KEGG   ENZYME: 3.4.22.49
Entry
EC 3.4.22.49                Enzyme                                 
Name
separase;
separin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
All bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage
Comment
In both budding yeast and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis. Budding yeast separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19. Type example of peptidase family C50.
History
EC 3.4.22.49 created 2003
Orthology
K02365  separase
Genes
HSA9700(ESPL1)
PTR451937(ESPL1)
PPS100986315(ESPL1)
GGO101147294(ESPL1)
PON100444516(ESPL1)
PPYG129010329(ESPL1)
NLE100589406(ESPL1)
HMH116481009(ESPL1)
SSYN129465870(ESPL1)
MCC702136(ESPL1)
MCF102144900(ESPL1)
MTHB126931096
MNI105474391(ESPL1)
CSAB103238391(ESPL1)
CATY105580273(ESPL1)
PANU101019541(ESPL1)
TGE112634147(ESPL1)
MLEU105528263(ESPL1)
RRO104670601(ESPL1)
RBB108521614(ESPL1)
TFN117090041(ESPL1)
PTEH111541935(ESPL1)
CANG105503575(ESPL1)
CJC100404434(ESPL1)
SBQ101048054(ESPL1)
CIMI108284855(ESPL1)
ANAN105715862(ESPL1)
CSYR103250910(ESPL1)
MMUR105870726(ESPL1)
LCAT123639770(ESPL1)
PCOQ105817396(ESPL1)
OGA100964680(ESPL1)
MMU105988(Espl1)
MCAL110310439(Espl1)
MPAH110334838(Espl1)
RNO315330(Espl1)
MCOC116080433(Espl1)
ANU117718844(Espl1)
ASYL127667519(Espl1)
MUN110552298(Espl1)
CGE100768842(Espl1)
MAUA101841056(Espl1)
PROB127226138(Espl1)
PLEU114696628(Espl1)
MORG121444236(Espl1) 121459432
MFOT126493608
AAMP119822827(Espl1)
NGI103738516(Espl1)
HGL101723260(Espl1)
CPOC100733255(Espl1)
CCAN109684045(Espl1)
DORD105997880(Espl1)
DSP122124210(Espl1)
PLOP125364055(Espl1)
NCAR124983017
MMMA107148806(Espl1)
ITI101977546(Espl1)
OCU100356105
OPI101534121(ESPL1)
TUP102498926(ESPL1)
GVR103592226(ESPL1)
CFA607879(ESPL1)
CLUD112667190(ESPL1)
VVP112921175(ESPL1)
VLG121479643(ESPL1)
NPO129517362(ESPL1)
AML100467596(ESPL1)
UMR103675668(ESPL1)
UAR123794703(ESPL1)
ELK111157921
LLV125106438
MPUF101682674(ESPL1)
MNP132019726(ESPL1)
MLK131838700(ESPL1)
NVS122891326(ESPL1)
ORO101369929(ESPL1)
EJU114225726(ESPL1)
ZCA113922576(ESPL1)
MLX118008799(ESPL1)
NSU110577440(ESPL1)
LWW102748877(ESPL1)
FCA101084118(ESPL1)
PYU121038492(ESPL1)
PCOO112867453(ESPL1)
PBG122473473(ESPL1)
PVIV125170723(ESPL1)
LRUF124502024
PTG102954819(ESPL1)
PPAD109249194(ESPL1)
PUC125919117
PLEZ122224610(ESPL1)
AJU106986457
HHV120247237(ESPL1)
BTA506740(ESPL1)
BOM102284437(ESPL1)
BIU109559041(ESPL1)
BBUB102401554(ESPL1)
BBIS105001575(ESPL1)
CHX102177959(ESPL1)
OAS101105898(ESPL1)
BTAX128048511(ESPL1)
CSUM138078842(ESPL1)
ODA120858293(ESPL1)
CCAD122427561(ESPL1)
MREE136167095(ESPL1)
OVR110138228(ESPL1)
MBEZ129537046(ESPL1)
SSC100153121(ESPL1)
CFR102522390(ESPL1)
CBAI105076279(ESPL1)
CDK105094570(ESPL1)
VPC102526528(ESPL1)
BACU103008542(ESPL1)
BMUS118902411(ESPL1)
LVE103076864(ESPL1)
OOR101286713(ESPL1)
DLE111173946(ESPL1)
PCAD102974477
PSIU116760526(ESPL1)
NASI112394344(ESPL1)
ECB100063779(ESPL1)
EPZ103559419(ESPL1)
EAI106835283(ESPL1)
MYB102259018(ESPL1)
MYD102752810(ESPL1)
MMYO118651695(ESPL1)
MLF102417742(ESPL1)
MDT132227665(ESPL1)
PKL118729068(ESPL1)
EFUS103285342(ESPL1)
MNA107528301(ESPL1)
DRO112318617(ESPL1)
AJM119043512(ESPL1)
PDIC114513150(ESPL1)
PHAS123813111(ESPL1)
MMF118624167(ESPL1)
PPAM129084557(ESPL1)
HAI109391774(ESPL1)
RFQ117029415(ESPL1)
PALE102895542(ESPL1)
PGIG120602112(ESPL1)
PVP105302660(ESPL1)
RAY107509850(ESPL1)
MJV108405368(ESPL1)
TOD119247985(ESPL1)
SARA101546252(ESPL1)
SFUM130029055(ESPL1)
SETR126022452(ESPL1)
LAV100671244(ESPL1)
TMU101351580
ETF101651389(ESPL1)
DNM101439768(ESPL1)
MDO100032809(ESPL1)
GAS123250223(ESPL1)
SHR100921010
AFZ127538318
PCW110194100(ESPL1)
TVP118850739(ESPL1)
PBRV138171638(ESPL1)
OAA103169813(ESPL1)
TACU119932926(ESPL1)
GGA425536(ESPL1)
PCOC116234926(ESPL1)
MGP104916907(ESPL1)
CJO107306949(ESPL1)
LMUT125685495(ESPL1)
NMEL110390892(ESPL1)
APLA119715384(ESPL1)
ACYG106029392(ESPL1)
CATA118261562(ESPL1)
AFUL116501724(ESPL1)
TGU115491336(ESPL1)
PMOA120500677(ESPL1)
OTC121333706(ESPL1)
PRUF121363968
GFR102044437(ESPL1)
OMA130265836(ESPL1)
PHI102109021(ESPL1)
ACOE138099905(ESPL1)
ETL114070102(ESPL1)
ZLE135459059(ESPL1)
HRT120764372(ESPL1)
FPG101919296(ESPL1)
FCH102059227(ESPL1)
SHAB115618608(ESPL1)
ACHC115350895(ESPL1)
HLE104830294(ESPL1)
AGEN126046659
HHAR128152170(ESPL1)
EGZ104132781(ESPL1)
NNI104009170(ESPL1)
PLET104618942
CUCA104055654(ESPL1)
BREG104638330
OHA104329060
CPEA104396549(ESPL1)
CVF104282021(ESPL1)
RTD128903827(ESPL1)
AAM106488008(ESPL1)
AROW112961067(ESPL1)
NPD112952278(ESPL1)
TGT104575510(ESPL1)
DNE112996065(ESPL1)
SCAM104152524(ESPL1)
ASN102377591(ESPL1)
AMJ102574406(ESPL1)
CPOO109323407(ESPL1)
PSS102455533(ESPL1)
CMY102933417(ESPL1)
CCAY125629332(ESPL1)
DCC119846052(ESPL1)
CPIC101941011(ESPL1)
TST117888594(ESPL1)
CABI116828489(ESPL1)
MRV120390887(ESPL1)
ACS100566013(espl1)
ASAO132765462(ESPL1)
PVT110070448(ESPL1)
SUND121921737(ESPL1)
PBI103063794(ESPL1)
PMUR107288516(ESPL1)
CTIG120303304(ESPL1)
TSR106550895(ESPL1)
PGUT117666488(ESPL1)
APRI131193692(ESPL1)
PTEX113444843(ESPL1)
NSS113416193(ESPL1)
VKO123029896(ESPL1)
PMUA114586316(ESPL1)
PRAF128406024(ESPL1)
ZVI118076682(ESPL1)
HCG128345454(ESPL1)
GJA107118969(ESPL1)
STOW125428170(ESPL1)
EMC129346258(ESPL1)
XLA431925(espl1.S) 733221(espl1.L)
XTR100158636(espl1)
NPR108786827(ESPL1)
RTEM120929323(ESPL1)
BBUF120996094(ESPL1)
BGAR122933341(ESPL1)
MUO115466723(ESPL1)
GSH117357444(ESPL1)
DRE797406(espl1)
SRX107711058 107740575
SANH107667390 107673592
SGH107582795 107585178
CCAR109063482 109091441
CAUA113094395(espl1)
CGIB127959757
PTET122347489(espl1)
LROH127167307(espl1)
OMC131542846(espl1)
PPRM120491369(espl1)
RKG130087544(espl1)
MAMB125273720(espl1)
CIDE127514559
CERY137010931(espl1)
MASI127446132 127449376
TROS130556889(espl1)
TDW130425288(espl1)
MANU129449996(espl1)
IPU108271745
IFU128615001(espl1)
PHYP113545840(espl1)
SMEO124382852(espl1)
TFD113662736(espl1) 125141227
TVC132844115(espl1)
TRN134316617(espl1)
AMEX103046696(espl1)
CMAO118808271(espl1)
EEE113575991(espl1)
SPIL134095936(espl1)
TRU101077884(espl1)
TFS130524493(espl1)
TNGGSTEN00027237G001
LCO104931366(espl1)
NCC104967240
TBEN117489633(espl1)
CGOB115008801(espl1)
PGEO117447403(espl1)
GACU117551158(espl1)
EMAC134882256(espl1)
ELY117256249(espl1)
EFO125896120(espl1)
PLEP121956374(espl1)
SLUC116065562(espl1)
ECRA117943793(espl1)
ESP116688706(espl1)
PFLV114554229(espl1)
GAT120834670(espl1)
PPUG119194157(espl1)
AFB129106018(espl1)
CLUM117730883(espl1)
PSWI130209032(espl1)
CANA137795871(espl1)
CVE137879395(espl1)
MSAM119886141(espl1)
SCHU122867223(espl1)
CUD121507034(espl1)
SPUL138606029(espl1)
LMIX132977782(espl1)
ALAT119021256(espl1)
ASTR137595454(espl1)
MZE101471736(espl1)
ONL102078894(espl1)
OAU116320386(espl1)
OLA101174584(espl1)
OML112145288(espl1)
CSAI133448740(espl1)
XMA102232020(espl1)
XCO114135107(espl1)
XHE116711188(espl1)
PRET103465369(espl1)
PFOR103147647(espl1)
PLAI106954425(espl1)
PMEI106924384(espl1)
GAF122834239(espl1)
PPRL129357583(espl1)
CVG107082120(espl1)
CTUL119776667(espl1)
GMU124856662(espl1)
NFU107384036(espl1)
KMR108235600(espl1)
ALIM106518044(espl1)
NWH119412569(espl1)
AOCE111588761(espl1)
EJA138201484(espl1)
BFRE138626579(espl1)
MCEP125007380(espl1)
CSEM103385986(espl1)
POV109628965(espl1)
SSEN122768258(espl1)
HHIP117761872(espl1)
HSP118104972(espl1)
PPLT128457003(espl1)
SMAU118309718(espl1)
LCF108881443
SDU111221621(espl1)
SLAL111667822(espl1)
XGL120783239(espl1)
HCQ109522611(espl1)
SSCV125977377(espl1)
SBIA133507700(espl1)
PEE133409250(espl1)
PTAO133483758(espl1)
BPEC110158716(espl1)
MALB109956223(espl1)
BSPL114855888(espl1)
SJO128355452(espl1)
SSCO134004311(espl1)
SASA106565678(espl1)
STRU115207813(espl1)
OTW112217676(espl1)
OMY110494335(espl1)
OGO124003497(espl1)
ONE115143182(espl1)
OKI109895832(espl1)
OKE118388557(espl1)
OMM135539995(espl1)
SALP111966917(espl1)
SNH120061159(espl1)
CCLU121575271
ELS105017151(espl1)
SFM108918227(espl1)
PKI111858657(espl1)
AANG118211359(espl1)
AROT135237662(espl1)
CCOG133109491(espl1)
LOC102696375(espl1)
PSPA121308896(espl1)
ARUT117400942 117967028
PSEX120524900(espl1)
LCM102366561(ESPL1)
LRJ133358334(ESPL1)
BFO118432840
BBEL109479122
SPU576865
LPIC129257038
APLC110975876
AJC117111827
CELCELE_Y47G6A.12(sep-1) CELE_ZK430.5(ZK430.5)
CBRCBG_14956(Cbr-sep-1)
CRQGCK72_002117
BMYBM_BM6621(Bm6621)
LOALOAG_04930
LGILOTGIDRAFT_230378
PVUL126821652
GAE121384969
HRF124116111
HASI137299167
CRG105325911
CANU128170954
CVN111128436
OED125647579
MYI110463375
PMAX117343195
MCAF127729004
MMER123559936
RPHI132746400
DPOL127863473
OBI106869135
OSN115209522
LAK106173788
NVE5515603
EPA110254628
ATEN116288580
AMIL114977839
PDAM113669626
HMG101239166
HSY130622695
AQU105312138
ATHAT4G22970(ESP)
ALY9303812
CRB17878951
CSAT104718008 104727823 104731195
EUSEUTSA_v10024187mg EUTSA_v10029518mg
BRP103860637 103861751
BNA106375763 106398538 106415125 106440466 106440619 111214417 125585778 125595404 125595406 125603850
BOE106301587 106316163 106337896 106343049
RSZ108808809 108842701
THJ104814230
CPAP110808249
CIT102627230
CICCICLE_v10000008mg
PVY116123826 116136111
MINC123206072 123214667
TCC18607368
GRA105786009
GHI107921536 107925336
GAB108466833
HSYR120145063
DZI111298142
EGR104455025
RARG115727564
GMX100791010 100805306
GSJ114385811 114422230
PVU137832847
VRA106775912
VAR108343196
VUN114188679
CCAJ109803269
APRC113852013
MTR11418825 25497699
TPRA123910420 123910680
CAM101501526
PSAT127085273
VVO131623306 131634316 131645137
LJA130722444
ADU107468818 107487547
AIP107623888
AHF112714932 112784436 112800459
LANG109334474
PCIN129306986
QSAO6P43_012254 O6P43_031553
FVE101294643
RCN112176206 112176381
PPER18791340
PMUM103319233
PAVI110764872
PDUL117615543
MSYL126603255
ZJU107427758
MNT21406896
CSAV115694687
CSV101203087
CMO103488503
BHJ120075849
MCHA111017677
CMAX111478544
CMOS111447831
CPEP111795502
RCU8277534
MEAN126660078
JCU105628784
HBR110633641
MESC110618533
POP7478128
PEU105114008
PALZ118029252
PNZ133702256
JRE109007053
CILL122309304
CAVE132192086
AGLU133872904
QSU111987076
QLO115977465
TWL119982436
VVI100259948
VRI117926741
SLY101263947
SPEN107008385
SOT102604188
SSTN125843969
SDUL129885817
CANN107839972
LBB132598730
NTA107804022 107828330
NSY104227270
NTO104086993
NAU109243351
INI109169153
ITR116019743
SIND105169434
OEU111411489
EGT105949607
SSPL121753928 121758961
SMIL131019378
SHIS125218490
APAN127262011
HAN110884718
ECAD122594979
LSV111878317
CCAV112517090
DCR108209499
CSIN114268452
RVL131308829
AEW130755560 130779728
DLT127793184
BVG104888210
SOE110783145
CQI110728401 110738838
ATRI130802134
MOF131164793
NNU104589335
MING122086603
TSS122666187
PSOM113346473 113356227
OSA4330866
OBR102702071
OGL127761172
BDI100825113
ATS109766103
TDC119315995 119322508
TAES123128537 123138403 123145658
TUA125514802
LPER127302599 127305987 127317065
LRD124647555 124647960 124681922 124690729
SBI8073776 8075210
ZMA103654220
MFLO136474898 136474977
SITA101777770 101782294
SVS117839564 117852376
PVIR120643306 120657316
PHAI112882964
PAUA133921123
PDA103696471
EGU105035069
ZOF121993191 121995083
DCT110108353
PEQ110020186
AOF109842386
MSIN131236470
ACAK137949359
NCOL116266278
ATR18424419
SMOSELMODRAFT_405667 SELMODRAFT_442839
PPP112285826
CRECHLRE_01g029200v5
VCNVOLCADRAFT_96349(espA)
CSLCOCSUDRAFT_40112
CVRCHLNCDRAFT_143874
APROF751_1252
OLUOSTLU_119551(cut1)
OTAOT_ostta02g00970
GSLGasu_44590
CCPCHC_T00004631001
SCEYGR098C(ESP1)
SEUBDI49_2057
SPAOSPAR_G03190
AGOAGOS_AAR089C
KLAKLLA0_D15136g
KMXKLMA_50439(ESP1)
LTHKLTH0E05478g
ZROZYRO0C12672g
CGR2888336(GVI51_G03091)
NCSNCAS_0E01080(NCAS0E01080)
NDINDAI_0G01210(NDAI0G01210)
TPFTPHA_0D04010(TPHA0D04010)
TBLTBLA_0C02250(TBLA0C02250)
TGBHG536_0G01540
TDLTDEL_0F03240(TDEL0F03240)
KAFKAFR_0K01610(KAFR0K01610)
KNGKNAG_0B01060(KNAG0B01060)
ZMKHG535_0B06080
DHADEHA2D01958g
PICPICST_28228(ESP1)
PGUPGUG_04920
SPAASPAPADRAFT_132760
LELPVL30_001409(ESP1)
LBG92208164(LODBEIA_P29680)
CALCAALFM_C101670CA(ESP1)
CTPCTRG_04463
COTCORT_0B10500
CDUCD36_01530
CTEN18250404(ESP1)
CLUCLUG_00834
PPAPAS_chr1-4_0541
PKZC5L36_0B04650
BNNFOA43_003297
BBRXBRETT_004142
OPAHPODL_00833
YLI2909702(YALI2_C01018g)
SLBAWJ20_4184(ESP1)
NCRNCU00205
NTENEUTE1DRAFT146400(NEUTE1DRAFT_146400)
SMP10808136(SMAC4_02224)
PANPODANSg5443
PBELQC761_710410(ESP1)
PPSDQC762_710410(ESP1)
PPSPQC763_710410(ESP1)
PPSAQC764_0105660(ESP1_1)
TTTTHITE_2146478
MTMMYCTH_2117988
CTHRCTHT_0070540
MGRMGG_06245
PPEIPpBr36_06738
PGRIPgNI_10009
SSCKSPSK_08265
FGRFGSG_05504
FPUFPSE_03499
FPOAFPOAC1_008159
FVNFVRRES_08714
FVRFVEG_07021
FOXFOXG_09389
NHENECHADRAFT_46823
FFCNCS54_01040800
FKRNCS57_01034300
FMUJ7337_009642
TRETRIREDRAFT_50913
TRRM419DRAFT_26189
TATV25780187(TrAtP1_012796)
TASP36612145(TrAFT101_009955)
MAW19246838(ESP1_2)
MAJMAA_03454
MBRN26244972(bimB)
PCHMVFPPC_04332
CMTCCM_07539
AMUSLMH87_009867
PLJ28883378(PLICBS_000649)
PTKZJDV02_007433(ESP1)
VALVDBG_06747
VDAVDAG_05810
CFJCFIO01_11437
CLUPCLUP02_03331
CHIGCH63R_02448
CDET87937184(CDEST_00681)
SAPOSAPIO_CDS5673
PFYPFICI_08012
SSLSS1G_07342
BFUBCIN_10g02490(Bcesp1)
MBEMBM_02389
PSCOLY89DRAFT_778661
GLZGLAREA_11949
ANIANIA_08783
AFMAFUA_5G09710
ACTACLA_012860
NFINFIA_077600
AORAO090005000276
ANGAn07g03090
AFVAFLA_003064
ALUCAKAW2_11864A
ACHEACHE_60910S
APUUAPUU_70349A
PCSN7525_001962
PDPPDIP_54810
POUPOX_a00830
TMFEYB26_008469
TRGTRUGW13939_00088
CIMCIMG_04712
CPW9697070(D8B26_008085)
UREUREG_01885
ABEARB_01287
TVETRV_01158
PBLPAAG_05691
PBNPADG_07698
AJEHCAG_04674
BGHBDBG_04545
PNOSNOG_00996
PTEPTT_18381
PTRR6345368(PtrM4_042950)
BZECOCCADRAFT_3922
BSCCOCSADRAFT_189437
BORCOCMIDRAFT_105691
AALTCC77DRAFT_979400
ADAC96085288(ACET3X_004966)
ARABEKO05_0004355
ZTRMYCGRDRAFT_92316
PFJMYCFIDRAFT_213087
FFUCLAFUR5_01701
CBETCB0940_01623
BCOMBAUCODRAFT_149939
TMLGSTUM_00009703001
SPO2539442(cut1)
SOMSOMG_04321(cut1)
CNECNB00660
CNBCNBB5030
CNGCNAG_07463
CGICGB_B9070W
CDEUCNBG_6117
CDEP91088426(L203_104216)
KMG30164637(I203_107931)
KNE92177837(IAR55_000577)
TASAA1Q1_05076
CCACCcaHIS019_0507290(ESP1)
TVSTRAVEDRAFT_41033
DSQDICSQDRAFT_163077
PCOPHACADRAFT_203784
SHSSTEHIDRAFT_76141
PSQPUNSTDRAFT_102931
ADLAURDEDRAFT_170753
FMEFOMMEDRAFT_171563
GTRGLOTRDRAFT_80657
RSXRhiXN_00146
LBCLACBIDRAFT_307095 LACBIDRAFT_317789
CCICC1G_02409
ABPAGABI1DRAFT80074(AGABI1DRAFT_80074)
ABVAGABI2DRAFT208386(AGABI2DRAFT_208386)
PCUBJR316_0008694
MRRMoror_3206
MOREE1B28_006233
SCMSCHCO_01122301(SCHCODRAFT_01122301)
CPUTCONPUDRAFT_138600
SLASERLADRAFT_445696
WSEWALSEDRAFT_60488
WICJ056_003644
UMAUMAG_03262
PFPPFL1_06503
SGRAEX895_005921
MGLMGL_1370
MRTMRET_3990
PGRPGTG_03501
PTRCPtA15_2A385
PSTRPst134EA_007153
MBRMONBRDRAFT_33070
SREPTSG_11533
EHIEHI_120330(182.t00017)
EDIEDI_265930
EIVEIN_059330
ACANACA1_053220
TETTTHERM_00297160
PTMGSPATT00003810001
AAFAURANDRAFT_72664
EHXEMIHUDRAFT_451944
GTTGUITHDRAFT_148744
 » show all
Reference
1  [PMID:12194817]
  Authors
Waizenegger I, Gimenez-Abian JF, Wernic D, Peters JM
  Title
Regulation of human separase by securin binding and autocleavage.
  Journal
Curr Biol 12:1368-78 (2002)
DOI:10.1016/S0960-9822(02)01073-4
  Sequence
[hsa:9700]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.49
IUBMB Enzyme Nomenclature: 3.4.22.49
ExPASy - ENZYME nomenclature database: 3.4.22.49
BRENDA, the Enzyme Database: 3.4.22.49
CAS: 351527-77-0
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