KEGG   ENZYME: 3.5.4.37
Entry
EC 3.5.4.37                 Enzyme                                 
Name
double-stranded RNA adenine deaminase;
ADAR;
double-stranded RNA adenosine deaminase;
dsRAD;
dsRNA adenosine deaminase;
DRADA1;
double-stranded RNA-specific adenosine deaminase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
double-stranded RNA adenine aminohydrolase
Reaction(IUBMB)
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
Substrate
adenine in double-stranded RNA;
H2O [CPD:C00001]
Product
hypoxanthine in double-stranded RNA;
NH3 [CPD:C00014]
Comment
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity [4].
History
EC 3.5.4.37 created 2013
Orthology
K12968  double-stranded RNA-specific adenosine deaminase
Genes
HSA103(ADAR)
PTR457349(ADAR)
PPS100988581(ADAR)
GGO101134621(ADAR)
PON100457633(ADAR)
NLE100607902(ADAR)
MCC718759(ADAR)
MCF101926284(ADAR)
CSAB103223917(ADAR)
CATY105593498(ADAR)
PANU101026850(ADAR)
TGE112618205(ADAR)
RRO104663489(ADAR)
TFN117075904(ADAR)
PTEH111543727(ADAR)
CJC100386367(ADAR)
SBQ101031414(ADAR)
CSYR103250006(ADAR)
MMUR105873198(ADAR)
OGA100941374(ADAR)
MMU56417(Adar)
MCAL110291799(Adar)
MPAH110320021(Adar)
RNO81635(Adar)
MCOC116093186(Adar)
MUN110562048(Adar)
CGE100760578(Adar)
PLEU114707958(Adar)
NGI103751329(Adar)
HGL101722209(Adar)
CPOC100731315(Adar)
CCAN109688036(Adar)
DORD105984887(Adar)
DSP122109246(Adar)
NCAR124983355
OCU100346984(ADAR)
OPI101527981(ADAR)
TUP102485185(ADAR)
CFA100855668(ADAR)
VVP112918890(ADAR)
VLG121484976(ADAR)
AML100470274(ADAR)
UMR103668714(ADAR)
UAH113245303(ADAR)
UAR123783391(ADAR)
ELK111138988
LLV125086092
MPUF101675332(ADAR)
ORO101367365(ADAR)
EJU114198712(ADAR)
ZCA113932110(ADAR)
MLX118013854(ADAR)
FCA101084681(ADAR)
PYU121015666(ADAR)
PBG122476118(ADAR)
PPAD109256299(ADAR)
AJU106988378(ADAR)
HHV120221535(ADAR)
BTA505134(ADAR)
BOM102267031(ADAR)
BBUB102413801(ADAR)
CHX102172585(ADAR)
ODA120855758(ADAR)
CCAD122432929(ADAR)
SSC100523784(ADAR)
CFR102512737(ADAR)
CBAI105068180(ADAR)
CDK105089080(ADAR)
VPC102527263(ADAR)
BACU103018582(ADAR)
LVE103077270(ADAR)
OOR101278697(ADAR)
DLE111166955(ADAR)
PCAD102979811(ADAR)
PSIU116750910(ADAR)
ECB100056984(ADAR)
EPZ103555415(ADAR)
EAI106828524(ADAR)
MYB102242753(ADAR)
MYD102754391(ADAR)
MMYO118672760(ADAR)
MLF102433169(ADAR)
MNA107543857(ADAR)
PKL118721102(ADAR)
DRO112316695(ADAR)
SHON118990185(ADAR)
AJM119061768(ADAR)
PDIC114488810(ADAR)
PHAS123804313(ADAR)
MMF118637050(ADAR)
RFQ117014567(ADAR)
PGIG120592241(ADAR)
PVP105296385(ADAR)
RAY107504718(ADAR)
MJV108393907(ADAR)
TOD119237217(ADAR)
SARA101553112(ADAR)
TMU101360020
DNM101424153(ADAR)
MDO100020840(ADAR)
GAS123247778(ADAR)
SHR100925968(ADAR)
PCW110211972(ADAR)
OAA103167888(ADAR)
GGA769675(ADAR)
PCOC116237321(ADAR)
MGP100541796(ADAR)
CJO107324489(ADAR)
NMEL110391260(ADAR)
APLA101796198(ADAR)
ACYG106048529(ADAR)
AFUL116499616(ADAR)
TGU100220215(ADAR)
LSR110471526(ADAR)
SCAN103823962(ADAR)
PMOA120498974(ADAR)
OTC121332158(ADAR)
PRUF121352167(ADAR)
GFR102033970(ADAR)
FAB101806137(ADAR)
PHI102105960(ADAR)
PMAJ107214561(ADAR)
CCAE111939463(ADAR)
ETL114068438(ADAR)
ZAB102064605(ADAR)
FPG101910869(ADAR)
FCH102049629(ADAR)
CLV102086506(ADAR)
EGZ104127874(ADAR)
NNI104012041(ADAR)
ACUN113490858(ADAR)
TALA104365296(ADAR)
PADL103920515(ADAR)
ACHC115346426(ADAR)
AAM106483717(ADAR)
AROW112973224(ADAR)
NPD112955220(ADAR)
DNE112995108(ADAR)
ASN102377665(ADAR)
AMJ102575445(ADAR)
CPOO109324760(ADAR)
GGN109303498(ADAR)
PSS102449470(ADAR)
CMY102941128(ADAR)
CPIC101936755(ADAR)
TST117888546(ADAR)
CABI116830121(ADAR)
MRV120390168(ADAR)
ACS103281753
PVT110081003(ADAR)
SUND121915309(ADAR)
PBI103050667(ADAR)
PMUR107285169(ADAR)
TSR106546970(ADAR)
PGUT117657417(ADAR)
VKO123032540(ADAR)
PMUA114586089(ADAR)
ZVI118075835(ADAR)
GJA107117082(ADAR)
XLA394279(adar-a) 397992(adar.S)
XTR100493195(adar)
NPR108798342(ADAR)
RTEM120920674(ADAR)
BBUF120981415(ADAR)
BGAR122921756(ADAR)
DRE58119(adar)
SRX107714681 107723499
SANH107657642
SGH107582078
CCAR109069003
CAUA113059109 113116748
PPRM120484300(adar)
MAMB125242935(adar)
IPU108265537(adar)
PHYP113545404(adar)
SMEO124384211(adar)
TFD113646833(adar)
AMEX103023414(adar)
EEE113591712(adar)
TRU101073967(adar)
LCO104922500(adar)
NCC104958853(adar)
CGOB115020800(adar)
ELY117265724(adar)
PLEP121945375(adar)
SLUC116049564(adar)
ECRA117946697(adar)
PFLV114556855(adar)
GAT120810483(adar)
PPUG119197717(adar)
MSAM119897576(adar)
CUD121513229(adar)
ALAT119005863(adar)
MZE101475397(adar)
ONL100707103(adar)
OAU116315701(adar)
OLA101155879(adar)
OML112143394(adar)
XMA102217978(adar)
XCO114141750(adar)
XHE116717193(adar)
PRET103478179(adar)
PFOR103140790(adar)
PLAI106962090(adar)
PMEI106930146(adar)
GAF122830951(adar)
CVG107088416(adar)
CTUL119786711(adar)
GMU124866009(adar)
NFU107374479(adar)
KMR108241070(adar)
ALIM106517188(adar)
NWH119409734(adar) 119410066
AOCE111582754(adar)
CSEM103388211(adar)
POV109633429(adar)
SSEN122774816(adar)
HHIP117776470(adar)
LCF108885934(adar)
SDU111230122(adar)
SLAL111656978(adar)
XGL120784244(adar)
HCQ109521078(adar)
BPEC110162987
MALB109964118(adar)
BSPL114843501(adar)
SASA106605901(adar)
OTW112238065 112238838
OMY110520838(adar) 110534250
OGO123998210 124005167
ONE115124133
SALP112075075
SNH120042113 120048755
ELS105024448(adar)
SFM108925759(adar)
PKI111840888(adar)
AANG118224938(adar)
PSPA121306932(adar)
LCM102360746(ADAR)
RTP109912767(adar)
BBEL109468498
CIN100183336
SPU584058
PCLA123770612
RSAN119405262
RMP119180667
VJA111272658
SDM118189760
CELCELE_T20H4.4(adr-2)
CRG105330468 105341503
PMAX117334379
MMER123531101
NVE5508360
ATEN116286315
MISMICPUN_105848
 » show all
Reference
1  [PMID:8144588]
  Authors
Hough RF, Bass BL
  Title
Purification of the Xenopus laevis double-stranded RNA adenosine deaminase.
  Journal
J Biol Chem 269:9933-9 (1994)
Reference
2  [PMID:9614652]
  Authors
O'Connell MA, Gerber A, Keegan LP
  Title
Purification of native and recombinant double-stranded RNA-specific adenosine deaminases.
  Journal
Methods 15:51-62 (1998)
DOI:10.1006/meth.1998.0605
Reference
3  [PMID:11421361]
  Authors
Wong SK, Sato S, Lazinski DW
  Title
Substrate recognition by ADAR1 and ADAR2.
  Journal
RNA 7:846-58 (2001)
DOI:10.1017/s135583820101007x
Reference
4  [PMID:16141067]
  Authors
Macbeth MR, Schubert HL, Vandemark AP, Lingam AT, Hill CP, Bass BL
  Title
Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing.
  Journal
Science 309:1534-9 (2005)
DOI:10.1126/science.1113150
  Sequence
[hsa:104]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.37
IUBMB Enzyme Nomenclature: 3.5.4.37
ExPASy - ENZYME nomenclature database: 3.5.4.37
BRENDA, the Enzyme Database: 3.5.4.37
LinkDB

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