KEGG   ENZYME: 3.5.1.24
Entry
EC 3.5.1.24                 Enzyme                                 
Name
choloylglycine hydrolase;
glycocholase;
bile salt hydrolase;
choloyltaurine hydrolase;
3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine amidohydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amides
Sysname
glycocholate amidohydrolase
Reaction(IUBMB)
glycocholate + H2O = cholate + glycine [RN:R05835]
Reaction(KEGG)
R05835;
(other) R02797 R03975 R03977 R04486 R04487
Substrate
glycocholate [CPD:C01921];
H2O [CPD:C00001]
Product
cholate [CPD:C00695];
glycine [CPD:C00037]
Comment
Also acts on the 3alpha,12alpha-dihydroxy-derivative, and on choloyl-taurine.
History
EC 3.5.1.24 created 1972
Pathway
ec00120  Primary bile acid biosynthesis
ec00121  Secondary bile acid biosynthesis
ec01100  Metabolic pathways
Orthology
K01442  choloylglycine hydrolase
Genes
EUN: UMNK88_pK8826
ECY: ECSE_P3-0046
END: A4308_12525
ADP: NCTC12871_00060(cbh)
LYA: RDV84_21905
VHA: VIBHAR_02193
VCA: M892_02375
VHR: AL538_01075
VOW: A9237_00885
VRO: BSZ04_16345
VSC: VSVS12_01375
VSH: BSZ05_14500
VAF: D1115_07550
VFI: VF_A0241
VFM: VFMJ11_A0276
PDS: CAY62_18360
ACOI: NQU59_15035
SHL: Shal_0591
SWD: Swoo_2365
SKH: STH12_02744
SSPA: K0I31_16580
SHNS: K0J45_16390
SRHS: K0I63_16515
THAP: FNC98_05995
HJA: BST95_01440
LOK: Loa_02519
LIB: E4T55_08905
LSS: NCTC12082_00361(yxeI)
LADL: NCTC12735_00521(yxeI)
FPH: Fphi_1659
FPT: BZ13_337
FPI: BF30_1937
FPM: LA56_512
FPX: KU46_1638
FPJ: LA02_1356
FRT: F7308_1470
FMI: F0R74_02775
FSR: KQR59_04385
FRL: FIP56_06295
AFRI: E3E15_03970
HTR: EPV75_08300
HMAR: HVMH_1071
THIO: AYJ59_05605
CYS: NYP54_04725
TSY: THSYN_15570
HCS: FF32_04300
HAG: BB497_10035
HBP: HPTD01_1484
HALK: CUU95_07905
NBA: CUN60_05670
BUR: Bcep18194_B0916
BAEN: L3V59_24300
PEW: KZJ38_25220
PTRP: DCO17_08270
PANI: DCO16_10975
PPAL: AOC06_07615
PYT: PKF023_07140
PIU: AOC20_07735
PUD: G9Q38_03850
AAQU: D3M96_12145
PHN: PAEH1_09890
BOZ: DBV39_15650
ODH: DHf2319_01470
CKE: B5M06_12040
KMN: HW532_10045
KAI: K32_37770 K32_46880
BME: BMEI0543
BMEL: DK63_882
BMI: BMEA_A1518
BMZ: BM28_A1479
BMG: BM590_A1467
BMW: BMNI_I1418
BMEE: DK62_2064
BMF: BAB1_1488
BMB: BruAb1_1463
BMC: BAbS19_I13900
BAA: BAA13334_I01625
BABO: DK55_1449
BABR: DO74_441
BABT: DK49_1206
BABB: DK48_671
BABU: DK53_1432
BABS: DK51_27
BABC: DO78_1353
BMS: BR1468
BSI: BS1330_I1462
BSF: BSS2_I1426
BSUI: BSSP1_I1486
BSUP: BSPT1_I1500
BSUV: BSPT2_I1483
BSUC: BSSP2_I1489
BMT: BSUIS_A1521
BSZ: DK67_843
BSV: BSVBI22_A1462
BSW: IY71_07215
BSG: IY72_06965
BOV: BOV_1422
BCS: BCAN_A1503
BSK: BCA52141_I2834
BOL: BCOUA_I1468
BCAR: DK60_1494
BCAS: DA85_07030
BMR: BMI_I1480
BPP: BPI_I1520
BPV: DK65_2014
BCET: V910_100537
BVL: BF3285c1_0073
BRU: BFS01_07065
BRJ: BKD03_14560
OIN: IAR37_14585
BIO: BR141012304_11248
OAN: Oant_1703
OAH: DR92_1186
OPS: A8A54_06885 A8A54_20325
BPSN: NIK97_15790
BRUC: LJ361_17790
OCR: HGK82_07795
OCL: GTN27_08150
OCC: KMS41_07280
OCH: CES85_1617
PSCQ: KHQ08_06870
STAR: G3545_07605
ANC: GBB76_05275
APRA: G3A50_02730 G3A50_18980
MSL: Msil_3557
MTUN: MTUNDRAET4_3160
MLG: CWB41_15845
MEDK: QEV83_09915
MCG: GL4_0503
METG: HT051_01810 HT051_01815 HT051_02635
BLAG: BLTE_23450(cbaH)
MHEY: H2LOC_004005
MECQ: MSC49_06630
MEY: TM49_03610 TM49_20510
MAAD: AZF01_03040 AZF01_05250 AZF01_16710
MMED: Mame_02037(cbh_1) Mame_02196(cbh_2)
MLUT: JET14_06540 JET14_18915
PSIN: CAK95_26095
NOH: G5V57_14685
PSF: PSE_3526
SIW: GH266_09320
ACUT: MRB58_00230
HCL: NCTC13205_00078(cbh)
SPAL: FM071_02045
SMAX: FJR03_00115
NSA: Nitsa_1273
SUN: SUN_1118 SUN_2455
DMA: DMR_42620
DCB: C3Y92_01835
DMS: E8L03_12800
PSEL: GM415_09795
PNW: SYK_15490
DSX: GD604_14285
DSD: GD606_11185
PBIZ: LWC08_15255
DPS: DP1182
DBK: DGMP_22020(cbaH)
DWD: DSCW_29670
DBR: Deba_2031
DMP: FAK_04230 FAK_26970
PRD: F7984_02150
LMO: lmo2067
LMN: LM5578_2268
LMY: LM5923_2219
LMT: LMRG_01217
LMOC: LMOSLCC5850_2128(bsh)
LMOD: LMON_2137
LMOW: AX10_04575
LMOQ: LM6179_02838(bsh)
LMR: LMR479A_2178(cbh)
LMOM: IJ09_14875
LMF: LMOf2365_2098(cbH)
LMC: Lm4b_02088
LMOG: BN389_20960(cbh)
LMP: MUO_10605
LMOL: LMOL312_2080(bsh)
LMOJ: LM220_01025
LMOZ: LM1816_13317
LMOX: AX24_08170
LMH: LMHCC_0491
LMQ: LMM7_2157(bsh)
LML: lmo4a_2118(bsh)
LMG: LMKG_00256
LMS: LMLG_0361
LMJ: LMOG_01160
LMW: LMOSLCC2755_2129(bsh)
LMX: LMOSLCC2372_2133(bsh)
LMZ: LMOSLCC2482_2125(bsh)
LMON: LMOSLCC2376_2021(bsh)
LMOS: LMOSLCC7179_2038(bsh)
LMOO: LMOSLCC2378_2091(bsh)
LMOY: LMOSLCC2479_2130(bsh)
LMOT: LMOSLCC2540_2160(bsh)
LMOA: LMOATCC19117_2087(bsh)
LMOK: CQ02_10710
LMV: Y193_05195
LSG: lse_2056(bsh)
LIV: LIV_2050(bsh)
LII: JL52_10765
LIW: AX25_10935
LMAR: LAX80_010100(bsh)
EAUR: NMQ00_13810(bsh)
PKU: AUO94_08995
PFAE: AJGP001_08295
SPAT: A0O21_03545
SCHJ: DDV21_007255
SRUM: GPZ88_07805
SACY: O6R09_03380(bsh) O6R09_05445(bsh)
LJO: LJ_1147 LJ_1412
LJF: FI9785_1052 FI9785_854
LJH: LJP_0828 LJP_1011c
LJN: T285_05035
LAC: LBA0892(bshA) LBA1078(bshB)
LAD: LA14_0914 LA14_1092
LAF: SD55_0913(bshA) SD55_1090(bshB)
LGA: LGAS_0959
LHL: LBHH_1220(cbh)
LHH: LBH_0786(cbh)
LCR: LCRIS_00906(cbh)
LAM: LA2_04690 LA2_06130
LAI: LAC30SC_04505 LAC30SC_05780
LAY: LAB52_04465 LAB52_05565
LPW: LpgJCM5343_07940 LpgJCM5343_09970
LUU: H4B44_06670
LIQ: KBW87_03680(bsh) KBW87_09595(bsh)
LPL: lp_3536(bsh1)
LPJ: JDM1_2822(bsh1)
LPT: zj316_0150(cbh)
LPS: LPST_C2886(bsh1)
LPR: LBP_cg2864
LPZ: Lp16_2762
LPB: SH83_14665
LARG: LPA65_15095
LRE: Lreu_0730
LRF: LAR_0701
LRT: LRI_1179
LRR: N134_04300
LMU: LBLM1_10135
LVA: LV515_03785
LFN: LF145_03730
LPAS: KZE55_04905(bsh)
LPOR: PRK60_04960(bsh)
LSL: LSL_1801
LSI: HN6_01574
LSJ: LSJ_0788 LSJ_2111
LAGL: BEN83_06190
LANI: FAX13_01030
LMUR: CPS94_09990
LFD: QFX10_02840(bsh)
EFA: EF0521
EFL: EF62_0879(cbh)
EFD: EFD32_0436 EFD32_1847(cbh1) EFD32_1916(cbh3)
EFS: EFS1_0461
EFN: DENG_00539
EFC: EFAU004_01766 EFAU004_01892
EFAU: EFAU085_01787 EFAU085_01918
EFU: HMPREF0351_11722(cbh2) HMPREF0351_11857(cbh3)
EFM: M7W_1078 M7W_1119 M7W_1156
EFT: M395_05290
EHR: EHR_09940 EHR_11510
ECAS: ECBG_02025
EMU: EMQU_1455
EDU: LIU_08430
EGA: AL523_11285
ETH: CK496_06880
EAV: EH197_01690 EH197_17560
ELAC: I4Q40_04945
ECEC: NCTC12421_02229(cbh_1) NCTC12421_02387(cbh_2)
EIE: ENLAB_30050
ENI: CXM95_06650
VLC: G314FT_16730(cbh)
ALOY: CJ190_008655(bsh)
CML: BN424_2909(cbH)
CPE: CPE0709
CPF: CPF_0705(cbh)
CBB: CLD_2374
CBF: CLI_2250
CBM: CBF_2236
CBJ: H04402_02216
CLT: CM240_1766(cbh)
CLD: CLSPO_c22400
CNN: CNEO_1150(cbh)
RUK: A4V00_06830
RUC: LCN94_02585(bsh)
PFAA: MM59RIKEN_19130
VFA: MM35RIKEN_11690
SVJ: NQ490_05350(bsh)
AMUR: ADH66_02135
FWA: DCMF_14235
ELM: ELI_1322 ELI_1856
EMT: CPZ25_011475
ELIM: B2M23_16225
EVN: NQ558_04955(bsh)
BPEN: NQ488_02665(bsh)
BCRO: NQ527_08770(bsh)
RRK: H8S51_002210(bsh) H8S51_005350(bsh)
BWX: NQ550_01420(bsh)
BMAS: LK422_16425(bsh)
BLUI: Blut17040_02510(bsh_1) Blut17040_34050(bsh_2)
RLR: NQ541_03745(bsh)
WCP: H9Q76_10825
SSUN: H9Q77_06840
MFOR: NQ534_05100(bsh)
CLE: Clole_2713
CEW: EKH84_16375
PBIF: KXZ80_01940 KXZ80_16485(bsh)
ROC: HF520_07105
RIL: CRIB_857
PHX: KGNDJEFE_01093(cbh)
IBR: NQ514_03985(bsh)
CMIU: B1H56_09150
PGK: M9426_09060(bsh)
AARG: Aargi30884_20240
ABSI: A9CBEGH2_18120
AMUO: KWG62_00310(bsh) KWG62_12690(bsh)
ALLO: KWG61_09625
TUR: AT726_06045 AT726_08870
TSG: HLK68_04930 HLK68_07680 HLK68_08040
TBB: J0J69_09040(bsh) J0J69_11500(bsh) J0J69_12075(bsh)
TFC: T23_03840(cbaH) T23_04480 T23_13610(cbh)
CMIT: NQ499_05325(bsh)
LCAL: ATTO_06000
SHI: Shel_12270
AEQ: AEQU_1348
AHAT: ADCFC_10310
CCHO: CCHOA_10235(cbh)
NAD: NCTC11293_00282(yxeI)
RHQ: IM25_02745
RRT: 4535765_04107(cbh)
RCR: NCTC10994_01103(cbh)
RGOR: NMQ04_17760(bsh)
DIZ: CT688_16215
DPC: A6048_10685
MIP: AXH82_07600
MPAL: BO218_13760
MWA: E4K62_09545
MOY: CVS54_00163(cbh)
MSF: IT882_10130
MCAW: F6J84_01105
MLZ: F6J85_09165
MICS: C1N74_13405
MPAO: IZR02_00865(bsh)
MARK: QUC20_13390(bsh)
MSUF: KV394_06010
MYL: C3E77_00485
SALD: FVA74_05805
MANT: BHD05_03695
AOG: LH407_09190(bsh)
AJG: KKR91_01570(bsh)
ASUN: KG104_07885(bsh)
ACAO: NF551_11050(bsh)
AZH: MUK71_06960(bsh)
AGEG: MUG94_01225(bsh)
AKO: N9A08_06495(bsh)
AZX: N2K95_14855(bsh)
AJR: N2K98_15855(bsh)
CDON: KKR89_01625(bsh)
CWAN: KG103_01665(bsh)
CFEN: KG102_16480(bsh)
CWN: NP075_01740(bsh)
CCHE: NP064_15205(bsh)
CXIE: NP048_01685(bsh)
NOI: FCL41_09945
NMAR: HPC71_13480
NFC: KG111_07030(bsh)
AEZ: C3E78_15230
AEF: GEV26_07670
ASEZ: H9L21_03880
ADB: NP095_03810(bsh)
AWN: NQV15_08045(bsh)
ALIL: D5R93_00815
BLO: BL0796
BLJ: BLD_0536(cbaH)
BLN: Blon_1453
BLON: BLIJ_1499
BLF: BLIF_0937
BLL: BLJ_0948
BLB: BBMN68_536(cbaH)
BLM: BLLJ_0817
BLK: BLNIAS_01547
BLG: BIL_10200
BLZ: BLGT_05070
BLX: GS08_04925
BAD: BAD_0856
BADL: BADO_0911
BADO: BBMN23_0992
BLA: BLA_1379
BLC: Balac_0863(bsh)
BLT: Balat_0863(bsh)
BBB: BIF_00207
BBC: BLC1_0823
BNM: BALAC2494_00268
BLV: BalV_0829(bsh)
BLW: W7Y_0865
BLS: W91_0886
BANI: BL12_04315(bsh)
BANL: BLAC_04390
BNI: BANAN_04270
BANM: EN10_04380
BDE: BDP_1106(cbh)
BDN: BBDE_1060
BBP: BBPR_0850(cbh)
BBI: BBIF_0879(cbh)
BBF: BBB_0854(cbh)
BBV: HMPREF9228_0895
BBRU: Bbr_0971(cbh)
BBRE: B12L_0890
BBRV: B689b_0983
BBRJ: B7017_1020
BBRC: B7019_1045
BBRN: B2258_0935
BBRS: BS27_0970(cbh)
BBRD: BBBR_0919
BTP: D805_0402
BKA: AH68_05530
BKS: BBKW_0991
BCAT: BBCT_0907
BPSP: AH67_04680
BPSC: BBPC_0908
BCHO: BcFMB_07045
BFJ: B19861_09420(bsh)
SYNC: CB0101_03470
SNG: SNE_A17210
RUFI: K0V07_01085
RML: FF011L_31620
ROL: CA51_28730(cbh)
RUV: EC9_31470(cbh)
GMR: GmarT_23860
GFM: Enr17x_25030(cbh)
ULI: ETAA1_63420
PCOR: KS4_01870(cbh)
SCOR: J3U87_31995
FVA: FV113G1_28320 FV113G1_29080
FUL: C4N20_09600
FMO: C4N19_07925
FHO: H9Q81_02010
CSOM: MKD34_01085
BFS: BF9343_1433(cbh)
BFB: VU15_14395 VU15_18620
BXY: BXY_10230
BOA: Bovatus_02350(cbh_2)
BCAE: A4V03_14545
BIS: DXK01_017585
BUN: Bun01g_25460
BEG: INE88_03395(cbh_1)
BSAL: K6V25_15150
BVU: BVU_2699
BSA: Bacsa_1560
BDO: EL88_06530
BDH: GV66_14440
PCOP: I6J50_16520
DYS: G7050_12935
DYH: G7051_13290
PDI: BDI_1550
PARC: CI960_12015
PGOL: K6V26_16620
BVS: BARVI_00680
COPR: Cop2CBH44_13780
CFAS: Cfast33896_08420
BVIR: I6J59_00230
BFH: F1611_13995
PCLR: PC1C4_14630
AFD: Alfi_1795
ACOU: A5CBH24_17950
ADA: A5CPEGH6_23320
AIT: AI2BBH_10610 AI2BBH_19080
ASEN: NQ519_13215
AIU: NQ491_10245
COY: HF329_17165
FLM: MY04_4579
FYA: KMW28_05260 KMW28_06095
WIN: WPG_3359
PRS: B9H02_11275
PROW: OO006_09110 OO006_09520 OO006_11220
PROI: OO005_08760 OO005_10275
MEIS: PXD04_06835(bsh)
METV: K4897_06545(bsh)
MFC: BRM9_1563
MFI: DSM1535_2252(cbh)
MCUB: MCBB_0969(cbh)
MSUB: BK009_01470
METN: BK008_09455
METO: CIT02_03540
MEUZ: KRP56_01830
 » show all
Reference
1  [PMID:6016335]
  Authors
Nair PP, Gordon M, Reback J
  Title
The enzymatic cleavage of the carbon-nitrogen bond in 3-alpha, 7-alpha, 12-alpha-trihydroxy-5-beta-cholan-24-oylglycine.
  Journal
J Biol Chem 242:7-11 (1967)
Reference
2  [PMID:10993]
  Authors
Stellwag EJ, Hylemon PB.
  Title
Purification and characterization of bile salt hydrolase from Bacteroides fragilis subsp. fragilis.
  Journal
Biochim Biophys Acta 452:165-76 (1976)
DOI:10.1016/0005-2744(76)90068-1
Other DBs
ExplorEnz - The Enzyme Database: 3.5.1.24
IUBMB Enzyme Nomenclature: 3.5.1.24
ExPASy - ENZYME nomenclature database: 3.5.1.24
BRENDA, the Enzyme Database: 3.5.1.24
CAS: 37289-07-9
LinkDB

DBGET integrated database retrieval system