KEGG   ENZYME: 3.5.3.3
Entry
EC 3.5.3.3                  Enzyme                                 
Name
creatinase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In linear amidines
Sysname
creatine amidinohydrolase
Reaction(IUBMB)
creatine + H2O = sarcosine + urea [RN:R01566]
Reaction(KEGG)
R01566
Substrate
creatine [CPD:C00300];
H2O [CPD:C00001]
Product
sarcosine [CPD:C00213];
urea [CPD:C00086]
History
EC 3.5.3.3 created 1961
Pathway
ec00260  Glycine, serine and threonine metabolism
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K08688  creatinase
Genes
KOEA225_0582
KOMHR38_27865
KQUAVR78_26185
KLLBJF97_29060
RTGNCTC13098_04904
PAETNCTC13378_02035
PREPCA10_04400
PPSEBN5_0137(pepQ)
PFUWKF707C_3990
PCQPcP3B5_01400
PPUPP_3667(creA)
PPFPput_2062
PPGPputGB1_2232
PPWPputW619_2236 PputW619_3269
PPTPPS_2272
PPBPPUBIRD1_2061
PPIYSA_09478
PPXT1E_1754
PPUHB479_11675
PPUTL483_19245 L483_21915
PPUNPP4_21260
PPUDDW66_2531
PMONX969_09705
PMOTX970_09365
PPJRK21_01101 RK21_02556
PFLPFL_5299(pepQ)
PPRCPFLCHA0_c52730
PPROPPC_5277(pepQ)
PSZPSTAB_0117(pepQ)
PSVPVLB_11000
PKCPKB_0197
PFZAV641_10105
PLQAA042_21005
PPSYAOC04_06990
PSOSPOS17_5264
PSETTHL1_383
PSILPMA3_12795
PUMHGP31_12510
PPSHG5J76_16960
PLALFXN65_02105
PTAENCTC10697_01986
ABYp3ABAYE0029
ANORR32_18285
ACWA0J50_18930
CBERB5D82_04830
GAIIMCC3135_30825
HAKKO116_00409
HCOLOKO_00393
HCAMI4484_01405
HSXHNO51_01270
HSVHNO53_01140
HTXEKK97_01530
KUSB9G99_06170
KMAB9H00_08960
PAURFGL86_03370
MARSA8C75_10585 A8C75_10600
OCEGU3_07685
ZDFAN401_07415
TSNW908_00585
THINCRN91_00800
UTELVJ83_12490
PSENH8B_1341
BVIBcep1808_7033
BCENDM39_6465
BPSLWS57_17245
BYIBYI23_C008510
BUEBRPE67_CCDS02700
BPHBphy_6284
BCAIK788_0002690
PHSC2L64_23065
PTERC2L65_24320
CABASBC2_54610
CDNBN940_07841
APETToN1_50180
AZAAZKH_p0039
AZIAzCIB_2141
ACOMCEW83_15360
AZDCDA09_08580
DDNDND132_1424
MAMOA6B35_32655
MESWA9K65_021920
HOEIMCC20628_00244
AMIHCO731_00744
ORMHTY61_00085
EAKEKH55_4032
SHZshn_25500
SOJK6301_19550
OAHDR92_4431
OCHCES85_3141
MMYRMXMO3_02428 MXMO3_03570
MEYTM49_10610
MMEDMame_02389
PPHRAPZ00_19930
LAPACP90_26620
LABRCHH27_21055
LABPFJ695_02520
LABTFIU93_04385
LAGGB0E33_10665
ACUTMRB58_05270
SILSPO3327
SITTM1040_2491
RUAD1823_06430
RUTFIU92_06605
JANJann_2612
RDERD1_0929(cln)
RLIRLO149_c001400
DSHDshi_2126
PGAPGA1_c29630
PGLPGA2_c27540
PGDGal_00468
PHPPhaeoP97_00541
PPICPhaeoP14_02733
PHQD1820_09500
OATOAN307_c09630
OAROA238_c34120
OTMOSB_23980
OCTFTO60_02795
LMDMETH_15315
LEJETW24_16930
LAQUR2C4_15410
REDroselon_01692
MALGMALG_03308
YANAYJ57_07135
TPROGa0080559_TMP2015
PABYGa0080574_TMP2148
SUAMBOO69_10895
SULZC1J03_21620
SULIC1J05_07180
SPOTG6548_02980
SMEDJNX03_01015 JNX03_15845
SPSESULPSESMR1_03417
TOMBWR18_15040
RMMROSMUCSMR3_01886 ROSMUCSMR3_02680
ROKRAK1035_0496 RAK1035_1299
RIDRIdsm_00352
ROMEI983_17195
ROHFIU89_00525
AHTANTHELSMS3_00845
SAGUCDO87_10985
THAACFI11_18345
OCDFHY55_04750
MARUFIU81_09290
ROTFIV09_17195
MALUKU6B_52850
TGLHFZ77_15505
HATRC74_16535
PALXGQA70_18695
RSPRSP_1752
RSHRsph17029_0398
RSQRsph17025_2498
RSKRSKD131_0051
CAZTLV780_11435
RCPRCAP_rcc00431(creA)
RHPLPB142_15105
RBLB6K69_08745
PDEPden_1018 Pden_1692 Pden_1738 Pden_3409
PAMIJCM7686_pAMI1p057
PYEA6J80_03015
PZHCX676_16335
PAROCUV01_13195
PAMNJCM7685_2117 pAMV3p0177
PARSDRW48_01200
PPANESD82_15440
PSANHGN31_07295
PTPRCA23_c24450
RSUNHU_03374
RHMB5V46_13935
RHCRGUI_0492
RMBK529_011925
DAAAKL17_3129
THWBMG03_09810
TECAKL02_009330
LVSLOKVESSMR4R_00345 LOKVESSMR4R_01079
RBGBG454_11820
GEHHYN69_00580 HYN69_00620 HYN69_04205
GFUKM031_06700
TAWEI545_09525
SALOEF888_19755
SEDIEBB79_00635
PPRUFDP22_19585
PAEDG5B38_14000
PSHQF3W81_16500
POZI0K15_13090
PALWPSAL_024750
PGVSL003B_2641
THASC6Y53_08965
GCEKYE46_03060
NSMJO391_12640
FAQG5B39_01290
TIIDY252_00035
PUBSAR11_0687(pepQ)
PEGE5R92_02635
APMHIMB5_00002710
APBSAR116_0762
PARHI5S86_12640 I5S86_18545
EACEAL2_808p07360(creA)
MMATMMAGJ_51430
CKPckrop_1220
CTERA606_03785
CFNCFAL_02435
CCYCSCMU_08960
ROPROP_15090
ROAPd630_LPD05992
RKOJWS14_09375
ARTArth_3728
ARRARUE_c39580
ARMART_1482
ARLAFL94_16215
AAQAOC05_01730 AOC05_01745
ARHAHiyo8_21830
ARYATC04_01700
ARZAUT26_18115
ARUASPU41_21240
ARQBWQ92_15530
ARXARZXY2_4271
ACRYAC20117_10945 AC20117_11645
ARTHC3B78_00905
ARTPE5206_00145 E5206_04485 E5206_09860
AAUAAur_3822
PUEFV140_19820
PNVJMY29_18515
ACHAchl_3303
APNAsphe3_02360
PSNINIBR502771_07965
PSEYGU243_17165
AAIAARI_27250
GCRGcLGCM259_2776 GcLGCM259_2912
GLUF0M17_13405
GPRJQN66_16545
KRHKRH_03000
KFVAS188_03515
KRSEQG70_01845 EQG70_16520
KVRCIB50_0000398
SATKSA2016_1118
CIGE7744_12835
PAEYKUF55_02960
BRVCFK39_04640
BRZCFK38_06515
DVADAD186_08130
DJJCOP05_06865
DNIHX89_12200
YIMJ5M86_00600
ORNDV701_04015
BLYA2T55_01300
BLUTEW640_04005
MPHMLP_20240
MMARMODMU_3069
SACEGIY23_15095
RXYRxyl_0461
 » show all
Reference
1  [PMID:14791411]
  Authors
ROCHE J, LACOMBE G, GIRARD H.
  Title
[On the specificity of certain bacterial deguanidases generating urea and on arginindihydrolase.]
  Journal
Biochim Biophys Acta 6:210-6 (1950)
DOI:10.1016/0006-3002(50)90093-x
Reference
2  [PMID:8443]
  Authors
Yoshimoto T, Oka I, Tsuru D.
  Title
Purification, crystallization, and some properties of creatine amidinohydrolase from Pseudomonas putida.
  Journal
J Biochem (Tokyo) 79:1381-3 (1976)
DOI:10.1093/oxfordjournals.jbchem.a131193
Other DBs
ExplorEnz - The Enzyme Database: 3.5.3.3
IUBMB Enzyme Nomenclature: 3.5.3.3
ExPASy - ENZYME nomenclature database: 3.5.3.3
BRENDA, the Enzyme Database: 3.5.3.3
CAS: 37340-58-2
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