLA : 431925(espl1.S) 733221(espl1.L)
SANH : 107667390 107673592
CCAR : 109063482 109091441
MASI : 127446132 127449376
TFD : 113662736(espl1) 125141227
ARUT : 117400942 117967028
CEL : CELE_Y47G6A.12(sep-1) CELE_ZK430.5(ZK430.5)
CBR : CBG_14956(Cbr-sep-1)
CSAT : 104718008 104727823 104731195
EUS : EUTSA_v10024187mg EUTSA_v10029518mg
BNA : 106375763 106398538 106415125 106440466 106440619 111214417 125585778 125595404 125595406 125603850
BOE : 106301587 106316163 106337896 106343049
MINC : 123206072 123214667
TPRA : 123910420 123910680
VVO : 131623306 131634316 131645137
AHF : 112714932 112784436 112800459
QSA : O6P43_012254 O6P43_031553
SSPL : 121753928 121758961
PSOM : 113346473 113356227
TAES : 123128537 123138403 123145658
LPER : 127302599 127305987 127317065
LRD : 124647555 124647960 124681922 124690729
MFLO : 136474898 136474977
SITA : 101777770 101782294
PVIR : 120643306 120657316
SMO : SELMODRAFT_405667 SELMODRAFT_442839
VCN : VOLCADRAFT_96349(espA)
CGR : 2888336(GVI51_G03091)
NCS : NCAS_0E01080(NCAS0E01080)
NDI : NDAI_0G01210(NDAI0G01210)
TPF : TPHA_0D04010(TPHA0D04010)
TBL : TBLA_0C02250(TBLA0C02250)
TDL : TDEL_0F03240(TDEL0F03240)
KAF : KAFR_0K01610(KAFR0K01610)
KNG : KNAG_0B01060(KNAG0B01060)
LBG : 92208164(LODBEIA_P29680)
CAL : CAALFM_C101670CA(ESP1)
YLI : 2909702(YALI2_C01018g)
NTE : NEUTE1DRAFT146400(NEUTE1DRAFT_146400)
SMP : 10808136(SMAC4_02224)
PPSA : QC764_0105660(ESP1_1)
TATV : 25780187(TrAtP1_012796)
TASP : 36612145(TrAFT101_009955)
PLJ : 28883378(PLICBS_000649)
CDET : 87937184(CDEST_00681)
BFU : BCIN_10g02490(Bcesp1)
CPW : 9697070(D8B26_008085)
PTRR : 6345368(PtrM4_042950)
ADAC : 96085288(ACET3X_004966)
CDEP : 91088426(L203_104216)
KMG : 30164637(I203_107931)
KNE : 92177837(IAR55_000577)
CCAC : CcaHIS019_0507290(ESP1)
LBC : LACBIDRAFT_307095 LACBIDRAFT_317789
ABP : AGABI1DRAFT80074(AGABI1DRAFT_80074)
ABV : AGABI2DRAFT208386(AGABI2DRAFT_208386)
SCM : SCHCO_01122301(SCHCODRAFT_01122301)
EHI : EHI_120330(182.t00017)
» show all
Taxonomy
Reference
Authors
Waizenegger I, Gimenez-Abian JF, Wernic D, Peters JM
Title
Regulation of human separase by securin binding and autocleavage.
Journal
Sequence
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.22.49
LinkDB
All DBs