KEGG   ENZYME: 3.4.24.86
Entry
EC 3.4.24.86                Enzyme                                 
Name
ADAM 17 endopeptidase;
tumor necrosis factor alpha-converting enzyme;
TACE
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metalloendopeptidases
Reaction(IUBMB)
Narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala!Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumour necrosis factor alpha (TNFalpha). Similarly cleaves other membrane-anchored, cell-surface proteins to "shed" the extracellular domains
Comment
In peptidase family M12. In vivo, the cleavage of tumour necrosis factor alpha precursor releases the soluble, 17-kDa TNFalpha, which induces inflammation.
History
EC 3.4.24.86 created 2003
Orthology
K06059  disintegrin and metalloproteinase domain-containing protein 17
Genes
HSA6868(ADAM17)
PTR459018(ADAM17)
PPS100988650(ADAM17)
GGO101152705(ADAM17)
PON100439426(ADAM17)
NLE100605134(ADAM17)
MCC694429(ADAM17)
MCF102116784(ADAM17)
CSAB103220846(ADAM17)
CATY105587543(ADAM17)
PANU100126726(ADAM17)
TGE112604761(ADAM17)
RRO104675213(ADAM17)
RBB108516165(ADAM17)
TFN117062750(ADAM17)
PTEH111531765(ADAM17)
CJC100406520(ADAM17)
SBQ101049053(ADAM17)
CSYR103273750(ADAM17)
MMUR105882940(ADAM17)
OGA100947870(ADAM17)
MMU11491(Adam17)
MCAL110306467(Adam17)
MPAH110324376(Adam17)
RNO57027(Adam17)
MCOC116080989(Adam17)
MUN110564190(Adam17)
CGE100684971(Adam17)
PLEU114698857(Adam17)
NGI103747629(Adam17)
HGL101720924(Adam17)
CPOC100732916(Adam17)
CCAN109695934(Adam17)
DORD105983695(Adam17)
DSP122108773(Adam17)
NCAR124962735
OCU100101613(ADAM17)
OPI101532279(ADAM17)
TUP102496316(ADAM17)
CFA475662(ADAM17)
VVP112927728(ADAM17)
VLG121491142(ADAM17)
AML100482770(ADAM17)
UMR103675912(ADAM17)
UAH113269710(ADAM17)
UAR123778537(ADAM17)
ELK111154187
LLV125108380
MPUF101678822(ADAM17)
ORO101378266(ADAM17)
EJU114205773(ADAM17)
ZCA113937386(ADAM17)
MLX118007302 118007360
FCA101089004(ADAM17)
PYU121044072(ADAM17)
PBG122497481(ADAM17)
PTG102948618(ADAM17)
PPAD109268814(ADAM17)
AJU106982950(ADAM17)
HHV120231128(ADAM17)
BTA517541(ADAM17)
BOM102279111(ADAM17)
BIU109566404(ADAM17)
BBUB102393245(ADAM17)
CHX102188327(ADAM17)
OAS101116815(ADAM17)
ODA120851888(ADAM17)
CCAD122442085(ADAM17)
SSC397343(ADAM17)
CFR102508816(ADAM17)
CBAI105076036(ADAM17)
CDK105091236(ADAM17)
VPC102542735(ADAM17)
BACU103004501(ADAM17)
LVE103086820(ADAM17)
OOR101272366(ADAM17)
DLE111164496(ADAM17)
PCAD102978565(ADAM17)
PSIU116763969(ADAM17)
ECB100072496(ADAM17)
EPZ103543937 103560849(ADAM17)
EAI106847480(ADAM17)
MYB102256292(ADAM17)
MYD102767398(ADAM17)
MMYO118669297(ADAM17)
MLF102425078(ADAM17)
MNA107526643(ADAM17)
PKL118715935(ADAM17)
HAI109386655(ADAM17)
DRO112297707(ADAM17)
SHON118988749(ADAM17)
AJM119053993(ADAM17)
PDIC114499294(ADAM17)
PHAS123822573(ADAM17)
MMF118630463(ADAM17)
RFQ117032918(ADAM17)
PALE102894565(ADAM17)
PGIG120622059(ADAM17)
PVP105295437(ADAM17)
RAY107498263(ADAM17)
MJV108398652 108406598
TOD119259567(ADAM17)
SARA101541255(ADAM17)
LAV100663807(ADAM17)
TMU101350544
DNM101418734(ADAM17)
MDO100032069(ADAM17)
GAS123237029(ADAM17)
SHR100926795(ADAM17)
PCW110212614(ADAM17)
OAA100086345(ADAM17)
GGA421931(ADAM17)
PCOC116240757(ADAM17)
MGP100549409(ADAM17)
CJO107312200(ADAM17)
NMEL110395713(ADAM17)
APLA101794295(ADAM17)
ACYG106030708(ADAM17)
AFUL116487500(ADAM17)
TGU100225922(ADAM17)
LSR110467958(ADAM17)
SCAN103820444(ADAM17)
PMOA120505304(ADAM17)
OTC121344379(ADAM17)
PRUF121359136(ADAM17)
GFR102034165(ADAM17)
FAB101814343(ADAM17)
PHI102106429(ADAM17)
PMAJ107201529(ADAM17)
CCAE111925944(ADAM17)
CCW104685448(ADAM17)
ETL114058979(ADAM17)
ZAB102062655(ADAM17)
FPG101924106(ADAM17)
FCH102055911(ADAM17)
CLV102098173(ADAM17)
EGZ104127159(ADAM17)
NNI104013024(ADAM17)
ACUN113478354(ADAM17)
TALA104357741(ADAM17)
PADL103924054(ADAM17)
ACHC115350914(ADAM17)
AAM106494759(ADAM17)
AROW112976492(ADAM17)
NPD112945452(ADAM17)
DNE112981540(ADAM17)
ASN102373202(ADAM17)
AMJ102560812(ADAM17)
CPOO109312094(ADAM17)
GGN109300145(ADAM17)
PSS102454376(ADAM17)
CMY102933390(ADAM17)
CPIC101938160(ADAM17)
TST117875291(ADAM17)
CABI116823114(ADAM17)
MRV120401271(ADAM17)
ACS100563907(adam17)
PVT110080585(ADAM17)
SUND121927898(ADAM17)
PBI103060091(ADAM17)
PMUR107295813(ADAM17)
PGUT117674213(ADAM17)
VKO123017146(ADAM17)
PMUA114593781(ADAM17)
ZVI118082396(ADAM17)
GJA107112820(ADAM17)
STOW125433705(ADAM17)
XLA108718238(adam17.S) 733430(adam17.L)
XTR100492947(adam17)
NPR108789869(ADAM17)
RTEM120936358(ADAM17)
BBUF120997413(ADAM17)
BGAR122933687 122934891
DRE324142(adam17a) 560657(adam17b)
SRX107707689 107721298(adam17) 107752755 107756583
SANH107655315 107668236 107679802(adam17) 107693239
SGH107549102 107553270 107563905 107601850
CCAR109102614 109108207
CAUA113060579 113062863 113063206 113078559 113117279
PPRM120476738(adam17a) 120493978(adam17b)
MAMB125269329(adam17a) 125277828(adam17b)
IPU108257789(adam17b) 108270063(adam17a)
PHYP113531802 113538559(adam17)
SMEO124377472(adam17b) 124390219(adam17a)
TFD113655629(adam17b) 113659686(adam17a)
AMEX103041369 103041996
EEE113570511 113579136(adam17)
TRU101063716(adam17) 101075639
TNGGSTEN00003450G001 GSTEN00032183G001
LCO104922135 104938532
NCC104953609(adam17)
CGOB115027586(adam17)
ELY117266979(adam17a) 117270804(adam17b)
PLEP121953389(adam17a) 121955712
SLUC116035705(adam17a) 116061359
ECRA117936317(adam17a)
PFLV114546481(adam17)
GAT120815238 120833295(adam17a)
PPUG119195236 119227477(adam17a)
MSAM119909392(adam17b) 119910413(adam17a)
CUD121521362(adam17b) 121526184(adam17a)
MZE101474055 101477206
ONL100692440 100700935
OAU116312411(adam17b) 116334721(adam17a)
OLA101165277 101171872
OML112149788(adam17a) 112157702(adam17b)
XMA102222153 102227287(adam17)
XCO114134256 114158418(adam17)
XHE116709412 116734229(adam17)
PRET103457157(adam17) 103458871
PFOR103144243 103146799(adam17)
PLAI106954181 106958488(adam17)
PMEI106925343(adam17) 106926881
GAF122825649(adam17b) 122846679(adam17a)
CVG107087577 107089571(adam17)
CTUL119784254(adam17a) 119789424(adam17b)
GMU124855404 124882393(adam17b)
NFU107377926 107392286(adam17)
KMR108236986(adam17a) 108249691(adam17b)
ALIM106521553 106530770(adam17)
NWH119418690(adam17b) 119427330(adam17a)
AOCE111565930 111587227
CSEM103377555(adam17) 103381366
POV109628009 109647613 109647706
SSEN122782844(adam17a) 122784344(adam17b)
HHIP117755872(adam17a) 117758776(adam17b)
LCF108888136(adam17) 108891569
SDU111225559 111236091
SLAL111644771(adam17) 111672592
XGL120788898(adam17b) 120795416(adam17a)
HCQ109526133(adam17) 109531720
BPEC110155414(adam17) 110164254
MALB109955016 109974460
SASA106566892 106607660 106610723
OTW112217454(adam17b) 112247281 112256502(adam17a)
OMY110498110 110505320(adam17a) 110522060(adam17b)
OGO123994869(adam17b) 124001138 124046303(adam17a)
ONE115138326 115139643 115146388
SALP111963100 111968888 111972678
SNH120019620(adam17b) 120023088(adam17a) 120060189
ELS105016077 105017805 114829444
SFM108921884(adam17)
PKI111842019
AANG118223873 118230860(adam17b)
LOC102682214(adam17)
PSPA121315402 121317536(adam17b)
ARUT117402183(adam17a) 117411384(adam17b)
LCM102367618(ADAM17)
CMK103187122(adam17b)
RTP109924946(adam17)
BFO118404014
BBEL109473119
CIN100175230
SCLV120332865
SPU585715
APLC110985040
SKO102803736
DMEDmel_CG7908(Tace)
DER6554190
DSE6612793
DSIDsimw501_GD21492(Dsim_GD21492)
DYADyak_GE10847
DAN6501584
DSR110186406
DPODpse_GA26934
DPE6594801
DMN108155302
DWI6650344
DGR6567576
DMODmoj_GI10801
DAZ108609115
DNV108659297
DHE111596420
DVI6635224
CCAT101448581
BOD106618981
MDE101891592
SCAC106081862
LCQ111686124
AGAAgaP_AGAP002381
ACOZ120949087
AARA120894455
AAG5563722
AALB109424331
CQUCpipJ_CPIJ005931
CPII120421188
CNS116346870
AME551599
ACER108000097
ALAB122717424
BIM100745543
BBIF117212151
BVK117240411
BVAN117162798
BTER100645870
BPYO122566715
CCAL108623713
OBB114877479
MGEN117227229
NMEA116432844
CGIG122396464
SOC105197464
MPHA105839042
AEC105143101
ACEP105623272
PBAR105427116
VEM105561144
HST105184135
DQU106750237
CFO105258924
FEX115241593
LHU105669279
PGC109861730
OBO105282848
PCF106793988
PFUC122521241
VPS122637869
NVI100119121
CSOL105364600
TPRE106654176
MDL103578657
CGLO123270939
FAS105266951
DAM107041094
AGIF122855408
CCIN107265431
TCA663540
DPA109537991
SOY115875020
ATD109602707
CSET123315085 123318618
AGB108914225
LDC111506628
NVL108563900
APLN108738958 112904002
PPYR116161187
OTU111419993
BMOR101742406
BMAN114240363
MSEX115440097
DPLKGM_202512
BANY112051369
PMAC106713573
PPOT106104922
PXU106122629
PRAP111003508
HAW110384278
TNL113503404
SLIU111354966
OFU114352070
PXY105386060
API100158671
DNX107167450
AGS114130986
RMD113559354
BTAB109032996
DCI103515131
CLEC106673239
HHAL106685230
NLU111053184
PHUPhum_PHUM024730
FOC113217343
ZNE110836194
CSEC111874896 111875197
FCD110845600
DPXDAPPUDRAFT_314368
DMK116925958 123470055
PVM113801174 113801176
PJA122247615 122264652
PCHN125046731 125046761
HAME121869162
PCLA123764791
PTRU123504923
HAZT108674819
EAF111713207
LSM121117760 121118487
ISCIscW_ISCW001461
DSV119460684
RSAN119396531
RMP119174711
VDE111247675 111248881 111249277 111249387 111250104 111250143
VJA111259527 111264350 111264356 111265748 111269090 111269228
DFR124498186 124498350
CSCU111618821
PTEP107455115
SDM118180981
CELCELE_ZK154.7(adm-4)
CBRCBG_16796(Cbr-adm-4)
BMYBM_BM7430(Bma-adm-4)
LOALOAG_03310
NAINECAME_00683
TSPTsp_02601
LGILOTGIDRAFT_140416 LOTGIDRAFT_218462
PCAN112559081 112559083 112559089 112559955 112560031 112560314 112561901 112570179 112577068
BGT106052851 106054305 106057281 106057282 106057867 106068788
GAE121387517 121387804
HRF124125268 124149260
HRJ124265245 124272395
CRG105322445 105330896 105338334 105338464 105348437
MYI110445809 110449224 110453479 110456857 110458138
PMAX117317391 117317665 117317752 117339393
MMER123538796 123538949
OBI106881514
OSN115220007
LAK106153651
SMMSmp_175340.1
OVIT265_01230
EGLEGR_00581
NVE5511423
EPA110250562
ATEN116292316
ADF107358831
AMIL114948654
PDAM113681067
SPIS111328065
DGT114528597
XEN124447472
HMG100210793
TADTRIADDRAFT_58971
AQU105311941 105312617 105315908
EINEint_060290
EHEEHEL_060310
EROEROM_060290
MBRMONBRDRAFT_22131 MONBRDRAFT_22277 MONBRDRAFT_24567
SREPTSG_06305 PTSG_07102 PTSG_07278
 » show all
Reference
1  [PMID:11733179]
  Authors
Black RA.
  Title
Tumor necrosis factor-alpha converting enzyme.
  Journal
Int J Biochem Cell Biol 34:1-5 (2002)
DOI:10.1016/S1357-2725(01)00097-8
Other DBs
ExplorEnz - The Enzyme Database: 3.4.24.86
IUBMB Enzyme Nomenclature: 3.4.24.86
ExPASy - ENZYME nomenclature database: 3.4.24.86
BRENDA, the Enzyme Database: 3.4.24.86
CAS: 151769-16-3
LinkDB

DBGET integrated database retrieval system