Entry
Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
BRITE hierarchy
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
History
EC 3.4.24.86 created 2003
Orthology
K06059 disintegrin and metalloproteinase domain-containing protein 17
Genes
PROB : 127215298 127237593(Adam17)
MORG : 121432399(Adam17) 121438902
EPZ : 103543937 103560849(ADAM17)
MJV : 108398652(ADAM17) 108406598
XLA : 108718238(adam17.S) 733430(adam17.L)
BGAR : 122933687 122934891
DRE : 324142(adam17a) 560657(adam17b)
SRX : 107707689 107721298(adam17) 107752755 107756583
SANH : 107655315 107668236 107679802(adam17) 107693239
SGH : 107549102 107553270 107563905 107601850
CCAR : 109102614 109108207
CAUA : 113060579 113062863 113063206 113078559 113117279
CGIB : 127933475 127938250 127976588 127983609
PTET : 122324794(adam17b) 122361857(adam17a)
LROH : 127179302(adam17a) 127182844(adam17b)
OMC : 131523616(adam17a) 131527724(adam17b)
PPRM : 120476738(adam17a) 120493978(adam17b)
RKG : 130075457(adam17b) 130080283(adam17a)
MAMB : 125269329(adam17a) 125277828(adam17b)
CIDE : 127498026 127498187 127502958
CERY : 137006447(adam17a) 137019014(adam17b)
MASI : 127410155 127411257 127416487 127455512
TROS : 130560624(adam17a) 130565599(adam17b)
TDW : 130434396(adam17b) 130437270(adam17a)
MANU : 129417404(adam17a) 129429321(adam17b)
IPU : 108257789(adam17b) 108270063(adam17a)
IFU : 128601062(adam17b) 128612996(adam17a)
PHYP : 113531802 113538559(adam17)
SMEO : 124377472(adam17b) 124390219(adam17a)
TFD : 113655629(adam17b) 113659686(adam17a)
TVC : 132843230(adam17b) 132852675(adam17a)
TRN : 134320106(adam17b) 134324943(adam17a)
AMEX : 103041369(adam17a) 103041996(adam17b)
CMAO : 118815633(adam17b) 118823462(adam17a)
EEE : 113570511 113579136(adam17)
CHAR : 105897061(adam17b) 105897267(adam17a)
TRU : 101063716(adam17) 101075639
TFS : 130516153(adam17b) 130539694(adam17a)
TNG : GSTEN00003450G001 GSTEN00032183G001
EMAC : 134877193(adam17b) 134881429(adam17a)
ELY : 117266979(adam17a) 117270804(adam17b)
EFO : 125896904(adam17b) 125900530(adam17a)
PLEP : 121953389(adam17a) 121955712
SLUC : 116035705(adam17a) 116061359
GAT : 120815238 120833295(adam17a)
PPUG : 119195236 119227477(adam17a)
AFB : 129103252(adam17a) 129107002(adam17b)
MSAM : 119909392(adam17b) 119910413(adam17a)
SCHU : 122861718(adam17a) 122862643(adam17b)
CUD : 121521362(adam17b) 121526184(adam17a)
ALAT : 119004926(adam17a) 119012752(adam17b)
OAU : 116312411(adam17b) 116334721(adam17a)
OML : 112149788(adam17a) 112157702(adam17b)
CSAI : 133461983(adam17a) 133464880(adam17b)
XMA : 102222153 102227287(adam17)
XCO : 114134256 114158418(adam17)
XHE : 116709412 116734229(adam17)
PRET : 103457157(adam17) 103458871
PFOR : 103144243 103146799(adam17)
PLAI : 106954181 106958488(adam17)
PMEI : 106925343(adam17) 106926881
GAF : 122825649(adam17b) 122846679(adam17a)
PPRL : 129354515(adam17b) 129374730
CVG : 107087577 107089571(adam17)
CTUL : 119784254(adam17a) 119789424(adam17b)
GMU : 124855404 124882393(adam17b)
NFU : 107377926 107392286(adam17)
KMR : 108236986(adam17a) 108249691(adam17b)
ALIM : 106521553 106530770(adam17)
NWH : 119418690(adam17b) 119427330(adam17a)
AOCE : 111565930 111587227
MCEP : 124998878(adam17b) 125023604(adam17a)
CSEM : 103377555(adam17) 103381366
POV : 109628009 109647613 109647706
SSEN : 122782844(adam17a) 122784344(adam17b)
HHIP : 117755872(adam17a) 117758776(adam17b)
HSP : 118104017(adam17b) 118116343(adam17a)
PPLT : 128450646(adam17a) 128460522(adam17b)
SMAU : 118286480(adam17a) 118289970(adam17b)
LCF : 108888136(adam17a) 108891569(adam17b)
SLAL : 111644771(adam17) 111672592
XGL : 120788898(adam17b) 120795416(adam17a)
HCQ : 109526133(adam17) 109531720
SSCV : 125981403 125990485
SBIA : 133496315(adam17b) 133513442(adam17a)
PEE : 133412516(adam17a) 133417292(adam17b)
PTAO : 133468402(adam17b) 133488146(adam17a)
BPEC : 110155414(adam17) 110164254
MALB : 109955016 109974460
BSPL : 114847944(adam17a) 114849978(adam17b)
SJO : 128375934(adam17a) 128377021(adam17b)
SASA : 106566892 106607660 106610723
STRU : 115162529 115172824 115195042
OTW : 112217454(adam17b) 112247281 112256502(adam17a)
OMY : 110498110 110505320(adam17a) 110522060(adam17b)
OGO : 123994869(adam17b) 124001138 124046303(adam17a)
ONE : 115138326 115139643 115146388
OKI : 109866323 109894643 109903890
OKE : 118362310 118368488 118386674(adam17b)
SALP : 111963100 111968888 111972678
SNH : 120019620(adam17b) 120023088(adam17a) 120060189
CCLU : 121539398 121545088 121566828(adam17b)
ELS : 105016077 105017805 114829444
AANG : 118223873 118230860(adam17b)
PSPA : 121315402 121317536(adam17b)
ARUT : 117402183(adam17a) 117411384(adam17b)
PMRN : 116942526 116951388(ADAM17)
LRJ : 133340851 133340852 133349091
DSI : Dsimw501_GD21492(Dsim_GD21492)
CSET : 123315085 123318618
APLN : 108738958 112904002
ACOO : 126839611 126843026
CSEC : 111874896 111875197
PCHN : 125046731 125046761
PMOO : 119591392 119591553
MNZ : 135204219 135204236 135204237
PPOI : 119100663 119100666 119100667
VDE : 111247675 111248881 111249277 111249387 111250104 111250143
VJA : 111259527 111264350 111264356 111265748 111269090 111269228
CBR : CBG_16796(Cbr-adm-4)
BMY : BM_BM7430(Bma-adm-4)
LGI : LOTGIDRAFT_140416 LOTGIDRAFT_218462
PVUL : 126831602 126832499
PCAN : 112559081 112559083 112559089 112559955 112560031 112560314 112561901 112570179 112577068
BGT : 106052851 106054305 106057281 106057282 106057867 106068788
CRG : 105322445 105330896 105338334 105338464 105348437
CANU : 128156361 128179872 128180124 128192123 128192532
CVN : 111123307 111125232 111126918 111127133 111127575 111127576 111133224
OED : 125668371 125680934 125681006 125681301
MYI : 110445809 110449224 110453479 110456857 110458138
PMAX : 117317391 117317665 117317752 117339393
MMER : 123538796 123538949
RPHI : 132721796 132721819
DPOL : 127831834 127848415
MAEA : 128204382 128240386 128242344 128242345 128243947 128244826 128245060
SHX : MS3_00006789(ADAM17)
LLON : 135502975 135503323
AQU : 105311941 105312617 105315908
MBR : MONBRDRAFT_22131 MONBRDRAFT_22277 MONBRDRAFT_24567
SRE : PTSG_06305 PTSG_07102 PTSG_07278
» show all
Taxonomy
Reference
Authors
Black RA.
Title
Tumor necrosis factor-alpha converting enzyme.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.24.86
LinkDB
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