KEGG   ENZYME: 3.5.4.44
Entry
EC 3.5.4.44                 Enzyme                                 
Name
ectoine hydrolase;
doeA (gene name)
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amidines
Sysname
ectoine aminohydrolase
Reaction(IUBMB)
ectoine + H2O = (2S)-2-acetamido-4-aminobutanoate [RN:R09800]
Reaction(KEGG)
R09800
Substrate
ectoine [CPD:C06231];
H2O [CPD:C00001]
Product
(2S)-2-acetamido-4-aminobutanoate [CPD:C19929]
Comment
The enzyme, found in some halophilic bacteria, is involved in the degradation of the compatible solute ectoine. The enzyme, which belongs to peptidase family M24, only acts in the direction of ectoine hydrolysis. It also produces smaller amounts of (2S)-4-acetamido-2-aminobutanoate, which is recycled back to ectoine by EC 4.2.1.108, ectoine synthase.
History
EC 3.5.4.44 created 2017
Pathway
ec00260  Glycine, serine and threonine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K15783  ectoine hydrolase
Genes
CAMAF384_12935
IZHFEM41_17295(doeA)
SMAFD781_2283
SRZAXX16_2864
SERMCLM71_11810(doeA)
SRHZFO014_21980(doeA)
VAGN646_3801
VEXVEA_000632
VNAPN96_17665
VEJVEJY3_17226
VSCVSVS12_01930
VAFD1115_22165(doeA)
VNLD3H41_20745(doeA)
VKABTD91_20440
GHOAL542_02290(doeA)
SALYE8E00_14710(doeA)
SKSFCN78_14010(doeA)
SCOTHBA18_14650(doeA)
PAPPSPA7_4378(eutD)
PMKMDS_0056
PFUWKF707C_22180
PCQPcP3B5_00230
PMUIG4G71_02705(doeA)
PPUPP_4432
PPTPPS_0719
PPIYSA_00599
PPUHB479_04040
PPUDDW66_0726 DW66_1185
PFVPsefu_0029
PMONX969_02015
PMOTX970_02005
PPJRK21_04289
PCIPCH70_18590
PFEPSF113_4816
PMANOU5_4501
PCGAXG94_20235
PSTTCH92_00105
PBAPSEBR_a4653
PBCCD58_05095
PDRH681_00255
PALLUYA_00160
PUMHGP31_27400(doeA)
PLALFXN65_00110(doeA)
PSEJHNQ25_01235(doeA)
PKHJLK41_00140(doeA)
PTYJWV26_10520(doeA)
PMAOPMYSY11_0800(doeA)
PANHHU763_003780(doeA)
PALVKSS97_05930(doeA)
PZAHU749_024495(doeA)
PTAENCTC10697_00682(pepP_1)
GAIIMCC3135_07185(doeA_1) IMCC3135_09905(doeA_2)
CSACsal_2732
HELHELO_3665(doeA)
HCSFF32_01830
HAKKO116_01203
HAMHALO1223
HHUAR456_15085
HCOLOKO_00473
HSIBOX17_04125
HALOBWR19_14485
HHHCLM76_01780(doeA)
HBEBEI_2959(doeA)
HAGBB497_00065
HAFC8233_14545(doeA)
HALKCUU95_10305(doeA)
HVNEI420_15845(doeA)
HOLHORIV_52460
HSRHSBAA_50420
HMDCTT34_14385(doeA)
HAXIHAALTHF_21760n
HTTHZS52_10955(doeA)
HCAMI4484_15860(doeA)
HPIZGYM47_13615(doeA)
HSXHNO51_15785(doeA)
HSVHNO53_16355(doeA)
HTXEKK97_17870(doeA)
HAAA5892_06415
CMAIBFX80_03185
CAMHLCW13_14030(doeA)
KUSB9G99_10900
KMAB9H00_03900
KUYFY550_04105(doeA)
PAURFGL86_17275(doeA)
NIKF5I99_17985
OCEGU3_04560 GU3_08065 GU3_08085
OCMCBP12_08025
OPFCBP31_10115
ZDFAN401_02320 AN401_02345
TSNW908_02365
THINCRN91_07760
BVIBcep1808_5462
BCNBcen_5803
BCHBcen2424_6167
BCMBcenmc03_6648
BCJBCAS0027
BCENDM39_6671(eutD)
BCEWDM40_5477(eutD)
BCEOI35_7026
BAMBamb_6020
BACBamMC406_5776
BMJBMULJ_05387(pepQ)
BMUBmul_6143
BMKDM80_6599(eutD)
BMULNP80_5360(eutD)
BCEDDM42_6398(eutD)
BDLAK34_5360(eutD)
BDFWI26_29885
BLATWK25_18050
BTEIWS51_29690
BPSLWS57_18495
BUGBC1001_4311
BGFBC1003_5085
BYIBYI23_B003710
BUEBRPE67_BCDS06280
BUQAC233_27920
BXEBxe_C0063
BXBDR64_8362(eutD)
BPHBphy_3862
BGEBC1002_4838
BPXBUPH_00896
BFNOI25_3926(eutD)
BCAIK788_0000262
PSPWBJG93_22495(doeA)
PARABTO02_06320 BTO02_27255
PTERC2L65_27875(doeA)
PGPCUJ91_28295(doeA)
PTSCUJ90_21845(doeA)
PEWKZJ38_29855(doeA)
CABASBC2_38090(doeA)
BUOBRPE64_BCDS09550
BOHAKI39_12960
PIGEGT29_03410
VEIVeis_2149
APETToN1_21090(doeA1) ToN1_21100(doeA2)
ACOMCEW83_01835(doeA) CEW83_01840(doeA)
ANTArnit_1221
AHSAHALO_1645(doeA)
AMARAMRN_1667(doeA)
ACAAACAN_1695(doeA)
DMSE8L03_14000(doeA)
DWDDSCW_13820 DSCW_13910
DALKDSCA_33490 DSCA_33560
MLOmlr7141
MLNA9174_24825 A9174_29925 A9174_31385 A9174_32045
MCIMesci_2507 Mesci_4400
MOPMesop_4848 Mesop_5921
MAMMesau_05393
MAMOA6B35_17580 A6B35_24255
MESWA9K65_013110 A9K65_024320 A9K65_031015 A9K65_031170
MESMEJ066_12525 EJ066_28925(doeA)
MESPC1M53_04395(doeA)
MHUAMCHK_0652(doeA) MCHK_1813
MJREB229_24905 EB229_30510(doeA) EB229_32010(doeA) EB229_32765
MERDEB233_21625 EB233_26610(doeA) EB233_30455 EB233_30520
MESRFGU64_08280(doeA)
MESOBSQ44_02090
HOEIMCC20628_03272
RPODE0E05_14125(doeA)
NIYFQ775_21085(doeA)
NKIKW403_16725(doeA)
ORMHTY61_13210(doeA)
KMNHW532_10920(doeA) HW532_14360
SMESM_b20434(eutD)
SMKSinme_3746
SMQSinmeB_4242
SMXSM11_pD1188(eutD)
SMIBN406_06240
SMEGC770_GR4pD1177
SMELSM2011_b20434(eutD)
SMERDU99_31140
SMDSmed_3693
RHINGR_a01460 NGR_a01470 NGR_b23250
SFHSFHH103_04917
SFDUSDA257_c31390
SIXBSY16_5544(eutD)
SAMESAMCFNEI73_pB0212 SAMCFNEI73_pB0218 SAMCFNEI73_pC1835
SINOSS05631_b62080
EADOV14_b1416
EAHFA04_31170
ESJSJ05684_b43240
EAKEKH55_4170
EMXFKV68_23470 FKV68_31040(doeA) FKV68_31080 FKV68_31715(doeA)
ATUAtu4757
ATAAWN88_05985
AGRAGROH133_09405
ATFAch5_44890(doeA)
AROB0909_16545(doeA)
AGTEYD00_19140(doeA)
RETRHE_PF00180
RECRHECIAT_PC0000374
RELREMIM1_PC00109 REMIM1_PC00118(eutD-1) REMIM1_PC00148(eutD-2) REMIM1_PC00149 REMIM1_PE00247 REMIM1_PF00736(eutD-3)
REPIE4803_PC00199(eutD)
REIIE4771_PB00253 IE4771_PD00200(eutD)
RLEpRL120054
RLTRleg2_5521
RLGRleg_5242
RLBRLEG3_09340
RLURLEG12_04775
RTRRTCIAT899_PB01870 RTCIAT899_PB01900 RTCIAT899_PC08140(eutD)
RIRBN877_II1096
RPUSCFBP5875_19350(doeA)
RHLLPU83_pLPU83d1324
RGARGR602_PC02175(eutD)
RHNAMJ98_PE00274(eutD)
RPHAAMC79_PD00407(eutD)
RHXAMK02_PD00140(eutD)
RHVBA939_21235
RHKKim5_PC00184(eutD)
REZAMJ99_PD00274(eutD)
RJGCCGE525_32200(doeA)
RHRCKA34_29665(doeA)
RADCO657_24830 CO657_26065(doeA)
ROYG3A56_16940(doeA)
RHIDFFM81_023130(doeA)
RBQJ2J99_22090(doeA) J2J99_30815 J2J99_30825 J2J99_30865 J2J99_31785 J2J99_31800
RLNJ0663_22890(doeA)
RBANJ2J98_21075(doeA) J2J98_26260 J2J98_26275
RRGJ3P73_24735(doeA) J3P73_35965
NGLRG1141_PA13040(eutD)
NGGRG540_PA14020(eutD)
NEOCYG48_20840(doeA)
RHTNT26_3906
RFVRFYW14_03940
SHZshn_23130 shn_29350
SOJK6301_18985(doeA)
ABAWD5400_05160
BRJBKD03_11990
OINIAR37_18905(doeA)
BIOBR141012304_10758
OANOant_3467
OAHDR92_3019(eutD)
OPSA8A54_16015
OCHCES85_4623(eutD)
OCRHGK82_19825(doeA)
OCLGTN27_18040(doeA)
BRCBCCGELA001_29725
BICLMTR13_25345 LMTR13_25690 LMTR13_25715 LMTR13_25880 LMTR13_25960
BARHWN72_09825
BVVBHK69_14645 BHK69_30100 BHK69_30125
BOIBLM15_05205
BOFFQV39_24130
LNEFZC33_33975(doeA)
APOLK9D25_11765(doeA)
MOCBB934_24610
MIVC4E04_10105(doeA)
CHELAL346_21850
CDQBOQ54_17555
PHLKKY_228
DEAFPZ08_18115(doeA)
MMYRMXMO3_03371
HDIHDIA_2075
MEYTM49_08170
MAADAZF01_00750
MMEDMame_00077 Mame_02830(pepQ_3)
MLUTJET14_01955
AALAIGS74_01715(doeA) IGS74_03140
AALMLUX29_03025(doeA)
BRND1F64_10805(doeA)
NOHG5V57_08425 G5V57_30425
RBMTEF_15100
LAPACP90_14950
LABRCHH27_05510(doeA)
LABPFJ695_10260(doeA)
LABTFIU93_20645(pepQ2)
LAGGB0E33_26780
SIWGH266_08155(doeA)
ACUTMRB58_12640(doeA)
SILSPO1140(doeA)
SITTM1040_1921
RUAD1823_06465
RUTFIU92_06570
JANJann_0850
RDERD1_3474
RLIRLO149_c026710(eutD)
RPONG3256_07570
PGAPGA1_c07820
PGLPGA2_c07600
PGDGal_02709
PHPPhaeoP97_02538
PPICPhaeoP14_00703
PHQD1820_16985
OATOAN307_c10570(eutD)
OAROA238_c05420(eutD1) OA238_c23670(eutD2)
OTMOSB_17100
OCTFTO60_07550
LMDMETH_14375
LEJETW24_15270(doeA)
LAQUR2C4_20340(doeA)
REDroselon_00427
CIDP73_1149
MALGMALG_03274
CONTQ29_09645
YPACCEW88_15400(doeA)
YANAYJ57_18830
TPROGa0080559_TMP1087 Ga0080559_TMP3721
PABYGa0080574_TMP3094
SUAMBOO69_15095
SULZC1J03_19360
SULIC1J05_07235(doeA)
SULDB5M07_16365
SPOTG6548_05620(doeA)
SMEDJNX03_02425(doeA)
SINLDSM14862_03215(doeA)
SPSESULPSESMR1_03271(doeA)
TOMBWR18_17445
RMMROSMUCSMR3_02212(doeA)
ROKRAK1035_0974
RIDRIdsm_05126
ROMEI983_17935
ROHFIU89_20095
AHTANTHELSMS3_04452(doeA)
SAGUCDO87_04685
OCDFHY55_15520
MARUFIU81_12470
ROTFIV09_16800
MALUKU6B_39230
TGLHFZ77_11085
HATRC74_00115 RC74_18035
PALXGQA70_01790(doeA)
RSQRsph17025_3177
CAZTLV780_15620(doeA)
PDEPden_0287
PYEA6J80_21895(doeA)
PZHCX676_02845(doeA)
PAROCUV01_01765(doeA)
PARSDRW48_07115(doeA)
PARREOJ32_08975(doeA)
PKDF8A10_17635(doeA)
PLIAE4191_06420(doeA)
PSANHGN31_00605(doeA)
PMAUCP157_01850(doeA)
PTPRCA23_c24340
RSUNHU_01997(eutD)
RHMB5V46_09455
RHCRGUI_3313
RMBK529_004490
DAAAKL17_0186
DONBSK21_06450
THWBMG03_16185
TECAKL02_015690
LVSLOKVESSMR4R_00538(doeA)
RBGBG454_09340
SALOEF888_15660
SEDIEBB79_11115 EBB79_14100
HMLHmaOT1_18505(doeA)
LITFPZ52_11025(doeA)
PPRUFDP22_11890
PAEDG5B38_12865
MONG8E03_07580(doeA)
PSHQF3W81_04280
PALWPSAL_009750(doeA)
PPAFI8N54_09435
PGVSL003B_2647
RBZB9057_07075
THASC6Y53_13270
HDHG5B40_08315(doeA)
CMAGCBW24_12515
GCEKYE46_04390
FAQG5B39_06375(doeA)
PALGHFP57_02005
SHUMSTHU_07270
ATIAL072_17685
HTQFRZ44_00880 FRZ44_08400 FRZ44_35360
HADHFRZ61_08310
TXITH3_02590
THACCSC3H3_02845(doeA)
TIIDY252_18730(doeA)
PUBSAR11_1338(y4tM)
PEGE5R92_06560
APMHIMB5_00009770
SNEANBZ79_05525(doeA)
GSTHW35_17680 HW35_17715
BFDNCTC4823_03387 NCTC4823_03388(pepQ_2) NCTC4823_03395(pepQ_3)
BCOBcell_3360
BMEGBG04_5939
PARHI5S86_22750(doeA)
BCLABC0020
BLEBleG1_4014
BKWBkAM31D_11445
BONA361_15545
OCNCUC15_04445
GTNGTNG_2272 GTNG_2288
HHDHBHAL_4917
HMNHM131_02830
HLIHLI_13335
VIRX953_14790
VHLBME96_14130
VILCFK37_11340
VNECFK40_15750
VIMGWK91_09505 GWK91_12205
LAOAOX59_17770
SJEAAV35_007875
AQTFN924_17770
GRCGI584_02830
RUEDT065_02165 DT065_13450
SALEEPH95_01510 EPH95_13645
MSEMGMB29_22080
SEDDERJ70_06570 ERJ70_18310
BBEVBBEV_1548(pepP)
STEAC0679_03045
SHVAAT16_02010
PBJVN24_22255
PRTAUC31_05560
PANABBH88_16750
PDGBCM40_12125
PHCBBI08_16660
PMARB0X71_04260
PPLABBI15_00160
PLXCW734_05910
PMATBBI11_05385
PDECH1Q58_04530
PANCE2636_15860
KPULGXN76_11640
KEBGXN75_13265
CACECACET_c38080
CFMBJL90_04765
AMTAmet_1194
GFEGferi_03360 Gferi_03415
DMIDesmer_3359
FWADCMF_21820
ACAEHYG86_07860
HPKHprae_0064
MGOAFA91_27080
MBAIMB901379_01124
MSMMSMEG_2494
MSGMSMEI_2434
MSBLJ00_12415
MSNLI99_12415
MSHLI98_12420
CCYCSCMU_37550
NNONONO_c26800
RHBNY08_428
RFAA3L23_03751(doeA)
RHSA3Q41_04489(doeA)
GBRGbro_4077
GPOGPOL_c44040
GORKTR9_4008
GTABCM27_21060
GRUGCWB2_20415
GOMD7316_04409(doeA)
GAVC5O27_07690
GODGKZ92_19335
GJIH1R19_01230 H1R19_19420
GOILK459_13210
GHNMVF96_19905
SMALSMALA_8299
AARCG127AT_06580
AGGC1N71_08255
PSEVUSB125703_01939(doeA)
GSDM3M28_10520
ACRYAC20117_04245
GLUF0M17_16010
KPLKPaMU14_00695
KFVAS188_01275
KRSEQG70_03255
KODHBK84_10630
LMOIVV02_11300
ARSADJ73_04465
SERJSGUI_0402
ORNDV701_10760
ORZFNH13_14110
BLYA2T55_10320
BLINBLSMQ_2278
BCAUI6G59_13850
GYUFE374_14490
PBOPACID_31230
AACIASQ49_06565
AJIC0Z10_01005
MIKFOE78_15800
MICGGJV80_09825
NROK8W59_04940
SSMSpirs_0573
IPOIlyop_0097
HDLHALDL1_11275
HJEHacjB3_03825
HGIABY42_16910
HALEG3A49_07505
HLAHlac_1051
HALQHrr1229_000995
SRUBC2R22_00565
HALGHUG10_11110
HALUHUG12_01630
HACBHbl1158_16060
HAHHalar_1735
HTUHtur_2943
HDABB347_08890
HJTDVR14_13195
HSALJMJ58_13720
HLOJ0X27_13500
HAKZJ0X25_01335
NMGNmag_3760
HXAHalxa_0592
NPENatpe_0777
NVRFEJ81_04025
NAYHYG81_06970
HALYHYG82_09925
NOUNatoc_1848
HLRHALLA_02180
NAGAArcMg_2880
NANAArc1_0822
NBGDV706_10725
NASGCU68_01335
 » show all
Reference
1  [PMID:20849449]
  Authors
Schwibbert K, Marin-Sanguino A, Bagyan I, Heidrich G, Lentzen G, Seitz H, Rampp M, Schuster SC, Klenk HP, Pfeiffer F, Oesterhelt D, Kunte HJ
  Title
A blueprint of ectoine metabolism from the genome of the industrial producer Halomonas elongata DSM 2581 T.
  Journal
Environ Microbiol 13:1973-94 (2011)
DOI:10.1111/j.1462-2920.2010.02336.x
  Sequence
[hel:HELO_3665]
Other DBs
ExplorEnz - The Enzyme Database: 3.5.4.44
IUBMB Enzyme Nomenclature: 3.5.4.44
ExPASy - ENZYME nomenclature database: 3.5.4.44
BRENDA, the Enzyme Database: 3.5.4.44
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