KEGG ENZYME: 3.5.99.11

ENZYME: 3.5.99.11

Entry

EC 3.5.99.11                Enzyme

Name

2-aminomuconate deaminase (2-hydroxymuconate-forming);
cnbZ (gene name)

Class

Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In other compounds

Sysname

2-aminomuconate aminohydrolase [(2Z,4E)-2-hydroxyhexa-2,4-dienedioate-forming]

Reaction(IUBMB)

2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3

Reaction(KEGG)

(other) R11532

Substrate

2-aminomuconate [CPD:C02220];
H2O [CPD:C00001]

Product

(2Z,4E)-2-hydroxyhexa-2,4-dienedioate;
NH3 [CPD:C00014]

Comment

The enzyme, characterized from the bacterium Comamonas testosteroni CNB-1, converts 2-aminomuconate to 2-hydroxyhexa-2,4-dienedioate, unlike the enzymes from Pseudomonas, which produce (3E)-2-oxohex-3-enedioate (see EC 3.5.99.5, 2-aminomuconate deaminase). The enzyme also acts on 2-amino-5-chloromuconate.

History

EC 3.5.99.11 created 2016 as EC 3.5.1.120, transferred 2017 to EC 3.5.99.11

Orthology

K20931

2-aminomuconate deaminase (2-hydroxymuconate-forming)

Reference

1 [PMID:17259310]

Authors

Liu L, Wu JF, Ma YF, Wang SY, Zhao GP, Liu SJ

Title

A novel deaminase involved in chloronitrobenzene and nitrobenzene degradation with Comamonas sp. strain CNB-1.

Journal