KEGG   ENZYME: 3.4.24.7
Entry
EC 3.4.24.7                 Enzyme                                 
Name
interstitial collagenase;
vertebrate collagenase;
matrix metalloproteinase 1
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775!Ile in the alpha1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue
Comment
The enzyme takes its name from substrates of the interstitial collagen group - types I, II and III, all of which are cleaved in the helical domain. However, alpha-macroglobulins are cleaved much more rapidly. The enzyme is widely distributed in vertebrate animals. Type example of peptidase family M10
History
EC 3.4.24.7 created 1978
Orthology
K01388  matrix metalloproteinase-1 (interstitial collagenase)
Genes
HSA4312(MMP1)
PTR451510(MMP1)
PPS100995251(MMP1)
GGO101131051(MMP1)
PON100459931(MMP1)
NLE100582292(MMP1)
MCC703653(MMP1)
MCF102142258(MMP1)
MTHB126936364
CSAB103248335(MMP1)
CATY105588779(MMP1)
PANU101000222(MMP1)
TGE112607316(MMP1)
RRO104674665(MMP1)
RBB108514074(MMP1)
TFN117081260(MMP1)
PTEH111540071(MMP1)
CJC100400727(MMP1)
SBQ101051246(MMP1)
CSYR103277141(MMP1)
MMUR105871610 105874564(MMP1) 105874586
LCAT123641886(MMP1) 123641888
OGA100951906(MMP1)
MMU83995(Mmp1a) 83996(Mmp1b)
MCAL110302197 110302562
MPAH110327208
RNO300338(Mmp1b) 300339(Mmp1)
MCOC116072562 116072563
MUN110542734 110542735
CGE100754854
MAUA101824185
PLEU114708012(Mmp1)
MORG121451946
AAMP119810622
NGI103731579 103731678
HGL101697620(Mmp1)
CPOC100727966
CCAN109689286(Mmp1)
DORD105980664(Mmp1)
DSP122110407(Mmp1)
NCAR124959000
OCU100009110(MMP1)
OPI101527643(MMP1)
TUP102489479(MMP1) 102490608
CFA489428(MMP1)
CLUD112671438(MMP1)
VVP112925907
VLG121500184(MMP1)
AML100478167(MMP1) 100481181
UMR103662453(MMP1) 103662455
UAH113259797 113260135
UAR123792352 123792354(MMP1)
ELK111153766 111153845
LLV125078735 125078737
MPUF101688986(MMP1) 101689258
ORO101369292 101371070
EJU114211360
ZCA113915492(MMP1)
MLX118013155
NSU110586222 110586384
FCA101083957 101084217(MMP1)
PYU121020759 121020786
PBG122482471 122482878
LRUF124504840
PTG102951453 102970572(MMP1)
PPAD109257509 109257536
AJU106976478 106976487
HHV120219691 120223090
BTA112441463 281308(MMP1)
BOM102264402(MMP1)
BIU109569224 109569225
BBUB102402661 112579733 112579734(MMP1)
CHX102170620(MMP1)
OAS101120355(MMP1)
ODA120876148(MMP1)
CCAD122449754 122450309
SSC397320(MMP1)
CFR102517049(MMP1)
CBAI105067595(MMP1)
CDK105087169(MMP1)
VPC102528439(MMP1)
BACU103009752(MMP1)
LVE103089047(MMP1)
OOR101270980(MMP1)
DLE111167568(MMP1)
PCAD102996438(MMP1)
PSIU116758693(MMP1)
ECB100033896(MMP1)
EPZ103552636(MMP1)
EAI106843117(MMP1)
MYB102253167(MMP1)
MYD102770236(MMP1)
MMYO118664460(MMP1)
MLF102426724 102432629
MNA107532387(MMP1)
PKL118713253(MMP1)
HAI109376363
DRO112317543(MMP1)
SHON118975722(MMP1)
AJM119054054(MMP1)
PDIC114499949(MMP1)
PHAS123805463(MMP1)
MMF118627979(MMP1)
RFQ117031217(MMP1)
PALE102893881(MMP1)
PVP105297437
RAY107504633(MMP1)
MJV108385449(MMP1)
TOD119240913(MMP1)
SARA101545391(MMP1)
LAV100656422(MMP1)
TMU101341516
DNM101411093(MMP1) 101432285
MDO100012472(MMP1)
GAS123238994
SHR100915062(MMP1)
PCW110215019
OAA100078975
GGA418982(MMP1)
PCOC116230604
MGP100543241
CJO107308399
NMEL110389878
APLA101798298
ACYG106034204
AFUL116496881
TGU100218575
LSR110470054
SCAN103827284
PMOA120506634
OTC121342523
PRUF121364174
GFR102045551(MMP1)
FAB101811360(MMP1)
PHI102110938
PMAJ107213683
CCAE111924335
CCW104690063
CBRC103617951
ETL114067040
ZAB102070166
ACHL103805364
FPG101924590(MMP1)
FCH102051111
CLV102089808
EGZ104128912
NNI104023069
PLET104617131
PCRI104023704
ACUN113477011
TALA104368301
PADL103915454
AFOR103895111
ACHC115353351
HALD104314247
CCRI104163037
CSTI104555988
EHS104508788
CMAC104473095
MUI104542490
FGA104081956
GSTE104255837
LDI104351210
MNB103774352
OHA104333033
NNT104409993
DPUB104296583
PGUU104468559
ACAR104532860
AVIT104279809
CVF104290312
AAM106495498
AROW112971957
NPD112943713
TGT104571780
DNE112988755
SCAM104151761
ASN102387149 102387900 102388159
AMJ102563438(MMP8) 102563684(MMP1) 109281824
CPOO109306732 109306733 109306734
GGN109303295 109303296 109303297
PSS102448178
CMY114018917
CPIC101949233 101949502
TST117871172 117871174
CABI116814901
MRV120375402 120395357
ACS100552848 100553051
PVT110089072
SUND121927281
CTIG120313875
TSR106552779
PGUT117660852
VKO123029456
PMUA114595663
ZVI118084936
GJA107119159
STOW125430822
XLA108708733(mmp1.L) 495287(mmp1.S)
XTR594916(mmp1)
NPR108795960
RTEM120929038
BBUF120994012 120996396
BGAR122930997 122931327
BBEL109462004
VEM105565628
OSN115222658
 » show all
Reference
1  [PMID:3009463]
  Authors
Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ.
  Title
Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.
  Journal
J Biol Chem 261:6600-5 (1986)
  Sequence
[hsa:4312]
Reference
2  [PMID:3041177]
  Authors
Birkedal-Hansen H.
  Title
Catabolism and turnover of collagens: collagenases.
  Journal
Methods Enzymol 144:140-71 (1987)
DOI:10.1016/0076-6879(87)44177-3
Reference
3  [PMID:3032960]
  Authors
Fields GB, Van Wart HE, Birkedal-Hansen H.
  Title
Sequence specificity of human skin fibroblast collagenase. Evidence for the role of collagen structure in determining the collagenase cleavage site.
  Journal
J Biol Chem 262:6221-6 (1987)
Reference
4  [PMID:2462561]
  Authors
Sottrup-Jensen L, Birkedal-Hansen H.
  Title
Human fibroblast collagenase-alpha-macroglobulin interactions. Localization of cleavage sites in the bait regions of five mammalian alpha-macroglobulins.
  Journal
J Biol Chem 264:393-401 (1989)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.7
IUBMB Enzyme Nomenclature: 3.4.24.7
ExPASy - ENZYME nomenclature database: 3.4.24.7
BRENDA, the Enzyme Database: 3.4.24.7
CAS: 9001-12-1
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